Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostaglandin G/H synthase 2 (Homo sapiens (Human)) | BDBM50266017 (5-(3,5-di-tert-butyl-4-hydroxyphenyl)-3H-1,2-dithi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute Curated by ChEMBL | Assay Description Inhibition of human recombinant COX2 expressed in Sf21 cells assessed as effect on prostaglandin E2 production by ELISA | Bioorg Med Chem Lett 19: 459-61 (2008) Article DOI: 10.1016/j.bmcl.2008.11.045 BindingDB Entry DOI: 10.7270/Q2QZ29T1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Homo sapiens (Human)) | BDBM17638 (2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute Curated by ChEMBL | Assay Description Inhibition of human platelet COX1 assessed as effect on prostaglandin E2 production by ELISA | Bioorg Med Chem Lett 19: 459-61 (2008) Article DOI: 10.1016/j.bmcl.2008.11.045 BindingDB Entry DOI: 10.7270/Q2QZ29T1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 2 (Homo sapiens (Human)) | BDBM50266016 (5-(3,5-di-tert-butyl-4-methoxyphenyl)-3H-1,2-dithi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute Curated by ChEMBL | Assay Description Inhibition of human recombinant COX2 expressed in Sf21 cells assessed as effect on prostaglandin E2 production by ELISA | Bioorg Med Chem Lett 19: 459-61 (2008) Article DOI: 10.1016/j.bmcl.2008.11.045 BindingDB Entry DOI: 10.7270/Q2QZ29T1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 2 (Homo sapiens (Human)) | BDBM22369 (4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute Curated by ChEMBL | Assay Description Inhibition of human recombinant COX2 expressed in Sf21 cells assessed as effect on prostaglandin E2 production by ELISA | Bioorg Med Chem Lett 19: 459-61 (2008) Article DOI: 10.1016/j.bmcl.2008.11.045 BindingDB Entry DOI: 10.7270/Q2QZ29T1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Prostaglandin G/H synthase 1 (Homo sapiens (Human)) | BDBM50266017 (5-(3,5-di-tert-butyl-4-hydroxyphenyl)-3H-1,2-dithi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute Curated by ChEMBL | Assay Description Inhibition of human platelet COX1 assessed as effect on prostaglandin E2 production by ELISA | Bioorg Med Chem Lett 19: 459-61 (2008) Article DOI: 10.1016/j.bmcl.2008.11.045 BindingDB Entry DOI: 10.7270/Q2QZ29T1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Homo sapiens (Human)) | BDBM50266016 (5-(3,5-di-tert-butyl-4-methoxyphenyl)-3H-1,2-dithi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute Curated by ChEMBL | Assay Description Inhibition of human platelet COX1 assessed as effect on prostaglandin E2 production by ELISA | Bioorg Med Chem Lett 19: 459-61 (2008) Article DOI: 10.1016/j.bmcl.2008.11.045 BindingDB Entry DOI: 10.7270/Q2QZ29T1 | |||||||||||
More data for this Ligand-Target Pair |