Found 33 hits Enz. Inhib. hit(s) with all data for entry = 50016751 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM50173155
(4-(2,3,5,6-Tetrafluoro-3'-trifluoromethoxy-bipheny...)Show SMILES OC(=O)C1=C(CSC1)C(=O)Nc1c(F)c(F)c(c(F)c1F)-c1cccc(OC(F)(F)F)c1 |t:3| Show InChI InChI=1S/C19H10F7NO4S/c20-12-11(7-2-1-3-8(4-7)31-19(24,25)26)13(21)15(23)16(14(12)22)27-17(28)9-5-32-6-10(9)18(29)30/h1-4H,5-6H2,(H,27,28)(H,29,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM15344
(2-({2,3,5,6-tetrafluoro-4-[3-(trifluoromethoxy)phe...)Show SMILES OC(=O)C1=C(CCC1)C(=O)Nc1c(F)c(F)c(c(F)c1F)-c1cccc(OC(F)(F)F)c1 |t:3| Show InChI InChI=1S/C20H12F7NO4/c21-13-12(8-3-1-4-9(7-8)32-20(25,26)27)14(22)16(24)17(15(13)23)28-18(29)10-5-2-6-11(10)19(30)31/h1,3-4,7H,2,5-6H2,(H,28,29)(H,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Rattus norvegicus (rat)) | BDBM14712
((2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)pheny...)Show InChI InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,10H,1H3,(H,17,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibitory activity against rat dihydroorotate dehydrogenase |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM50173152
(2-(3,5-Difluoro-3'-methoxy-biphenyl-4-ylcarbamoyl)...)Show SMILES COc1cccc(c1)-c1cc(F)c(NC(=O)C2=C(CCC2)C(O)=O)c(F)c1 |t:17| Show InChI InChI=1S/C20H17F2NO4/c1-27-13-5-2-4-11(8-13)12-9-16(21)18(17(22)10-12)23-19(24)14-6-3-7-15(14)20(25)26/h2,4-5,8-10H,3,6-7H2,1H3,(H,23,24)(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM50173145
(2-[3-Chloro-4-(2-chloro-6-fluoro-benzyloxy)-phenyl...)Show SMILES OC(=O)C1=C(CCC1)C(=O)Nc1ccc(OCc2c(F)cccc2Cl)c(Cl)c1 |t:3| Show InChI InChI=1S/C20H16Cl2FNO4/c21-15-5-2-6-17(23)14(15)10-28-18-8-7-11(9-16(18)22)24-19(25)12-3-1-4-13(12)20(26)27/h2,5-9H,1,3-4,10H2,(H,24,25)(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM50173151
(4-(3,5-Difluoro-3'-trifluoromethoxy-biphenyl-4-ylc...)Show SMILES OC(=O)C1=C(CSC1)C(=O)Nc1c(F)cc(cc1F)-c1cccc(OC(F)(F)F)c1 |t:3| Show InChI InChI=1S/C19H12F5NO4S/c20-14-5-10(9-2-1-3-11(4-9)29-19(22,23)24)6-15(21)16(14)25-17(26)12-7-30-8-13(12)18(27)28/h1-6H,7-8H2,(H,25,26)(H,27,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM15343
(2-({2,6-difluoro-4-[3-(trifluoromethoxy)phenyl]phe...)Show SMILES OC(=O)C1=C(CCC1)C(=O)Nc1c(F)cc(cc1F)-c1cccc(OC(F)(F)F)c1 |t:3| Show InChI InChI=1S/C20H14F5NO4/c21-15-8-11(10-3-1-4-12(7-10)30-20(23,24)25)9-16(22)17(15)26-18(27)13-5-2-6-14(13)19(28)29/h1,3-4,7-9H,2,5-6H2,(H,26,27)(H,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM50173144
(4-[3-Chloro-4-(2-chloro-6-fluoro-benzyloxy)-phenyl...)Show SMILES OC(=O)C1=C(COC1)C(=O)Nc1ccc(OCc2c(F)cccc2Cl)c(Cl)c1 |t:3| Show InChI InChI=1S/C19H14Cl2FNO5/c20-14-2-1-3-16(22)13(14)9-28-17-5-4-10(6-15(17)21)23-18(24)11-7-27-8-12(11)19(25)26/h1-6H,7-9H2,(H,23,24)(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM50173159
(4-(2,3,5,6-Tetrafluoro-3'-trifluoromethoxy-bipheny...)Show SMILES OC(=O)C1=C(COC1)C(=O)Nc1c(F)c(F)c(c(F)c1F)-c1cccc(OC(F)(F)F)c1 |t:3| Show InChI InChI=1S/C19H10F7NO5/c20-12-11(7-2-1-3-8(4-7)32-19(24,25)26)13(21)15(23)16(14(12)22)27-17(28)9-5-31-6-10(9)18(29)30/h1-4H,5-6H2,(H,27,28)(H,29,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Rattus norvegicus (rat)) | BDBM15344
(2-({2,3,5,6-tetrafluoro-4-[3-(trifluoromethoxy)phe...)Show SMILES OC(=O)C1=C(CCC1)C(=O)Nc1c(F)c(F)c(c(F)c1F)-c1cccc(OC(F)(F)F)c1 |t:3| Show InChI InChI=1S/C20H12F7NO4/c21-13-12(8-3-1-4-9(7-8)32-20(25,26)27)14(22)16(24)17(15(13)23)28-18(29)10-5-2-6-11(10)19(30)31/h1,3-4,7H,2,5-6H2,(H,28,29)(H,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibitory activity against rat dihydroorotate dehydrogenase |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM50173148
(4-[3,5-Dibromo-4-(2-chloro-6-fluoro-benzyloxy)-phe...)Show SMILES OC(=O)C1=C(CSC1)C(=O)Nc1cc(Br)c(OCc2c(F)cccc2Cl)c(Br)c1 |t:3| Show InChI InChI=1S/C19H13Br2ClFNO4S/c20-13-4-9(24-18(25)11-7-29-8-12(11)19(26)27)5-14(21)17(13)28-6-10-15(22)2-1-3-16(10)23/h1-5H,6-8H2,(H,24,25)(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 105 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM50173158
(2-[3,5-Dibromo-4-(2-chloro-6-fluoro-benzyloxy)-phe...)Show SMILES OC(=O)C1=C(CCC1)C(=O)Nc1cc(Br)c(OCc2c(F)cccc2Cl)c(Br)c1 |t:3| Show InChI InChI=1S/C20H15Br2ClFNO4/c21-14-7-10(25-19(26)11-3-1-4-12(11)20(27)28)8-15(22)18(14)29-9-13-16(23)5-2-6-17(13)24/h2,5-8H,1,3-4,9H2,(H,25,26)(H,27,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM50173161
(2-(4-Benzyloxy-3,5-dibromo-phenylcarbamoyl)-cyclop...)Show SMILES OC(=O)C1=C(CCC1)C(=O)Nc1cc(Br)c(OCc2ccccc2)c(Br)c1 |t:3| Show InChI InChI=1S/C20H17Br2NO4/c21-16-9-13(23-19(24)14-7-4-8-15(14)20(25)26)10-17(22)18(16)27-11-12-5-2-1-3-6-12/h1-3,5-6,9-10H,4,7-8,11H2,(H,23,24)(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 127 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM50173149
(4-(3-Fluoro-3'-methoxy-biphenyl-4-ylcarbamoyl)-2,5...)Show SMILES COc1cccc(c1)-c1ccc(NC(=O)C2=C(CSC2)C(O)=O)c(F)c1 |t:16| Show InChI InChI=1S/C19H16FNO4S/c1-25-13-4-2-3-11(7-13)12-5-6-17(16(20)8-12)21-18(22)14-9-26-10-15(14)19(23)24/h2-8H,9-10H2,1H3,(H,21,22)(H,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 131 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM16111
(2-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}c...)Show SMILES COc1cccc(c1)-c1ccc(NC(=O)C2=C(CCC2)C(O)=O)c(F)c1 |t:16| Show InChI InChI=1S/C20H18FNO4/c1-26-14-5-2-4-12(10-14)13-8-9-18(17(21)11-13)22-19(23)15-6-3-7-16(15)20(24)25/h2,4-5,8-11H,3,6-7H2,1H3,(H,22,23)(H,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 134 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Mus musculus) | BDBM14712
((2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)pheny...)Show InChI InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,10H,1H3,(H,17,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 156 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibitory activity against mouse dihydroorotate dehydrogenase |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM50173146
(4-(4-Benzyloxy-3,5-dibromo-phenylcarbamoyl)-2,5-di...)Show SMILES OC(=O)C1=C(CSC1)C(=O)Nc1cc(Br)c(OCc2ccccc2)c(Br)c1 |t:3| Show InChI InChI=1S/C19H15Br2NO4S/c20-15-6-12(22-18(23)13-9-27-10-14(13)19(24)25)7-16(21)17(15)26-8-11-4-2-1-3-5-11/h1-7H,8-10H2,(H,22,23)(H,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 173 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM50173160
(4-(3,5-Difluoro-3'-trifluoromethoxy-biphenyl-4-ylc...)Show SMILES OC(=O)C1=C(COC1)C(=O)Nc1c(F)cc(cc1F)-c1cccc(OC(F)(F)F)c1 |t:3| Show InChI InChI=1S/C19H12F5NO5/c20-14-5-10(9-2-1-3-11(4-9)30-19(22,23)24)6-15(21)16(14)25-17(26)12-7-29-8-13(12)18(27)28/h1-6H,7-8H2,(H,25,26)(H,27,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 205 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM50173156
(4-(3-Fluoro-3'-methoxy-biphenyl-4-ylcarbamoyl)-2,5...)Show SMILES COc1cccc(c1)-c1ccc(NC(=O)C2=C(COC2)C(O)=O)c(F)c1 |t:16| Show InChI InChI=1S/C19H16FNO5/c1-25-13-4-2-3-11(7-13)12-5-6-17(16(20)8-12)21-18(22)14-9-26-10-15(14)19(23)24/h2-8H,9-10H2,1H3,(H,21,22)(H,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM16109
(2-[(4-phenylphenyl)carbamoyl]cyclopent-1-ene-1-car...)Show SMILES OC(=O)C1=C(CCC1)C(=O)Nc1ccc(cc1)-c1ccccc1 |t:3| Show InChI InChI=1S/C19H17NO3/c21-18(16-7-4-8-17(16)19(22)23)20-15-11-9-14(10-12-15)13-5-2-1-3-6-13/h1-3,5-6,9-12H,4,7-8H2,(H,20,21)(H,22,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM14712
((2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)pheny...)Show InChI InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,10H,1H3,(H,17,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Mus musculus) | BDBM15344
(2-({2,3,5,6-tetrafluoro-4-[3-(trifluoromethoxy)phe...)Show SMILES OC(=O)C1=C(CCC1)C(=O)Nc1c(F)c(F)c(c(F)c1F)-c1cccc(OC(F)(F)F)c1 |t:3| Show InChI InChI=1S/C20H12F7NO4/c21-13-12(8-3-1-4-9(7-8)32-20(25,26)27)14(22)16(24)17(15(13)23)28-18(29)10-5-2-6-11(10)19(30)31/h1,3-4,7H,2,5-6H2,(H,28,29)(H,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 422 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibitory activity against mouse dihydroorotate dehydrogenase |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Rattus norvegicus (rat)) | BDBM15343
(2-({2,6-difluoro-4-[3-(trifluoromethoxy)phenyl]phe...)Show SMILES OC(=O)C1=C(CCC1)C(=O)Nc1c(F)cc(cc1F)-c1cccc(OC(F)(F)F)c1 |t:3| Show InChI InChI=1S/C20H14F5NO4/c21-15-8-11(10-3-1-4-12(7-10)30-20(23,24)25)9-16(22)17(15)26-18(27)13-5-2-6-14(13)19(28)29/h1,3-4,7-9H,2,5-6H2,(H,26,27)(H,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 504 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibitory activity against rat dihydroorotate dehydrogenase |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM50173157
(4-(Biphenyl-4-ylcarbamoyl)-2,5-dihydro-thiophene-3...)Show SMILES OC(=O)C1=C(CSC1)C(=O)Nc1ccc(cc1)-c1ccccc1 |t:3| Show InChI InChI=1S/C18H15NO3S/c20-17(15-10-23-11-16(15)18(21)22)19-14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,19,20)(H,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 667 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM50173153
(2-(3-Fluoro-3'-methoxy-biphenyl-4-ylcarbamoyl)-5-h...)Show SMILES COc1cccc(c1)-c1ccc(NC(=O)C2=C(C(O)CC2)C(O)=O)c(F)c1 |t:16| Show InChI InChI=1S/C20H18FNO5/c1-27-13-4-2-3-11(9-13)12-5-7-16(15(21)10-12)22-19(24)14-6-8-17(23)18(14)20(25)26/h2-5,7,9-10,17,23H,6,8H2,1H3,(H,22,24)(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 680 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Rattus norvegicus (rat)) | BDBM50173144
(4-[3-Chloro-4-(2-chloro-6-fluoro-benzyloxy)-phenyl...)Show SMILES OC(=O)C1=C(COC1)C(=O)Nc1ccc(OCc2c(F)cccc2Cl)c(Cl)c1 |t:3| Show InChI InChI=1S/C19H14Cl2FNO5/c20-14-2-1-3-16(22)13(14)9-28-17-5-4-10(6-15(17)21)23-18(24)11-7-27-8-12(11)19(25)26/h1-6H,7-9H2,(H,23,24)(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibitory activity against rat dihydroorotate dehydrogenase |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM50173147
(2-(3-Fluoro-3'-methoxy-biphenyl-4-ylcarbamoyl)-3-h...)Show SMILES COc1cccc(c1)-c1ccc(NC(=O)C2=C(CCC2O)C(O)=O)c(F)c1 |t:16| Show InChI InChI=1S/C20H18FNO5/c1-27-13-4-2-3-11(9-13)12-5-7-16(15(21)10-12)22-19(24)18-14(20(25)26)6-8-17(18)23/h2-5,7,9-10,17,23H,6,8H2,1H3,(H,22,24)(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Rattus norvegicus (rat)) | BDBM16109
(2-[(4-phenylphenyl)carbamoyl]cyclopent-1-ene-1-car...)Show SMILES OC(=O)C1=C(CCC1)C(=O)Nc1ccc(cc1)-c1ccccc1 |t:3| Show InChI InChI=1S/C19H17NO3/c21-18(16-7-4-8-17(16)19(22)23)20-15-11-9-14(10-12-15)13-5-2-1-3-6-13/h1-3,5-6,9-12H,4,7-8H2,(H,20,21)(H,22,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibitory activity against rat dihydroorotate dehydrogenase |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Mus musculus) | BDBM50173144
(4-[3-Chloro-4-(2-chloro-6-fluoro-benzyloxy)-phenyl...)Show SMILES OC(=O)C1=C(COC1)C(=O)Nc1ccc(OCc2c(F)cccc2Cl)c(Cl)c1 |t:3| Show InChI InChI=1S/C19H14Cl2FNO5/c20-14-2-1-3-16(22)13(14)9-28-17-5-4-10(6-15(17)21)23-18(24)11-7-27-8-12(11)19(25)26/h1-6H,7-9H2,(H,23,24)(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibitory activity against mouse dihydroorotate dehydrogenase |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Mus musculus) | BDBM15343
(2-({2,6-difluoro-4-[3-(trifluoromethoxy)phenyl]phe...)Show SMILES OC(=O)C1=C(CCC1)C(=O)Nc1c(F)cc(cc1F)-c1cccc(OC(F)(F)F)c1 |t:3| Show InChI InChI=1S/C20H14F5NO4/c21-15-8-11(10-3-1-4-12(7-10)30-20(23,24)25)9-16(22)17(15)26-18(27)13-5-2-6-14(13)19(28)29/h1,3-4,7-9H,2,5-6H2,(H,26,27)(H,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibitory activity against mouse dihydroorotate dehydrogenase |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM50173150
(2-(4-Benzyloxy-phenylcarbamoyl)-cyclopent-1-enecar...)Show SMILES OC(=O)C1=C(CCC1)C(=O)Nc1ccc(OCc2ccccc2)cc1 |t:3| Show InChI InChI=1S/C20H19NO4/c22-19(17-7-4-8-18(17)20(23)24)21-15-9-11-16(12-10-15)25-13-14-5-2-1-3-6-14/h1-3,5-6,9-12H,4,7-8,13H2,(H,21,22)(H,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Homo sapiens (Human)) | BDBM50173154
(4-(Biphenyl-4-ylcarbamoyl)-1,1-dioxo-2,5-dihydro-1...)Show SMILES OC(=O)C1=C(CS(=O)(=O)C1)C(=O)Nc1ccc(cc1)-c1ccccc1 |t:3| Show InChI InChI=1S/C18H15NO5S/c20-17(15-10-25(23,24)11-16(15)18(21)22)19-14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,19,20)(H,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase (quinone), mitochondrial
(Mus musculus) | BDBM16109
(2-[(4-phenylphenyl)carbamoyl]cyclopent-1-ene-1-car...)Show SMILES OC(=O)C1=C(CCC1)C(=O)Nc1ccc(cc1)-c1ccccc1 |t:3| Show InChI InChI=1S/C19H17NO3/c21-18(16-7-4-8-17(16)19(22)23)20-15-11-9-14(10-12-15)13-5-2-1-3-6-13/h1-3,5-6,9-12H,4,7-8H2,(H,20,21)(H,22,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
4SC AG
Curated by ChEMBL
| Assay Description Inhibitory activity against mouse dihydroorotate dehydrogenase |
Bioorg Med Chem Lett 15: 4854-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.053 BindingDB Entry DOI: 10.7270/Q2HX1C7N |
More data for this Ligand-Target Pair | |