Compile Data Set for Download or QSAR

Found 51 hits Enz. Inhib. hit(s) with all data for entry = 50005010   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537670 (CHEMBL4641380) Show SMILES Cc1nn(C2CCCS2(=O)=O)c2ncc(cc12)C(=O)c1cc(F)ccc1O Show InChI InChI=1S/C18H16FN3O4S/c1-10-13-7-11(17(24)14-8-12(19)4-5-15(14)23)9-20-18(13)22(21-10)16-3-2-6-27(16,25)26/h4-5,7-9,16,23H,2-3,6H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Tested for inhibition of cGMP-dependent protein kinase from bovine lung				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537669 (CHEMBL4643608) Show SMILES Cc1nn(C2CCOCC2)c2ncc(cc12)C(=O)c1ccccc1O Show InChI InChI=1S/C19H19N3O3/c1-12-16-10-13(18(24)15-4-2-3-5-17(15)23)11-20-19(16)22(21-12)14-6-8-25-9-7-14/h2-5,10-11,14,23H,6-9H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at CB1 receptor by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537671 (CHEMBL4633843) Show SMILES Cc1nn(C2CCOC2)c2ncc(cc12)C(=O)c1ccccc1O Show InChI InChI=1S/C18H17N3O3/c1-11-15-8-12(17(23)14-4-2-3-5-16(14)22)9-19-18(15)21(20-11)13-6-7-24-10-13/h2-5,8-9,13,22H,6-7,10H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Tested for inhibition of cGMP-dependent protein kinase from bovine lung				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537648 (CHEMBL4640596) Show SMILES Cc1nn(CCO)c2ncc(cc12)C(=O)c1cc(Cl)ccc1O Show InChI InChI=1S/C16H14ClN3O3/c1-9-12-6-10(8-18-16(12)20(19-9)4-5-21)15(23)13-7-11(17)2-3-14(13)22/h2-3,6-8,21-22H,4-5H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537661 (CHEMBL4648946) Show SMILES Cc1nn(-c2ccccn2)c2ncc(cc12)C(=O)c1cc(F)ccc1O Show InChI InChI=1S/C19H13FN4O2/c1-11-14-8-12(18(26)15-9-13(20)5-6-16(15)25)10-22-19(14)24(23-11)17-4-2-3-7-21-17/h2-10,25H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at CB1 receptor by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537646 (CHEMBL512270) Show SMILES Cc1nn(C)c2ncc(cc12)C(=O)c1cc(F)ccc1O Show InChI InChI=1S/C15H12FN3O2/c1-8-11-5-9(7-17-15(11)19(2)18-8)14(21)12-6-10(16)3-4-13(12)20/h3-7,20H,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537649 (CHEMBL1723285) Show SMILES Cc1nn(CCO)c2ncc(cc12)C(=O)c1cc(F)ccc1O Show InChI InChI=1S/C16H14FN3O3/c1-9-12-6-10(8-18-16(12)20(19-9)4-5-21)15(23)13-7-11(17)2-3-14(13)22/h2-3,6-8,21-22H,4-5H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Epidermal growth factor receptor autophosphorylation in A431 human epidermoid carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537665 (CHEMBL4648066) Show SMILES Cc1nn(-c2ccccc2F)c2ncc(cc12)C(=O)c1ccccc1O Show InChI InChI=1S/C20H14FN3O2/c1-12-15-10-13(19(26)14-6-2-5-9-18(14)25)11-22-20(15)24(23-12)17-8-4-3-7-16(17)21/h2-11,25H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at CB1 receptor by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537662 (CHEMBL4647748) Show SMILES Cc1nn(-c2cc(C)ccn2)c2ncc(cc12)C(=O)c1ccccc1O Show InChI InChI=1S/C20H16N4O2/c1-12-7-8-21-18(9-12)24-20-16(13(2)23-24)10-14(11-22-20)19(26)15-5-3-4-6-17(15)25/h3-11,25H,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at CB1 receptor by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537643 (CHEMBL1506565) Show SMILES Cc1n[nH]c2ncc(cc12)C(=O)c1cc(F)ccc1O Show InChI InChI=1S/C14H10FN3O2/c1-7-10-4-8(6-16-14(10)18-17-7)13(20)11-5-9(15)2-3-12(11)19/h2-6,19H,1H3,(H,16,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537629 (CHEMBL4635339) Show SMILES CCn1ncc(C(=O)c2cc(Cl)c(cc2OC)N(C)S(=O)(=O)N(C)C)c1O Show InChI InChI=1S/C16H21ClN4O5S/c1-6-21-16(23)11(9-18-21)15(22)10-7-12(17)13(8-14(10)26-5)20(4)27(24,25)19(2)3/h7-9,23H,6H2,1-5H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537628 (CHEMBL4643853) Show SMILES Cc1nn(-c2ccccn2)c2ncc(cc12)C(=O)c1ccccc1O Show InChI InChI=1S/C19H14N4O2/c1-12-15-10-13(18(25)14-6-2-3-7-16(14)24)11-21-19(15)23(22-12)17-8-4-5-9-20-17/h2-11,24H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair				3D Structure (crystal)
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537628 (CHEMBL4643853) Show SMILES Cc1nn(-c2ccccn2)c2ncc(cc12)C(=O)c1ccccc1O Show InChI InChI=1S/C19H14N4O2/c1-12-15-10-13(18(25)14-6-2-3-7-16(14)24)11-21-19(15)23(22-12)17-8-4-5-9-20-17/h2-11,24H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	66.1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Tested for inhibition of cGMP-dependent protein kinase from bovine lung				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair				3D Structure (crystal)
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537659 (CHEMBL4646298) Show SMILES Cc1nn(-c2ccccn2)c2ncc(cc12)C(=O)c1cc(Cl)ccc1O Show InChI InChI=1S/C19H13ClN4O2/c1-11-14-8-12(18(26)15-9-13(20)5-6-16(15)25)10-22-19(14)24(23-11)17-4-2-3-7-21-17/h2-10,25H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at CB1 receptor by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537647 (CHEMBL1403506) Show SMILES Cc1nn(C)c2ncc(cc12)C(=O)c1ccccc1O Show InChI InChI=1S/C15H13N3O2/c1-9-12-7-10(8-16-15(12)18(2)17-9)14(20)11-5-3-4-6-13(11)19/h3-8,19H,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537667 (CHEMBL4639207) Show SMILES Cc1nn(-c2ncccn2)c2ncc(cc12)C(=O)c1ccccc1O Show InChI InChI=1S/C18H13N5O2/c1-11-14-9-12(16(25)13-5-2-3-6-15(13)24)10-21-17(14)23(22-11)18-19-7-4-8-20-18/h2-10,24H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at CB1 receptor by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537668 (CHEMBL4647815) Show SMILES Cc1nn(-c2ccncn2)c2ncc(cc12)C(=O)c1ccccc1O Show InChI InChI=1S/C18H13N5O2/c1-11-14-8-12(17(25)13-4-2-3-5-15(13)24)9-20-18(14)23(22-11)16-6-7-19-10-21-16/h2-10,24H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at CB1 receptor by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537652 (CHEMBL4640293) Show SMILES Cc1nn(-c2ccccc2)c2ncc(cc12)C(=O)c1cc(F)ccc1O Show InChI InChI=1S/C20H14FN3O2/c1-12-16-9-13(19(26)17-10-14(21)7-8-18(17)25)11-22-20(16)24(23-12)15-5-3-2-4-6-15/h2-11,25H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at CB1 receptor by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537639 (CHEMBL4639296) Show SMILES CC1CC(=O)C(C(=O)c2cc(C)c3c(-c4nn(C)cc4CCS3(=O)=O)c2C)C(=O)C1 |(27.74,-4.11,;29.07,-4.89,;29.07,-6.43,;30.4,-7.21,;30.39,-8.75,;31.72,-6.44,;33.06,-7.21,;33.05,-8.75,;34.39,-6.44,;34.39,-4.9,;35.72,-4.13,;35.71,-2.59,;37.05,-4.9,;37.06,-6.45,;38.29,-7.4,;38.16,-8.95,;39.59,-9.56,;39.93,-11.06,;40.6,-8.39,;39.8,-7.05,;40.47,-5.64,;39.79,-4.24,;38.26,-3.91,;37.49,-2.57,;39.03,-2.57,;35.72,-7.21,;35.72,-8.75,;31.73,-4.9,;33.07,-4.13,;30.41,-4.13,)| Show InChI InChI=1S/C22H24N2O5S/c1-11-7-16(25)19(17(26)8-11)21(27)15-9-12(2)22-18(13(15)3)20-14(10-24(4)23-20)5-6-30(22,28)29/h9-11,19H,5-8H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	324	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537641 (CHEMBL4647303) Show SMILES O=S(=O)(Nc1nccs1)c1ccc2N(CCc3ccncc3)CCOc2c1 Show InChI InChI=1S/C18H18N4O3S2/c23-27(24,21-18-20-8-12-26-18)15-1-2-16-17(13-15)25-11-10-22(16)9-5-14-3-6-19-7-4-14/h1-4,6-8,12-13H,5,9-11H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	575	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537626 (CHEMBL4645869) Show SMILES O=S(=O)(Nc1ccccn1)c1ccc2OCCOc2c1 Show InChI InChI=1S/C13H12N2O4S/c16-20(17,15-13-3-1-2-6-14-13)10-4-5-11-12(9-10)19-8-7-18-11/h1-6,9H,7-8H2,(H,14,15)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	603	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Epidermal growth factor receptor autophosphorylation in A431 human epidermoid carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537664 (CHEMBL4637016) Show SMILES Cc1nn(-c2ccc(F)cc2)c2ncc(cc12)C(=O)c1ccccc1O Show InChI InChI=1S/C20H14FN3O2/c1-12-17-10-13(19(26)16-4-2-3-5-18(16)25)11-22-20(17)24(23-12)15-8-6-14(21)7-9-15/h2-11,25H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	820	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at CB1 receptor by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537653 (CHEMBL4643582) Show SMILES Cc1nn(-c2ccccc2)c2ncc(cc12)C(=O)c1ccccc1O Show InChI InChI=1S/C20H15N3O2/c1-13-17-11-14(19(25)16-9-5-6-10-18(16)24)12-21-20(17)23(22-13)15-7-3-2-4-8-15/h2-12,24H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at CB1 receptor by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537645 (CHEMBL467988) Show SMILES Cc1nn(C)c2ncc(cc12)C(=O)c1cc(C)ccc1O Show InChI InChI=1S/C16H15N3O2/c1-9-4-5-14(20)13(6-9)15(21)11-7-12-10(2)18-19(3)16(12)17-8-11/h4-8,20H,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	970	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537637 (CHEMBL4644624) Show SMILES CC(C)NC(=O)C1CCC(CC1)n1c2cc(Cn3cncn3)ccc2[nH]\c1=N/C(=O)c1ccc(F)cc1 |(65.7,-55.57,;64.19,-55.25,;63.71,-53.79,;63.16,-56.4,;61.66,-56.08,;60.63,-57.23,;61.18,-54.62,;59.67,-54.3,;59.19,-52.84,;60.22,-51.69,;61.72,-52,;62.2,-53.47,;59.73,-50.24,;58.26,-49.77,;56.92,-50.55,;55.59,-49.78,;54.25,-50.55,;54.25,-52.09,;53.01,-52.99,;53.49,-54.46,;55.03,-54.46,;55.51,-53,;55.59,-48.24,;56.92,-47.47,;58.26,-48.23,;59.72,-47.74,;60.63,-48.99,;62.17,-48.98,;62.94,-47.64,;62.16,-46.31,;64.48,-47.63,;65.25,-48.96,;66.79,-48.95,;67.55,-47.62,;69.09,-47.6,;66.77,-46.28,;65.23,-46.3,)| Show InChI InChI=1S/C27H30FN7O2/c1-17(2)31-25(36)20-6-10-22(11-7-20)35-24-13-18(14-34-16-29-15-30-34)3-12-23(24)32-27(35)33-26(37)19-4-8-21(28)9-5-19/h3-5,8-9,12-13,15-17,20,22H,6-7,10-11,14H2,1-2H3,(H,31,36)(H,32,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.29E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Epidermal growth factor receptor autophosphorylation in A431 human epidermoid carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537655 (CHEMBL4649728) Show SMILES Cc1nn(-c2cccc(C)c2)c2ncc(cc12)C(=O)c1ccccc1O Show InChI InChI=1S/C21H17N3O2/c1-13-6-5-7-16(10-13)24-21-18(14(2)23-24)11-15(12-22-21)20(26)17-8-3-4-9-19(17)25/h3-12,25H,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.36E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at CB1 receptor by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537660 (CHEMBL4634222) Show SMILES Cc1nn(-c2ccccn2)c2ncc(cc12)C(=O)c1cc(C)ccc1O Show InChI InChI=1S/C20H16N4O2/c1-12-6-7-17(25)16(9-12)19(26)14-10-15-13(2)23-24(20(15)22-11-14)18-5-3-4-8-21-18/h3-11,25H,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.72E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at CB1 receptor by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM154387 (US9012443, 427) Show SMILES COc1cc(ccc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccc(F)cn1)C(F)(F)F Show InChI InChI=1S/C22H15F4N3O3S/c1-32-19-11-14(22(24,25)26)2-5-18(19)21-17-6-4-16(10-13(17)8-9-27-21)33(30,31)29-20-7-3-15(23)12-28-20/h2-12H,1H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM154206 (US9012443, 219) Show SMILES COc1cc(ccc1-c1nc(Cl)cc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F Show InChI InChI=1S/C20H13ClF3N3O3S2/c1-30-16-10-12(20(22,23)24)2-4-15(16)18-14-5-3-13(8-11(14)9-17(21)26-18)32(28,29)27-19-25-6-7-31-19/h2-10H,1H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537644 (CHEMBL1582054) Show SMILES COc1ccc(O)c(c1)C(=O)c1cnc2n(C)nc(C)c2c1 Show InChI InChI=1S/C16H15N3O3/c1-9-12-6-10(8-17-16(12)19(2)18-9)15(21)13-7-11(22-3)4-5-14(13)20/h4-8,20H,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537638 (CHEMBL4648561) Show SMILES CCCc1cc([nH]n1)C(=O)N1CCC(CC1)C1Nc2ccccc2S(=O)(=O)N1 Show InChI InChI=1S/C19H25N5O3S/c1-2-5-14-12-16(22-21-14)19(25)24-10-8-13(9-11-24)18-20-15-6-3-4-7-17(15)28(26,27)23-18/h3-4,6-7,12-13,18,20,23H,2,5,8-11H2,1H3,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537635 (CHEMBL4634771) Show SMILES OC(=O)[C@H]1CC[C@H](CC1)n1c2cc(CN3CCCCC3)ccc2[nH]\c1=N/C(=O)c1ccc(F)cc1 |r,wU:6.9,3.2,(11.83,-58.54,;12.86,-57.4,;14.37,-57.71,;12.38,-55.93,;10.87,-55.61,;10.39,-54.16,;11.42,-53.01,;12.93,-53.32,;13.41,-54.78,;10.94,-51.55,;9.47,-51.09,;8.13,-51.86,;6.79,-51.09,;5.46,-51.86,;4.13,-51.09,;2.79,-51.86,;1.46,-51.09,;1.46,-49.55,;2.79,-48.78,;4.13,-49.55,;6.79,-49.55,;8.12,-48.78,;9.46,-49.54,;10.92,-49.06,;11.84,-50.3,;13.38,-50.29,;14.14,-48.95,;13.36,-47.62,;15.68,-48.94,;16.45,-50.28,;17.99,-50.27,;18.76,-48.93,;20.3,-48.92,;17.97,-47.6,;16.43,-47.61,)| Show InChI InChI=1S/C27H31FN4O3/c28-21-9-5-19(6-10-21)25(33)30-27-29-23-13-4-18(17-31-14-2-1-3-15-31)16-24(23)32(27)22-11-7-20(8-12-22)26(34)35/h4-6,9-10,13,16,20,22H,1-3,7-8,11-12,14-15,17H2,(H,34,35)(H,29,30,33)/t20-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537633 (CHEMBL4635573) Show SMILES CC1(C)C(O)=C(C(N)=O)C(=O)c2cc(ccc12)C(=O)NCCc1ccccc1 |t:4| Show InChI InChI=1S/C22H22N2O4/c1-22(2)16-9-8-14(12-15(16)18(25)17(19(22)26)20(23)27)21(28)24-11-10-13-6-4-3-5-7-13/h3-9,12,26H,10-11H2,1-2H3,(H2,23,27)(H,24,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Epidermal growth factor receptor autophosphorylation in A431 human epidermoid carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537630 (CHEMBL4633966) Show SMILES CCOC(=O)C1=C(O)C2(CCC(CC2)=CC(=O)OC)c2ccc(Cl)cc2C1=O |c:5,(51.74,-21.29,;50.4,-20.52,;49.07,-21.29,;47.73,-20.52,;47.73,-18.98,;46.41,-21.3,;45.07,-20.53,;45.08,-18.99,;43.73,-21.3,;43.72,-19.76,;42.39,-18.99,;41.06,-19.77,;41.07,-21.31,;42.41,-22.07,;39.72,-19,;39.72,-17.46,;38.38,-16.7,;41.05,-16.69,;41.04,-15.15,;43.75,-22.84,;42.42,-23.6,;42.42,-25.15,;43.75,-25.92,;43.75,-27.46,;45.09,-25.15,;45.09,-23.6,;46.41,-22.83,;47.74,-23.6,)| Show InChI InChI=1S/C21H21ClO6/c1-3-28-20(26)17-18(24)14-11-13(22)4-5-15(14)21(19(17)25)8-6-12(7-9-21)10-16(23)27-2/h4-5,10-11,25H,3,6-9H2,1-2H3/b12-10-	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537642 (CHEMBL4638594) Show SMILES Cn1nc(c2[C@H](CC(=O)Nc12)c1ccc2cccc(O)c2n1)-c1cccnc1 |r| Show InChI InChI=1S/C21H17N5O2/c1-26-21-18(20(25-26)13-5-3-9-22-11-13)14(10-17(28)24-21)15-8-7-12-4-2-6-16(27)19(12)23-15/h2-9,11,14,27H,10H2,1H3,(H,24,28)/t14-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.37E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537632 (CHEMBL4594142) Show SMILES CC1(C)Oc2c(CCO)c3occ(-c4ccc(O)c(O)c4)c(=O)c3c(O)c2C=C1 |c:30| Show InChI InChI=1S/C22H20O7/c1-22(2)7-5-12-18(26)17-19(27)14(11-3-4-15(24)16(25)9-11)10-28-21(17)13(6-8-23)20(12)29-22/h3-5,7,9-10,23-26H,6,8H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537627 (CHEMBL4641013) Show SMILES CCOC(=O)c1c(C)n(C)c2cc(Nc3ccccc3)c(O)cc12 Show InChI InChI=1S/C19H20N2O3/c1-4-24-19(23)18-12(2)21(3)16-11-15(17(22)10-14(16)18)20-13-8-6-5-7-9-13/h5-11,20,22H,4H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.76E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537634 (CHEMBL4639502) Show SMILES FC(F)(F)Oc1cccc(c1)-n1nnnc1N1CCN(CC1)c1ncnc2sc3CCCc3c12 Show InChI InChI=1S/C21H19F3N8OS/c22-21(23,24)33-14-4-1-3-13(11-14)32-20(27-28-29-32)31-9-7-30(8-10-31)18-17-15-5-2-6-16(15)34-19(17)26-12-25-18/h1,3-4,11-12H,2,5-10H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537625 (CHEMBL4648044) Show SMILES CCOC(=O)CNCc1c(C(=O)CC)c2cc(OC)c(Br)cc2n1C Show InChI InChI=1S/C18H23BrN2O4/c1-5-15(22)18-11-7-16(24-4)12(19)8-13(11)21(3)14(18)9-20-10-17(23)25-6-2/h7-8,20H,5-6,9-10H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.94E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537624 (CHEMBL4635045) Show SMILES Cc1ccc(C(=O)c2ccccc2O)c(O)n1 Show InChI InChI=1S/C13H11NO3/c1-8-6-7-10(13(17)14-8)12(16)9-4-2-3-5-11(9)15/h2-7,15H,1H3,(H,14,17)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.13E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537640 (CHEMBL4637484) Show SMILES Clc1cccc(c1)N(CC(=O)N[C@H]1CC[C@@H](CC1)n1c2ccccc2[nH]c1=O)S(=O)(=O)c1cccnc1 |r,wU:12.12,wD:15.19,(52.18,-10.93,;52.18,-9.39,;50.83,-8.62,;50.83,-7.08,;52.16,-6.31,;53.5,-7.08,;53.5,-8.62,;54.83,-6.31,;56.17,-7.08,;57.5,-6.3,;57.5,-4.76,;58.83,-7.08,;60.16,-6.3,;60.16,-4.76,;61.49,-3.99,;62.82,-4.76,;62.82,-6.3,;61.49,-7.07,;64.16,-4,;65.56,-4.61,;66.03,-6.08,;67.53,-6.4,;68.57,-5.25,;68.09,-3.79,;66.6,-3.48,;65.83,-2.14,;64.32,-2.46,;63.18,-1.43,;54.82,-4.76,;55.58,-3.42,;56.36,-4.75,;53.49,-4,;52.17,-4.77,;50.83,-4.01,;50.83,-2.47,;52.16,-1.69,;53.5,-2.46,)| Show InChI InChI=1S/C26H26ClN5O4S/c27-18-5-3-6-21(15-18)31(37(35,36)22-7-4-14-28-16-22)17-25(33)29-19-10-12-20(13-11-19)32-24-9-2-1-8-23(24)30-26(32)34/h1-9,14-16,19-20H,10-13,17H2,(H,29,33)(H,30,34)/t19-,20-	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537631 (CHEMBL4636699) Show SMILES FC(F)(F)c1cccc(NC(=O)N2CCC(CC2)S(=O)(=O)Nc2nccs2)c1 Show InChI InChI=1S/C16H17F3N4O3S2/c17-16(18,19)11-2-1-3-12(10-11)21-15(24)23-7-4-13(5-8-23)28(25,26)22-14-20-6-9-27-14/h1-3,6,9-10,13H,4-5,7-8H2,(H,20,22)(H,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537636 (CHEMBL4648024) Show SMILES OC(=O)c1ccc2c(c[nH]c2c1)C(c1c[nH]c2cc(ccc12)C(O)=O)c1ccc(Cl)cc1Cl Show InChI InChI=1S/C25H16Cl2N2O4/c26-14-3-6-17(20(27)9-14)23(18-10-28-21-7-12(24(30)31)1-4-15(18)21)19-11-29-22-8-13(25(32)33)2-5-16(19)22/h1-11,23,28-29H,(H,30,31)(H,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Epidermal growth factor receptor autophosphorylation in A431 human epidermoid carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537650 (CHEMBL4635913) Show SMILES COc1ccc(O)c(c1)C(=O)c1cnc2n(nc(C)c2c1)-c1ccccc1 Show InChI InChI=1S/C21H17N3O3/c1-13-17-10-14(20(26)18-11-16(27-2)8-9-19(18)25)12-22-21(17)24(23-13)15-6-4-3-5-7-15/h3-12,25H,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cells				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537656 (CHEMBL4635842) Show SMILES Cc1nn(-c2ccc(C)cc2)c2ncc(cc12)C(=O)c1cc(C)ccc1O Show InChI InChI=1S/C22H19N3O2/c1-13-4-7-17(8-5-13)25-22-18(15(3)24-25)11-16(12-23-22)21(27)19-10-14(2)6-9-20(19)26/h4-12,26H,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at CB1 receptor by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537658 (CHEMBL4634336) Show SMILES CN(C)C(=O)c1cnc2n(nc(C)c2c1)-c1ccccn1 Show InChI InChI=1S/C15H15N5O/c1-10-12-8-11(15(21)19(2)3)9-17-14(12)20(18-10)13-6-4-5-7-16-13/h4-9H,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at CB1 receptor by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537654 (CHEMBL4643587) Show SMILES COc1ccc(O)c(c1)C(=O)c1cnc2n(nc(C)c2c1)-c1cccc(C)c1 Show InChI InChI=1S/C22H19N3O3/c1-13-5-4-6-16(9-13)25-22-18(14(2)24-25)10-15(12-23-22)21(27)19-11-17(28-3)7-8-20(19)26/h4-12,26H,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at CB1 receptor by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537663 (CHEMBL4636826) Show SMILES Cc1nn(-c2ccc(F)cc2)c2ncc(cc12)C(=O)c1cc(C)ccc1O Show InChI InChI=1S/C21H16FN3O2/c1-12-3-8-19(26)18(9-12)20(27)14-10-17-13(2)24-25(21(17)23-11-14)16-6-4-15(22)5-7-16/h3-11,26H,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at CB1 receptor by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537666 (CHEMBL4633879) Show SMILES COc1ccc(O)c(c1)C(=O)c1cnc2n(nc(C)c2c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C21H16ClN3O3/c1-12-17-8-13(20(27)18-10-16(28-2)6-7-19(18)26)11-23-21(17)25(24-12)15-5-3-4-14(22)9-15/h3-11,26H,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at CB1 receptor by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair
Sepiapterin reductase (Homo sapiens (Human))	BDBM50537657 (CHEMBL4636874) Show SMILES Cc1nn(-c2ccccn2)c2ncc(cc12)C(O)=O Show InChI InChI=1S/C13H10N4O2/c1-8-10-6-9(13(18)19)7-15-12(10)17(16-8)11-4-2-3-5-14-11/h2-7H,1H3,(H,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Antagonist activity at CB1 receptor by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126793 BindingDB Entry DOI: 10.7270/Q2Z89G99
					More data for this Ligand-Target Pair

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