Compile Data Set for Download or QSAR

Found 114 hits Enz. Inhib. hit(s) with all data for entry = 50046723   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128023 (CHEMBL3628281) Show SMILES CC1(C)C2C1C(=O)N(C2=O)c1ccc(NC(=O)c2ccccn2)cc1Cl Show InChI InChI=1S/C19H16ClN3O3/c1-19(2)14-15(19)18(26)23(17(14)25)13-7-6-10(9-11(13)20)22-16(24)12-5-3-4-8-21-12/h3-9,14-15H,1-2H3,(H,22,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50258140 (CHEMBL521982 | N-(4-(trifluoromethyl)oxazol-2-yl)-...) Show SMILES FC(F)(F)c1coc(NC(=O)C2c3ccccc3Oc3ccccc23)n1 Show InChI InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-25-17(22-14)23-16(24)15-10-5-1-3-7-12(10)26-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of CYP2C9 in human liver microsomes by LC-MS/MS analysis				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50127985 (CHEMBL3628113) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of CYP2C9 in human liver microsomes by LC-MS/MS analysis				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Homo sapiens (Human))	BDBM50258140 (CHEMBL521982 | N-(4-(trifluoromethyl)oxazol-2-yl)-...) Show SMILES FC(F)(F)c1coc(NC(=O)C2c3ccccc3Oc3ccccc23)n1 Show InChI InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-25-17(22-14)23-16(24)15-10-5-1-3-7-12(10)26-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of CYP1A2 in human liver microsomes by LC-MS/MS analysis				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Homo sapiens (Human))	BDBM50127985 (CHEMBL3628113) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.52E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of CYP1A2 in human liver microsomes by LC-MS/MS analysis				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50128021 (CHEMBL3628116) Show SMILES Clc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ncccc2Cl)cc1Cl Show InChI InChI=1S/C20H10Cl3N3O3/c21-12-4-1-3-11-16(12)20(29)26(19(11)28)15-7-6-10(9-14(15)23)25-18(27)17-13(22)5-2-8-24-17/h1-9H,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of CYP2C9 in human liver microsomes by LC-MS/MS analysis				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50127985 (CHEMBL3628113) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of CYP2D6 in human liver microsomes by LC-MS/MS analysis				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50127993 (CHEMBL3628115) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccncc3C2=O)c(Cl)c1 Show InChI InChI=1S/C19H12ClN3O4/c1-10-5-7-27-16(10)17(24)22-11-2-3-15(14(20)8-11)23-18(25)12-4-6-21-9-13(12)19(23)26/h2-9H,1H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of CYP2D6 in human liver microsomes by LC-MS/MS analysis				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50258140 (CHEMBL521982 | N-(4-(trifluoromethyl)oxazol-2-yl)-...) Show SMILES FC(F)(F)c1coc(NC(=O)C2c3ccccc3Oc3ccccc23)n1 Show InChI InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-25-17(22-14)23-16(24)15-10-5-1-3-7-12(10)26-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of CYP2D6 in human liver microsomes by LC-MS/MS analysis				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50128021 (CHEMBL3628116) Show SMILES Clc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ncccc2Cl)cc1Cl Show InChI InChI=1S/C20H10Cl3N3O3/c21-12-4-1-3-11-16(12)20(29)26(19(11)28)15-7-6-10(9-14(15)23)25-18(27)17-13(22)5-2-8-24-17/h1-9H,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of CYP2D6 in human liver microsomes by LC-MS/MS analysis				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50127965 (CHEMBL3628112) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(Cl)cc3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H12Cl2N2O4/c1-10-6-7-28-17(10)18(25)23-12-3-5-16(15(22)9-12)24-19(26)13-4-2-11(21)8-14(13)20(24)27/h2-9H,1H3,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of CYP3A4 in human liver microsomes by LC-MS/MS analysis				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50127985 (CHEMBL3628113) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of CYP3A4 in human liver microsomes by LC-MS/MS analysis				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50127993 (CHEMBL3628115) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccncc3C2=O)c(Cl)c1 Show InChI InChI=1S/C19H12ClN3O4/c1-10-5-7-27-16(10)17(24)22-11-2-3-15(14(20)8-11)23-18(25)12-4-6-21-9-13(12)19(23)26/h2-9H,1H3,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of CYP3A4 in human liver microsomes by LC-MS/MS analysis				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50258140 (CHEMBL521982 | N-(4-(trifluoromethyl)oxazol-2-yl)-...) Show SMILES FC(F)(F)c1coc(NC(=O)C2c3ccccc3Oc3ccccc23)n1 Show InChI InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-25-17(22-14)23-16(24)15-10-5-1-3-7-12(10)26-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of CYP3A4 in human liver microsomes by LC-MS/MS analysis				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50128021 (CHEMBL3628116) Show SMILES Clc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ncccc2Cl)cc1Cl Show InChI InChI=1S/C20H10Cl3N3O3/c21-12-4-1-3-11-16(12)20(29)26(19(11)28)15-7-6-10(9-14(15)23)25-18(27)17-13(22)5-2-8-24-17/h1-9H,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of CYP3A4 in human liver microsomes by LC-MS/MS analysis				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50127993 (CHEMBL3628115) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccncc3C2=O)c(Cl)c1 Show InChI InChI=1S/C19H12ClN3O4/c1-10-5-7-27-16(10)17(24)22-11-2-3-15(14(20)8-11)23-18(25)12-4-6-21-9-13(12)19(23)26/h2-9H,1H3,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of CYP2C9 in human liver microsomes by LC-MS/MS analysis				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50127965 (CHEMBL3628112) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(Cl)cc3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H12Cl2N2O4/c1-10-6-7-28-17(10)18(25)23-12-3-5-16(15(22)9-12)24-19(26)13-4-2-11(21)8-14(13)20(24)27/h2-9H,1H3,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of CYP2C9 in human liver microsomes by LC-MS/MS analysis				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Homo sapiens (Human))	BDBM50128021 (CHEMBL3628116) Show SMILES Clc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ncccc2Cl)cc1Cl Show InChI InChI=1S/C20H10Cl3N3O3/c21-12-4-1-3-11-16(12)20(29)26(19(11)28)15-7-6-10(9-14(15)23)25-18(27)17-13(22)5-2-8-24-17/h1-9H,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of CYP1A2 in human liver microsomes by LC-MS/MS analysis				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Homo sapiens (Human))	BDBM50127993 (CHEMBL3628115) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccncc3C2=O)c(Cl)c1 Show InChI InChI=1S/C19H12ClN3O4/c1-10-5-7-27-16(10)17(24)22-11-2-3-15(14(20)8-11)23-18(25)12-4-6-21-9-13(12)19(23)26/h2-9H,1H3,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of CYP1A2 in human liver microsomes by LC-MS/MS analysis				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Homo sapiens (Human))	BDBM50127965 (CHEMBL3628112) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(Cl)cc3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H12Cl2N2O4/c1-10-6-7-28-17(10)18(25)23-12-3-5-16(15(22)9-12)24-19(26)13-4-2-11(21)8-14(13)20(24)27/h2-9H,1H3,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of CYP1A2 in human liver microsomes by LC-MS/MS analysis				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50127965 (CHEMBL3628112) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(Cl)cc3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H12Cl2N2O4/c1-10-6-7-28-17(10)18(25)23-12-3-5-16(15(22)9-12)24-19(26)13-4-2-11(21)8-14(13)20(24)27/h2-9H,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of CYP2D6 in human liver microsomes by LC-MS/MS analysis				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128022 (CHEMBL3628280) Show SMILES [H][C@]12C[C@]([H])(C=C1)[C@]1([H])C(=O)N(C(=O)[C@]21[H])c1ccc(NC(=O)c2ccccn2)cc1Cl |r,c:5| Show InChI InChI=1S/C21H16ClN3O3/c22-14-10-13(24-19(26)15-3-1-2-8-23-15)6-7-16(14)25-20(27)17-11-4-5-12(9-11)18(17)21(25)28/h1-8,10-12,17-18H,9H2,(H,24,26)/t11-,12-,17-,18+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	291	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50128021 (CHEMBL3628116) Show SMILES Clc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ncccc2Cl)cc1Cl Show InChI InChI=1S/C20H10Cl3N3O3/c21-12-4-1-3-11-16(12)20(29)26(19(11)28)15-7-6-10(9-14(15)23)25-18(27)17-13(22)5-2-8-24-17/h1-9H,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	356	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128021 (CHEMBL3628116) Show SMILES Clc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ncccc2Cl)cc1Cl Show InChI InChI=1S/C20H10Cl3N3O3/c21-12-4-1-3-11-16(12)20(29)26(19(11)28)15-7-6-10(9-14(15)23)25-18(27)17-13(22)5-2-8-24-17/h1-9H,(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	390	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128024 (CHEMBL3628092) Show SMILES Clc1cc(NC(=O)c2cnn[nH]2)ccc1N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C17H10ClN5O3/c18-12-7-9(20-15(24)13-8-19-22-21-13)5-6-14(12)23-16(25)10-3-1-2-4-11(10)17(23)26/h1-8H,(H,20,24)(H,19,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128025 (CHEMBL3628091) Show SMILES Clc1cc(NC(=O)c2cnc[nH]2)ccc1N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C18H11ClN4O3/c19-13-7-10(22-16(24)14-8-20-9-21-14)5-6-15(13)23-17(25)11-3-1-2-4-12(11)18(23)26/h1-9H,(H,20,21)(H,22,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128026 (CHEMBL3628090) Show SMILES Clc1cc(NC(=O)c2cn[nH]c2)ccc1N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C18H11ClN4O3/c19-14-7-11(22-16(24)10-8-20-21-9-10)5-6-15(14)23-17(25)12-3-1-2-4-13(12)18(23)26/h1-9H,(H,20,21)(H,22,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128027 (CHEMBL3628089) Show SMILES Clc1cc(NC(=O)c2cncs2)ccc1N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C18H10ClN3O3S/c19-13-7-10(21-16(23)15-8-20-9-26-15)5-6-14(13)22-17(24)11-3-1-2-4-12(11)18(22)25/h1-9H,(H,21,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128028 (CHEMBL3628088) Show SMILES Clc1cc(NC(=O)c2cscn2)ccc1N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C18H10ClN3O3S/c19-13-7-10(21-16(23)14-8-26-9-20-14)5-6-15(13)22-17(24)11-3-1-2-4-12(11)18(22)25/h1-9H,(H,21,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.47E+3	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128029 (CHEMBL3628087) Show SMILES Clc1cc(NC(=O)c2ccno2)ccc1N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C18H10ClN3O4/c19-13-9-10(21-16(23)15-7-8-20-26-15)5-6-14(13)22-17(24)11-3-1-2-4-12(11)18(22)25/h1-9H,(H,21,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128030 (CHEMBL3628086) Show SMILES Clc1cc(NC(=O)c2cocn2)ccc1N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C18H10ClN3O4/c19-13-7-10(21-16(23)14-8-26-9-20-14)5-6-15(13)22-17(24)11-3-1-2-4-12(11)18(22)25/h1-9H,(H,21,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128031 (CHEMBL3628085) Show SMILES Clc1cc(NC(=O)c2ncco2)ccc1N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C18H10ClN3O4/c19-13-9-10(21-15(23)16-20-7-8-26-16)5-6-14(13)22-17(24)11-3-1-2-4-12(11)18(22)25/h1-9H,(H,21,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128043 (CHEMBL3628084) Show SMILES Clc1cc(NC(=O)c2cnco2)ccc1N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C18H10ClN3O4/c19-13-7-10(21-16(23)15-8-20-9-26-15)5-6-14(13)22-17(24)11-3-1-2-4-12(11)18(22)25/h1-9H,(H,21,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128099 (CHEMBL3628083) Show SMILES Clc1cc(NC(=O)c2ccc[nH]2)ccc1N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C19H12ClN3O3/c20-14-10-11(22-17(24)15-6-3-9-21-15)7-8-16(14)23-18(25)12-4-1-2-5-13(12)19(23)26/h1-10,21H,(H,22,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128115 (CHEMBL3628082) Show SMILES Clc1cc(NC(=O)c2cccs2)ccc1N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C19H11ClN2O3S/c20-14-10-11(21-17(23)16-6-3-9-26-16)7-8-15(14)22-18(24)12-4-1-2-5-13(12)19(22)25/h1-10H,(H,21,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128116 (CHEMBL3628081) Show SMILES Clc1cc(NC(=O)c2ccco2)ccc1N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C19H11ClN2O4/c20-14-10-11(21-17(23)16-6-3-9-26-16)7-8-15(14)22-18(24)12-4-1-2-5-13(12)19(22)25/h1-10H,(H,21,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50127993 (CHEMBL3628115) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccncc3C2=O)c(Cl)c1 Show InChI InChI=1S/C19H12ClN3O4/c1-10-5-7-27-16(10)17(24)22-11-2-3-15(14(20)8-11)23-18(25)12-4-6-21-9-13(12)19(23)26/h2-9H,1H3,(H,22,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	99	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128117 (CHEMBL3628114) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(F)cc3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H12ClFN2O4/c1-10-6-7-28-17(10)18(25)23-12-3-5-16(15(21)9-12)24-19(26)13-4-2-11(22)8-14(13)20(24)27/h2-9H,1H3,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50127985 (CHEMBL3628113) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	32	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50127965 (CHEMBL3628112) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(Cl)cc3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H12Cl2N2O4/c1-10-6-7-28-17(10)18(25)23-12-3-5-16(15(22)9-12)24-19(26)13-4-2-11(21)8-14(13)20(24)27/h2-9H,1H3,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	81	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128118 (CHEMBL3628111) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H12Cl2N2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(14(22)9-11)24-19(26)12-3-2-4-13(21)16(12)20(24)27/h2-9H,1H3,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	33	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128119 (CHEMBL3628110) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(C)cc3C2=O)c(Cl)c1 Show InChI InChI=1S/C21H15ClN2O4/c1-11-3-5-14-15(9-11)21(27)24(20(14)26)17-6-4-13(10-16(17)22)23-19(25)18-12(2)7-8-28-18/h3-10H,1-2H3,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	54	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128120 (CHEMBL3628109) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c(Cl)c1 Show InChI InChI=1S/C21H15ClN2O4/c1-11-4-3-5-14-17(11)21(27)24(20(14)26)16-7-6-13(10-15(16)22)23-19(25)18-12(2)8-9-28-18/h3-10H,1-2H3,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128121 (CHEMBL3628108) Show SMILES Clc1cc(NC(=O)c2coc3ccccc23)ccc1N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C23H13ClN2O4/c24-18-11-13(25-21(27)17-12-30-20-8-4-3-5-14(17)20)9-10-19(18)26-22(28)15-6-1-2-7-16(15)23(26)29/h1-12H,(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128122 (CHEMBL3628107) Show SMILES Clc1cc(NC(=O)c2cc3ccccc3o2)ccc1N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C23H13ClN2O4/c24-17-12-14(25-21(27)20-11-13-5-1-4-8-19(13)30-20)9-10-18(17)26-22(28)15-6-2-3-7-16(15)23(26)29/h1-12H,(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128123 (CHEMBL3628106) Show SMILES Cc1cc(C)c(o1)C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1 Show InChI InChI=1S/C21H15ClN2O4/c1-11-9-12(2)28-18(11)19(25)23-13-7-8-17(16(22)10-13)24-20(26)14-5-3-4-6-15(14)21(24)27/h3-10H,1-2H3,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128124 (CHEMBL3628105) Show SMILES Clc1cc(NC(=O)c2occc2-c2ccccc2)ccc1N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C25H15ClN2O4/c26-20-14-16(27-23(29)22-17(12-13-32-22)15-6-2-1-3-7-15)10-11-21(20)28-24(30)18-8-4-5-9-19(18)25(28)31/h1-14H,(H,27,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128125 (CHEMBL3628104) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H13ClN2O4/c1-11-8-9-27-17(11)18(24)22-12-6-7-16(15(21)10-12)23-19(25)13-4-2-3-5-14(13)20(23)26/h2-10H,1H3,(H,22,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	97	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128126 (CHEMBL3628103) Show SMILES Clc1cc(NC(=O)c2ccc(o2)-c2ccccc2)ccc1N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C25H15ClN2O4/c26-19-14-16(27-23(29)22-13-12-21(32-22)15-6-2-1-3-7-15)10-11-20(19)28-24(30)17-8-4-5-9-18(17)25(28)31/h1-14H,(H,27,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128127 (CHEMBL3628102) Show SMILES CS(=O)(=O)c1ccc(o1)C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H13ClN2O6S/c1-30(27,28)17-9-8-16(29-17)18(24)22-11-6-7-15(14(21)10-11)23-19(25)12-4-2-3-5-13(12)20(23)26/h2-10H,1H3,(H,22,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair

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