Compile Data Set for Download or QSAR

Found 23 hits Enz. Inhib. hit(s) with all data for entry = 50028309   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 1 (RAT)	BDBM50258142 (2,7-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...) Show SMILES Fc1ccc2Oc3ccc(F)cc3C(C(=O)Nc3nc(co3)C(F)(F)F)c2c1 Show InChI InChI=1S/C18H9F5N2O3/c19-8-1-3-12-10(5-8)15(11-6-9(20)2-4-13(11)28-12)16(26)25-17-24-14(7-27-17)18(21,22)23/h1-7,15H,(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	90	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258224 (CHEMBL522875 | rac-2-fluoro-N-(5-(trifluoromethyl)...) Show SMILES Fc1ccc2Oc3ccccc3C(C(=O)Nc3ncc(o3)C(F)(F)F)c2c1 Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-13-11(7-9)15(10-3-1-2-4-12(10)26-13)16(25)24-17-23-8-14(27-17)18(20,21)22/h1-8,15H,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	67	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258225 (2,7-difluoro-N-(oxazol-2-yl)-9H-xanthene-9-carboxa...) Show SMILES Fc1ccc2Oc3ccc(F)cc3C(C(=O)Nc3ncco3)c2c1 Show InChI InChI=1S/C17H10F2N2O3/c18-9-1-3-13-11(7-9)15(16(22)21-17-20-5-6-23-17)12-8-10(19)2-4-14(12)24-13/h1-8,15H,(H,20,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	124	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258223 (CHEMBL494960 | rac-4-fluoro-N-(5-(trifluoromethyl)...) Show SMILES Fc1cccc2C(C(=O)Nc3ncc(o3)C(F)(F)F)c3ccccc3Oc12 Show InChI InChI=1S/C18H10F4N2O3/c19-11-6-3-5-10-14(9-4-1-2-7-12(9)26-15(10)11)16(25)24-17-23-8-13(27-17)18(20,21)22/h1-8,14H,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	131	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258225 (2,7-difluoro-N-(oxazol-2-yl)-9H-xanthene-9-carboxa...) Show SMILES Fc1ccc2Oc3ccc(F)cc3C(C(=O)Nc3ncco3)c2c1 Show InChI InChI=1S/C17H10F2N2O3/c18-9-1-3-13-11(7-9)15(16(22)21-17-20-5-6-23-17)12-8-10(19)2-4-14(12)24-13/h1-8,15H,(H,20,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	140	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258227 (4,5-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...) Show SMILES Fc1cccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3cccc(F)c3Oc12 Show InChI InChI=1S/C18H9F5N2O3/c19-10-5-1-3-8-13(9-4-2-6-11(20)15(9)28-14(8)10)16(26)25-17-24-12(7-27-17)18(21,22)23/h1-7,13H,(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	161	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258186 (4,5-difluoro-N-(5-(trifluoromethyl)oxazol-2-yl)-9H...) Show SMILES Fc1cccc2C(C(=O)Nc3ncc(o3)C(F)(F)F)c3cccc(F)c3Oc12 Show InChI InChI=1S/C18H9F5N2O3/c19-10-5-1-3-8-13(9-4-2-6-11(20)15(9)28-14(8)10)16(26)25-17-24-7-12(27-17)18(21,22)23/h1-7,13H,(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	162	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258140 (CHEMBL521982 | N-(4-(trifluoromethyl)oxazol-2-yl)-...) Show SMILES FC(F)(F)c1coc(NC(=O)C2c3ccccc3Oc3ccccc23)n1 Show InChI InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-25-17(22-14)23-16(24)15-10-5-1-3-7-12(10)26-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	202	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258139 (CHEMBL492378 | N-(5-methyl-1,2,4-oxadiazol-3-yl)-9...) Show SMILES Cc1nc(NC(=O)C2c3ccccc3Oc3ccccc23)no1 Show InChI InChI=1S/C17H13N3O3/c1-10-18-17(20-23-10)19-16(21)15-11-6-2-4-8-13(11)22-14-9-5-3-7-12(14)15/h2-9,15H,1H3,(H,19,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	220	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258184 (CHEMBL492979 | rac-3-fluoro-N-(4-(trifluoromethyl)...) Show SMILES Fc1ccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3ccccc3Oc2c1 Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-11-13(7-9)27-12-4-2-1-3-10(12)15(11)16(25)24-17-23-14(8-26-17)18(20,21)22/h1-8,15H,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	260	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258226 (CHEMBL494966 | N-(5-(trifluoromethyl)oxazol-2-yl)-...) Show SMILES FC(F)(F)c1cnc(NC(=O)C2c3ccccc3Oc3ccccc23)o1 Show InChI InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-22-17(26-14)23-16(24)15-10-5-1-3-7-12(10)25-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	394	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258185 (CHEMBL522161 | rac-4-fluoro-N-(4-(trifluoromethyl)...) Show SMILES Fc1cccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3ccccc3Oc12 Show InChI InChI=1S/C18H10F4N2O3/c19-11-6-3-5-10-14(9-4-1-2-7-12(9)27-15(10)11)16(25)24-17-23-13(8-26-17)18(20,21)22/h1-8,14H,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258224 (CHEMBL522875 | rac-2-fluoro-N-(5-(trifluoromethyl)...) Show SMILES Fc1ccc2Oc3ccccc3C(C(=O)Nc3ncc(o3)C(F)(F)F)c2c1 Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-13-11(7-9)15(10-3-1-2-4-12(10)26-13)16(25)24-17-23-8-14(27-17)18(20,21)22/h1-8,15H,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258223 (CHEMBL494960 | rac-4-fluoro-N-(5-(trifluoromethyl)...) Show SMILES Fc1cccc2C(C(=O)Nc3ncc(o3)C(F)(F)F)c3ccccc3Oc12 Show InChI InChI=1S/C18H10F4N2O3/c19-11-6-3-5-10-14(9-4-1-2-7-12(9)26-15(10)11)16(25)24-17-23-8-13(27-17)18(20,21)22/h1-8,14H,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	21	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258186 (4,5-difluoro-N-(5-(trifluoromethyl)oxazol-2-yl)-9H...) Show SMILES Fc1cccc2C(C(=O)Nc3ncc(o3)C(F)(F)F)c3cccc(F)c3Oc12 Show InChI InChI=1S/C18H9F5N2O3/c19-10-5-1-3-8-13(9-4-2-6-11(20)15(9)28-14(8)10)16(26)25-17-24-7-12(27-17)18(21,22)23/h1-7,13H,(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258226 (CHEMBL494966 | N-(5-(trifluoromethyl)oxazol-2-yl)-...) Show SMILES FC(F)(F)c1cnc(NC(=O)C2c3ccccc3Oc3ccccc23)o1 Show InChI InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-22-17(26-14)23-16(24)15-10-5-1-3-7-12(10)25-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	38	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258141 (CHEMBL492570 | rac-2-fluoro-N-(4-(trifluoromethyl)...) Show SMILES Fc1ccc2Oc3ccccc3C(C(=O)Nc3nc(co3)C(F)(F)F)c2c1 Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-13-11(7-9)15(10-3-1-2-4-12(10)27-13)16(25)24-17-23-14(8-26-17)18(20,21)22/h1-8,15H,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258184 (CHEMBL492979 | rac-3-fluoro-N-(4-(trifluoromethyl)...) Show SMILES Fc1ccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3ccccc3Oc2c1 Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-11-13(7-9)27-12-4-2-1-3-10(12)15(11)16(25)24-17-23-14(8-26-17)18(20,21)22/h1-8,15H,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258142 (2,7-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...) Show SMILES Fc1ccc2Oc3ccc(F)cc3C(C(=O)Nc3nc(co3)C(F)(F)F)c2c1 Show InChI InChI=1S/C18H9F5N2O3/c19-8-1-3-12-10(5-8)15(11-6-9(20)2-4-13(11)28-12)16(26)25-17-24-14(7-27-17)18(21,22)23/h1-7,15H,(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	44	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258227 (4,5-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...) Show SMILES Fc1cccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3cccc(F)c3Oc12 Show InChI InChI=1S/C18H9F5N2O3/c19-10-5-1-3-8-13(9-4-2-6-11(20)15(9)28-14(8)10)16(26)25-17-24-12(7-27-17)18(21,22)23/h1-7,13H,(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	47	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258139 (CHEMBL492378 | N-(5-methyl-1,2,4-oxadiazol-3-yl)-9...) Show SMILES Cc1nc(NC(=O)C2c3ccccc3Oc3ccccc23)no1 Show InChI InChI=1S/C17H13N3O3/c1-10-18-17(20-23-10)19-16(21)15-11-6-2-4-8-13(11)22-14-9-5-3-7-12(14)15/h2-9,15H,1H3,(H,19,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	52	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258140 (CHEMBL521982 | N-(4-(trifluoromethyl)oxazol-2-yl)-...) Show SMILES FC(F)(F)c1coc(NC(=O)C2c3ccccc3Oc3ccccc23)n1 Show InChI InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-25-17(22-14)23-16(24)15-10-5-1-3-7-12(10)26-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	56	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258185 (CHEMBL522161 | rac-4-fluoro-N-(4-(trifluoromethyl)...) Show SMILES Fc1cccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3ccccc3Oc12 Show InChI InChI=1S/C18H10F4N2O3/c19-11-6-3-5-10-14(9-4-1-2-7-12(9)27-15(10)11)16(25)24-17-23-13(8-26-17)18(20,21)22/h1-8,14H,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	102	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair