Found 13 hits Enz. Inhib. hit(s) with all data for entry = 50031513 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of human recombinant COX2 by enzyme immuno assay |
Bioorg Med Chem Lett 20: 2168-73 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.040 BindingDB Entry DOI: 10.7270/Q2HT2PGV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50314585
((1-Difluoromethyl-2-oxo-1,2-dihydropyridin-5-yl)ac...)Show InChI InChI=1S/C8H7F2NO3/c9-8(10)11-4-5(3-7(13)14)1-2-6(11)12/h1-2,4,8H,3H2,(H,13,14) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of human recombinant COX2 by enzyme immuno assay |
Bioorg Med Chem Lett 20: 2168-73 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.040 BindingDB Entry DOI: 10.7270/Q2HT2PGV |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of ovine COX1 by enzyme immuno assay |
Bioorg Med Chem Lett 20: 2168-73 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.040 BindingDB Entry DOI: 10.7270/Q2HT2PGV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50314587
(2-(1-Difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)...)Show InChI InChI=1S/C9H9F2NO3/c1-5(8(14)15)6-2-3-12(9(10)11)7(13)4-6/h2-5,9H,1H3,(H,14,15) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of human recombinant COX2 by enzyme immuno assay |
Bioorg Med Chem Lett 20: 2168-73 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.040 BindingDB Entry DOI: 10.7270/Q2HT2PGV |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50314586
(2-(1-Difluoromethyl-2-oxo-1,2-dihydropyridin-3-yl)...)Show InChI InChI=1S/C9H9F2NO3/c1-5(8(14)15)6-3-2-4-12(7(6)13)9(10)11/h2-5,9H,1H3,(H,14,15) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of human recombinant COX2 by enzyme immuno assay |
Bioorg Med Chem Lett 20: 2168-73 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.040 BindingDB Entry DOI: 10.7270/Q2HT2PGV |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50314584
((1-Difluoromethyl-2-oxo-1,2-dihydropyridin-3-yl)ac...)Show InChI InChI=1S/C8H7F2NO3/c9-8(10)11-3-1-2-5(7(11)14)4-6(12)13/h1-3,8H,4H2,(H,12,13) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of ovine COX1 by enzyme immuno assay |
Bioorg Med Chem Lett 20: 2168-73 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.040 BindingDB Entry DOI: 10.7270/Q2HT2PGV |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50314588
(2-(1-Difluoromethyl-2-oxo-1,2-dihydropyridin-5-yl)...)Show InChI InChI=1S/C9H9F2NO3/c1-5(8(14)15)6-2-3-7(13)12(4-6)9(10)11/h2-5,9H,1H3,(H,14,15) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of human recombinant COX2 by enzyme immuno assay |
Bioorg Med Chem Lett 20: 2168-73 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.040 BindingDB Entry DOI: 10.7270/Q2HT2PGV |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50314585
((1-Difluoromethyl-2-oxo-1,2-dihydropyridin-5-yl)ac...)Show InChI InChI=1S/C8H7F2NO3/c9-8(10)11-4-5(3-7(13)14)1-2-6(11)12/h1-2,4,8H,3H2,(H,13,14) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of ovine COX1 by enzyme immuno assay |
Bioorg Med Chem Lett 20: 2168-73 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.040 BindingDB Entry DOI: 10.7270/Q2HT2PGV |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50314584
((1-Difluoromethyl-2-oxo-1,2-dihydropyridin-3-yl)ac...)Show InChI InChI=1S/C8H7F2NO3/c9-8(10)11-3-1-2-5(7(11)14)4-6(12)13/h1-3,8H,4H2,(H,12,13) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of human recombinant COX2 by enzyme immuno assay |
Bioorg Med Chem Lett 20: 2168-73 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.040 BindingDB Entry DOI: 10.7270/Q2HT2PGV |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50314588
(2-(1-Difluoromethyl-2-oxo-1,2-dihydropyridin-5-yl)...)Show InChI InChI=1S/C9H9F2NO3/c1-5(8(14)15)6-2-3-7(13)12(4-6)9(10)11/h2-5,9H,1H3,(H,14,15) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of ovine COX1 by enzyme immuno assay |
Bioorg Med Chem Lett 20: 2168-73 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.040 BindingDB Entry DOI: 10.7270/Q2HT2PGV |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50314587
(2-(1-Difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)...)Show InChI InChI=1S/C9H9F2NO3/c1-5(8(14)15)6-2-3-12(9(10)11)7(13)4-6/h2-5,9H,1H3,(H,14,15) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of ovine COX1 by enzyme immuno assay |
Bioorg Med Chem Lett 20: 2168-73 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.040 BindingDB Entry DOI: 10.7270/Q2HT2PGV |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50314589
((1-Difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)ac...)Show InChI InChI=1S/C8H7F2NO3/c9-8(10)11-2-1-5(3-6(11)12)4-7(13)14/h1-3,8H,4H2,(H,13,14) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.29E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of human recombinant COX2 by enzyme immuno assay |
Bioorg Med Chem Lett 20: 2168-73 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.040 BindingDB Entry DOI: 10.7270/Q2HT2PGV |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50314586
(2-(1-Difluoromethyl-2-oxo-1,2-dihydropyridin-3-yl)...)Show InChI InChI=1S/C9H9F2NO3/c1-5(8(14)15)6-3-2-4-12(7(6)13)9(10)11/h2-5,9H,1H3,(H,14,15) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.65E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of ovine COX1 by enzyme immuno assay |
Bioorg Med Chem Lett 20: 2168-73 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.040 BindingDB Entry DOI: 10.7270/Q2HT2PGV |
More data for this Ligand-Target Pair | |