BindingDB PrimarySearch

Found 14 hits Enz. Inhib. hit(s) with all data for entry = 50038677
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50243238 (({2-Bromo-4-[40-bromo-30-(difluorosulfamoylmethyl)...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Waterloo Curated by ChEMBL					Assay Description Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cells				Bioorg Med Chem 16: 6764-77 (2008) Article DOI: 10.1016/j.bmc.2008.05.062 BindingDB Entry DOI: 10.7270/Q2930V2P
University of Waterloo Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50243240 ((3-((R)-2-((S)-2-((S)-2-((S)-2-((S)-2-amino-3-carb...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Waterloo Curated by ChEMBL					Assay Description Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cells				Bioorg Med Chem 16: 6764-77 (2008) Article DOI: 10.1016/j.bmc.2008.05.062 BindingDB Entry DOI: 10.7270/Q2930V2P
University of Waterloo Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50243239 ({2-Bromo-4-[40-bromo-30-(difluorosulfamoylmethyl)b...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Waterloo Curated by ChEMBL					Assay Description Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cells				Bioorg Med Chem 16: 6764-77 (2008) Article DOI: 10.1016/j.bmc.2008.05.062 BindingDB Entry DOI: 10.7270/Q2930V2P
University of Waterloo Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50243237 ([2-Bromo-4-(40-bromo-30-sulfamoylbiphenyl-4-ylmeth...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	1.03E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Waterloo Curated by ChEMBL					Assay Description Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cells				Bioorg Med Chem 16: 6764-77 (2008) Article DOI: 10.1016/j.bmc.2008.05.062 BindingDB Entry DOI: 10.7270/Q2930V2P
University of Waterloo Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50243236 ([2-Bromo-4-(40-bromo-30-sulfamoylbiphenyl-4-ylmeth...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.06E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Waterloo Curated by ChEMBL					Assay Description Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cells				Bioorg Med Chem 16: 6764-77 (2008) Article DOI: 10.1016/j.bmc.2008.05.062 BindingDB Entry DOI: 10.7270/Q2930V2P
University of Waterloo Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50243184 ({[2-Bromo-4-(40-bromo-30-sulfamoylbiphenyl-4-ylmet...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
University of Waterloo Curated by ChEMBL					Assay Description Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cells				Bioorg Med Chem 16: 6764-77 (2008) Article DOI: 10.1016/j.bmc.2008.05.062 BindingDB Entry DOI: 10.7270/Q2930V2P
University of Waterloo Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50243238 (({2-Bromo-4-[40-bromo-30-(difluorosulfamoylmethyl)...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
University of Waterloo Curated by ChEMBL					Assay Description Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cells				Bioorg Med Chem 16: 6764-77 (2008) Article DOI: 10.1016/j.bmc.2008.05.062 BindingDB Entry DOI: 10.7270/Q2930V2P
University of Waterloo Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50243239 ({2-Bromo-4-[40-bromo-30-(difluorosulfamoylmethyl)b...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Waterloo Curated by ChEMBL					Assay Description Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cells				Bioorg Med Chem 16: 6764-77 (2008) Article DOI: 10.1016/j.bmc.2008.05.062 BindingDB Entry DOI: 10.7270/Q2930V2P
University of Waterloo Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50243241 (CID44560696 \| PTP1B inhibitor 3 \| {3-[(2R)-2-[(2S)...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Waterloo Curated by ChEMBL					Assay Description Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cells				Bioorg Med Chem 16: 6764-77 (2008) Article DOI: 10.1016/j.bmc.2008.05.062 BindingDB Entry DOI: 10.7270/Q2930V2P
University of Waterloo Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50243236 ([2-Bromo-4-(40-bromo-30-sulfamoylbiphenyl-4-ylmeth...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Waterloo Curated by ChEMBL					Assay Description Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cells				Bioorg Med Chem 16: 6764-77 (2008) Article DOI: 10.1016/j.bmc.2008.05.062 BindingDB Entry DOI: 10.7270/Q2930V2P
University of Waterloo Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50243237 ([2-Bromo-4-(40-bromo-30-sulfamoylbiphenyl-4-ylmeth...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Waterloo Curated by ChEMBL					Assay Description Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cells				Bioorg Med Chem 16: 6764-77 (2008) Article DOI: 10.1016/j.bmc.2008.05.062 BindingDB Entry DOI: 10.7270/Q2930V2P
University of Waterloo Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50075312 ((Difluoro-naphthalen-2-yl-methyl)-phosphonic acid ...) Show SMILES OP(O)(=O)C(F)(F)c1ccc2ccccc2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Waterloo Curated by ChEMBL					Assay Description Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cells				Bioorg Med Chem 16: 6764-77 (2008) Article DOI: 10.1016/j.bmc.2008.05.062 BindingDB Entry DOI: 10.7270/Q2930V2P
University of Waterloo Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50243311 ((S)-4-((S)-2-((S)-2-((S)-2-amino-3-carboxypropanam...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Waterloo Curated by ChEMBL					Assay Description Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cells				Bioorg Med Chem 16: 6764-77 (2008) Article DOI: 10.1016/j.bmc.2008.05.062 BindingDB Entry DOI: 10.7270/Q2930V2P
University of Waterloo Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50072598 (CHEMBL109646 \| Sodium; difluoro-naphthalen-2-yl-me...) Show SMILES [O-]S(=O)(=O)C(F)(F)c1ccc2ccccc2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.75E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Waterloo Curated by ChEMBL					Assay Description Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cells				Bioorg Med Chem 16: 6764-77 (2008) Article DOI: 10.1016/j.bmc.2008.05.062 BindingDB Entry DOI: 10.7270/Q2930V2P
University of Waterloo Curated by ChEMBL					More data for this Ligand-Target Pair