Compile Data Set for Download or QSAR

Found 39 hits Enz. Inhib. hit(s) with all data for entry = 50039349   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50335231 (3-{5-[4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1...) Show SMILES CC(C)(O)C(=O)N1CCN(CC1)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F |t:20| Show InChI InChI=1S/C27H25F3N4O4/c1-26(2,38)25(37)34-11-9-33(10-12-34)15-7-8-19(27(28,29)30)17(13-15)21-22(24(36)32-23(21)35)18-14-31-20-6-4-3-5-16(18)20/h3-8,13-14,31,38H,9-12H2,1-2H3,(H,32,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GSK3-beta				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N |r| Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak1 expressed in insect cells using 70 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N |r| Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50335231 (3-{5-[4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1...) Show SMILES CC(C)(O)C(=O)N1CCN(CC1)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F |t:20| Show InChI InChI=1S/C27H25F3N4O4/c1-26(2,38)25(37)34-11-9-33(10-12-34)15-7-8-19(27(28,29)30)17(13-15)21-22(24(36)32-23(21)35)18-14-31-20-6-4-3-5-16(18)20/h3-8,13-14,31,38H,9-12H2,1-2H3,(H,32,35,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N |r| Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak2 expressed in insect cells using 20 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50335231 (3-{5-[4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1...) Show SMILES CC(C)(O)C(=O)N1CCN(CC1)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F |t:20| Show InChI InChI=1S/C27H25F3N4O4/c1-26(2,38)25(37)34-11-9-33(10-12-34)15-7-8-19(27(28,29)30)17(13-15)21-22(24(36)32-23(21)35)18-14-31-20-6-4-3-5-16(18)20/h3-8,13-14,31,38H,9-12H2,1-2H3,(H,32,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of PKCalpha				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N |r| Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50335237 (3-(1H-indol-3-yl)-4-[2-(4-oxo-piperidin-1-yl)-5-tr...) Show SMILES FC(F)(F)c1cnc(nc1C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)N1CCC(=O)CC1 |t:11| Show InChI InChI=1S/C22H16F3N5O3/c23-22(24,25)14-10-27-21(30-7-5-11(31)6-8-30)28-18(14)17-16(19(32)29-20(17)33)13-9-26-15-4-2-1-3-12(13)15/h1-4,9-10,26H,5-8H2,(H,29,32,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50335235 (4-{3-[4-(1H-Indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-p...) Show SMILES FC(F)(F)c1ccc(cc1C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)N1CCN(CC1)C=O |t:11| Show InChI InChI=1S/C24H19F3N4O3/c25-24(26,27)18-6-5-14(31-9-7-30(13-32)8-10-31)11-16(18)20-21(23(34)29-22(20)33)17-12-28-19-4-2-1-3-15(17)19/h1-6,11-13,28H,7-10H2,(H,29,33,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Mus musculus)	BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N |r| Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of Jak3-mediated IL2-induced Stat5 phosphorylation in mouse CTLL cells by cell-based assay				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Protein kinase C theta type (Homo sapiens (Human))	BDBM50335231 (3-{5-[4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1...) Show SMILES CC(C)(O)C(=O)N1CCN(CC1)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F |t:20| Show InChI InChI=1S/C27H25F3N4O4/c1-26(2,38)25(37)34-11-9-33(10-12-34)15-7-8-19(27(28,29)30)17(13-15)21-22(24(36)32-23(21)35)18-14-31-20-6-4-3-5-16(18)20/h3-8,13-14,31,38H,9-12H2,1-2H3,(H,32,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of PKCtheta				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50335233 (3-(1H-Indol-3-yl)-4-(5-piperazin-1-yl-2-trifluorom...) Show SMILES FC(F)(F)c1ccc(cc1C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)N1CCNCC1 |t:11| Show InChI InChI=1S/C23H19F3N4O2/c24-23(25,26)17-6-5-13(30-9-7-27-8-10-30)11-15(17)19-20(22(32)29-21(19)31)16-12-28-18-4-2-1-3-14(16)18/h1-6,11-12,27-28H,7-10H2,(H,29,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	133	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N |r| Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	176	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Tyk2 expressed in insect cells using 35 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM50335237 (3-(1H-indol-3-yl)-4-[2-(4-oxo-piperidin-1-yl)-5-tr...) Show SMILES FC(F)(F)c1cnc(nc1C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)N1CCC(=O)CC1 |t:11| Show InChI InChI=1S/C22H16F3N5O3/c23-22(24,25)14-10-27-21(30-7-5-11(31)6-8-30)28-18(14)17-16(19(32)29-20(17)33)13-9-26-15-4-2-1-3-12(13)15/h1-4,9-10,26H,5-8H2,(H,29,32,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	253	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak1 expressed in insect cells using 70 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50335237 (3-(1H-indol-3-yl)-4-[2-(4-oxo-piperidin-1-yl)-5-tr...) Show SMILES FC(F)(F)c1cnc(nc1C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)N1CCC(=O)CC1 |t:11| Show InChI InChI=1S/C22H16F3N5O3/c23-22(24,25)14-10-27-21(30-7-5-11(31)6-8-30)28-18(14)17-16(19(32)29-20(17)33)13-9-26-15-4-2-1-3-12(13)15/h1-4,9-10,26H,5-8H2,(H,29,32,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak2 expressed in insect cells using 20 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50335234 (3-(5-Dimethylamino-2-trifluoromethyl-phenyl)-4-(1H...) Show SMILES CN(C)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F |t:10| Show InChI InChI=1S/C21H16F3N3O2/c1-27(2)11-7-8-15(21(22,23)24)13(9-11)17-18(20(29)26-19(17)28)14-10-25-16-6-4-3-5-12(14)16/h3-10,25H,1-2H3,(H,26,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	423	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50335236 (3-(1H-Indol-3-yl)-4-(5-morpholin-4-yl-2-trifluorom...) Show SMILES FC(F)(F)c1ccc(cc1C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)N1CCOCC1 |t:11| Show InChI InChI=1S/C23H18F3N3O3/c24-23(25,26)17-6-5-13(29-7-9-32-10-8-29)11-15(17)19-20(22(31)28-21(19)30)16-12-27-18-4-2-1-3-14(16)18/h1-6,11-12,27H,7-10H2,(H,28,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50335231 (3-{5-[4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1...) Show SMILES CC(C)(O)C(=O)N1CCN(CC1)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F |t:20| Show InChI InChI=1S/C27H25F3N4O4/c1-26(2,38)25(37)34-11-9-33(10-12-34)15-7-8-19(27(28,29)30)17(13-15)21-22(24(36)32-23(21)35)18-14-31-20-6-4-3-5-16(18)20/h3-8,13-14,31,38H,9-12H2,1-2H3,(H,32,35,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	525	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of Jak3-mediated IL15-induced Stat5 phosphorylation in human MO7 cells by cell-based assay				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM50335233 (3-(1H-Indol-3-yl)-4-(5-piperazin-1-yl-2-trifluorom...) Show SMILES FC(F)(F)c1ccc(cc1C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)N1CCNCC1 |t:11| Show InChI InChI=1S/C23H19F3N4O2/c24-23(25,26)17-6-5-13(30-9-7-27-8-10-30)11-15(17)19-20(22(32)29-21(19)31)16-12-28-18-4-2-1-3-14(16)18/h1-6,11-12,27-28H,7-10H2,(H,29,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	737	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak1 expressed in insect cells using 70 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM50335235 (4-{3-[4-(1H-Indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-p...) Show SMILES FC(F)(F)c1ccc(cc1C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)N1CCN(CC1)C=O |t:11| Show InChI InChI=1S/C24H19F3N4O3/c25-24(26,27)18-6-5-14(31-9-7-30(13-32)8-10-31)11-16(18)20-21(23(34)29-22(20)33)17-12-28-19-4-2-1-3-15(17)19/h1-6,11-13,28H,7-10H2,(H,29,33,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	754	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak1 expressed in insect cells using 70 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM50335231 (3-{5-[4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1...) Show SMILES CC(C)(O)C(=O)N1CCN(CC1)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F |t:20| Show InChI InChI=1S/C27H25F3N4O4/c1-26(2,38)25(37)34-11-9-33(10-12-34)15-7-8-19(27(28,29)30)17(13-15)21-22(24(36)32-23(21)35)18-14-31-20-6-4-3-5-16(18)20/h3-8,13-14,31,38H,9-12H2,1-2H3,(H,32,35,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak1 expressed in insect cells using 70 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Mus musculus)	BDBM50335231 (3-{5-[4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1...) Show SMILES CC(C)(O)C(=O)N1CCN(CC1)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F |t:20| Show InChI InChI=1S/C27H25F3N4O4/c1-26(2,38)25(37)34-11-9-33(10-12-34)15-7-8-19(27(28,29)30)17(13-15)21-22(24(36)32-23(21)35)18-14-31-20-6-4-3-5-16(18)20/h3-8,13-14,31,38H,9-12H2,1-2H3,(H,32,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.29E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of Jak3-mediated IL2-induced Stat5 phosphorylation in mouse CTLL cells by cell-based assay				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50335235 (4-{3-[4-(1H-Indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-p...) Show SMILES FC(F)(F)c1ccc(cc1C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)N1CCN(CC1)C=O |t:11| Show InChI InChI=1S/C24H19F3N4O3/c25-24(26,27)18-6-5-14(31-9-7-30(13-32)8-10-31)11-16(18)20-21(23(34)29-22(20)33)17-12-28-19-4-2-1-3-15(17)19/h1-6,11-13,28H,7-10H2,(H,29,33,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.44E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak2 expressed in insect cells using 20 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50335231 (3-{5-[4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1...) Show SMILES CC(C)(O)C(=O)N1CCN(CC1)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F |t:20| Show InChI InChI=1S/C27H25F3N4O4/c1-26(2,38)25(37)34-11-9-33(10-12-34)15-7-8-19(27(28,29)30)17(13-15)21-22(24(36)32-23(21)35)18-14-31-20-6-4-3-5-16(18)20/h3-8,13-14,31,38H,9-12H2,1-2H3,(H,32,35,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak2 expressed in insect cells using 20 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50335237 (3-(1H-indol-3-yl)-4-[2-(4-oxo-piperidin-1-yl)-5-tr...) Show SMILES FC(F)(F)c1cnc(nc1C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)N1CCC(=O)CC1 |t:11| Show InChI InChI=1S/C22H16F3N5O3/c23-22(24,25)14-10-27-21(30-7-5-11(31)6-8-30)28-18(14)17-16(19(32)29-20(17)33)13-9-26-15-4-2-1-3-12(13)15/h1-4,9-10,26H,5-8H2,(H,29,32,33)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	4.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Tyk2 expressed in insect cells using 35 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM50335234 (3-(5-Dimethylamino-2-trifluoromethyl-phenyl)-4-(1H...) Show SMILES CN(C)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F |t:10| Show InChI InChI=1S/C21H16F3N3O2/c1-27(2)11-7-8-15(21(22,23)24)13(9-11)17-18(20(29)26-19(17)28)14-10-25-16-6-4-3-5-12(14)16/h3-10,25H,1-2H3,(H,26,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak1 expressed in insect cells using 70 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50335233 (3-(1H-Indol-3-yl)-4-(5-piperazin-1-yl-2-trifluorom...) Show SMILES FC(F)(F)c1ccc(cc1C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)N1CCNCC1 |t:11| Show InChI InChI=1S/C23H19F3N4O2/c24-23(25,26)17-6-5-13(30-9-7-27-8-10-30)11-15(17)19-20(22(32)29-21(19)31)16-12-28-18-4-2-1-3-14(16)18/h1-6,11-12,27-28H,7-10H2,(H,29,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak2 expressed in insect cells using 20 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50335235 (4-{3-[4-(1H-Indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-p...) Show SMILES FC(F)(F)c1ccc(cc1C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)N1CCN(CC1)C=O |t:11| Show InChI InChI=1S/C24H19F3N4O3/c25-24(26,27)18-6-5-14(31-9-7-30(13-32)8-10-31)11-16(18)20-21(23(34)29-22(20)33)17-12-28-19-4-2-1-3-15(17)19/h1-6,11-13,28H,7-10H2,(H,29,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Tyk2 expressed in insect cells using 35 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM50335236 (3-(1H-Indol-3-yl)-4-(5-morpholin-4-yl-2-trifluorom...) Show SMILES FC(F)(F)c1ccc(cc1C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)N1CCOCC1 |t:11| Show InChI InChI=1S/C23H18F3N3O3/c24-23(25,26)17-6-5-13(29-7-9-32-10-8-29)11-15(17)19-20(22(31)28-21(19)30)16-12-27-18-4-2-1-3-14(16)18/h1-6,11-12,27H,7-10H2,(H,28,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak1 expressed in insect cells using 70 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50335231 (3-{5-[4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1...) Show SMILES CC(C)(O)C(=O)N1CCN(CC1)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F |t:20| Show InChI InChI=1S/C27H25F3N4O4/c1-26(2,38)25(37)34-11-9-33(10-12-34)15-7-8-19(27(28,29)30)17(13-15)21-22(24(36)32-23(21)35)18-14-31-20-6-4-3-5-16(18)20/h3-8,13-14,31,38H,9-12H2,1-2H3,(H,32,35,36)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Tyk2 expressed in insect cells using 35 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50335234 (3-(5-Dimethylamino-2-trifluoromethyl-phenyl)-4-(1H...) Show SMILES CN(C)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F |t:10| Show InChI InChI=1S/C21H16F3N3O2/c1-27(2)11-7-8-15(21(22,23)24)13(9-11)17-18(20(29)26-19(17)28)14-10-25-16-6-4-3-5-12(14)16/h3-10,25H,1-2H3,(H,26,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak2 expressed in insect cells using 20 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM50335232 (3-(5-Fluoro-2-trifluoromethyl-phenyl)-4-(1H-indol-...) Show SMILES Fc1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F |t:8| Show InChI InChI=1S/C19H10F4N2O2/c20-9-5-6-13(19(21,22)23)11(7-9)15-16(18(27)25-17(15)26)12-8-24-14-4-2-1-3-10(12)14/h1-8,24H,(H,25,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak1 expressed in insect cells using 70 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50335236 (3-(1H-Indol-3-yl)-4-(5-morpholin-4-yl-2-trifluorom...) Show SMILES FC(F)(F)c1ccc(cc1C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)N1CCOCC1 |t:11| Show InChI InChI=1S/C23H18F3N3O3/c24-23(25,26)17-6-5-13(29-7-9-32-10-8-29)11-15(17)19-20(22(31)28-21(19)30)16-12-27-18-4-2-1-3-14(16)18/h1-6,11-12,27H,7-10H2,(H,28,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak2 expressed in insect cells using 20 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50335233 (3-(1H-Indol-3-yl)-4-(5-piperazin-1-yl-2-trifluorom...) Show SMILES FC(F)(F)c1ccc(cc1C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)N1CCNCC1 |t:11| Show InChI InChI=1S/C23H19F3N4O2/c24-23(25,26)17-6-5-13(30-9-7-27-8-10-30)11-15(17)19-20(22(32)29-21(19)31)16-12-28-18-4-2-1-3-14(16)18/h1-6,11-12,27-28H,7-10H2,(H,29,31,32)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Tyk2 expressed in insect cells using 35 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50335232 (3-(5-Fluoro-2-trifluoromethyl-phenyl)-4-(1H-indol-...) Show SMILES Fc1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F |t:8| Show InChI InChI=1S/C19H10F4N2O2/c20-9-5-6-13(19(21,22)23)11(7-9)15-16(18(27)25-17(15)26)12-8-24-14-4-2-1-3-10(12)14/h1-8,24H,(H,25,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak2 expressed in insect cells using 20 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50335232 (3-(5-Fluoro-2-trifluoromethyl-phenyl)-4-(1H-indol-...) Show SMILES Fc1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F |t:8| Show InChI InChI=1S/C19H10F4N2O2/c20-9-5-6-13(19(21,22)23)11(7-9)15-16(18(27)25-17(15)26)12-8-24-14-4-2-1-3-10(12)14/h1-8,24H,(H,25,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Tyk2 expressed in insect cells using 35 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50335236 (3-(1H-Indol-3-yl)-4-(5-morpholin-4-yl-2-trifluorom...) Show SMILES FC(F)(F)c1ccc(cc1C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)N1CCOCC1 |t:11| Show InChI InChI=1S/C23H18F3N3O3/c24-23(25,26)17-6-5-13(29-7-9-32-10-8-29)11-15(17)19-20(22(31)28-21(19)30)16-12-27-18-4-2-1-3-14(16)18/h1-6,11-12,27H,7-10H2,(H,28,30,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Tyk2 expressed in insect cells using 35 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50335234 (3-(5-Dimethylamino-2-trifluoromethyl-phenyl)-4-(1H...) Show SMILES CN(C)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F |t:10| Show InChI InChI=1S/C21H16F3N3O2/c1-27(2)11-7-8-15(21(22,23)24)13(9-11)17-18(20(29)26-19(17)28)14-10-25-16-6-4-3-5-12(14)16/h3-10,25H,1-2H3,(H,26,28,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Tyk2 expressed in insect cells using 35 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50335232 (3-(5-Fluoro-2-trifluoromethyl-phenyl)-4-(1H-indol-...) Show SMILES Fc1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F |t:8| Show InChI InChI=1S/C19H10F4N2O2/c20-9-5-6-13(19(21,22)23)11(7-9)15-16(18(27)25-17(15)26)12-8-24-14-4-2-1-3-10(12)14/h1-8,24H,(H,25,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATP				J Med Chem 54: 284-8 (2011) Article DOI: 10.1021/jm101157q BindingDB Entry DOI: 10.7270/Q2BP03S5
					More data for this Ligand-Target Pair