Compile Data Set for Download or QSAR

Found 141 hits Enz. Inhib. hit(s) with all data for entry = 50039407   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM22334 (BW A4C | BW4C | BWA4C | BWA4C, 10 | CHEMBL314360 |...) Show SMILES CC(=O)N(O)C\C=C\c1cccc(Oc2ccccc2)c1 Show InChI InChI=1S/C17H17NO3/c1-14(19)18(20)12-6-8-15-7-5-11-17(13-15)21-16-9-3-2-4-10-16/h2-11,13,20H,12H2,1H3/b8-6+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM22334 (BW A4C | BW4C | BWA4C | BWA4C, 10 | CHEMBL314360 |...) Show SMILES CC(=O)N(O)C\C=C\c1cccc(Oc2ccccc2)c1 Show InChI InChI=1S/C17H17NO3/c1-14(19)18(20)12-6-8-15-7-5-11-17(13-15)21-16-9-3-2-4-10-16/h2-11,13,20H,12H2,1H3/b8-6+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM22334 (BW A4C | BW4C | BWA4C | BWA4C, 10 | CHEMBL314360 |...) Show SMILES CC(=O)N(O)C\C=C\c1cccc(Oc2ccccc2)c1 Show InChI InChI=1S/C17H17NO3/c1-14(19)18(20)12-6-8-15-7-5-11-17(13-15)21-16-9-3-2-4-10-16/h2-11,13,20H,12H2,1H3/b8-6+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM22334 (BW A4C | BW4C | BWA4C | BWA4C, 10 | CHEMBL314360 |...) Show SMILES CC(=O)N(O)C\C=C\c1cccc(Oc2ccccc2)c1 Show InChI InChI=1S/C17H17NO3/c1-14(19)18(20)12-6-8-15-7-5-11-17(13-15)21-16-9-3-2-4-10-16/h2-11,13,20H,12H2,1H3/b8-6+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341269 ((Z)-2-(4-Chlorophenyl)-5-(4-methoxybenzylidene)-5H...) Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(Cl)cc2)cc1 |c:9| Show InChI InChI=1S/C17H12ClNO2S/c1-21-14-8-2-11(3-9-14)10-15-16(20)19-17(22-15)12-4-6-13(18)7-5-12/h2-10H,1H3/b15-10-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341269 ((Z)-2-(4-Chlorophenyl)-5-(4-methoxybenzylidene)-5H...) Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(Cl)cc2)cc1 |c:9| Show InChI InChI=1S/C17H12ClNO2S/c1-21-14-8-2-11(3-9-14)10-15-16(20)19-17(22-15)12-4-6-13(18)7-5-12/h2-10H,1H3/b15-10-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341275 ((Z)-2-(4-Acetylphenyl)-5-(4-methoxybenzylidene)-5H...) Show SMILES COc1ccc(C=C2SC(=NC2=O)c2ccc(cc2)C(C)=O)cc1 |w:6.5,c:9| Show InChI InChI=1S/C19H15NO3S/c1-12(21)14-5-7-15(8-6-14)19-20-18(22)17(24-19)11-13-3-9-16(23-2)10-4-13/h3-11H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341275 ((Z)-2-(4-Acetylphenyl)-5-(4-methoxybenzylidene)-5H...) Show SMILES COc1ccc(C=C2SC(=NC2=O)c2ccc(cc2)C(C)=O)cc1 |w:6.5,c:9| Show InChI InChI=1S/C19H15NO3S/c1-12(21)14-5-7-15(8-6-14)19-20-18(22)17(24-19)11-13-3-9-16(23-2)10-4-13/h3-11H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341278 ((Z)-2-(4-Chlorophenyl)-5-(4-hydroxybenzylidene)-5H...) Show SMILES Oc1ccc(\C=C2/SC(=NC2=O)c2ccc(Cl)cc2)cc1 |c:8| Show InChI InChI=1S/C16H10ClNO2S/c17-12-5-3-11(4-6-12)16-18-15(20)14(21-16)9-10-1-7-13(19)8-2-10/h1-9,19H/b14-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341278 ((Z)-2-(4-Chlorophenyl)-5-(4-hydroxybenzylidene)-5H...) Show SMILES Oc1ccc(\C=C2/SC(=NC2=O)c2ccc(Cl)cc2)cc1 |c:8| Show InChI InChI=1S/C16H10ClNO2S/c17-12-5-3-11(4-6-12)16-18-15(20)14(21-16)9-10-1-7-13(19)8-2-10/h1-9,19H/b14-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341277 ((Z)-2-(3-Fluorophenyl)-5-(4-methoxybenzylidene)-5H...) Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2cccc(F)c2)cc1 |c:9| Show InChI InChI=1S/C17H12FNO2S/c1-21-14-7-5-11(6-8-14)9-15-16(20)19-17(22-15)12-3-2-4-13(18)10-12/h2-10H,1H3/b15-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341277 ((Z)-2-(3-Fluorophenyl)-5-(4-methoxybenzylidene)-5H...) Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2cccc(F)c2)cc1 |c:9| Show InChI InChI=1S/C17H12FNO2S/c1-21-14-7-5-11(6-8-14)9-15-16(20)19-17(22-15)12-3-2-4-13(18)10-12/h2-10H,1H3/b15-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341259 (5-(2,5-dimethoxybenzylidene)-2-p-tolylthiazol-4(5H...) Show SMILES COc1ccc(OC)c(\C=C2/SC(=NC2=O)c2ccc(C)cc2)c1 |c:12| Show InChI InChI=1S/C19H17NO3S/c1-12-4-6-13(7-5-12)19-20-18(21)17(24-19)11-14-10-15(22-2)8-9-16(14)23-3/h4-11H,1-3H3/b17-11-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341276 ((Z)-2-(3-Acetylphenyl)-5-(4-methoxybenzylidene)-5H...) Show SMILES COc1ccc(C=C2SC(=NC2=O)c2cccc(c2)C(C)=O)cc1 |w:6.5,c:9| Show InChI InChI=1S/C19H15NO3S/c1-12(21)14-4-3-5-15(11-14)19-20-18(22)17(24-19)10-13-6-8-16(23-2)9-7-13/h3-11H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341259 (5-(2,5-dimethoxybenzylidene)-2-p-tolylthiazol-4(5H...) Show SMILES COc1ccc(OC)c(\C=C2/SC(=NC2=O)c2ccc(C)cc2)c1 |c:12| Show InChI InChI=1S/C19H17NO3S/c1-12-4-6-13(7-5-12)19-20-18(21)17(24-19)11-14-10-15(22-2)8-9-16(14)23-3/h4-11H,1-3H3/b17-11-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341276 ((Z)-2-(3-Acetylphenyl)-5-(4-methoxybenzylidene)-5H...) Show SMILES COc1ccc(C=C2SC(=NC2=O)c2cccc(c2)C(C)=O)cc1 |w:6.5,c:9| Show InChI InChI=1S/C19H15NO3S/c1-12(21)14-4-3-5-15(11-14)19-20-18(22)17(24-19)10-13-6-8-16(23-2)9-7-13/h3-11H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341270 ((Z)-5-(4-Methoxybenzylidene)-2-phenylthiazol-5H-th...) Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccccc2)cc1 |c:9| Show InChI InChI=1S/C17H13NO2S/c1-20-14-9-7-12(8-10-14)11-15-16(19)18-17(21-15)13-5-3-2-4-6-13/h2-11H,1H3/b15-11-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341270 ((Z)-5-(4-Methoxybenzylidene)-2-phenylthiazol-5H-th...) Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccccc2)cc1 |c:9| Show InChI InChI=1S/C17H13NO2S/c1-20-14-9-7-12(8-10-14)11-15-16(19)18-17(21-15)13-5-3-2-4-6-13/h2-11H,1H3/b15-11-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341271 ((Z)-Methyl-2-(4-((4-oxo-2-(p-tolyl)-4H-thiazol-5-y...) Show SMILES COC(=O)COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)cc1 |c:13| Show InChI InChI=1S/C20H17NO4S/c1-13-3-7-15(8-4-13)20-21-19(23)17(26-20)11-14-5-9-16(10-6-14)25-12-18(22)24-2/h3-11H,12H2,1-2H3/b17-11-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341271 ((Z)-Methyl-2-(4-((4-oxo-2-(p-tolyl)-4H-thiazol-5-y...) Show SMILES COC(=O)COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)cc1 |c:13| Show InChI InChI=1S/C20H17NO4S/c1-13-3-7-15(8-4-13)20-21-19(23)17(26-20)11-14-5-9-16(10-6-14)25-12-18(22)24-2/h3-11H,12H2,1-2H3/b17-11-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341266 (5-(-3-phenylallylidene)-2-p-tolylthiazol-4(5H)-one...) Show SMILES Cc1ccc(cc1)C1=NC(=O)\C(S1)=C\C=C\c1ccccc1 |t:8| Show InChI InChI=1S/C19H15NOS/c1-14-10-12-16(13-11-14)19-20-18(21)17(22-19)9-5-8-15-6-3-2-4-7-15/h2-13H,1H3/b8-5+,17-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341266 (5-(-3-phenylallylidene)-2-p-tolylthiazol-4(5H)-one...) Show SMILES Cc1ccc(cc1)C1=NC(=O)\C(S1)=C\C=C\c1ccccc1 |t:8| Show InChI InChI=1S/C19H15NOS/c1-14-10-12-16(13-11-14)19-20-18(21)17(22-19)9-5-8-15-6-3-2-4-7-15/h2-13H,1H3/b8-5+,17-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341277 ((Z)-2-(3-Fluorophenyl)-5-(4-methoxybenzylidene)-5H...) Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2cccc(F)c2)cc1 |c:9| Show InChI InChI=1S/C17H12FNO2S/c1-21-14-7-5-11(6-8-14)9-15-16(20)19-17(22-15)12-3-2-4-13(18)10-12/h2-10H,1H3/b15-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341277 ((Z)-2-(3-Fluorophenyl)-5-(4-methoxybenzylidene)-5H...) Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2cccc(F)c2)cc1 |c:9| Show InChI InChI=1S/C17H12FNO2S/c1-21-14-7-5-11(6-8-14)9-15-16(20)19-17(22-15)12-3-2-4-13(18)10-12/h2-10H,1H3/b15-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341269 ((Z)-2-(4-Chlorophenyl)-5-(4-methoxybenzylidene)-5H...) Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(Cl)cc2)cc1 |c:9| Show InChI InChI=1S/C17H12ClNO2S/c1-21-14-8-2-11(3-9-14)10-15-16(20)19-17(22-15)12-4-6-13(18)7-5-12/h2-10H,1H3/b15-10-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341269 ((Z)-2-(4-Chlorophenyl)-5-(4-methoxybenzylidene)-5H...) Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(Cl)cc2)cc1 |c:9| Show InChI InChI=1S/C17H12ClNO2S/c1-21-14-8-2-11(3-9-14)10-15-16(20)19-17(22-15)12-4-6-13(18)7-5-12/h2-10H,1H3/b15-10-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341267 (5-(4-tert-butylbenzylidene)-2-phenylthiazol-4(5H)-...) Show SMILES CC(C)(C)c1ccc(\C=C2/SC(=NC2=O)c2ccccc2)cc1 |c:11| Show InChI InChI=1S/C20H19NOS/c1-20(2,3)16-11-9-14(10-12-16)13-17-18(22)21-19(23-17)15-7-5-4-6-8-15/h4-13H,1-3H3/b17-13-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341254 (5-(5-chloro-2-hydroxy-3-methoxybenzylidene)-2-phen...) Show SMILES COc1cc(Cl)cc(\C=C2/SC(=NC2=O)c2ccccc2)c1O |c:11| Show InChI InChI=1S/C17H12ClNO3S/c1-22-13-9-12(18)7-11(15(13)20)8-14-16(21)19-17(23-14)10-5-3-2-4-6-10/h2-9,20H,1H3/b14-8-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341253 (5-(3-chlorobenzylidene)-2-p-tolylthiazol-4(5H)-one...) Show SMILES Cc1ccc(cc1)C1=NC(=O)\C(S1)=C\c1cccc(Cl)c1 |t:8| Show InChI InChI=1S/C17H12ClNOS/c1-11-5-7-13(8-6-11)17-19-16(20)15(21-17)10-12-3-2-4-14(18)9-12/h2-10H,1H3/b15-10-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341258 ((Z)-5-(4-Methoxybenzylidene)-2-(p-tolyl)-5H-thiazo...) Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)cc1 |c:9| Show InChI InChI=1S/C18H15NO2S/c1-12-3-7-14(8-4-12)18-19-17(20)16(22-18)11-13-5-9-15(21-2)10-6-13/h3-11H,1-2H3/b16-11-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341268 (5-(anthracen-9-ylmethylene)-2-phenylthiazol-4(5H)-...) Show SMILES O=C1N=C(S\C1=C/c1c2ccccc2cc2ccccc12)c1ccccc1 |c:2| Show InChI InChI=1S/C24H15NOS/c26-23-22(27-24(25-23)16-8-2-1-3-9-16)15-21-19-12-6-4-10-17(19)14-18-11-5-7-13-20(18)21/h1-15H/b22-15-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341267 (5-(4-tert-butylbenzylidene)-2-phenylthiazol-4(5H)-...) Show SMILES CC(C)(C)c1ccc(\C=C2/SC(=NC2=O)c2ccccc2)cc1 |c:11| Show InChI InChI=1S/C20H19NOS/c1-20(2,3)16-11-9-14(10-12-16)13-17-18(22)21-19(23-17)15-7-5-4-6-8-15/h4-13H,1-3H3/b17-13-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341254 (5-(5-chloro-2-hydroxy-3-methoxybenzylidene)-2-phen...) Show SMILES COc1cc(Cl)cc(\C=C2/SC(=NC2=O)c2ccccc2)c1O |c:11| Show InChI InChI=1S/C17H12ClNO3S/c1-22-13-9-12(18)7-11(15(13)20)8-14-16(21)19-17(23-14)10-5-3-2-4-6-10/h2-9,20H,1H3/b14-8-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341253 (5-(3-chlorobenzylidene)-2-p-tolylthiazol-4(5H)-one...) Show SMILES Cc1ccc(cc1)C1=NC(=O)\C(S1)=C\c1cccc(Cl)c1 |t:8| Show InChI InChI=1S/C17H12ClNOS/c1-11-5-7-13(8-6-11)17-19-16(20)15(21-17)10-12-3-2-4-14(18)9-12/h2-10H,1H3/b15-10-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341258 ((Z)-5-(4-Methoxybenzylidene)-2-(p-tolyl)-5H-thiazo...) Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)cc1 |c:9| Show InChI InChI=1S/C18H15NO2S/c1-12-3-7-14(8-4-12)18-19-17(20)16(22-18)11-13-5-9-15(21-2)10-6-13/h3-11H,1-2H3/b16-11-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341268 (5-(anthracen-9-ylmethylene)-2-phenylthiazol-4(5H)-...) Show SMILES O=C1N=C(S\C1=C/c1c2ccccc2cc2ccccc12)c1ccccc1 |c:2| Show InChI InChI=1S/C24H15NOS/c26-23-22(27-24(25-23)16-8-2-1-3-9-16)15-21-19-12-6-4-10-17(19)14-18-11-5-7-13-20(18)21/h1-15H/b22-15-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341274 ((Z)-5-(4-Methoxybenzylidene)-2-(4-methoxyphenyl)-5...) Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(OC)cc2)cc1 |c:9| Show InChI InChI=1S/C18H15NO3S/c1-21-14-7-3-12(4-8-14)11-16-17(20)19-18(23-16)13-5-9-15(22-2)10-6-13/h3-11H,1-2H3/b16-11-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341274 ((Z)-5-(4-Methoxybenzylidene)-2-(4-methoxyphenyl)-5...) Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(OC)cc2)cc1 |c:9| Show InChI InChI=1S/C18H15NO3S/c1-21-14-7-3-12(4-8-14)11-16-17(20)19-18(23-16)13-5-9-15(22-2)10-6-13/h3-11H,1-2H3/b16-11-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341259 (5-(2,5-dimethoxybenzylidene)-2-p-tolylthiazol-4(5H...) Show SMILES COc1ccc(OC)c(\C=C2/SC(=NC2=O)c2ccc(C)cc2)c1 |c:12| Show InChI InChI=1S/C19H17NO3S/c1-12-4-6-13(7-5-12)19-20-18(21)17(24-19)11-14-10-15(22-2)8-9-16(14)23-3/h4-11H,1-3H3/b17-11-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341265 (5-benzylidene-2-p-tolylthiazol-4(5H)-one | CHEMBL1...) Show SMILES Cc1ccc(cc1)C1=NC(=O)\C(S1)=C\c1ccccc1 |t:8| Show InChI InChI=1S/C17H13NOS/c1-12-7-9-14(10-8-12)17-18-16(19)15(20-17)11-13-5-3-2-4-6-13/h2-11H,1H3/b15-11-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341259 (5-(2,5-dimethoxybenzylidene)-2-p-tolylthiazol-4(5H...) Show SMILES COc1ccc(OC)c(\C=C2/SC(=NC2=O)c2ccc(C)cc2)c1 |c:12| Show InChI InChI=1S/C19H17NO3S/c1-12-4-6-13(7-5-12)19-20-18(21)17(24-19)11-14-10-15(22-2)8-9-16(14)23-3/h4-11H,1-3H3/b17-11-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341265 (5-benzylidene-2-p-tolylthiazol-4(5H)-one | CHEMBL1...) Show SMILES Cc1ccc(cc1)C1=NC(=O)\C(S1)=C\c1ccccc1 |t:8| Show InChI InChI=1S/C17H13NOS/c1-12-7-9-14(10-8-12)17-18-16(19)15(20-17)11-13-5-3-2-4-6-13/h2-11H,1H3/b15-11-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341276 ((Z)-2-(3-Acetylphenyl)-5-(4-methoxybenzylidene)-5H...) Show SMILES COc1ccc(C=C2SC(=NC2=O)c2cccc(c2)C(C)=O)cc1 |w:6.5,c:9| Show InChI InChI=1S/C19H15NO3S/c1-12(21)14-4-3-5-15(11-14)19-20-18(22)17(24-19)10-13-6-8-16(23-2)9-7-13/h3-11H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341276 ((Z)-2-(3-Acetylphenyl)-5-(4-methoxybenzylidene)-5H...) Show SMILES COc1ccc(C=C2SC(=NC2=O)c2cccc(c2)C(C)=O)cc1 |w:6.5,c:9| Show InChI InChI=1S/C19H15NO3S/c1-12(21)14-4-3-5-15(11-14)19-20-18(22)17(24-19)10-13-6-8-16(23-2)9-7-13/h3-11H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341260 (2-p-tolyl-5-(2,3,4-trimethoxybenzylidene)thiazol-4...) Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)c(OC)c1OC |c:9| Show InChI InChI=1S/C20H19NO4S/c1-12-5-7-13(8-6-12)20-21-19(22)16(26-20)11-14-9-10-15(23-2)18(25-4)17(14)24-3/h5-11H,1-4H3/b16-11-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341278 ((Z)-2-(4-Chlorophenyl)-5-(4-hydroxybenzylidene)-5H...) Show SMILES Oc1ccc(\C=C2/SC(=NC2=O)c2ccc(Cl)cc2)cc1 |c:8| Show InChI InChI=1S/C16H10ClNO2S/c17-12-5-3-11(4-6-12)16-18-15(20)14(21-16)9-10-1-7-13(19)8-2-10/h1-9,19H/b14-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341278 ((Z)-2-(4-Chlorophenyl)-5-(4-hydroxybenzylidene)-5H...) Show SMILES Oc1ccc(\C=C2/SC(=NC2=O)c2ccc(Cl)cc2)cc1 |c:8| Show InChI InChI=1S/C16H10ClNO2S/c17-12-5-3-11(4-6-12)16-18-15(20)14(21-16)9-10-1-7-13(19)8-2-10/h1-9,19H/b14-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341266 (5-(-3-phenylallylidene)-2-p-tolylthiazol-4(5H)-one...) Show SMILES Cc1ccc(cc1)C1=NC(=O)\C(S1)=C\C=C\c1ccccc1 |t:8| Show InChI InChI=1S/C19H15NOS/c1-14-10-12-16(13-11-14)19-20-18(21)17(22-19)9-5-8-15-6-3-2-4-7-15/h2-13H,1H3/b8-5+,17-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341260 (2-p-tolyl-5-(2,3,4-trimethoxybenzylidene)thiazol-4...) Show SMILES COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)c(OC)c1OC |c:9| Show InChI InChI=1S/C20H19NO4S/c1-12-5-7-13(8-6-12)20-21-19(22)16(26-20)11-14-9-10-15(23-2)18(25-4)17(14)24-3/h5-11H,1-4H3/b16-11-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50341266 (5-(-3-phenylallylidene)-2-p-tolylthiazol-4(5H)-one...) Show SMILES Cc1ccc(cc1)C1=NC(=O)\C(S1)=C\C=C\c1ccccc1 |t:8| Show InChI InChI=1S/C19H15NOS/c1-14-10-12-16(13-11-14)19-20-18(21)17(22-19)9-5-8-15-6-3-2-4-7-15/h2-13H,1H3/b8-5+,17-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
					More data for this Ligand-Target Pair

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