Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM18207 ((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 0.508 | n/a | n/a | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Antagonist activity at glucocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as inhibition of transactivation activity a... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mineralocorticoid receptor (Homo sapiens (Human)) | BDBM19214 ((1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 9.27 | n/a | n/a | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Antagonist activity at mineralocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as inhibition of transactivation activit... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Estrogen receptor beta (Homo sapiens (Human)) | BDBM17292 ((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 10.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Antagonist activity at ERbeta-LBD in human U2OS cells transfected with Gal4-DBD assessed as inhibition of transactivation activity after 18 hrs by lu... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM17292 ((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 21.0 | n/a | n/a | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Antagonist activity at ERalpha-LBD in human U2OS cells transfected with Gal4-DBD assessed as inhibition of transactivation activity after 18 hrs by l... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50417023 (CHEMBL1258901) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.13E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Antagonist activity at glucocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as inhibition of transactivation activity a... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mineralocorticoid receptor (Homo sapiens (Human)) | BDBM50417023 (CHEMBL1258901) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.81E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Antagonist activity at mineralocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as inhibition of transactivation activit... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mineralocorticoid receptor (Homo sapiens (Human)) | BDBM50417030 (CHEMBL1257167) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Antagonist activity at mineralocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as inhibition of transactivation activit... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50417022 (CHEMBL1258783) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.36E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Antagonist activity at glucocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as inhibition of transactivation activity a... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor beta (Homo sapiens (Human)) | BDBM50417028 (CHEMBL1258902) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Agonist activity at ERbeta-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity after 18 hrs by lucifer... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor beta (Homo sapiens (Human)) | BDBM50417029 (CHEMBL1257168) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 5.19E+3 | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Agonist activity at ERbeta-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity after 18 hrs by lucifer... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM50417025 (CHEMBL1257284) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.66E+3 | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Agonist activity at ERalpha-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity after 18 hrs by lucife... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM50417023 (CHEMBL1258901) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 35.5 | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Agonist activity at ERalpha-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity after 18 hrs by lucife... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM50417030 (CHEMBL1257167) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 403 | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Agonist activity at ERalpha-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity after 18 hrs by lucife... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM50417028 (CHEMBL1258902) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 485 | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Agonist activity at ERalpha-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity after 18 hrs by lucife... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mineralocorticoid receptor (Homo sapiens (Human)) | BDBM19214 ((1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 0.338 | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Agonist activity at mineralocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity aft... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Estrogen receptor beta (Homo sapiens (Human)) | BDBM17292 ((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 0.458 | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Agonist activity at ERbeta-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity after 18 hrs by lucifer... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM17292 ((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 2.77 | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Agonist activity at ERalpha-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity after 18 hrs by lucife... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM50417022 (CHEMBL1258783) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 9.95E+3 | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Agonist activity at ERalpha-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity after 18 hrs by lucife... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM50417027 (CHEMBL1256103) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.03E+3 | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Agonist activity at ERalpha-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity after 18 hrs by lucife... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM50417029 (CHEMBL1257168) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 4.03E+3 | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Agonist activity at ERalpha-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity after 18 hrs by lucife... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM50417024 (CHEMBL1256102) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.08E+3 | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Agonist activity at ERalpha-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity after 18 hrs by lucife... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50417026 (CHEMBL1256105) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.73 | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Agonist activity at glucocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity after ... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor beta (Homo sapiens (Human)) | BDBM50417023 (CHEMBL1258901) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 129 | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Agonist activity at ERbeta-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity after 18 hrs by lucifer... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor beta (Homo sapiens (Human)) | BDBM50417027 (CHEMBL1256103) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 52 | n/a | n/a | n/a | n/a |
Charles University in Prague Curated by ChEMBL | Assay Description Agonist activity at ERbeta-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity after 18 hrs by lucifer... | J Med Chem 53: 6947-53 (2010) Article DOI: 10.1021/jm100563h BindingDB Entry DOI: 10.7270/Q2PC33M2 | |||||||||||
More data for this Ligand-Target Pair |