Compile Data Set for Download or QSAR

Found 54 hits Enz. Inhib. hit(s) with all data for entry = 50010451   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M4 (RAT)	BDBM50538973 (CHEMBL4632855) Show SMILES Cn1nnc2ccc(cc12)C(=O)NC1CN(C1)c1cc(Cl)ncc1Cl Show InChI InChI=1S/C16H14Cl2N6O/c1-23-14-4-9(2-3-12(14)21-22-23)16(25)20-10-7-24(8-10)13-5-15(18)19-6-11(13)17/h2-6,10H,7-8H2,1H3,(H,20,25)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	721	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M4 receptor				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (RAT)	BDBM50539003 (CHEMBL4640254) Show SMILES Cn1nnc2ccc3c(NC4CN(C4)c4cc(Cl)ncc4Cl)ncnc3c12 Show InChI InChI=1S/C17H14Cl2N8/c1-26-16-12(24-25-26)3-2-10-15(16)21-8-22-17(10)23-9-6-27(7-9)13-4-14(19)20-5-11(13)18/h2-5,8-9H,6-7H2,1H3,(H,21,22,23)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	148	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M4 receptor				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (RAT)	BDBM50538994 (CHEMBL4634770) Show SMILES COc1cc(N2CC(C2)Nc2ncnc3c4c(C)n(C)nc4ccc23)c(Cl)cn1 Show InChI InChI=1S/C20H20ClN7O/c1-11-18-15(26-27(11)2)5-4-13-19(18)23-10-24-20(13)25-12-8-28(9-12)16-6-17(29-3)22-7-14(16)21/h4-7,10,12H,8-9H2,1-3H3,(H,23,24,25)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	226	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M4 receptor				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (RAT)	BDBM50538995 (CHEMBL4642156) Show SMILES Cc1n(C)nc2ccc3c(NCc4ccc(cc4)C(=O)NC4CCCC4)ncnc3c12 Show InChI InChI=1S/C24H26N6O/c1-15-21-20(29-30(15)2)12-11-19-22(21)26-14-27-23(19)25-13-16-7-9-17(10-8-16)24(31)28-18-5-3-4-6-18/h7-12,14,18H,3-6,13H2,1-2H3,(H,28,31)(H,25,26,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	168	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M4 receptor				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (RAT)	BDBM50538996 (CHEMBL4636845) Show SMILES Cc1n(C)nc2ccc3c(NCc4ccc(cc4)C(=O)NC4CCC4)ncnc3c12 Show InChI InChI=1S/C23H24N6O/c1-14-20-19(28-29(14)2)11-10-18-21(20)25-13-26-22(18)24-12-15-6-8-16(9-7-15)23(30)27-17-4-3-5-17/h6-11,13,17H,3-5,12H2,1-2H3,(H,27,30)(H,24,25,26)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	322	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M4 receptor				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (RAT)	BDBM50538997 (CHEMBL4635909) Show SMILES COc1ccc(CNc2ncnc3c4c(C)n(C)nc4ccc23)cc1F Show InChI InChI=1S/C19H18FN5O/c1-11-17-15(24-25(11)2)6-5-13-18(17)22-10-23-19(13)21-9-12-4-7-16(26-3)14(20)8-12/h4-8,10H,9H2,1-3H3,(H,21,22,23)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	181	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M4 receptor				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (RAT)	BDBM50538998 (CHEMBL4632962) Show SMILES Cc1n(C)nc2ccc(C(=O)NC3CN(C3)c3cc(Cl)ncc3Cl)c(N)c12 Show InChI InChI=1S/C18H18Cl2N6O/c1-9-16-13(24-25(9)2)4-3-11(17(16)21)18(27)23-10-7-26(8-10)14-5-15(20)22-6-12(14)19/h3-6,10H,7-8,21H2,1-2H3,(H,23,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	42	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M4 receptor				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (RAT)	BDBM50538999 (CHEMBL4641848) Show SMILES Cc1n(C)nc2ccc(C(=O)NC3CN(C3)c3ccc(nc3)C(F)(F)F)c(N)c12 Show InChI InChI=1S/C19H19F3N6O/c1-10-16-14(26-27(10)2)5-4-13(17(16)23)18(29)25-11-8-28(9-11)12-3-6-15(24-7-12)19(20,21)22/h3-7,11H,8-9,23H2,1-2H3,(H,25,29)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	112	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M4 receptor				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (RAT)	BDBM50539000 (CHEMBL4639222) Show SMILES COc1cc(N2CC(C2)NC(=O)c2ccc3nn(C)c(C)c3c2N)c(Cl)cn1 Show InChI InChI=1S/C19H21ClN6O2/c1-10-17-14(24-25(10)2)5-4-12(18(17)21)19(27)23-11-8-26(9-11)15-6-16(28-3)22-7-13(15)20/h4-7,11H,8-9,21H2,1-3H3,(H,23,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	82	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M4 receptor				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (RAT)	BDBM50539001 (CHEMBL4635732) Show SMILES Cc1n(C)nc2ccc(C(=O)NC3CN(C3)c3ncc(cc3Cl)C#N)c(N)c12 Show InChI InChI=1S/C19H18ClN7O/c1-10-16-15(25-26(10)2)4-3-13(17(16)22)19(28)24-12-8-27(9-12)18-14(20)5-11(6-21)7-23-18/h3-5,7,12H,8-9,22H2,1-2H3,(H,24,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	129	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M4 receptor				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (RAT)	BDBM50539002 (CHEMBL4638291) Show SMILES Cc1n(C)nc2ccc(C(=O)NC3CN(C3)c3ncc(Cl)cc3F)c(N)c12 Show InChI InChI=1S/C18H18ClFN6O/c1-9-15-14(24-25(9)2)4-3-12(16(15)21)18(27)23-11-7-26(8-11)17-13(20)5-10(19)6-22-17/h3-6,11H,7-8,21H2,1-2H3,(H,23,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	72	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M4 receptor				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (RAT)	BDBM50538969 (CHEMBL4632555) Show SMILES Cc1n(C)nc2ccc(cc12)C(=O)NC1CN(C1)c1cc(Cl)ncc1Cl Show InChI InChI=1S/C18H17Cl2N5O/c1-10-13-5-11(3-4-15(13)23-24(10)2)18(26)22-12-8-25(9-12)16-6-17(20)21-7-14(16)19/h3-7,12H,8-9H2,1-2H3,(H,22,26)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	259	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M4 receptor				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539003 (CHEMBL4640254) Show SMILES Cn1nnc2ccc3c(NC4CN(C4)c4cc(Cl)ncc4Cl)ncnc3c12 Show InChI InChI=1S/C17H14Cl2N8/c1-26-16-12(24-25-26)3-2-10-15(16)21-8-22-17(10)23-9-6-27(7-9)13-4-14(19)20-5-11(13)18/h2-5,8-9H,6-7H2,1H3,(H,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	63	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539004 (CHEMBL4643687) Show SMILES COc1ccc(CNc2ncnc3c4n(C)nnc4ccc23)cc1F Show InChI InChI=1S/C17H15FN6O/c1-24-16-13(22-23-24)5-4-11-15(16)20-9-21-17(11)19-8-10-3-6-14(25-2)12(18)7-10/h3-7,9H,8H2,1-2H3,(H,19,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	592	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539005 (CHEMBL4648135) Show SMILES Cn1nnc2ccc3c(NCc4ccc(cc4)C(C)(C)O)ncnc3c12 Show InChI InChI=1S/C19H20N6O/c1-19(2,26)13-6-4-12(5-7-13)10-20-18-14-8-9-15-17(25(3)24-23-15)16(14)21-11-22-18/h4-9,11,26H,10H2,1-3H3,(H,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.72E+3	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539006 (CHEMBL4638335) Show SMILES Cn1nnc2ccc3c(NC4CCCC4)ncnc3c12 Show InChI InChI=1S/C14H16N6/c1-20-13-11(18-19-20)7-6-10-12(13)15-8-16-14(10)17-9-4-2-3-5-9/h6-9H,2-5H2,1H3,(H,15,16,17)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	820	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539007 (CHEMBL4635779) Show SMILES COc1cc(N2CC(C2)Nc2ncnc3c4n(C)nnc4ccc23)c(Cl)cn1 Show InChI InChI=1S/C18H17ClN8O/c1-26-17-13(24-25-26)4-3-11-16(17)21-9-22-18(11)23-10-7-27(8-10)14-5-15(28-2)20-6-12(14)19/h3-6,9-10H,7-8H2,1-2H3,(H,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.49E+3	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539008 (CHEMBL4647876) Show SMILES Cn1nnc2ccc(C(=O)NC3CN(C3)c3cc(Cl)ncc3Cl)c(N)c12 Show InChI InChI=1S/C16H15Cl2N7O/c1-24-15-11(22-23-24)3-2-9(14(15)19)16(26)21-8-6-25(7-8)12-4-13(18)20-5-10(12)17/h2-5,8H,6-7,19H2,1H3,(H,21,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	91	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539009 (CHEMBL4639387) Show SMILES Cn1nnc2ccc(C(=O)NC3CN(C3)c3ncc(Cl)cc3F)c(N)c12 Show InChI InChI=1S/C16H15ClFN7O/c1-24-14-12(22-23-24)3-2-10(13(14)19)16(26)21-9-6-25(7-9)15-11(18)4-8(17)5-20-15/h2-5,9H,6-7,19H2,1H3,(H,21,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	364	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539010 (CHEMBL4644004) Show SMILES COc1cc(N2CC(C2)NC(=O)c2ccc3nnn(C)c3c2N)c(Cl)cn1 Show InChI InChI=1S/C17H18ClN7O2/c1-24-16-12(22-23-24)4-3-10(15(16)19)17(26)21-9-7-25(8-9)13-5-14(27-2)20-6-11(13)18/h3-6,9H,7-8,19H2,1-2H3,(H,21,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	373	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539011 (CHEMBL4633013) Show SMILES Cn1nnc2ccc(C(=O)NC3CN(C3)c3ncc(cc3Cl)C#N)c(N)c12 Show InChI InChI=1S/C17H15ClN8O/c1-25-15-13(23-24-25)3-2-11(14(15)20)17(27)22-10-7-26(8-10)16-12(18)4-9(5-19)6-21-16/h2-4,6,10H,7-8,20H2,1H3,(H,22,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	462	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539012 (CHEMBL4644929) Show SMILES Cn1nnc2ccc(C(=O)NC3CN(C3)c3ccnc(c3)C(F)(F)F)c(N)c12 Show InChI InChI=1S/C17H16F3N7O/c1-26-15-12(24-25-26)3-2-11(14(15)21)16(28)23-9-7-27(8-9)10-4-5-22-13(6-10)17(18,19)20/h2-6,9H,7-8,21H2,1H3,(H,23,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	814	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539013 (CHEMBL4647288) Show SMILES Cn1nnc2ccc(C(=O)NC3CN(C3)c3ccc(cn3)C#N)c(N)c12 Show InChI InChI=1S/C17H16N8O/c1-24-16-13(22-23-24)4-3-12(15(16)19)17(26)21-11-8-25(9-11)14-5-2-10(6-18)7-20-14/h2-5,7,11H,8-9,19H2,1H3,(H,21,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.72E+3	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539014 (CHEMBL4636668) Show SMILES Cn1nnc2ccc(C(=O)NC3CN(C3)c3ccc(F)c(F)c3)c(N)c12 Show InChI InChI=1S/C17H16F2N6O/c1-24-16-14(22-23-24)5-3-11(15(16)20)17(26)21-9-7-25(8-9)10-2-4-12(18)13(19)6-10/h2-6,9H,7-8,20H2,1H3,(H,21,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.43E+3	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539015 (CHEMBL4648817) Show SMILES Cn1nnc2ccc(C(=O)NC3CN(C3)c3ncc(F)cc3Cl)c(N)c12 Show InChI InChI=1S/C16H15ClFN7O/c1-24-14-12(22-23-24)3-2-10(13(14)19)16(26)21-9-6-25(7-9)15-11(17)4-8(18)5-20-15/h2-5,9H,6-7,19H2,1H3,(H,21,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539016 (CHEMBL4645945) Show SMILES Cn1nnc2ccc(C(=O)NC3CN(C3)c3cccc(Cl)n3)c(N)c12 Show InChI InChI=1S/C16H16ClN7O/c1-23-15-11(21-22-23)6-5-10(14(15)18)16(25)19-9-7-24(8-9)13-4-2-3-12(17)20-13/h2-6,9H,7-8,18H2,1H3,(H,19,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50538973 (CHEMBL4632855) Show SMILES Cn1nnc2ccc(cc12)C(=O)NC1CN(C1)c1cc(Cl)ncc1Cl Show InChI InChI=1S/C16H14Cl2N6O/c1-23-14-4-9(2-3-12(14)21-22-23)16(25)20-10-7-24(8-10)13-5-15(18)19-6-11(13)17/h2-6,10H,7-8H2,1H3,(H,20,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	675	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50538993 (CHEMBL4642055) Show SMILES Cc1n(C)nc2ccc3c(NC4CN(C4)c4cc(Cl)ncc4Cl)ncnc3c12 Show InChI InChI=1S/C19H17Cl2N7/c1-10-17-14(26-27(10)2)4-3-12-18(17)23-9-24-19(12)25-11-7-28(8-11)15-5-16(21)22-6-13(15)20/h3-6,9,11H,7-8H2,1-2H3,(H,23,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	275	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50538994 (CHEMBL4634770) Show SMILES COc1cc(N2CC(C2)Nc2ncnc3c4c(C)n(C)nc4ccc23)c(Cl)cn1 Show InChI InChI=1S/C20H20ClN7O/c1-11-18-15(26-27(11)2)5-4-13-19(18)23-10-24-20(13)25-12-8-28(9-12)16-6-17(29-3)22-7-14(16)21/h4-7,10,12H,8-9H2,1-3H3,(H,23,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	379	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50538995 (CHEMBL4642156) Show SMILES Cc1n(C)nc2ccc3c(NCc4ccc(cc4)C(=O)NC4CCCC4)ncnc3c12 Show InChI InChI=1S/C24H26N6O/c1-15-21-20(29-30(15)2)12-11-19-22(21)26-14-27-23(19)25-13-16-7-9-17(10-8-16)24(31)28-18-5-3-4-6-18/h7-12,14,18H,3-6,13H2,1-2H3,(H,28,31)(H,25,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	239	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50538996 (CHEMBL4636845) Show SMILES Cc1n(C)nc2ccc3c(NCc4ccc(cc4)C(=O)NC4CCC4)ncnc3c12 Show InChI InChI=1S/C23H24N6O/c1-14-20-19(28-29(14)2)11-10-18-21(20)25-13-26-22(18)24-12-15-6-8-16(9-7-15)23(30)27-17-4-3-5-17/h6-11,13,17H,3-5,12H2,1-2H3,(H,27,30)(H,24,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	475	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539017 (CHEMBL4633191) Show SMILES Cc1n(C)nc2ccc3c(NCc4ccc(cc4)C(=O)NCC(C)(C)C)ncnc3c12 Show InChI InChI=1S/C24H28N6O/c1-15-20-19(29-30(15)5)11-10-18-21(20)27-14-28-22(18)25-12-16-6-8-17(9-7-16)23(31)26-13-24(2,3)4/h6-11,14H,12-13H2,1-5H3,(H,26,31)(H,25,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	957	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539018 (CHEMBL4640311) Show SMILES [2H]C([2H])(Nc1ncnc2c3c(C)n(C)nc3ccc12)c1ccc(cc1)C(C)(C)O Show InChI InChI=1S/C21H23N5O/c1-13-18-17(25-26(13)4)10-9-16-19(18)23-12-24-20(16)22-11-14-5-7-15(8-6-14)21(2,3)27/h5-10,12,27H,11H2,1-4H3,(H,22,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	886	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539019 (CHEMBL4636269) Show SMILES Cc1n(C)nc2ccc3c(NCc4ccc(cc4)C(C)(C)O)ncnc3c12 Show InChI InChI=1S/C21H23N5O/c1-13-18-17(25-26(13)4)10-9-16-19(18)23-12-24-20(16)22-11-14-5-7-15(8-6-14)21(2,3)27/h5-10,12,27H,11H2,1-4H3,(H,22,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	552	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50538997 (CHEMBL4635909) Show SMILES COc1ccc(CNc2ncnc3c4c(C)n(C)nc4ccc23)cc1F Show InChI InChI=1S/C19H18FN5O/c1-11-17-15(24-25(11)2)6-5-13-18(17)22-10-23-19(13)21-9-12-4-7-16(26-3)14(20)8-12/h4-8,10H,9H2,1-3H3,(H,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	470	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539020 (CHEMBL4638044) Show SMILES Cc1n(C)nc2ccc3c(ncnc3c12)N1CC2(COC2)C1 Show InChI InChI=1S/C16H17N5O/c1-10-13-12(19-20(10)2)4-3-11-14(13)17-9-18-15(11)21-5-16(6-21)7-22-8-16/h3-4,9H,5-8H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	528	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539021 (CHEMBL4635539) Show SMILES Cc1n(C)nc2ccc3c(CC(C)(C)C)ncnc3c12 Show InChI InChI=1S/C16H20N4/c1-10-14-12(19-20(10)5)7-6-11-13(8-16(2,3)4)17-9-18-15(11)14/h6-7,9H,8H2,1-5H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	467	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539022 (CHEMBL4649056) Show SMILES Cc1n(C)nc2ccc3c(NC4CCCC4)ncnc3c12 Show InChI InChI=1S/C16H19N5/c1-10-14-13(20-21(10)2)8-7-12-15(14)17-9-18-16(12)19-11-5-3-4-6-11/h7-9,11H,3-6H2,1-2H3,(H,17,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	848	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539023 (CHEMBL4632514) Show SMILES Cc1n(C)nc2ccc3c(ncnc3c12)N1CCCC1 Show InChI InChI=1S/C15H17N5/c1-10-13-12(18-19(10)2)6-5-11-14(13)16-9-17-15(11)20-7-3-4-8-20/h5-6,9H,3-4,7-8H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	624	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539024 (CHEMBL4640119) Show SMILES Cc1n(C)nc2ccc3c(NCc4ccc(F)c(F)c4)ncnc3c12 Show InChI InChI=1S/C18H15F2N5/c1-10-16-15(24-25(10)2)6-4-12-17(16)22-9-23-18(12)21-8-11-3-5-13(19)14(20)7-11/h3-7,9H,8H2,1-2H3,(H,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.48E+3	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50538998 (CHEMBL4632962) Show SMILES Cc1n(C)nc2ccc(C(=O)NC3CN(C3)c3cc(Cl)ncc3Cl)c(N)c12 Show InChI InChI=1S/C18H18Cl2N6O/c1-9-16-13(24-25(9)2)4-3-11(17(16)21)18(27)23-10-7-26(8-10)14-5-15(20)22-6-12(14)19/h3-6,10H,7-8,21H2,1-2H3,(H,23,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	125	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50538999 (CHEMBL4641848) Show SMILES Cc1n(C)nc2ccc(C(=O)NC3CN(C3)c3ccc(nc3)C(F)(F)F)c(N)c12 Show InChI InChI=1S/C19H19F3N6O/c1-10-16-14(26-27(10)2)5-4-13(17(16)23)18(29)25-11-8-28(9-11)12-3-6-15(24-7-12)19(20,21)22/h3-7,11H,8-9,23H2,1-2H3,(H,25,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	137	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539000 (CHEMBL4639222) Show SMILES COc1cc(N2CC(C2)NC(=O)c2ccc3nn(C)c(C)c3c2N)c(Cl)cn1 Show InChI InChI=1S/C19H21ClN6O2/c1-10-17-14(24-25(10)2)5-4-12(18(17)21)19(27)23-11-8-26(9-11)15-6-16(28-3)22-7-13(15)20/h4-7,11H,8-9,21H2,1-3H3,(H,23,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	148	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539001 (CHEMBL4635732) Show SMILES Cc1n(C)nc2ccc(C(=O)NC3CN(C3)c3ncc(cc3Cl)C#N)c(N)c12 Show InChI InChI=1S/C19H18ClN7O/c1-10-16-15(25-26(10)2)4-3-13(17(16)22)19(28)24-12-8-27(9-12)18-14(20)5-11(6-21)7-23-18/h3-5,7,12H,8-9,22H2,1-2H3,(H,24,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	158	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539002 (CHEMBL4638291) Show SMILES Cc1n(C)nc2ccc(C(=O)NC3CN(C3)c3ncc(Cl)cc3F)c(N)c12 Show InChI InChI=1S/C18H18ClFN6O/c1-9-15-14(24-25(9)2)4-3-12(16(15)21)18(27)23-11-7-26(8-11)17-13(20)5-10(19)6-22-17/h3-6,11H,7-8,21H2,1-2H3,(H,23,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	244	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539025 (CHEMBL4642005) Show SMILES Cc1n(C)nc2ccc(C(=O)NC3CN(C3)c3ccc(F)c(F)c3)c(N)c12 Show InChI InChI=1S/C19H19F2N5O/c1-10-17-16(24-25(10)2)6-4-13(18(17)22)19(27)23-11-8-26(9-11)12-3-5-14(20)15(21)7-12/h3-7,11H,8-9,22H2,1-2H3,(H,23,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	619	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539026 (CHEMBL4637785) Show SMILES Cc1n(C)nc2ccc(C(=O)NC3CN(C3)c3cccc(Cl)n3)c(N)c12 Show InChI InChI=1S/C18H19ClN6O/c1-10-16-13(23-24(10)2)7-6-12(17(16)20)18(26)21-11-8-25(9-11)15-5-3-4-14(19)22-15/h3-7,11H,8-9,20H2,1-2H3,(H,21,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.45E+3	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539027 (CHEMBL4639628) Show SMILES Cc1n(C)nc2ccc(C(=O)NC3CN(C3)c3ncccc3F)c(N)c12 Show InChI InChI=1S/C18H19FN6O/c1-10-15-14(23-24(10)2)6-5-12(16(15)20)18(26)22-11-8-25(9-11)17-13(19)4-3-7-21-17/h3-7,11H,8-9,20H2,1-2H3,(H,22,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.55E+3	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50539028 (CHEMBL4638318) Show SMILES Cc1n(C)nc2ccc(C(=O)NC3CN(C3)c3ncc(F)cn3)c(N)c12 Show InChI InChI=1S/C17H18FN7O/c1-9-14-13(23-24(9)2)4-3-12(15(14)19)16(26)22-11-7-25(8-11)17-20-5-10(18)6-21-17/h3-6,11H,7-8,19H2,1-2H3,(H,22,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6.21E+3	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50538969 (CHEMBL4632555) Show SMILES Cc1n(C)nc2ccc(cc12)C(=O)NC1CN(C1)c1cc(Cl)ncc1Cl Show InChI InChI=1S/C18H17Cl2N5O/c1-10-13-5-11(3-4-15(13)23-24(10)2)18(26)22-12-8-25(9-12)16-6-17(20)21-7-14(16)19/h3-7,12H,8-9H2,1-2H3,(H,22,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	308	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induce...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126811 BindingDB Entry DOI: 10.7270/Q2J67MG1
					More data for this Ligand-Target Pair

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