Compile Data Set for Download or QSAR

Found 377 hits Enz. Inhib. hit(s) with all data for entry = 1361   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318337 (US10301317, Example 294 | US9624228, Example 294) Show SMILES CC(C1CCCC1)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318338 (US10301317, Example 295 | US9624228, Example 295) Show SMILES COc1ncc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2cccs2)C1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318322 (US10301317, Example 297 | US9624228, Example 279 |...) Show SMILES CC(C)N1C[C@H]([C@@H](C1)c1ccccc1)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318341 (US10301317, Example 298 | US9624228, Example 298) Show SMILES Cn1cc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2cccs2)C1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318342 (US10301317, Example 299 | US9624228, Example 299) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@H]1CCN(CC(F)(F)F)C1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318343 (US10301317, Example 300 | US9624228, Example 300) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(CC(F)(F)F)C[C@H]1c1ccc(F)cc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318344 (US10301317, Example 301 | US9624228, Example 301) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@H]1CCN(Cc2ccccc2)C1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318345 (US10301317, Example 302 | US9624228, Example 302) Show SMILES C[C@@H]1CN(CC(F)(F)F)C[C@H]1N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318266 (US10301317, Example 304 | US9624228, Example 222 |...) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(CC(F)(F)F)C[C@H]1c1ccccc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318349 (US10301317, Example 306 | US9624228, Example 306) Show SMILES CN1C[C@H]([C@@H](C1)c1ccccc1F)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1cc(C)nc(C)c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318291 (US10301317, Example 308 | US9624228, Example 248 |...) Show SMILES CN1C[C@H]([C@@H](C1)c1ccccc1)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1cc(C)nc(C)c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318353 (US10301317, Example 310 | US9624228, Example 310) Show SMILES Cc1cc(cc(C)n1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@H]1CCN(CC(F)(F)F)C1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318356 (US10301317, Example 313 | US9624228, Example 313) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCC[C@H](C1)NCc1ccccc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318357 (US9624228, Example 314) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@H]1CCC[C@H](C1)NCc1ccccc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318358 (US9624228, Example 315) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@H]1CCC[C@@H](C1)NCc1ccccc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318221 (BDBM318359 | US10301317, Example 177 | US9624228, ...) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCC[C@@H](C1)NCc1ccccc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318361 (US10301317, Example 318 | US9624228, Example 318) Show SMILES CC(c1ccccc1)c1cc2cc3c(n[nH]c3cc2[nH]c1=O)-c1ccnc(c1)N1CCN(C)CC1 Show InChI InChI=1S/C28H26N6O/c1-18(19-6-4-3-5-7-19)22-14-21-15-23-25(17-24(21)30-28(22)35)31-32-27(23)20-8-9-29-26(16-20)34-12-10-33(2)11-13-34/h3-9,14-18H,10-13H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318364 (US10301317, Example 321 | US9624228, Example 321) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(CC(F)(F)F)C[C@H]1c1cccs1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318366 (US10301317, Example 323 | US9624228, Example 323) Show SMILES CC(c1ccccc1)c1cc2cc3c(n[nH]c3cc2[nH]c1=O)-c1ccnnc1 Show InChI InChI=1S/C22H15N5O/c1-13(14-5-3-2-4-6-14)17-9-16-10-18-20(11-19(16)25-22(17)28)26-27-21(18)15-7-8-23-24-12-15/h2-13H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318368 (US10301317, Example 325 | US9624228, Example 325) Show SMILES CC(c1ccccc1)c1cc2cc3c(n[nH]c3cc2[nH]c1=O)-c1ccnc(c1)N1CCOCC1 Show InChI InChI=1S/C27H23N5O2/c1-17(18-5-3-2-4-6-18)21-13-20-14-22-24(16-23(20)29-27(21)33)30-31-26(22)19-7-8-28-25(15-19)32-9-11-34-12-10-32/h2-8,13-17H,9-12H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318369 (US10301317, Example 326 | US9624228, Example 326) Show SMILES CC(c1ccccc1)c1cc2cc3c(n[nH]c3cc2[nH]c1=O)-c1ccncc1 Show InChI InChI=1S/C23H16N4O/c1-14(15-5-3-2-4-6-15)18-11-17-12-19-21(13-20(17)25-23(18)28)26-27-22(19)16-7-9-24-10-8-16/h2-14H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318371 (US10301317, Example 328 | US9624228, Example 328) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3[nH]c(=O)c(cc3cc12)C(CO)c1ccccc1 Show InChI InChI=1S/C24H18N4O2/c1-14-9-16(7-8-25-14)23-19-11-17-10-18(20(13-29)15-5-3-2-4-6-15)24(30)26-21(17)12-22(19)27-28-23/h2-12,20,29H,13H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318373 (US10301317, Example 330 | US9624228, Example 330) Show SMILES CC(c1ccccc1)c1cc2cc3c(n[nH]c3cc2[nH]c1=O)-c1cccnc1 Show InChI InChI=1S/C23H16N4O/c1-14(15-6-3-2-4-7-15)18-10-17-11-19-21(12-20(17)25-23(18)28)26-27-22(19)16-8-5-9-24-13-16/h2-14H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318374 (US10301317, Example 331 | US9624228, Example 331) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(CC(F)(F)F)C[C@H]1C(F)(F)F |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318375 (US10301317, Example 332 | US9624228, Example 332) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3[nH]c(=O)c(cc3cc12)C1CCCN(Cc2ccccc2)C1 Show InChI InChI=1S/C28H25N5O/c1-18-12-20(9-10-29-18)27-24-14-22-13-23(28(34)30-25(22)15-26(24)31-32-27)21-8-5-11-33(17-21)16-19-6-3-2-4-7-19/h2-4,6-7,9-10,12-15,21H,5,8,11,16-17H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318376 (US10301317, Example 333 | US9624228, Example 333) Show SMILES CC(c1ccccc1)c1cc2cc3c(n[nH]c3cc2[nH]c1=O)-c1cnn(C)c1 Show InChI InChI=1S/C22H17N5O/c1-13(14-6-4-3-5-7-14)17-8-15-9-18-20(10-19(15)24-22(17)28)25-26-21(18)16-11-23-27(2)12-16/h3-13H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318377 (US10301317, Example 334 | US9624228, Example 334) Show SMILES CC(c1ccccc1)c1cc2cc3c(n[nH]c3cc2[nH]c1=O)-c1cnc(N)nc1 Show InChI InChI=1S/C22H16N6O/c1-12(13-5-3-2-4-6-13)16-7-14-8-17-19(9-18(14)26-21(16)29)27-28-20(17)15-10-24-22(23)25-11-15/h2-12H,1H3,(H2,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318378 (US10301317, Example 335 | US9624228, Example 335) Show SMILES CC(c1ccccc1)c1cc2cc3c(n[nH]c3cc2[nH]c1=O)-c1cccnc1C Show InChI InChI=1S/C24H18N4O/c1-14(16-7-4-3-5-8-16)19-11-17-12-20-22(13-21(17)26-24(19)29)27-28-23(20)18-9-6-10-25-15(18)2/h3-14H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318379 (US10301317, Example 336 | US9624228, Example 336) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3[nH]c(=O)c(cc3cc12)C1CCCN(Cc2cc(F)ccc2F)C1 Show InChI InChI=1S/C28H23F2N5O/c1-16-9-17(6-7-31-16)27-23-12-19-11-22(28(36)32-25(19)13-26(23)33-34-27)18-3-2-8-35(14-18)15-20-10-21(29)4-5-24(20)30/h4-7,9-13,18H,2-3,8,14-15H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318380 (US10301317, Example 338 | US9624228, Example 338) Show SMILES CC(c1ccccc1)c1cc2cc3c(NC4CCOCC4)n[nH]c3cc2[nH]c1=O Show InChI InChI=1S/C23H22N4O2/c1-14(15-5-3-2-4-6-15)18-11-16-12-19-21(13-20(16)25-23(18)28)26-27-22(19)24-17-7-9-29-10-8-17/h2-6,11-14,17,24H,7-10H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318285 (US10301317, Example 339 | US9624228, Example 242 |...) Show SMILES Cc1cc(cc(C)n1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(CC(F)(F)F)C[C@H]1c1ccccc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318382 (US10301317, Example 340 | US9624228, Example 340) Show SMILES FC(F)(F)CN1C[C@H]([C@@H](C1)c1ccccc1)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnnc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318383 (US10301317, Example 341 | US9624228, Example 341) Show SMILES FC(F)(F)CN1C[C@H]([C@@H](C1)c1ccccc1)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1cccnc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318384 (US10301317, Example 342 | US9624228, Example 342) Show SMILES FC(F)(F)CN1C[C@H]([C@@H](C1)c1ccccc1)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccncc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318386 (US10301317, Example 344 | US9624228, Example 344) Show SMILES CC(c1ccccc1)c1cc2cc3c(n[nH]c3cc2[nH]c1=O)-c1ccnc(N)c1 Show InChI InChI=1S/C23H17N5O/c1-13(14-5-3-2-4-6-14)17-9-16-10-18-20(12-19(16)26-23(17)29)27-28-22(18)15-7-8-25-21(24)11-15/h2-13H,1H3,(H2,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318387 (US10301317, Example 345 | US9624228, Example 345) Show SMILES CC(c1ccccc1)c1cc2cc3c(n[nH]c3cc2[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C22H20N4O2/c1-14(15-5-3-2-4-6-15)17-11-16-12-18-20(13-19(16)23-22(17)27)24-25-21(18)26-7-9-28-10-8-26/h2-6,11-14H,7-10H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318388 (US10301317, Example 346 | US9624228, Example 346) Show SMILES Cn1cc(ccc1=O)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(CC(F)(F)F)C[C@H]1c1ccccc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318389 (US10301317, Example 347 | US9624228, Example 347) Show SMILES CC(c1ccccc1)c1cc2cc3c(n[nH]c3cc2[nH]c1=O)-c1ccc(=O)n(C)c1 Show InChI InChI=1S/C24H18N4O2/c1-14(15-6-4-3-5-7-15)18-10-17-11-19-21(12-20(17)25-24(18)30)26-27-23(19)16-8-9-22(29)28(2)13-16/h3-14H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318390 (US10301317, Example 348 | US9624228, Example 348) Show SMILES COc1ncc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(CC(F)(F)F)C[C@H]1c1ccccc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318391 (US10301317, Example 349 | US9624228, Example 349) Show SMILES Cc1ncc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(CC(F)(F)F)C[C@H]1c1ccccc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318393 (US10301317, Example 351 | US9624228, Example 351) Show SMILES Nc1ncc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(CC(F)(F)F)C[C@H]1c1ccccc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318394 (US10301317, Example 352 | US9624228, Example 352) Show SMILES Cn1cc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(CC(F)(F)F)C[C@H]1c1ccccc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318395 (US10301317, Example 353 | US9624228, Example 353) Show SMILES COc1ccc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(C)C[C@H]1c1ccccc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318396 (US10301317, Example 354 | US9624228, Example 354) Show SMILES COc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(C)C[C@H]1c1ccccc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318397 (US10301317, Example 355 | US9624228, Example 355) Show SMILES COc1ncc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(C)C[C@H]1c1ccccc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318398 (US10301317, Example 356 | US9624228, Example 356) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(CCC#N)C[C@H]1c1ccccc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318399 (US10301317, Example 357 | US9624228, Example 357) Show SMILES C[C@H](c1ccccc1)c1cc2cc3c(NC4CCOCC4)n[nH]c3cc2[nH]c1=O |r| Show InChI InChI=1S/C23H22N4O2/c1-14(15-5-3-2-4-6-15)18-11-16-12-19-21(13-20(16)25-23(18)28)26-27-22(19)24-17-7-9-29-10-8-17/h2-6,11-14,17,24H,7-10H2,1H3/t14-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318404 (US10301317, Example 362 | US9624228, Example 362) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CN(CC(F)F)C[C@H]1c1ccccc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318405 (US10301317, Example 363 | US9624228, Example 363) Show SMILES Cc1cc(cc(C)n1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@H]1CCCN(Cc2ccccc2)C1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318406 (US10301317, Example 364 | US9624228, Example 364) Show SMILES COc1ncc(cn1)-c1n[nH]c2cc3[nH]c(=O)c(cc3cc12)C1CCCN(Cc2ccccc2)C1 Show InChI InChI=1S/C27H24N6O2/c1-35-27-28-13-20(14-29-27)25-22-11-19-10-21(26(34)30-23(19)12-24(22)31-32-25)18-8-5-9-33(16-18)15-17-6-3-2-4-7-17/h2-4,6-7,10-14,18H,5,8-9,15-16H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair

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