Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 492 | n/a | n/a | n/a | n/a | n/a |
Yale University | Assay Description AlphaScreen technology based high-throughput (ALPHA) assay is used to identify inhibitors of Hsp90-TPR2A interaction. | ACS Chem Biol 3: 645-54 (2008) Article DOI: 10.1021/cb800162x BindingDB Entry DOI: 10.7270/Q22N50N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM36528 (3-benzyl-1-ethyl-6-methyl-1H,5H,6H,7H-pyrimido[5,4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 4.27E+3 | n/a | n/a | n/a | 37 |
Yale University | Assay Description Cell assay using BT474, SKBR3 and MCF-12F cell lines measured by WST-1 colorimetric cell proliferation assay. | ACS Chem Biol 3: 645-54 (2008) Article DOI: 10.1021/cb800162x BindingDB Entry DOI: 10.7270/Q22N50N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM36527 (1,6-dimethyl-3-phenyl-1H,5H,6H,7H-pyrimido[5,4-e][...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 585 | n/a | n/a | n/a | n/a | n/a |
Yale University | Assay Description AlphaScreen technology based high-throughput (ALPHA) assay is used to identify inhibitors of Hsp90-TPR2A interaction. | ACS Chem Biol 3: 645-54 (2008) Article DOI: 10.1021/cb800162x BindingDB Entry DOI: 10.7270/Q22N50N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM31044 (1-Ethyl-6-methyl-3-thiophen-2-yl-1H-pyrimido[5,4-e...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 365 | n/a | n/a | n/a | n/a | n/a |
Yale University | Assay Description AlphaScreen technology based high-throughput (ALPHA) assay is used to identify inhibitors of Hsp90-TPR2A interaction. | ACS Chem Biol 3: 645-54 (2008) Article DOI: 10.1021/cb800162x BindingDB Entry DOI: 10.7270/Q22N50N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM31040 (1-Ethyl-6-methyl-3-phenyl-1H-pyrimido[5,4-e][1,2,4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a |
Yale University | Assay Description AlphaScreen technology based high-throughput (ALPHA) assay is used to identify inhibitors of Hsp90-TPR2A interaction. | ACS Chem Biol 3: 645-54 (2008) Article DOI: 10.1021/cb800162x BindingDB Entry DOI: 10.7270/Q22N50N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM36528 (3-benzyl-1-ethyl-6-methyl-1H,5H,6H,7H-pyrimido[5,4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 182 | n/a | n/a | n/a | n/a | n/a |
Yale University | Assay Description AlphaScreen technology based high-throughput (ALPHA) assay is used to identify inhibitors of Hsp90-TPR2A interaction. | ACS Chem Biol 3: 645-54 (2008) Article DOI: 10.1021/cb800162x BindingDB Entry DOI: 10.7270/Q22N50N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 365 | n/a | n/a | n/a | 8.0 | n/a |
Yale University | Assay Description A fluorescence polarization (FP) assay monitor the fluorescein-labeled C-terminal Hsp90 peptide-TPRA interaction. FP assay will also confirm binding... | ACS Chem Biol 3: 645-54 (2008) Article DOI: 10.1021/cb800162x BindingDB Entry DOI: 10.7270/Q22N50N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM34905 (1,6-dimethyl-3-propyl-pyrimido[5,4-e][1,2,4]triazi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 202 | n/a | n/a | n/a | 8.0 | n/a |
Yale University | Assay Description A fluorescence polarization (FP) assay monitor the fluorescein-labeled C-terminal Hsp90 peptide-TPRA interaction. FP assay will also confirm binding... | ACS Chem Biol 3: 645-54 (2008) Article DOI: 10.1021/cb800162x BindingDB Entry DOI: 10.7270/Q22N50N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM36527 (1,6-dimethyl-3-phenyl-1H,5H,6H,7H-pyrimido[5,4-e][...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | 8.0 | n/a |
Yale University | Assay Description A fluorescence polarization (FP) assay monitor the fluorescein-labeled C-terminal Hsp90 peptide-TPRA interaction. FP assay will also confirm binding... | ACS Chem Biol 3: 645-54 (2008) Article DOI: 10.1021/cb800162x BindingDB Entry DOI: 10.7270/Q22N50N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM31044 (1-Ethyl-6-methyl-3-thiophen-2-yl-1H-pyrimido[5,4-e...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 308 | n/a | n/a | n/a | 8.0 | n/a |
Yale University | Assay Description A fluorescence polarization (FP) assay monitor the fluorescein-labeled C-terminal Hsp90 peptide-TPRA interaction. FP assay will also confirm binding... | ACS Chem Biol 3: 645-54 (2008) Article DOI: 10.1021/cb800162x BindingDB Entry DOI: 10.7270/Q22N50N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM31040 (1-Ethyl-6-methyl-3-phenyl-1H-pyrimido[5,4-e][1,2,4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 928 | n/a | n/a | n/a | 8.0 | n/a |
Yale University | Assay Description A fluorescence polarization (FP) assay monitor the fluorescein-labeled C-terminal Hsp90 peptide-TPRA interaction. FP assay will also confirm binding... | ACS Chem Biol 3: 645-54 (2008) Article DOI: 10.1021/cb800162x BindingDB Entry DOI: 10.7270/Q22N50N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM36528 (3-benzyl-1-ethyl-6-methyl-1H,5H,6H,7H-pyrimido[5,4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 566 | n/a | n/a | n/a | 8.0 | n/a |
Yale University | Assay Description A fluorescence polarization (FP) assay monitor the fluorescein-labeled C-terminal Hsp90 peptide-TPRA interaction. FP assay will also confirm binding... | ACS Chem Biol 3: 645-54 (2008) Article DOI: 10.1021/cb800162x BindingDB Entry DOI: 10.7270/Q22N50N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM34671 (1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 946 | n/a | n/a | n/a | 37 |
Yale University | Assay Description Cell assay using BT474, SKBR3 and MCF-12F cell lines measured by WST-1 colorimetric cell proliferation assay. | ACS Chem Biol 3: 645-54 (2008) Article DOI: 10.1021/cb800162x BindingDB Entry DOI: 10.7270/Q22N50N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM34905 (1,6-dimethyl-3-propyl-pyrimido[5,4-e][1,2,4]triazi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 917 | n/a | n/a | n/a | 37 |
Yale University | Assay Description Cell assay using BT474, SKBR3 and MCF-12F cell lines measured by WST-1 colorimetric cell proliferation assay. | ACS Chem Biol 3: 645-54 (2008) Article DOI: 10.1021/cb800162x BindingDB Entry DOI: 10.7270/Q22N50N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM36527 (1,6-dimethyl-3-phenyl-1H,5H,6H,7H-pyrimido[5,4-e][...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 690 | n/a | n/a | n/a | 37 |
Yale University | Assay Description Cell assay using BT474, SKBR3 and MCF-12F cell lines measured by WST-1 colorimetric cell proliferation assay. | ACS Chem Biol 3: 645-54 (2008) Article DOI: 10.1021/cb800162x BindingDB Entry DOI: 10.7270/Q22N50N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM31044 (1-Ethyl-6-methyl-3-thiophen-2-yl-1H-pyrimido[5,4-e...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.21E+3 | n/a | n/a | n/a | 37 |
Yale University | Assay Description Cell assay using BT474, SKBR3 and MCF-12F cell lines measured by WST-1 colorimetric cell proliferation assay. | ACS Chem Biol 3: 645-54 (2008) Article DOI: 10.1021/cb800162x BindingDB Entry DOI: 10.7270/Q22N50N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM31040 (1-Ethyl-6-methyl-3-phenyl-1H-pyrimido[5,4-e][1,2,4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.72E+3 | n/a | n/a | n/a | 37 |
Yale University | Assay Description Cell assay using BT474, SKBR3 and MCF-12F cell lines measured by WST-1 colorimetric cell proliferation assay. | ACS Chem Biol 3: 645-54 (2008) Article DOI: 10.1021/cb800162x BindingDB Entry DOI: 10.7270/Q22N50N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM34905 (1,6-dimethyl-3-propyl-pyrimido[5,4-e][1,2,4]triazi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 414 | n/a | n/a | n/a | n/a | n/a |
Yale University | Assay Description AlphaScreen technology based high-throughput (ALPHA) assay is used to identify inhibitors of Hsp90-TPR2A interaction. | ACS Chem Biol 3: 645-54 (2008) Article DOI: 10.1021/cb800162x BindingDB Entry DOI: 10.7270/Q22N50N6 | |||||||||||
More data for this Ligand-Target Pair |