Compile Data Set for Download or QSAR

Found 249 hits Enz. Inhib. hit(s) with all data for entry = 2343   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM187100 (US9670157, 114 3-Methyl-1-[4-(4-methyl-pyrazol-1-y...) Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4c(C)cc(CN)cc4C)c(C)n3)cc2)c1 Show InChI InChI=1S/C27H32N6O/c1-18-12-30-32(14-18)15-22-5-7-23(8-6-22)16-33-17-26(21(4)31-33)27(34)29-13-25-19(2)9-24(11-28)10-20(25)3/h5-10,12,14,17H,11,13,15-16,28H2,1-4H3,(H,29,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM187097 (US9670157, 111 1-[4-(4-Methyl-pyrazol-1-ylmethyl)-...) Show SMILES Cc1cnn(Cc2ccc(Cn3cc(cn3)C(=O)NCc3c(C)cc(CN)cc3C)cc2)c1 Show InChI InChI=1S/C26H30N6O/c1-18-11-29-31(14-18)15-21-4-6-22(7-5-21)16-32-17-24(12-30-32)26(33)28-13-25-19(2)8-23(10-27)9-20(25)3/h4-9,11-12,14,17H,10,13,15-16,27H2,1-3H3,(H,28,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM187104 (US9670157, 118 1-[4-(4-Methyl-pyrazol-1-ylmethyl)-...) Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4c(C)cc(CN)cc4C)c(n3)C(F)(F)F)cc2)c1 Show InChI InChI=1S/C27H29F3N6O/c1-17-11-33-35(13-17)14-20-4-6-21(7-5-20)15-36-16-24(25(34-36)27(28,29)30)26(37)32-12-23-18(2)8-22(10-31)9-19(23)3/h4-9,11,13,16H,10,12,14-15,31H2,1-3H3,(H,32,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM187092 (US9670157, 106 1-[4-(4-Methyl-pyrazol-1-ylmethyl)-...) Show SMILES Cc1cnn(Cc2ccc(Cn3cc(cn3)C(=O)NCc3ccc(CN)cc3C)cc2)c1 Show InChI InChI=1S/C25H28N6O/c1-18-11-28-30(14-18)15-20-3-5-21(6-4-20)16-31-17-24(13-29-31)25(32)27-12-23-8-7-22(10-26)9-19(23)2/h3-9,11,13-14,17H,10,12,15-16,26H2,1-2H3,(H,27,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM187099 (US9670157, 113 1-[4-(4-Methyl-pyrazol-1-ylmethyl)-...) Show SMILES Cc1cnn(Cc2ccc(Cn3cc(nn3)C(=O)NCc3c(C)cc(CN)cc3C)cc2)c1 Show InChI InChI=1S/C25H29N7O/c1-17-11-28-31(13-17)14-20-4-6-21(7-5-20)15-32-16-24(29-30-32)25(33)27-12-23-18(2)8-22(10-26)9-19(23)3/h4-9,11,13,16H,10,12,14-15,26H2,1-3H3,(H,27,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM187098 (US9670157, 112 1-[4-(4-Methyl-pyrazol-1-ylmethyl)-...) Show SMILES Cc1cnn(Cc2ccc(Cn3cnc(c3)C(=O)NCc3c(C)cc(CN)cc3C)cc2)c1 Show InChI InChI=1S/C26H30N6O/c1-18-11-30-32(13-18)15-22-6-4-21(5-7-22)14-31-16-25(29-17-31)26(33)28-12-24-19(2)8-23(10-27)9-20(24)3/h4-9,11,13,16-17H,10,12,14-15,27H2,1-3H3,(H,28,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM187110 (US9670157, 124 3-Methyl-1-(2-methyl-quinolin-6-ylm...) Show SMILES Cc1nn(Cc2ccc3nc(C)ccc3c2)cc1C(=O)NCc1c(C)cc(CN)cc1C Show InChI InChI=1S/C26H29N5O/c1-16-9-21(12-27)10-17(2)23(16)13-28-26(32)24-15-31(30-19(24)4)14-20-6-8-25-22(11-20)7-5-18(3)29-25/h5-11,15H,12-14,27H2,1-4H3,(H,28,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM187093 (US9670157, 107 1-[4-(4-Methyl-pyrazol-1-ylmethyl)-...) Show SMILES Cc1cnn(Cc2ccc(Cn3cnc(c3)C(=O)NCc3ccc(CN)cc3C)cc2)c1 Show InChI InChI=1S/C25H28N6O/c1-18-11-29-31(13-18)15-21-5-3-20(4-6-21)14-30-16-24(28-17-30)25(32)27-12-23-8-7-22(10-26)9-19(23)2/h3-9,11,13,16-17H,10,12,14-15,26H2,1-2H3,(H,27,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM187111 (US9670157, 125 5-Methyl-1-(2-methyl-quinolin-6-ylm...) Show SMILES Cc1c(cnn1Cc1ccc2nc(C)ccc2c1)C(=O)NCc1c(C)cc(CN)cc1C Show InChI InChI=1S/C26H29N5O/c1-16-9-21(12-27)10-17(2)23(16)13-28-26(32)24-14-29-31(19(24)4)15-20-6-8-25-22(11-20)7-5-18(3)30-25/h5-11,14H,12-13,15,27H2,1-4H3,(H,28,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM187112 (US9670157, 126 1-(2-Methyl-quinolin-6-ylmethyl)-3-...) Show SMILES Cc1ccc2cc(Cn3cc(C(=O)NCc4c(C)cc(CN)cc4C)c(n3)C(F)(F)F)ccc2n1 Show InChI InChI=1S/C26H26F3N5O/c1-15-8-19(11-30)9-16(2)21(15)12-31-25(35)22-14-34(33-24(22)26(27,28)29)13-18-5-7-23-20(10-18)6-4-17(3)32-23/h4-10,14H,11-13,30H2,1-3H3,(H,31,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM187087 (US9670157, 101 2,5-Dimethyl-1-[4-(4-methyl-pyrazol...) Show SMILES Cc1cnn(Cc2ccc(Cn3c(C)cc(C(=O)NCc4c(C)cc(CN)cc4C)c3C)cc2)c1 Show InChI InChI=1S/C29H35N5O/c1-19-14-32-33(16-19)17-24-6-8-25(9-7-24)18-34-22(4)12-27(23(34)5)29(35)31-15-28-20(2)10-26(13-30)11-21(28)3/h6-12,14,16H,13,15,17-18,30H2,1-5H3,(H,31,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM187095 (US9670157, 109 1-[4-(4-Methyl-pyrazol-1-ylmethyl)-...) Show SMILES Cc1cnn(Cc2ccc(Cn3cc(nn3)C(=O)NCc3ccc(CN)cc3C)cc2)c1 Show InChI InChI=1S/C24H27N7O/c1-17-11-27-30(13-17)14-19-3-5-20(6-4-19)15-31-16-23(28-29-31)24(32)26-12-22-8-7-21(10-25)9-18(22)2/h3-9,11,13,16H,10,12,14-15,25H2,1-2H3,(H,26,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186837 (US9670157, 3 2,5-Dimethyl-1-(2-phenyl-thiazol-4-yl...) Show SMILES Cc1cc(C(=O)NCc2c(C)cc(CN)cc2C)c(C)n1Cc1csc(n1)-c1ccccc1 Show InChI InChI=1S/C27H30N4OS/c1-17-10-21(13-28)11-18(2)25(17)14-29-26(32)24-12-19(3)31(20(24)4)15-23-16-33-27(30-23)22-8-6-5-7-9-22/h5-12,16H,13-15,28H2,1-4H3,(H,29,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186920 (US9670157, 86 1-[4-(3,5-Dimethyl-pyrazol-1-ylmethy...) Show SMILES Cc1cc(C)n(Cc2ccc(Cn3cc(cn3)C(=O)NCc3ccc(CN)cc3)cc2)n1 Show InChI InChI=1S/C25H28N6O/c1-18-11-19(2)31(29-18)16-23-9-7-22(8-10-23)15-30-17-24(14-28-30)25(32)27-13-21-5-3-20(12-26)4-6-21/h3-11,14,17H,12-13,15-16,26H2,1-2H3,(H,27,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM362300 (5-Methyl-1-[4-(4-methyl-pyrazol-1-ylmethyl)-benzyl...) Show SMILES Cc1cnn(Cc2ccc(Cn3ncc(C(=O)NCc4c(C)cc(CN)cc4C)c3C)cc2)c1 Show InChI InChI=1S/C27H32N6O/c1-18-12-30-32(15-18)16-22-5-7-23(8-6-22)17-33-21(4)26(14-31-33)27(34)29-13-25-19(2)9-24(11-28)10-20(25)3/h5-10,12,14-15H,11,13,16-17,28H2,1-4H3,(H,29,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM187105 (US9670157, 119 1-[4-(4-Methyl-pyrazol-1-ylmethyl)-...) Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4ccc(CN)c(F)c4C)c(n3)C(F)(F)F)cc2)c1 Show InChI InChI=1S/C26H26F4N6O/c1-16-10-33-35(12-16)13-18-3-5-19(6-4-18)14-36-15-22(24(34-36)26(28,29)30)25(37)32-11-21-8-7-20(9-31)23(27)17(21)2/h3-8,10,12,15H,9,11,13-14,31H2,1-2H3,(H,32,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM187088 (US9670157, 102 1-Ethyl-4-methyl-5-[4-(4-methyl-pyr...) Show SMILES CCn1c(cc(C)c1Cc1ccc(Cn2cc(C)cn2)cc1)C(=O)NCc1c(C)cc(CN)cc1C Show InChI InChI=1S/C30H37N5O/c1-6-35-28(14-24-7-9-25(10-8-24)19-34-18-20(2)16-33-34)23(5)13-29(35)30(36)32-17-27-21(3)11-26(15-31)12-22(27)4/h7-13,16,18H,6,14-15,17,19,31H2,1-5H3,(H,32,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186952 (US9670157, 94 2,5-Dimethyl-1-[4-(2-oxo-2H-pyridin-...) Show SMILES Cc1cc(C(=O)NCc2c(C)cc(CN)cc2C)c(C)n1Cc1ccc(Cn2ccccc2=O)cc1 Show InChI InChI=1S/C30H34N4O2/c1-20-13-26(16-31)14-21(2)28(20)17-32-30(36)27-15-22(3)34(23(27)4)19-25-10-8-24(9-11-25)18-33-12-6-5-7-29(33)35/h5-15H,16-19,31H2,1-4H3,(H,32,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186919 (US9670157, 85 1-[4-(4-Methyl-pyrazol-1-ylmethyl)-b...) Show SMILES Cc1cnn(Cc2ccc(Cn3cc(cn3)C(=O)NCc3ccc(CN)cc3)cc2)c1 Show InChI InChI=1S/C24H26N6O/c1-18-11-27-29(14-18)15-21-6-8-22(9-7-21)16-30-17-23(13-28-30)24(31)26-12-20-4-2-19(10-25)3-5-20/h2-9,11,13-14,17H,10,12,15-16,25H2,1H3,(H,26,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186836 (US9670157, 2 2,5-Dimethyl-1-(2-phenyl-thiazol-4-yl...) Show SMILES Cc1cc(C(=O)NCc2ccc(CN)cc2C)c(C)n1Cc1csc(n1)-c1ccccc1 Show InChI InChI=1S/C26H28N4OS/c1-17-11-20(13-27)9-10-22(17)14-28-25(31)24-12-18(2)30(19(24)3)15-23-16-32-26(29-23)21-7-5-4-6-8-21/h4-12,16H,13-15,27H2,1-3H3,(H,28,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM362280 (1-Ethyl-4-methyl-5-[4-(2-oxo-2H-pyridin-1-ylmethyl...) Show SMILES CCn1c(Cc2ccc(Cn3ccccc3=O)cc2)c(C)cc1C(=O)NCc1c(C)cc(CN)cc1C Show InChI InChI=1S/C31H36N4O2/c1-5-35-28(17-24-9-11-25(12-10-24)20-34-13-7-6-8-30(34)36)23(4)16-29(35)31(37)33-19-27-21(2)14-26(18-32)15-22(27)3/h6-16H,5,17-20,32H2,1-4H3,(H,33,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM187115 (US9670157, 129 1-(2-Pyrrolidin-1-yl-pyridin-4-ylme...) Show SMILES Cc1cc(CN)cc(C)c1CNC(=O)c1cn(Cc2ccnc(c2)N2CCCC2)nc1C(F)(F)F Show InChI InChI=1S/C25H29F3N6O/c1-16-9-19(12-29)10-17(2)20(16)13-31-24(35)21-15-34(32-23(21)25(26,27)28)14-18-5-6-30-22(11-18)33-7-3-4-8-33/h5-6,9-11,15H,3-4,7-8,12-14,29H2,1-2H3,(H,31,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186956 (US9670157, 97 2,5-Dimethyl-1-[4-(4-methyl-pyrazol-...) Show SMILES Cc1cnn(Cc2ccc(Cn3c(C)cc(C(=O)NCc4ccc(CN)cc4C)c3C)cc2)c1 Show InChI InChI=1S/C28H33N5O/c1-19-14-31-32(16-19)17-23-5-7-24(8-6-23)18-33-21(3)12-27(22(33)4)28(34)30-15-26-10-9-25(13-29)11-20(26)2/h5-12,14,16H,13,15,17-18,29H2,1-4H3,(H,30,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186949 (US9670157, 91 2,5-Dimethyl-1-[4-(2-oxo-2H-pyridin-...) Show SMILES Cc1cc(C(=O)NCc2ccc(CN)cc2C)c(C)n1Cc1ccc(Cn2ccccc2=O)cc1 Show InChI InChI=1S/C29H32N4O2/c1-20-14-25(16-30)11-12-26(20)17-31-29(35)27-15-21(2)33(22(27)3)19-24-9-7-23(8-10-24)18-32-13-5-4-6-28(32)34/h4-15H,16-19,30H2,1-3H3,(H,31,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM187090 (US9670157, 104 1-[4-(4-Methyl-pyrazol-1-ylmethyl)-...) Show SMILES Cc1cnn(Cc2ccc(Cn3cnc(c3)C(=O)NCc3ccc(CN)cc3)cc2)c1 Show InChI InChI=1S/C24H26N6O/c1-18-11-28-30(13-18)15-22-8-6-21(7-9-22)14-29-16-23(27-17-29)24(31)26-12-20-4-2-19(10-25)3-5-20/h2-9,11,13,16-17H,10,12,14-15,25H2,1H3,(H,26,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186888 (US9670157, 54 2,5-Dimethyl-1-(2-phenyl-thiazol-4-y...) Show SMILES COc1cc(CN)ccc1CNC(=O)c1cc(C)n(Cc2csc(n2)-c2ccccc2)c1C Show InChI InChI=1S/C26H28N4O2S/c1-17-11-23(25(31)28-14-21-10-9-19(13-27)12-24(21)32-3)18(2)30(17)15-22-16-33-26(29-22)20-7-5-4-6-8-20/h4-12,16H,13-15,27H2,1-3H3,(H,28,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM187094 (US9670157, 108 1-[4-(4-Methyl-pyrazol-1-ylmethyl)-...) Show SMILES Cc1cnn(Cc2ccc(Cn3cc(nn3)C(=O)NCc3ccc(CN)cc3)cc2)c1 Show InChI InChI=1S/C23H25N7O/c1-17-11-26-29(13-17)14-20-6-8-21(9-7-20)15-30-16-22(27-28-30)23(31)25-12-19-4-2-18(10-24)3-5-19/h2-9,11,13,16H,10,12,14-15,24H2,1H3,(H,25,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM362284 (1-Ethyl-4-methyl-5-[4-(4-methyl-pyrazol-1-ylmethyl...) Show SMILES CCn1c(cc(C)c1Cc1ccc(Cn2cc(C)cn2)cc1)C(=O)NCc1ccc(CN)cc1C Show InChI InChI=1S/C29H35N5O/c1-5-34-27(14-23-6-8-24(9-7-23)19-33-18-20(2)16-32-33)22(4)13-28(34)29(35)31-17-26-11-10-25(15-30)12-21(26)3/h6-13,16,18H,5,14-15,17,19,30H2,1-4H3,(H,31,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186950 (US9670157, 92 1-Ethyl-4-methyl-5-[4-(2-oxo-2H-pyri...) Show SMILES CCn1c(Cc2ccc(Cn3ccccc3=O)cc2)c(C)cc1C(=O)NCc1ccc(CN)cc1C Show InChI InChI=1S/C30H34N4O2/c1-4-34-27(17-23-8-10-24(11-9-23)20-33-14-6-5-7-29(33)35)22(3)16-28(34)30(36)32-19-26-13-12-25(18-31)15-21(26)2/h5-16H,4,17-20,31H2,1-3H3,(H,32,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM187103 (US9670157, 117 1-[4-(4-Methyl-pyrazol-1-ylmethyl)-...) Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4ccc(CN)c(F)c4)c(n3)C(F)(F)F)cc2)c1 Show InChI InChI=1S/C25H24F4N6O/c1-16-10-32-34(12-16)13-17-2-4-18(5-3-17)14-35-15-21(23(33-35)25(27,28)29)24(36)31-11-19-6-7-20(9-30)22(26)8-19/h2-8,10,12,15H,9,11,13-14,30H2,1H3,(H,31,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186884 (US9670157, 50 2,5-Dimethyl-1-(2-phenyl-thiazol-4-y...) Show SMILES Cc1cc(C(=O)NCc2ccc(CN)cc2C(F)(F)F)c(C)n1Cc1csc(n1)-c1ccccc1 Show InChI InChI=1S/C26H25F3N4OS/c1-16-10-22(24(34)31-13-20-9-8-18(12-30)11-23(20)26(27,28)29)17(2)33(16)14-21-15-35-25(32-21)19-6-4-3-5-7-19/h3-11,15H,12-14,30H2,1-2H3,(H,31,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186835 (US9670157, 1 2,5-Dimethyl-1-(2-phenyl-thiazol-4-yl...) Show SMILES Cc1cc(C(=O)NCc2ccc(CN)cc2)c(C)n1Cc1csc(n1)-c1ccccc1 Show InChI InChI=1S/C25H26N4OS/c1-17-12-23(24(30)27-14-20-10-8-19(13-26)9-11-20)18(2)29(17)15-22-16-31-25(28-22)21-6-4-3-5-7-21/h3-12,16H,13-15,26H2,1-2H3,(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186955 (US9670157, 96 2,5-Dimethyl-1-[4-(4-methyl-pyrazol-...) Show SMILES Cc1cnn(Cc2ccc(Cn3c(C)cc(C(=O)NCc4ccc(CN)cc4)c3C)cc2)c1 Show InChI InChI=1S/C27H31N5O/c1-19-14-30-31(16-19)17-24-8-10-25(11-9-24)18-32-20(2)12-26(21(32)3)27(33)29-15-23-6-4-22(13-28)5-7-23/h4-12,14,16H,13,15,17-18,28H2,1-3H3,(H,29,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186881 (US9670157, 47 2,5-Dimethyl-1-(2-phenyl-thiazol-4-y...) Show SMILES Cc1cc(C(=O)NCc2ccc(CN)cc2F)c(C)n1Cc1csc(n1)-c1ccccc1 Show InChI InChI=1S/C25H25FN4OS/c1-16-10-22(24(31)28-13-20-9-8-18(12-27)11-23(20)26)17(2)30(16)14-21-15-32-25(29-21)19-6-4-3-5-7-19/h3-11,15H,12-14,27H2,1-2H3,(H,28,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186883 (US9670157, 49 2,5-Dimethyl-1-(2-phenyl-thiazol-4-y...) Show SMILES Cc1cc(C(=O)NCc2ccc(CN)cc2Cl)c(C)n1Cc1csc(n1)-c1ccccc1 Show InChI InChI=1S/C25H25ClN4OS/c1-16-10-22(24(31)28-13-20-9-8-18(12-27)11-23(20)26)17(2)30(16)14-21-15-32-25(29-21)19-6-4-3-5-7-19/h3-11,15H,12-14,27H2,1-2H3,(H,28,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186948 (US9670157, 90 2,5-Dimethyl-1-[4-(2-oxo-2H-pyridin-...) Show SMILES Cc1cc(C(=O)NCc2ccc(CN)cc2)c(C)n1Cc1ccc(Cn2ccccc2=O)cc1 Show InChI InChI=1S/C28H30N4O2/c1-20-15-26(28(34)30-17-23-8-6-22(16-29)7-9-23)21(2)32(20)19-25-12-10-24(11-13-25)18-31-14-4-3-5-27(31)33/h3-15H,16-19,29H2,1-2H3,(H,30,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	114	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186838 (US9670157, 4 2,5-Dimethyl-1-(2-phenyl-thiazol-4-yl...) Show SMILES Cc1cc(C(=O)NCc2ccc(cc2)C2(N)CC2)c(C)n1Cc1csc(n1)-c1ccccc1 Show InChI InChI=1S/C27H28N4OS/c1-18-14-24(25(32)29-15-20-8-10-22(11-9-20)27(28)12-13-27)19(2)31(18)16-23-17-33-26(30-23)21-6-4-3-5-7-21/h3-11,14,17H,12-13,15-16,28H2,1-2H3,(H,29,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	121	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186879 (US9670157, 45 2,5-Dimethyl-1-(2-phenyl-thiazol-4-y...) Show SMILES Cc1cc(C(=O)NCc2ccc(CN)c(F)c2)c(C)n1Cc1csc(n1)-c1ccccc1 Show InChI InChI=1S/C25H25FN4OS/c1-16-10-22(24(31)28-13-18-8-9-20(12-27)23(26)11-18)17(2)30(16)14-21-15-32-25(29-21)19-6-4-3-5-7-19/h3-11,15H,12-14,27H2,1-2H3,(H,28,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	135	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186863 (US9670157, 29 1-[2-(3-Fluoro-phenyl)-thiazol-4-ylm...) Show SMILES Cc1cc(C(=O)NCc2ccc(CN)cc2)c(C)n1Cc1csc(n1)-c1cccc(F)c1 Show InChI InChI=1S/C25H25FN4OS/c1-16-10-23(24(31)28-13-19-8-6-18(12-27)7-9-19)17(2)30(16)14-22-15-32-25(29-22)20-4-3-5-21(26)11-20/h3-11,15H,12-14,27H2,1-2H3,(H,28,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM187109 (US9670157, 123 1-Ethyl-4-methyl-5-(2-phenyl-thiazo...) Show SMILES CCn1c(Cc2ccc(Cn3ccccc3=O)cc2)c(C)cc1C(=O)NCc1ccc(CN)cc1 Show InChI InChI=1S/C29H32N4O2/c1-3-33-26(17-22-7-13-25(14-8-22)20-32-15-5-4-6-28(32)34)21(2)16-27(33)29(35)31-19-24-11-9-23(18-30)10-12-24/h4-16H,3,17-20,30H2,1-2H3,(H,31,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	151	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM187107 (US9670157, 121 1-Ethyl-4-methyl-5-[4-(4-methyl-pyr...) Show SMILES CCn1c(cc(C)c1Cc1ccc(Cn2cc(C)cn2)cc1)C(=O)NCc1ccc(CN)cc1 Show InChI InChI=1S/C28H33N5O/c1-4-33-26(14-22-5-11-25(12-6-22)19-32-18-20(2)16-31-32)21(3)13-27(33)28(34)30-17-24-9-7-23(15-29)8-10-24/h5-13,16,18H,4,14-15,17,19,29H2,1-3H3,(H,30,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	155	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186871 (US9670157, 37 2,5-Dimethyl-1-(2-thiophen-3-yl-thia...) Show SMILES Cc1cc(C(=O)NCc2ccc(CN)cc2)c(C)n1Cc1csc(n1)-c1ccsc1 Show InChI InChI=1S/C23H24N4OS2/c1-15-9-21(22(28)25-11-18-5-3-17(10-24)4-6-18)16(2)27(15)12-20-14-30-23(26-20)19-7-8-29-13-19/h3-9,13-14H,10-12,24H2,1-2H3,(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186850 (US9670157, 16 2,5-Dimethyl-1-(6-phenyl-pyridin-2-y...) Show SMILES Cc1cc(C(=O)NCc2ccc(CN)cc2)c(C)n1Cc1cccc(n1)-c1ccccc1 Show InChI InChI=1S/C27H28N4O/c1-19-15-25(27(32)29-17-22-13-11-21(16-28)12-14-22)20(2)31(19)18-24-9-6-10-26(30-24)23-7-4-3-5-8-23/h3-15H,16-18,28H2,1-2H3,(H,29,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	186	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186877 (US9670157, 43 2,5-Dimethyl-1-(2-phenyl-thiazol-4-y...) Show SMILES Cc1cc(C(=O)NCc2ccc(CN)nc2)c(C)n1Cc1csc(n1)-c1ccccc1 Show InChI InChI=1S/C24H25N5OS/c1-16-10-22(23(30)27-13-18-8-9-20(11-25)26-12-18)17(2)29(16)14-21-15-31-24(28-21)19-6-4-3-5-7-19/h3-10,12,15H,11,13-14,25H2,1-2H3,(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	196	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186870 (US9670157, 36 2,5-Dimethyl-1-(2-pyridin-2-yl-thiaz...) Show SMILES Cc1cc(C(=O)NCc2ccc(CN)cc2)c(C)n1Cc1csc(n1)-c1ccccn1 Show InChI InChI=1S/C24H25N5OS/c1-16-11-21(23(30)27-13-19-8-6-18(12-25)7-9-19)17(2)29(16)14-20-15-31-24(28-20)22-5-3-4-10-26-22/h3-11,15H,12-14,25H2,1-2H3,(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	203	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186947 (US9670157, 89 1-[4-(2-Oxo-2H-pyridin-1-ylmethyl)-b...) Show SMILES NC1(CC1)c1ccc(CNC(=O)c2cnn(Cc3ccc(Cn4ccccc4=O)cc3)c2)cc1 Show InChI InChI=1S/C27H27N5O2/c28-27(12-13-27)24-10-8-20(9-11-24)15-29-26(34)23-16-30-32(19-23)18-22-6-4-21(5-7-22)17-31-14-2-1-3-25(31)33/h1-11,14,16,19H,12-13,15,17-18,28H2,(H,29,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	226	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186865 (US9670157, 31 2,5-Dimethyl-1-(2-pyridin-3-yl-thiaz...) Show SMILES Cc1cc(C(=O)NCc2ccc(CN)cc2)c(C)n1Cc1csc(n1)-c1cccnc1 Show InChI InChI=1S/C24H25N5OS/c1-16-10-22(23(30)27-12-19-7-5-18(11-25)6-8-19)17(2)29(16)14-21-15-31-24(28-21)20-4-3-9-26-13-20/h3-10,13,15H,11-12,14,25H2,1-2H3,(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	251	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Kallikrein-1 (Homo sapiens (Human))	BDBM187110 (US9670157, 124 3-Methyl-1-(2-methyl-quinolin-6-ylm...) Show SMILES Cc1nn(Cc2ccc3nc(C)ccc3c2)cc1C(=O)NCc1c(C)cc(CN)cc1C Show InChI InChI=1S/C26H29N5O/c1-16-9-21(12-27)10-17(2)23(16)13-28-26(32)24-15-31(30-19(24)4)14-20-6-8-25-22(11-20)7-5-18(3)29-25/h5-11,15H,12-14,27H2,1-4H3,(H,28,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	301	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM362236 (2,5-Dimethyl-1-(2-phenyl-thiazol-4-ylmethyl)-1H-py...) Show SMILES C[C@H](N)c1ccc(CNC(=O)c2cc(C)n(Cc3csc(n3)-c3ccccc3)c2C)cc1 Show InChI InChI=1S/C26H28N4OS/c1-17-13-24(25(31)28-14-20-9-11-21(12-10-20)18(2)27)19(3)30(17)15-23-16-32-26(29-23)22-7-5-4-6-8-22/h4-13,16,18H,14-15,27H2,1-3H3,(H,28,31)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	341	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM186842 (US9670157, 19 2,5-Dimethyl-1-(5-methyl-2-phenyl-ox...) Show SMILES Cc1cc(C(=O)NCc2ccc(CN)cc2)c(C)n1Cc1csc(c1)-c1cccnc1 Show InChI InChI=1S/C25H26N4OS/c1-17-10-23(25(30)28-13-20-7-5-19(12-26)6-8-20)18(2)29(17)15-21-11-24(31-16-21)22-4-3-9-27-14-22/h3-11,14,16H,12-13,15,26H2,1-2H3,(H,28,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	348	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US9834513 (2017) BindingDB Entry DOI: 10.7270/Q2348NPS
					More data for this Ligand-Target Pair

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