Compile Data Set for Download or QSAR

Found 643 hits Enz. Inhib. hit(s) with all data for entry = 8616   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM50073545 (CHEMBL3408949 | US10358436, Example A151 | US99078...) Show SMILES O=C1Nc2ccccc2[C@]11C[C@H]1c1ccc2c(\C=C\c3cccc(CN4CCOCC4)c3)n[nH]c2c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50073545 (CHEMBL3408949 | US10358436, Example A151 | US99078...) Show SMILES O=C1Nc2ccccc2[C@]11C[C@H]1c1ccc2c(\C=C\c3cccc(CN4CCOCC4)c3)n[nH]c2c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50073545 (CHEMBL3408949 | US10358436, Example A151 | US99078...) Show SMILES O=C1Nc2ccccc2[C@]11C[C@H]1c1ccc2c(\C=C\c3cccc(CN4CCOCC4)c3)n[nH]c2c1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM375440 (US10358436, Example A152 | US9907800, Example A152) Show SMILES O=C1Nc2ccccc2[C@]11CC1c1ccc2c(\C=C\c3cccc(CN4CCOCC4)c3)n[nH]c2c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM375443 (US10358436, Example A154 | US9907800, Example A154) Show SMILES O=C1Nc2ccccc2[C@]11CC1c1ccc2c(n[nH]c2c1)-c1ccc(CN2CCOCC2)cc1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM408741 (US10358436, Example A155) Show SMILES CN1CCN(Cc2ccc(cc2)-c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccccc23)CC1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM375445 (US10358436, Example A156 | US9907800, Example A156) Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1n[nH]c2cc(ccc12)[C@@H]1C[C@@]11C(=O)Nc2ccccc12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM408743 (US10358436, Example A157) Show SMILES CN1CCN(CC1)c1ccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccccc23)cn1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM50044658 (CHEMBL3353344 | US10358436, Example A158) Show SMILES Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccccc23)c(C)n1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50044658 (CHEMBL3353344 | US10358436, Example A158) Show SMILES Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccccc23)c(C)n1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM375449 (US10358436, Example A159 | US9907800, Example A159) Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(CCN4CCOCC4)cc3)c2c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM375449 (US10358436, Example A159 | US9907800, Example A159) Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(CCN4CCOCC4)cc3)c2c1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM375450 (US10358436, Example A160 | US9907800, Example A160) Show SMILES CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)N(CC(N)=O)c3ccccc23)cc1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM375450 (US10358436, Example A160 | US9907800, Example A160) Show SMILES CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)N(CC(N)=O)c3ccccc23)cc1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM375451 (US10358436, Example A161 | US9907800, Example A161) Show SMILES Cc1cc(\C=C\c2n[nH]c3cc(ccc23)C2C[C@@]22C(=O)Nc3ccccc23)ccn1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM375451 (US10358436, Example A161 | US9907800, Example A161) Show SMILES Cc1cc(\C=C\c2n[nH]c3cc(ccc23)C2C[C@@]22C(=O)Nc3ccccc23)ccn1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM408748 (US10358436, Example A162) Show SMILES CN(C)Cc1cccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccccc23)c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM408748 (US10358436, Example A162) Show SMILES CN(C)Cc1cccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccccc23)c1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM375453 (US10358436, Example A163 | US9907800, Example A163) Show SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(\C=C\c5ccc(nc5)N5CCNCC5)n[nH]c4c3)c2c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM375453 (US10358436, Example A163 | US9907800, Example A163) Show SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(\C=C\c5ccc(nc5)N5CCNCC5)n[nH]c4c3)c2c1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM375454 (US10358436, Example A164 | US9907800, Example A164) Show SMILES CN(C)Cc1cccc(\C=C\c2n[nH]c3cc(ccc23)C2C[C@@]22C(=O)N(CC(N)=O)c3ccccc23)c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM375454 (US10358436, Example A164 | US9907800, Example A164) Show SMILES CN(C)Cc1cccc(\C=C\c2n[nH]c3cc(ccc23)C2C[C@@]22C(=O)N(CC(N)=O)c3ccccc23)c1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM408751 (US10358436, Example A165) Show SMILES NC(=O)CN1C(=O)[C@@]2(C[C@H]2c2ccc3c(\C=C\c4ccc(CN5CCCCC5)cc4)n[nH]c3c2)c2ccccc12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM408751 (US10358436, Example A165) Show SMILES NC(=O)CN1C(=O)[C@@]2(C[C@H]2c2ccc3c(\C=C\c4ccc(CN5CCCCC5)cc4)n[nH]c3c2)c2ccccc12 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM408752 (US10358436, Example A166) Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(CN(C)C)cc3)c2c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM408752 (US10358436, Example A166) Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(CN(C)C)cc3)c2c1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM50044673 (CHEMBL3353353 | US10358436, Example A167) Show SMILES CCc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN(C)C)cc5)n[nH]c4c3)c2c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50044673 (CHEMBL3353353 | US10358436, Example A167) Show SMILES CCc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN(C)C)cc5)n[nH]c4c3)c2c1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM408754 (US10358436, Example A168) Show SMILES COc1cc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN(C)C)cc5)n[nH]c4c3)c2cc1OC |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM408754 (US10358436, Example A168) Show SMILES COc1cc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN(C)C)cc5)n[nH]c4c3)c2cc1OC |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM375459 (US10358436, Example A169 | US9907800, Example A169) Show SMILES CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)C2C[C@@]22C(=O)Nc3ccc(C)cc23)cc1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM375459 (US10358436, Example A169 | US9907800, Example A169) Show SMILES CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)C2C[C@@]22C(=O)Nc3ccc(C)cc23)cc1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM375461 (US10358436, Example A171 | US9907800, Example A171) Show SMILES CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)C2C[C@@]22C(=O)Nc3ccc(Cl)cc23)cc1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM375461 (US10358436, Example A171 | US9907800, Example A171) Show SMILES CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)C2C[C@@]22C(=O)Nc3ccc(Cl)cc23)cc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM375461 (US10358436, Example A171 | US9907800, Example A171) Show SMILES CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)C2C[C@@]22C(=O)Nc3ccc(Cl)cc23)cc1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM375463 (US10358436, Example A172 | US9907800, Example A172) Show SMILES CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)C2C[C@@]22C(=O)Nc3ncccc23)cc1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM375463 (US10358436, Example A172 | US9907800, Example A172) Show SMILES CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)C2C[C@@]22C(=O)Nc3ncccc23)cc1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM375464 (US10358436, Example A173 | US9907800, Example A173) Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cc(ccc12)C1C[C@@]11C(=O)Nc2ccc(C)cc12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM375464 (US10358436, Example A173 | US9907800, Example A173) Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cc(ccc12)C1C[C@@]11C(=O)Nc2ccc(C)cc12 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM375465 (US10358436, Example A174 | US9907800, Example A174) Show SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(\C=C\c5ccc(cc5)N5CCN(C)CC5)n[nH]c4c3)c2c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM375465 (US10358436, Example A174 | US9907800, Example A174) Show SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(\C=C\c5ccc(cc5)N5CCN(C)CC5)n[nH]c4c3)c2c1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM375466 (US10358436, Example A175 | US9907800, Example A175) Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(cc5)N5CCN(C)CC5)n[nH]c4c3)c2c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM375466 (US10358436, Example A175 | US9907800, Example A175) Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(cc5)N5CCN(C)CC5)n[nH]c4c3)c2c1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM408771 (US10358436, Example A176) Show SMILES CC(C)CCN1C(=O)[C@@]2(C[C@H]2c2ccc3c(\C=C\c4ccc(CN(C)C)cc4)n[nH]c3c2)c2ccccc12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM375331 (US10358436, Example A51 | US9907800, Example A177 ...) Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CCN6CCOCC6)cc5)n[nH]c4c3)c2c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM375331 (US10358436, Example A51 | US9907800, Example A177 ...) Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CCN6CCOCC6)cc5)n[nH]c4c3)c2c1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM375331 (US10358436, Example A51 | US9907800, Example A177 ...) Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CCN6CCOCC6)cc5)n[nH]c4c3)c2c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM375331 (US10358436, Example A51 | US9907800, Example A177 ...) Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CCN6CCOCC6)cc5)n[nH]c4c3)c2c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM375331 (US10358436, Example A51 | US9907800, Example A177 ...) Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CCN6CCOCC6)cc5)n[nH]c4c3)c2c1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 [1-391] (Homo sapiens (Human))	BDBM408774 (US10358436, Example A179) Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(cc5)C(=O)N5CCN(C)CC5)n[nH]c4c3)c2c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University Health Network US Patent					Assay Description Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...				US Patent US10358436 (2019) BindingDB Entry DOI: 10.7270/Q2K939WH
					More data for this Ligand-Target Pair

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