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Compile Data Set for Download or QSAR

Found 544 hits Enz. Inhib. hit(s) with all data for entry = 8759   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324894
PNG
(7-cyclopropyl-2-(2- | US10189841, Compound I-100 |...)
Show SMILES Cn1cc(nc1-c1ccc(Cn2c3nc(ncc3n(C3CC3)c2=O)-c2ccccc2C2CC2)cc1)C(F)(F)F
Show InChI InChI=1S/C29H25F3N6O/c1-36-16-24(29(30,31)32)34-26(36)19-8-6-17(7-9-19)15-37-27-23(38(28(37)39)20-12-13-20)14-33-25(35-27)22-5-3-2-4-21(22)18-10-11-18/h2-9,14,16,18,20H,10-13,15H2,1H3
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324895
PNG
(7-cyclopropyl-2-(2- | US10189841, Compound I-101 |...)
Show SMILES Cn1cc(nc1-c1ccc(Cn2c3nc(ncc3n(C3CC3)c2=O)-c2cccnc2C2CC2)cc1)C(F)(F)F
Show InChI InChI=1S/C28H24F3N7O/c1-36-15-22(28(29,30)31)34-25(36)18-6-4-16(5-7-18)14-37-26-21(38(27(37)39)19-10-11-19)13-33-24(35-26)20-3-2-12-32-23(20)17-8-9-17/h2-7,12-13,15,17,19H,8-11,14H2,1H3
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324899
PNG
(2-(2-isopropylpyridin-3- | US10189841, Compound I-...)
Show SMILES CC(C)c1ncccc1-c1ncc2n(C)c(=O)n(Cc3ccc(cc3)-c3nc(cn3C)C(F)(F)F)c2n1
Show InChI InChI=1S/C26H24F3N7O/c1-15(2)21-18(6-5-11-30-21)22-31-12-19-24(33-22)36(25(37)35(19)4)13-16-7-9-17(10-8-16)23-32-20(14-34(23)3)26(27,28)29/h5-12,14-15H,13H2,1-4H3
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324900
PNG
(9-(4-(1-(2- | US10189841, Compound I-106 | US10399...)
Show SMILES CC(C)c1ccccc1-c1ncc2n(C)c(=O)n(Cc3ccc(cc3)-c3nc(cn3CCO)C(F)(F)F)c2n1
Show InChI InChI=1S/C28H27F3N6O2/c1-17(2)20-6-4-5-7-21(20)24-32-14-22-26(34-24)37(27(39)35(22)3)15-18-8-10-19(11-9-18)25-33-23(28(29,30)31)16-36(25)12-13-38/h4-11,14,16-17,38H,12-13,15H2,1-3H3
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324902
PNG
(2-(2-isopropylpyridin-3- | US10189841, Compound I-...)
Show SMILES CC(C)c1ncccc1-c1ncc2n(C)c(=O)n(c2n1)C1(CC1)c1ccc(cc1)-c1nc(cn1C)C(F)(F)F
Show InChI InChI=1S/C28H26F3N7O/c1-16(2)22-19(6-5-13-32-22)23-33-14-20-25(35-23)38(26(39)37(20)4)27(11-12-27)18-9-7-17(8-10-18)24-34-21(15-36(24)3)28(29,30)31/h5-10,13-16H,11-12H2,1-4H3
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324904
PNG
(2-(2-isopropylphenyl)-7- | US10189841, Compound I-...)
Show SMILES CC(C)c1ccccc1-c1ncc2n(C)c(=O)n(Cc3ccc(cc3)-c3nc(cn3C3COC3)C(F)(F)F)c2n1
Show InChI InChI=1S/C29H27F3N6O2/c1-17(2)21-6-4-5-7-22(21)25-33-12-23-27(35-25)38(28(39)36(23)3)13-18-8-10-19(11-9-18)26-34-24(29(30,31)32)14-37(26)20-15-40-16-20/h4-12,14,17,20H,13,15-16H2,1-3H3
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324907
PNG
(2-(2-isopropylpyridin-3- | US10189841, Compound I-...)
Show SMILES CC(C)c1ncccc1-c1ncc2n(C)c(=O)n(Cc3ccc(cc3)-n3nc(cc3C)C(F)(F)F)c2n1
Show InChI InChI=1S/C26H24F3N7O/c1-15(2)22-19(6-5-11-30-22)23-31-13-20-24(32-23)35(25(37)34(20)4)14-17-7-9-18(10-8-17)36-16(3)12-21(33-36)26(27,28)29/h5-13,15H,14H2,1-4H3
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324908
PNG
(9-(4-(1-cyclopropyl-4- | US10189841, Compound I-11...)
Show SMILES CC(C)c1ncccc1-c1ncc2n(C)c(=O)n(Cc3ccc(cc3)-c3nc(cn3C3CC3)C(F)(F)F)c2n1
Show InChI InChI=1S/C28H26F3N7O/c1-16(2)23-20(5-4-12-32-23)24-33-13-21-26(35-24)38(27(39)36(21)3)14-17-6-8-18(9-7-17)25-34-22(28(29,30)31)15-37(25)19-10-11-19/h4-9,12-13,15-16,19H,10-11,14H2,1-3H3
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324909
PNG
((R)-2-(2- | US10189841, Compound I-115 | US1039998...)
Show SMILES CC(C)c1ncccc1-c1ncc2n(C)c(=O)n([C@H](C)c3ccc(cc3)-c3nc(cn3C)C(F)(F)F)c2n1 |r|
Show InChI InChI=1S/C27H26F3N7O/c1-15(2)22-19(7-6-12-31-22)23-32-13-20-25(34-23)37(26(38)36(20)5)16(3)17-8-10-18(11-9-17)24-33-21(14-35(24)4)27(28,29)30/h6-16H,1-5H3/t16-/m1/s1
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324910
PNG
((S)-2-(2- | US10189841, Compound I-116 | US1039998...)
Show SMILES CC(C)c1ncccc1-c1ncc2n(C)c(=O)n([C@@H](C)c3ccc(cc3)-c3nc(cn3C)C(F)(F)F)c2n1 |r|
Show InChI InChI=1S/C27H26F3N7O/c1-15(2)22-19(7-6-12-31-22)23-32-13-20-25(34-23)37(26(38)36(20)5)16(3)17-8-10-18(11-9-17)24-33-21(14-35(24)4)27(28,29)30/h6-16H,1-5H3/t16-/m0/s1
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324911
PNG
(2-(2-isopropylpyridin-3- | US10189841, Compound I-...)
Show SMILES CC(C)c1ncccc1-c1ncc2n(C)c(=O)n(Cc3ccc(cc3)-n3nc(cc3N3CCOCC3)C(F)(F)F)c2n1
Show InChI InChI=1S/C29H29F3N8O2/c1-18(2)25-21(5-4-10-33-25)26-34-16-22-27(35-26)39(28(41)37(22)3)17-19-6-8-20(9-7-19)40-24(38-11-13-42-14-12-38)15-23(36-40)29(30,31)32/h4-10,15-16,18H,11-14,17H2,1-3H3
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324912
PNG
(2-(2-isopropylpyridin-3- | US10189841, Compound I-...)
Show SMILES COc1cc(C)n(n1)-c1ccc(Cn2c3nc(ncc3n(C)c2=O)-c2cccnc2C(C)C)cc1
Show InChI InChI=1S/C26H27N7O2/c1-16(2)23-20(7-6-12-27-23)24-28-14-21-25(29-24)32(26(34)31(21)4)15-18-8-10-19(11-9-18)33-17(3)13-22(30-33)35-5/h6-14,16H,15H2,1-5H3
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324914
PNG
(2-(2-isopropylpyridin-3- | US10189841, Compound I-...)
Show SMILES COCCn1c2cnc(nc2n(Cc2ccc(cc2)-c2nc(cn2C)C(F)(F)F)c1=O)-c1cccnc1C(C)C
Show InChI InChI=1S/C28H28F3N7O2/c1-17(2)23-20(6-5-11-32-23)24-33-14-21-26(35-24)38(27(39)37(21)12-13-40-4)15-18-7-9-19(10-8-18)25-34-22(16-36(25)3)28(29,30)31/h5-11,14,16-17H,12-13,15H2,1-4H3
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324920
PNG
(9-(3-fluoro-4-(1-methyl- | US10189841, Compound I-...)
Show SMILES CC(C)c1ncccc1-c1ncc2n(C)c(=O)n(Cc3ccc(-c4nc(cn4C)C(F)(F)F)c(F)c3)c2n1
Show InChI InChI=1S/C26H23F4N7O/c1-14(2)21-17(6-5-9-31-21)22-32-11-19-24(34-22)37(25(38)36(19)4)12-15-7-8-16(18(27)10-15)23-33-20(13-35(23)3)26(28,29)30/h5-11,13-14H,12H2,1-4H3
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324899
PNG
(2-(2-isopropylpyridin-3- | US10189841, Compound I-...)
Show SMILES CC(C)c1ncccc1-c1ncc2n(C)c(=O)n(Cc3ccc(cc3)-c3nc(cn3C)C(F)(F)F)c2n1
Show InChI InChI=1S/C26H24F3N7O/c1-15(2)21-18(6-5-11-30-21)22-31-12-19-24(33-22)36(25(37)35(19)4)13-16-7-9-17(10-8-16)23-32-20(14-34(23)3)26(27,28)29/h5-12,14-15H,13H2,1-4H3
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324899
PNG
(2-(2-isopropylpyridin-3- | US10189841, Compound I-...)
Show SMILES CC(C)c1ncccc1-c1ncc2n(C)c(=O)n(Cc3ccc(cc3)-c3nc(cn3C)C(F)(F)F)c2n1
Show InChI InChI=1S/C26H24F3N7O/c1-15(2)21-18(6-5-11-30-21)22-31-12-19-24(33-22)36(25(37)35(19)4)13-16-7-9-17(10-8-16)23-32-20(14-34(23)3)26(27,28)29/h5-12,14-15H,13H2,1-4H3
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324899
PNG
(2-(2-isopropylpyridin-3- | US10189841, Compound I-...)
Show SMILES CC(C)c1ncccc1-c1ncc2n(C)c(=O)n(Cc3ccc(cc3)-c3nc(cn3C)C(F)(F)F)c2n1
Show InChI InChI=1S/C26H24F3N7O/c1-15(2)21-18(6-5-11-30-21)22-31-12-19-24(33-22)36(25(37)35(19)4)13-16-7-9-17(10-8-16)23-32-20(14-34(23)3)26(27,28)29/h5-12,14-15H,13H2,1-4H3
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324926
PNG
(2-(2-(2-hydroxypropan- | US10189841, Compound I-13...)
Show SMILES Cn1cc(nc1-c1ccc(Cn2c3nc(ncc3n(C)c2=O)-c2ccccc2C(C)(C)O)cc1)C(F)(F)F
Show InChI InChI=1S/C27H25F3N6O2/c1-26(2,38)19-8-6-5-7-18(19)22-31-13-20-24(33-22)36(25(37)35(20)4)14-16-9-11-17(12-10-16)23-32-21(15-34(23)3)27(28,29)30/h5-13,15,38H,14H2,1-4H3
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324931
PNG
(2-(2- | US10189841, Compound I-137 | US10399980, C...)
Show SMILES Cn1cc(nc1-c1ccc(Cn2c3nc(ncc3n(C)c2=O)-c2cccnc2OC2CC2)cc1)C(F)(F)F
Show InChI InChI=1S/C26H22F3N7O2/c1-34-14-20(26(27,28)29)32-22(34)16-7-5-15(6-8-16)13-36-23-19(35(2)25(36)37)12-31-21(33-23)18-4-3-11-30-24(18)38-17-9-10-17/h3-8,11-12,14,17H,9-10,13H2,1-2H3
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324932
PNG
(2-(2-isopropylphenyl)-9-(4- | US10189841, Compound...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-c3nc(cn3C)C(F)(F)F)c2n1
Show InChI InChI=1S/C26H23F3N6O/c1-15(2)18-6-4-5-7-19(18)22-30-12-20-24(33-22)35(25(36)31-20)13-16-8-10-17(11-9-16)23-32-21(14-34(23)3)26(27,28)29/h4-12,14-15H,13H2,1-3H3,(H,31,36)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324939
PNG
(9-(4-(1H-pyrazol-1- | US10189841, Compound I-145 |...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-n3cccn3)c2n1
Show InChI InChI=1S/C24H22N6O/c1-16(2)19-6-3-4-7-20(19)22-25-14-21-23(28-22)29(24(31)27-21)15-17-8-10-18(11-9-17)30-13-5-12-26-30/h3-14,16H,15H2,1-2H3,(H,27,31)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324944
PNG
(2-(2-isopropylphenyl)-9-(4- | US10189841, Compound...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-c3nnc(C)o3)c2n1
Show InChI InChI=1S/C24H22N6O2/c1-14(2)18-6-4-5-7-19(18)21-25-12-20-22(27-21)30(24(31)26-20)13-16-8-10-17(11-9-16)23-29-28-15(3)32-23/h4-12,14H,13H2,1-3H3,(H,26,31)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324946
PNG
(2-(2-isopropylphenyl)-9-(4- | US10189841, Compound...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-c3noc(C)n3)c2n1
Show InChI InChI=1S/C24H22N6O2/c1-14(2)18-6-4-5-7-19(18)22-25-12-20-23(28-22)30(24(31)27-20)13-16-8-10-17(11-9-16)21-26-15(3)32-29-21/h4-12,14H,13H2,1-3H3,(H,27,31)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324952
PNG
((R)-9-(1-(4-(1H-pyrazol-1- | US10189841, Compound ...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n([C@H](C)c3ccc(cc3)-n3cccn3)c2n1 |r|
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324954
PNG
(2-(2-isopropylphenyl)-9-(4- | US10189841, Compound...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-c3nccn3C)c2n1
Show InChI InChI=1S/C25H24N6O/c1-16(2)19-6-4-5-7-20(19)22-27-14-21-24(29-22)31(25(32)28-21)15-17-8-10-18(11-9-17)23-26-12-13-30(23)3/h4-14,16H,15H2,1-3H3,(H,28,32)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324957
PNG
(9-((1R,2S)-2-(4-(1H- | US10189841, Compound I-163 ...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n([C@@H]3CC[C@H]3c3ccc(cc3)-n3cccn3)c2n1 |r|
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324963
PNG
(2-(2-isopropylphenyl)-9-(4- | US10189841, Compound...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-c3ncco3)c2n1
Show InChI InChI=1S/C24H21N5O2/c1-15(2)18-5-3-4-6-19(18)21-26-13-20-22(28-21)29(24(30)27-20)14-16-7-9-17(10-8-16)23-25-11-12-31-23/h3-13,15H,14H2,1-2H3,(H,27,30)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324964
PNG
(9-(4-(1H-pyrazol-1- | US10189841, Compound I-170 |...)
Show SMILES CC(C)c1c(F)cccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-n3cccn3)c2n1
Show InChI InChI=1S/C24H21FN6O/c1-15(2)21-18(5-3-6-19(21)25)22-26-13-20-23(29-22)30(24(32)28-20)14-16-7-9-17(10-8-16)31-12-4-11-27-31/h3-13,15H,14H2,1-2H3,(H,28,32)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324966
PNG
(2-(3-fluoro-2- | US10189841, Compound I-172 | US10...)
Show SMILES CC(C)c1c(F)cccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-c3nccn3C)c2n1
Show InChI InChI=1S/C25H23FN6O/c1-15(2)21-18(5-4-6-19(21)26)22-28-13-20-24(30-22)32(25(33)29-20)14-16-7-9-17(10-8-16)23-27-11-12-31(23)3/h4-13,15H,14H2,1-3H3,(H,29,33)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324967
PNG
(2-(2-isopropylphenyl)-9-(4- | US10189841, Compound...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-n3ccc(n3)N3CCN(C)CC3)c2n1
Show InChI InChI=1S/C29H32N8O/c1-20(2)23-6-4-5-7-24(23)27-30-18-25-28(32-27)36(29(38)31-25)19-21-8-10-22(11-9-21)37-13-12-26(33-37)35-16-14-34(3)15-17-35/h4-13,18,20H,14-17,19H2,1-3H3,(H,31,38)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324968
PNG
(2-(2-isopropylphenyl)-9-(4- | US10189841, Compound...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-n3ccc(n3)N3CCOCC3)c2n1
Show InChI InChI=1S/C28H29N7O2/c1-19(2)22-5-3-4-6-23(22)26-29-17-24-27(31-26)34(28(36)30-24)18-20-7-9-21(10-8-20)35-12-11-25(32-35)33-13-15-37-16-14-33/h3-12,17,19H,13-16,18H2,1-2H3,(H,30,36)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324969
PNG
(2-(2-isopropylphenyl)-9-(4- | US10189841, Compound...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-n3cc(C)nn3)c2n1
Show InChI InChI=1S/C24H23N7O/c1-15(2)19-6-4-5-7-20(19)22-25-12-21-23(27-22)30(24(32)26-21)14-17-8-10-18(11-9-17)31-13-16(3)28-29-31/h4-13,15H,14H2,1-3H3,(H,26,32)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324970
PNG
(9-(4-(5-fluoro-1-methyl-1H- | US10189841, Compound...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-c3ncc(F)n3C)c2n1
Show InChI InChI=1S/C25H23FN6O/c1-15(2)18-6-4-5-7-19(18)22-27-12-20-24(30-22)32(25(33)29-20)14-16-8-10-17(11-9-16)23-28-13-21(26)31(23)3/h4-13,15H,14H2,1-3H3,(H,29,33)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324971
PNG
(9-(3-fluoro-4-(1H-pyrazol- | US10189841, Compound ...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(c(F)c3)-n3cccn3)c2n1
Show InChI InChI=1S/C24H21FN6O/c1-15(2)17-6-3-4-7-18(17)22-26-13-20-23(29-22)30(24(32)28-20)14-16-8-9-21(19(25)12-16)31-11-5-10-27-31/h3-13,15H,14H2,1-2H3,(H,28,32)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324972
PNG
((R)-9-(1-(4- | US10189841, Compound I-178 | US1039...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n([C@H](C)c3ccc(F)cc3)c2n1 |r|
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324978
PNG
(2-(2-isopropylphenyl)-9-(4- | US10189841, Compound...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-n3nccc3C)c2n1
Show InChI InChI=1S/C25H24N6O/c1-16(2)20-6-4-5-7-21(20)23-26-14-22-24(29-23)30(25(32)28-22)15-18-8-10-19(11-9-18)31-17(3)12-13-27-31/h4-14,16H,15H2,1-3H3,(H,28,32)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324979
PNG
(2-(2-isopropylphenyl)-9-(4- | US10189841, Compound...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-n3nncc3C)c2n1
Show InChI InChI=1S/C24H23N7O/c1-15(2)19-6-4-5-7-20(19)22-25-13-21-23(28-22)30(24(32)27-21)14-17-8-10-18(11-9-17)31-16(3)12-26-29-31/h4-13,15H,14H2,1-3H3,(H,27,32)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324981
PNG
(6-((2-(2-isopropylphenyl)- | US10189841, Compound ...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc4C(=O)N(C)CCc4c3)c2n1
Show InChI InChI=1S/C25H25N5O2/c1-15(2)18-6-4-5-7-20(18)22-26-13-21-23(28-22)30(25(32)27-21)14-16-8-9-19-17(12-16)10-11-29(3)24(19)31/h4-9,12-13,15H,10-11,14H2,1-3H3,(H,27,32)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324982
PNG
(2-(3-fluoro-2- | US10189841, Compound I-188 | US10...)
Show SMILES CC(C)c1c(F)cccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-c3noc(C)n3)c2n1
Show InChI InChI=1S/C24H21FN6O2/c1-13(2)20-17(5-4-6-18(20)25)22-26-11-19-23(29-22)31(24(32)28-19)12-15-7-9-16(10-8-15)21-27-14(3)33-30-21/h4-11,13H,12H2,1-3H3,(H,28,32)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324983
PNG
(2-(3-fluoro-2- | US10189841, Compound I-189 | US10...)
Show SMILES CC(C)c1c(F)cccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-c3nnc(C)o3)c2n1
Show InChI InChI=1S/C24H21FN6O2/c1-13(2)20-17(5-4-6-18(20)25)21-26-11-19-22(28-21)31(24(32)27-19)12-15-7-9-16(10-8-15)23-30-29-14(3)33-23/h4-11,13H,12H2,1-3H3,(H,27,32)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324984
PNG
((R)-9-(1-(4-(3,5-dimethyl- | US10189841, Compound ...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n([C@H](C)c3ccc(cc3)-n3nc(C)cc3C)c2n1 |r|
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324985
PNG
((S)-9-(1-(4-(3,5-dimethyl- | US10189841, Compound ...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n([C@@H](C)c3ccc(cc3)-n3nc(C)cc3C)c2n1 |r|
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324986
PNG
(2-(2-isopropylphenyl)-9-(4- | US10189841, Compound...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-c3nc(cn3C3COC3)C(F)(F)F)c2n1
Show InChI InChI=1S/C28H25F3N6O2/c1-16(2)20-5-3-4-6-21(20)24-32-11-22-26(35-24)37(27(38)33-22)12-17-7-9-18(10-8-17)25-34-23(28(29,30)31)13-36(25)19-14-39-15-19/h3-11,13,16,19H,12,14-15H2,1-2H3,(H,33,38)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324987
PNG
(2-(3-fluoro-2- | US10189841, Compound I-193 | US10...)
Show SMILES CC(C)c1c(F)cccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-c3nc(cn3C)C(F)(F)F)c2n1
Show InChI InChI=1S/C26H22F4N6O/c1-14(2)21-17(5-4-6-18(21)27)22-31-11-19-24(34-22)36(25(37)32-19)12-15-7-9-16(10-8-15)23-33-20(13-35(23)3)26(28,29)30/h4-11,13-14H,12H2,1-3H3,(H,32,37)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324988
PNG
(2-(2-isopropylphenyl)-9-(4- | US10189841, Compound...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-n3nc(cc3C)C(F)(F)F)c2n1
Show InChI InChI=1S/C26H23F3N6O/c1-15(2)19-6-4-5-7-20(19)23-30-13-21-24(32-23)34(25(36)31-21)14-17-8-10-18(11-9-17)35-16(3)12-22(33-35)26(27,28)29/h4-13,15H,14H2,1-3H3,(H,31,36)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324989
PNG
(2-(2-isopropylphenyl)-9-(4- | US10189841, Compound...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-n3nc(C)cc3C(F)(F)F)c2n1
Show InChI InChI=1S/C26H23F3N6O/c1-15(2)19-6-4-5-7-20(19)23-30-13-21-24(32-23)34(25(36)31-21)14-17-8-10-18(11-9-17)35-22(26(27,28)29)12-16(3)33-35/h4-13,15H,14H2,1-3H3,(H,31,36)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324990
PNG
(1-(4-((2-(2- | US10189841, Compound I-196 | US1039...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-n3ccc(n3)C#N)c2n1
Show InChI InChI=1S/C25H21N7O/c1-16(2)20-5-3-4-6-21(20)23-27-14-22-24(29-23)31(25(33)28-22)15-17-7-9-19(10-8-17)32-12-11-18(13-26)30-32/h3-12,14,16H,15H2,1-2H3,(H,28,33)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324992
PNG
(9-(4-(4-chloro-1-methyl- | US10189841, Compound I-...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-c3nc(Cl)cn3C)c2n1
Show InChI InChI=1S/C25H23ClN6O/c1-15(2)18-6-4-5-7-19(18)22-27-12-20-24(30-22)32(25(33)28-20)13-16-8-10-17(11-9-16)23-29-21(26)14-31(23)3/h4-12,14-15H,13H2,1-3H3,(H,28,33)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324993
PNG
(1-(4-((2-(2- | US10189841, Compound I-199 | US1039...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-n3nc(cc3C#N)C#N)c2n1
Show InChI InChI=1S/C26H20N8O/c1-16(2)21-5-3-4-6-22(21)24-29-14-23-25(31-24)33(26(35)30-23)15-17-7-9-19(10-8-17)34-20(13-28)11-18(12-27)32-34/h3-11,14,16H,15H2,1-2H3,(H,30,35)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM324994
PNG
(9-(4-(2,5-dimethyloxazol-4- | US10189841, Compound...)
Show SMILES CC(C)c1ccccc1-c1ncc2[nH]c(=O)n(Cc3ccc(cc3)-c3nc(C)oc3C)c2n1
Show InChI InChI=1S/C26H25N5O2/c1-15(2)20-7-5-6-8-21(20)24-27-13-22-25(30-24)31(26(32)29-22)14-18-9-11-19(12-10-18)23-16(3)33-17(4)28-23/h5-13,15H,14H2,1-4H3,(H,29,32)
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FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
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