Compile Data Set for Download or QSAR

Found 302 hits Enz. Inhib. hit(s) with all data for entry = 9116   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442793 (US10653688, Compound 1) Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cc(N)cc(F)c1 Show InChI InChI=1S/C26H25FN6O/c1-32-6-8-33(9-7-32)25-14-18(4-5-29-25)26(34)31-24-13-20-10-17(2-3-19(20)16-30-24)21-11-22(27)15-23(28)12-21/h2-5,10-16H,6-9,28H2,1H3,(H,30,31,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	75	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442795 (US10653688, Compound 2) Show SMILES CC(C)Nc1cc(F)cc(c1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CCN(C)CC3)cc2c1 Show InChI InChI=1S/C29H31FN6O/c1-19(2)33-26-14-24(13-25(30)17-26)20-4-5-22-18-32-27(15-23(22)12-20)34-29(37)21-6-7-31-28(16-21)36-10-8-35(3)9-11-36/h4-7,12-19,33H,8-11H2,1-3H3,(H,32,34,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	354	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442797 (US10653688, Compound 3) Show SMILES CN1CCC(CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1ccccn1 Show InChI InChI=1S/C21H22N4O/c1-25-10-7-15(8-11-25)21(26)24-20-13-18-12-16(5-6-17(18)14-23-20)19-4-2-3-9-22-19/h2-6,9,12-15H,7-8,10-11H2,1H3,(H,23,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	260	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442808 (US10653688, Compound 4) Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=C)Nc1cc2cc(ccc2cn1)-c1ccccn1 Show InChI InChI=1S/C26H26N6/c1-19(20-8-10-28-26(17-20)32-13-11-31(2)12-14-32)30-25-16-23-15-21(6-7-22(23)18-29-25)24-5-3-4-9-27-24/h3-10,15-18H,1,11-14H2,2H3,(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	242	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442809 (US10653688, Compound 5) Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1ccnnc1 Show InChI InChI=1S/C24H23N7O/c1-30-8-10-31(11-9-30)23-14-18(4-6-25-23)24(32)29-22-13-21-12-17(2-3-19(21)15-26-22)20-5-7-27-28-16-20/h2-7,12-16H,8-11H2,1H3,(H,26,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442810 (US10653688, Compound 6) Show SMILES O=C(Nc1cc2cc(ccc2cn1)-c1cccnc1)C1CC1 Show InChI InChI=1S/C18H15N3O/c22-18(12-3-4-12)21-17-9-16-8-13(5-6-15(16)11-20-17)14-2-1-7-19-10-14/h1-2,5-12H,3-4H2,(H,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442813 (US10653688, Compound 60 | US10653688, Compound 7) Show SMILES O=C(CN1CCCC1)Nc1cc2cc(ccc2cn1)-c1cccnc1 Show InChI InChI=1S/C20H20N4O/c25-20(14-24-8-1-2-9-24)23-19-11-18-10-15(5-6-17(18)13-22-19)16-4-3-7-21-12-16/h3-7,10-13H,1-2,8-9,14H2,(H,22,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442818 (US10653688, Compound 19 | US10653688, Compound 8) Show SMILES CN1CCC(CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cccnc1 Show InChI InChI=1S/C21H22N4O/c1-25-9-6-15(7-10-25)21(26)24-20-12-19-11-16(4-5-18(19)14-23-20)17-3-2-8-22-13-17/h2-5,8,11-15H,6-7,9-10H2,1H3,(H,23,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442820 (US10653688, Compound 9) Show SMILES O=C(Nc1cc2cc(ccc2cn1)-c1cccnc1)C12CCN(CC1)CC2 Show InChI InChI=1S/C22H22N4O/c27-21(22-5-9-26(10-6-22)11-7-22)25-20-13-19-12-16(3-4-18(19)15-24-20)17-2-1-8-23-14-17/h1-4,8,12-15H,5-7,9-11H2,(H,24,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	26	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442821 (US10653688, Compound 10 | US10653688, Compound 151...) Show SMILES O=C(CN1CCOCC1)Nc1cc2cc(ccc2cn1)-c1cccnc1 Show InChI InChI=1S/C20H20N4O2/c25-20(14-24-6-8-26-9-7-24)23-19-11-18-10-15(3-4-17(18)13-22-19)16-2-1-5-21-12-16/h1-5,10-13H,6-9,14H2,(H,22,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442823 (US10653688, Compound 11 | US10653688, Compound 61) Show SMILES CN1CCN(CC(=O)Nc2cc3cc(ccc3cn2)-c2cccnc2)CC1 Show InChI InChI=1S/C21H23N5O/c1-25-7-9-26(10-8-25)15-21(27)24-20-12-19-11-16(4-5-18(19)14-23-20)17-3-2-6-22-13-17/h2-6,11-14H,7-10,15H2,1H3,(H,23,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442824 (US10653688, Compound 12) Show SMILES CN1CCCN(CC(=O)Nc2cc3cc(ccc3cn2)-c2cccnc2)CC1 Show InChI InChI=1S/C22H25N5O/c1-26-8-3-9-27(11-10-26)16-22(28)25-21-13-20-12-17(5-6-19(20)15-24-21)18-4-2-7-23-14-18/h2,4-7,12-15H,3,8-11,16H2,1H3,(H,24,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	17	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442825 (US10653688, Compound 13) Show SMILES CN1CCN(CC1)c1ccc(CC(=O)Nc2cc3cc(ccc3cn2)-c2cccnc2)cc1 Show InChI InChI=1S/C27H27N5O/c1-31-11-13-32(14-12-31)25-8-4-20(5-9-25)15-27(33)30-26-17-24-16-21(6-7-23(24)19-29-26)22-3-2-10-28-18-22/h2-10,16-19H,11-15H2,1H3,(H,29,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442826 (US10653688, Compound 14) Show SMILES Cc1nccn1CC(=O)Nc1cc2cc(ccc2cn1)-c1cccnc1 Show InChI InChI=1S/C20H17N5O/c1-14-22-7-8-25(14)13-20(26)24-19-10-18-9-15(4-5-17(18)12-23-19)16-3-2-6-21-11-16/h2-12H,13H2,1H3,(H,23,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442827 (US10653688, Compound 15) Show SMILES O=C(Cn1ccnc1)Nc1cc2cc(ccc2cn1)-c1cccnc1 Show InChI InChI=1S/C19H15N5O/c25-19(12-24-7-6-21-13-24)23-18-9-17-8-14(3-4-16(17)11-22-18)15-2-1-5-20-10-15/h1-11,13H,12H2,(H,22,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442829 (US10653688, Compound 16) Show SMILES Fc1cncc(c1)-c1ccc2cnc(NC(=O)[C@H]3C[C@@H](C3)N3CCOCC3)cc2c1 |r,wU:19.22,wD:17.17,(-1.33,3.85,;-1.33,2.31,;-2.67,1.54,;-2.67,,;-1.33,-.77,;;,1.54,;1.33,-.77,;1.33,-2.31,;2.67,-3.08,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;6.67,-.77,;8,,;8,1.54,;6.67,2.31,;9.34,2.31,;10.82,1.91,;11.22,3.4,;9.73,3.8,;12.56,4.17,;12.56,5.71,;13.89,6.48,;15.22,5.71,;15.22,4.17,;13.89,3.4,;5.33,,;4,-.77,;2.67,,)| Show InChI InChI=1S/C23H23FN4O2/c24-20-8-19(12-25-14-20)15-1-2-16-13-26-22(11-17(16)7-15)27-23(29)18-9-21(10-18)28-3-5-30-6-4-28/h1-2,7-8,11-14,18,21H,3-6,9-10H2,(H,26,27,29)/t18-,21-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442830 (US10653688, Compound 17) Show SMILES CN1CCN(C[C@H]2CC[C@@H](CC2)C(=O)Nc2cc3cc(ccc3cn2)-c2cncc(F)c2)CC1 |r,wU:6.5,wD:9.12,(18.67,1.54,;17.34,2.31,;17.34,3.85,;16,4.62,;14.67,3.85,;13.34,4.62,;12,3.85,;12,2.31,;10.67,1.54,;9.34,2.31,;9.34,3.85,;10.67,4.62,;8,1.54,;6.67,2.31,;8,,;6.67,-.77,;5.33,,;4,-.77,;2.67,,;1.33,-.77,;1.33,-2.31,;2.67,-3.08,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;;-1.33,-.77,;-2.67,,;-2.67,1.54,;-1.33,2.31,;-1.33,3.85,;,1.54,;14.67,2.31,;16,1.54,)| Show InChI InChI=1S/C27H32FN5O/c1-32-8-10-33(11-9-32)18-19-2-4-20(5-3-19)27(34)31-26-14-23-12-21(6-7-22(23)16-30-26)24-13-25(28)17-29-15-24/h6-7,12-17,19-20H,2-5,8-11,18H2,1H3,(H,30,31,34)/t19-,20-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442831 (US10653688, Compound 18) Show SMILES Fc1cncc(c1)-c1ccc2cnc(NC(=O)CN3CCCC3)cc2c1 Show InChI InChI=1S/C20H19FN4O/c21-18-8-17(10-22-12-18)14-3-4-15-11-23-19(9-16(15)7-14)24-20(26)13-25-5-1-2-6-25/h3-4,7-12H,1-2,5-6,13H2,(H,23,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	39	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442818 (US10653688, Compound 19 | US10653688, Compound 8) Show SMILES CN1CCC(CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cccnc1 Show InChI InChI=1S/C21H22N4O/c1-25-9-6-15(7-10-25)21(26)24-20-12-19-11-16(4-5-18(19)14-23-20)17-3-2-8-22-13-17/h2-5,8,11-15H,6-7,9-10H2,1H3,(H,23,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442834 (US10653688, Compound 20) Show SMILES CN1CCC(CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncc(F)c1 Show InChI InChI=1S/C21H21FN4O/c1-26-6-4-14(5-7-26)21(27)25-20-10-17-8-15(2-3-16(17)12-24-20)18-9-19(22)13-23-11-18/h2-3,8-14H,4-7H2,1H3,(H,24,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	31	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442835 (US10653688, Compound 21) Show SMILES CN1CCN(CC(=O)Nc2cc3cc(ccc3cn2)-c2ccc(F)nc2)CC1 Show InChI InChI=1S/C21H22FN5O/c1-26-6-8-27(9-7-26)14-21(28)25-20-11-18-10-15(2-3-17(18)13-24-20)16-4-5-19(22)23-12-16/h2-5,10-13H,6-9,14H2,1H3,(H,24,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	42	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442836 (US10653688, Compound 22) Show SMILES Fc1cncc(c1)-c1ccc2cnc(NC(=O)CN3CCNCC3)cc2c1 Show InChI InChI=1S/C20H20FN5O/c21-18-8-17(10-23-12-18)14-1-2-15-11-24-19(9-16(15)7-14)25-20(27)13-26-5-3-22-4-6-26/h1-2,7-12,22H,3-6,13H2,(H,24,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442837 (US10653688, Compound 23) Show SMILES Fc1cncc(c1)-c1ccc2cnc(NC(=O)CCC3CCOCC3)cc2c1 Show InChI InChI=1S/C22H22FN3O2/c23-20-10-19(12-24-14-20)16-2-3-17-13-25-21(11-18(17)9-16)26-22(27)4-1-15-5-7-28-8-6-15/h2-3,9-15H,1,4-8H2,(H,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	17	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442838 (US10653688, Compound 24) Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncc(F)c1 Show InChI InChI=1S/C25H23FN6O/c1-31-6-8-32(9-7-31)24-13-18(4-5-28-24)25(33)30-23-12-20-10-17(2-3-19(20)15-29-23)21-11-22(26)16-27-14-21/h2-5,10-16H,6-9H2,1H3,(H,29,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442839 (US10653688, Compound 25) Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncc(Cl)c1 Show InChI InChI=1S/C25H23ClN6O/c1-31-6-8-32(9-7-31)24-13-18(4-5-28-24)25(33)30-23-12-20-10-17(2-3-19(20)15-29-23)21-11-22(26)16-27-14-21/h2-5,10-16H,6-9H2,1H3,(H,29,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442840 (US10653688, Compound 26) Show SMILES FC(F)c1cncc(c1)-c1ccc2cnc(NC(=O)c3cccc(c3)C3CCNCC3)cc2c1 Show InChI InChI=1S/C27H24F2N4O/c28-26(29)24-12-23(14-31-15-24)19-4-5-21-16-32-25(13-22(21)11-19)33-27(34)20-3-1-2-18(10-20)17-6-8-30-9-7-17/h1-5,10-17,26,30H,6-9H2,(H,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	29	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442841 (US10653688, Compound 27) Show SMILES CN1CCC(CC1)c1cccc(c1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncc(c1)C(F)F Show InChI InChI=1S/C28H26F2N4O/c1-34-9-7-18(8-10-34)19-3-2-4-21(11-19)28(35)33-26-14-23-12-20(5-6-22(23)17-32-26)24-13-25(27(29)30)16-31-15-24/h2-6,11-18,27H,7-10H2,1H3,(H,32,33,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	29	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442875 (US10653688, Compound 57) Show SMILES O=C(Nc1cc2cc(ccc2cn1)-c1cncc(CN2CCOCC2)c1)C1CC1 Show InChI InChI=1S/C23H24N4O2/c28-23(17-1-2-17)26-22-11-20-10-18(3-4-19(20)14-25-22)21-9-16(12-24-13-21)15-27-5-7-29-8-6-27/h3-4,9-14,17H,1-2,5-8,15H2,(H,25,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442876 (US10653688, Compound 58) Show SMILES CNC(=O)c1cncc(c1)-c1ccc2cnc(NC(=O)C3CCN(C)CC3)cc2c1 Show InChI InChI=1S/C23H25N5O2/c1-24-22(29)20-10-19(12-25-13-20)16-3-4-17-14-26-21(11-18(17)9-16)27-23(30)15-5-7-28(2)8-6-15/h3-4,9-15H,5-8H2,1-2H3,(H,24,29)(H,26,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442877 (US10653688, Compound 59) Show SMILES CNC(=O)c1cncc(c1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CCN(C)CC3)cc2c1 Show InChI InChI=1S/C27H27N7O2/c1-28-26(35)23-12-22(15-29-16-23)18-3-4-20-17-31-24(13-21(20)11-18)32-27(36)19-5-6-30-25(14-19)34-9-7-33(2)8-10-34/h3-6,11-17H,7-10H2,1-2H3,(H,28,35)(H,31,32,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442813 (US10653688, Compound 60 | US10653688, Compound 7) Show SMILES O=C(CN1CCCC1)Nc1cc2cc(ccc2cn1)-c1cccnc1 Show InChI InChI=1S/C20H20N4O/c25-20(14-24-8-1-2-9-24)23-19-11-18-10-15(5-6-17(18)13-22-19)16-4-3-7-21-12-16/h3-7,10-13H,1-2,8-9,14H2,(H,22,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442823 (US10653688, Compound 11 | US10653688, Compound 61) Show SMILES CN1CCN(CC(=O)Nc2cc3cc(ccc3cn2)-c2cccnc2)CC1 Show InChI InChI=1S/C21H23N5O/c1-25-7-9-26(10-8-25)15-21(27)24-20-12-19-11-16(4-5-18(19)14-23-20)17-3-2-6-22-13-17/h2-6,11-14H,7-10,15H2,1H3,(H,23,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442821 (US10653688, Compound 10 | US10653688, Compound 151...) Show SMILES O=C(CN1CCOCC1)Nc1cc2cc(ccc2cn1)-c1cccnc1 Show InChI InChI=1S/C20H20N4O2/c25-20(14-24-6-8-26-9-7-24)23-19-11-18-10-15(3-4-17(18)13-22-19)16-2-1-5-21-12-16/h1-5,10-13H,6-9,14H2,(H,22,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442881 (US10653688, Compound 63 | US10653688, Compound 65) Show SMILES CN1CCC(CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnc(C)nc1 Show InChI InChI=1S/C21H23N5O/c1-14-22-12-19(13-23-14)16-3-4-17-11-24-20(10-18(17)9-16)25-21(27)15-5-7-26(2)8-6-15/h3-4,9-13,15H,5-8H2,1-2H3,(H,24,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	221	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442882 (US10653688, Compound 64) Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnc(C)nc1 Show InChI InChI=1S/C25H25N7O/c1-17-27-15-22(16-28-17)18-3-4-20-14-29-23(12-21(20)11-18)30-25(33)19-5-6-26-24(13-19)32-9-7-31(2)8-10-32/h3-6,11-16H,7-10H2,1-2H3,(H,29,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	158	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442881 (US10653688, Compound 63 | US10653688, Compound 65) Show SMILES CN1CCC(CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnc(C)nc1 Show InChI InChI=1S/C21H23N5O/c1-14-22-12-19(13-23-14)16-3-4-17-11-24-20(10-18(17)9-16)25-21(27)15-5-7-26(2)8-6-15/h3-4,9-13,15H,5-8H2,1-2H3,(H,24,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	48	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442884 (US10653688, Compound 66) Show SMILES O=C(Nc1cc2cc(ccc2cn1)-c1cccnn1)N1CCOCC1 Show InChI InChI=1S/C18H17N5O2/c24-18(23-6-8-25-9-7-23)21-17-11-15-10-13(3-4-14(15)12-19-17)16-2-1-5-20-22-16/h1-5,10-12H,6-9H2,(H,19,21,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	123	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442885 (US10653688, Compound 67) Show SMILES O=C(CN1CCOCC1)Nc1cc2cc(ccc2cn1)-c1ccnnn1 Show InChI InChI=1S/C18H18N6O2/c25-18(12-24-5-7-26-8-6-24)21-17-10-15-9-13(1-2-14(15)11-19-17)16-3-4-20-23-22-16/h1-4,9-11H,5-8,12H2,(H,19,21,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	29	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442886 (US10653688, Compound 68) Show SMILES O=C(CN1CCCC1)Nc1cc2cc(ccc2cn1)-c1ccnnc1 Show InChI InChI=1S/C19H19N5O/c25-19(13-24-7-1-2-8-24)23-18-10-17-9-14(3-4-15(17)11-20-18)16-5-6-21-22-12-16/h3-6,9-12H,1-2,7-8,13H2,(H,20,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	328	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442887 (US10653688, Compound 69) Show SMILES O=C(Nc1cc2cc(ccc2cn1)-c1cnccn1)C1C[C@@H](C1)N1CCOCC1 |r,wU:21.26,(6.67,2.31,;8,1.54,;8,,;6.67,-.77,;5.33,,;4,-.77,;2.67,,;1.33,-.77,;1.33,-2.31,;2.67,-3.08,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;;-1.33,-.77,;-2.67,,;-2.67,1.54,;-1.33,2.31,;,1.54,;9.34,2.31,;10.87,2.15,;11.34,3.61,;9.81,3.77,;12.63,4.45,;13.97,3.68,;15.3,4.45,;15.3,5.99,;13.97,6.76,;12.63,5.99,)| Show InChI InChI=1S/C22H23N5O2/c28-22(18-10-19(11-18)27-5-7-29-8-6-27)26-21-12-17-9-15(1-2-16(17)13-25-21)20-14-23-3-4-24-20/h1-4,9,12-14,18-19H,5-8,10-11H2,(H,25,26,28)/t18?,19-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442888 (US10653688, Compound 70) Show SMILES CN(C)[C@H]1CCC(CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnccn1 |r,wU:3.2,(13.34,6.16,;13.34,4.62,;14.67,3.85,;12,3.85,;12,2.31,;10.67,1.54,;9.34,2.31,;9.34,3.85,;10.67,4.62,;8,1.54,;6.67,2.31,;8,,;6.67,-.77,;5.33,,;4,-.77,;2.67,,;1.33,-.77,;1.33,-2.31,;2.67,-3.08,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;;-1.33,-.77,;-2.67,,;-2.67,1.54,;-1.33,2.31,;,1.54,)| Show InChI InChI=1S/C22H25N5O/c1-27(2)19-7-5-15(6-8-19)22(28)26-21-12-18-11-16(3-4-17(18)13-25-21)20-14-23-9-10-24-20/h3-4,9-15,19H,5-8H2,1-2H3,(H,25,26,28)/t15?,19-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	17	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442889 (US10653688, Compound 71) Show SMILES O=C(Nc1cc2cc(ccc2cn1)-c1cnccn1)C1CC[C@@H](CC1)N1CCOCC1 |r,wU:22.28,(6.67,2.31,;8,1.54,;8,,;6.67,-.77,;5.33,,;4,-.77,;2.67,,;1.33,-.77,;1.33,-2.31,;2.67,-3.08,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;;-1.33,-.77,;-2.67,,;-2.67,1.54,;-1.33,2.31,;,1.54,;9.34,2.31,;10.67,1.54,;12,2.31,;12,3.85,;10.67,4.62,;9.34,3.85,;13.34,4.62,;14.67,3.85,;16,4.62,;16,6.16,;14.67,6.93,;13.34,6.16,)| Show InChI InChI=1S/C24H27N5O2/c30-24(17-3-5-21(6-4-17)29-9-11-31-12-10-29)28-23-14-20-13-18(1-2-19(20)15-27-23)22-16-25-7-8-26-22/h1-2,7-8,13-17,21H,3-6,9-12H2,(H,27,28,30)/t17?,21-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442891 (US10653688, Compound 72) Show SMILES CC1CN(C[C@H]2CCC(CC2)C(=O)Nc2cc3cc(ccc3cn2)-c2cnccn2)C1 |r,wU:5.4,(18.27,1.92,;16.97,2.74,;15.28,2.68,;14.8,4.14,;13.34,4.62,;12,3.85,;12,2.31,;10.67,1.54,;9.34,2.31,;9.34,3.85,;10.67,4.62,;8,1.54,;6.67,2.31,;8,,;6.67,-.77,;5.33,,;4,-.77,;2.67,,;1.33,-.77,;1.33,-2.31,;2.67,-3.08,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;;-1.33,-.77,;-2.67,,;-2.67,1.54,;-1.33,2.31,;,1.54,;16.34,4.14,)| Show InChI InChI=1S/C25H29N5O/c1-17-14-30(15-17)16-18-2-4-19(5-3-18)25(31)29-24-11-22-10-20(6-7-21(22)12-28-24)23-13-26-8-9-27-23/h6-13,17-19H,2-5,14-16H2,1H3,(H,28,29,31)/t18-,19?	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442892 (US10653688, Compound 73) Show SMILES CN1CCN(C[C@H]2CCC(CC2)C(=O)Nc2cc3cc(ccc3cn2)-c2cnccn2)CC1 |r,wU:6.5,(19.2,2.72,;17.73,3.19,;16.59,2.16,;15.12,2.64,;14.8,4.14,;13.34,4.62,;12,3.85,;12,2.31,;10.67,1.54,;9.34,2.31,;9.34,3.85,;10.67,4.62,;8,1.54,;6.67,2.31,;8,,;6.67,-.77,;5.33,,;4,-.77,;2.67,,;1.33,-.77,;1.33,-2.31,;2.67,-3.08,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;;-1.33,-.77,;-2.67,,;-2.67,1.54,;-1.33,2.31,;,1.54,;15.95,5.17,;17.41,4.7,)| Show InChI InChI=1S/C26H32N6O/c1-31-10-12-32(13-11-31)18-19-2-4-20(5-3-19)26(33)30-25-15-23-14-21(6-7-22(23)16-29-25)24-17-27-8-9-28-24/h6-9,14-17,19-20H,2-5,10-13,18H2,1H3,(H,29,30,33)/t19-,20?	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442893 (US10653688, Compound 74) Show SMILES O=C(CN1CCCC1)Nc1cc2cc(ccc2cn1)-c1cnccn1 Show InChI InChI=1S/C19H19N5O/c25-19(13-24-7-1-2-8-24)23-18-10-16-9-14(3-4-15(16)11-22-18)17-12-20-5-6-21-17/h3-6,9-12H,1-2,7-8,13H2,(H,22,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	94	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442894 (US10653688, Compound 75) Show SMILES O=C(Nc1cc2cc(ccc2cn1)-c1cnccn1)C1CCNCC1 Show InChI InChI=1S/C19H19N5O/c25-19(13-3-5-20-6-4-13)24-18-10-16-9-14(1-2-15(16)11-23-18)17-12-21-7-8-22-17/h1-2,7-13,20H,3-6H2,(H,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442895 (US10653688, Compound 76) Show SMILES CN1CCC(F)(CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnccn1 Show InChI InChI=1S/C20H20FN5O/c1-26-8-4-20(21,5-9-26)19(27)25-18-11-16-10-14(2-3-15(16)12-24-18)17-13-22-6-7-23-17/h2-3,6-7,10-13H,4-5,8-9H2,1H3,(H,24,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	258	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442896 (US10653688, Compound 77) Show SMILES FCCN1CCC(CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnccn1 Show InChI InChI=1S/C21H22FN5O/c22-5-10-27-8-3-15(4-9-27)21(28)26-20-12-18-11-16(1-2-17(18)13-25-20)19-14-23-6-7-24-19/h1-2,6-7,11-15H,3-5,8-10H2,(H,25,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442897 (US10653688, Compound 78) Show SMILES O=C(Nc1cc2cc(ccc2cn1)-c1cnccn1)C1CCN(CC1)C1COC1 Show InChI InChI=1S/C22H23N5O2/c28-22(15-3-7-27(8-4-15)19-13-29-14-19)26-21-10-18-9-16(1-2-17(18)11-25-21)20-12-23-5-6-24-20/h1-2,5-6,9-12,15,19H,3-4,7-8,13-14H2,(H,25,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442898 (US10653688, Compound 79) Show SMILES O=C(CN1CCOCC1)Nc1cc2cc(ccc2cn1)-c1cnccn1 Show InChI InChI=1S/C19H19N5O2/c25-19(13-24-5-7-26-8-6-24)23-18-10-16-9-14(1-2-15(16)11-22-18)17-12-20-3-4-21-17/h1-4,9-12H,5-8,13H2,(H,22,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	79	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair

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