Compile Data Set for Download or QSAR

Found 212 hits Enz. Inhib. hit(s) with all data for entry = 9190   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM448228 (US10689705, Compound 5) Show SMILES CC1CCC(C)N1Cc1ccc2[nH]c(cc2c1)C(=O)c1cnn(c1N)-c1ccc2nc(C)[nH]c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR1 inhibitory activities of compounds were measured based on their activity to inhibit phosphorylation of the biotinylated peptide (EGPWLEEEEE...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM448227 (US10689705, Compound 4) Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3cc(CN4CCCC(F)C4)ccc3[nH]2)c1N Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.670	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR1 inhibitory activities of compounds were measured based on their activity to inhibit phosphorylation of the biotinylated peptide (EGPWLEEEEE...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM448229 (US10689705, Compound 6) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(OCC4(C)COC4)cc3[nH]2)c1N Show InChI InChI=1S/C25H24N6O3/c1-14-28-19-6-4-16(8-21(19)29-14)31-24(26)18(10-27-31)23(32)22-7-15-3-5-17(9-20(15)30-22)34-13-25(2)11-33-12-25/h3-10,30H,11-13,26H2,1-2H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.810	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR1 inhibitory activities of compounds were measured based on their activity to inhibit phosphorylation of the biotinylated peptide (EGPWLEEEEE...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50197685 (CHEMBL3681278 | US10689705, Compound 1) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCOCC4)cc3[nH]2)c1N Show InChI InChI=1S/C25H25N7O2/c1-15-28-20-5-4-18(12-22(20)29-15)32-25(26)19(13-27-32)24(33)23-11-17-3-2-16(10-21(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR1 inhibitory activities of compounds were measured based on their activity to inhibit phosphorylation of the biotinylated peptide (EGPWLEEEEE...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM448247 (US10689705, Compound 24) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(cc3[nH]2)-c2cnn(C)c2)c1N Show InChI InChI=1S/C24H20N8O/c1-13-28-19-6-5-17(9-21(19)29-13)32-24(25)18(11-27-32)23(33)22-8-15-4-3-14(7-20(15)30-22)16-10-26-31(2)12-16/h3-12,30H,25H2,1-2H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR1 inhibitory activities of compounds were measured based on their activity to inhibit phosphorylation of the biotinylated peptide (EGPWLEEEEE...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM448226 (US10689705, Compound 3) Show SMILES C[C@H]1COCCN1Cc1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2[nH]c(C)nc2c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR1 inhibitory activities of compounds were measured based on their activity to inhibit phosphorylation of the biotinylated peptide (EGPWLEEEEE...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM448268 (US10689705, Compound 45) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(OCCN4CCOCC4)cc3[nH]2)c1N Show InChI InChI=1S/C26H27N7O3/c1-16-29-21-5-3-18(13-23(21)30-16)33-26(27)20(15-28-33)25(34)24-12-17-2-4-19(14-22(17)31-24)36-11-8-32-6-9-35-10-7-32/h2-5,12-15,31H,6-11,27H2,1H3,(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR1 inhibitory activities of compounds were measured based on their activity to inhibit phosphorylation of the biotinylated peptide (EGPWLEEEEE...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM130903 (US10689705, Compound 7 | US8829199, 196) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCC(F)(F)CC4)cc3[nH]2)c1N Show InChI InChI=1S/C26H25F2N7O/c1-15-31-20-5-4-18(12-22(20)32-15)35-25(29)19(13-30-35)24(36)23-11-17-3-2-16(10-21(17)33-23)14-34-8-6-26(27,28)7-9-34/h2-5,10-13,33H,6-9,14,29H2,1H3,(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR1 inhibitory activities of compounds were measured based on their activity to inhibit phosphorylation of the biotinylated peptide (EGPWLEEEEE...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM448290 (US10689705, Compound 67) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(OC4CCOCC4)cc3[nH]2)c1N Show InChI InChI=1S/C25H24N6O3/c1-14-28-20-5-3-16(11-22(20)29-14)31-25(26)19(13-27-31)24(32)23-10-15-2-4-18(12-21(15)30-23)34-17-6-8-33-9-7-17/h2-5,10-13,17,30H,6-9,26H2,1H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR1 inhibitory activities of compounds were measured based on their activity to inhibit phosphorylation of the biotinylated peptide (EGPWLEEEEE...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM448283 (US10689705, Compound 60) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3cc(ccc3[nH]2)C(=O)N2CCCC(F)(F)C2)c1N Show InChI InChI=1S/C26H23F2N7O2/c1-14-31-20-6-4-17(11-21(20)32-14)35-24(29)18(12-30-35)23(36)22-10-16-9-15(3-5-19(16)33-22)25(37)34-8-2-7-26(27,28)13-34/h3-6,9-12,33H,2,7-8,13,29H2,1H3,(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR3 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448268 (US10689705, Compound 45) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(OCCN4CCOCC4)cc3[nH]2)c1N Show InChI InChI=1S/C26H27N7O3/c1-16-29-21-5-3-18(13-23(21)30-16)33-26(27)20(15-28-33)25(34)24-12-17-2-4-19(14-22(17)31-24)36-11-8-32-6-9-35-10-7-32/h2-5,12-15,31H,6-11,27H2,1H3,(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM50197685 (CHEMBL3681278 | US10689705, Compound 1) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCOCC4)cc3[nH]2)c1N Show InChI InChI=1S/C25H25N7O2/c1-15-28-20-5-4-18(12-22(20)29-15)32-25(26)19(13-27-32)24(33)23-11-17-3-2-16(10-21(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM50197685 (CHEMBL3681278 | US10689705, Compound 1) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCOCC4)cc3[nH]2)c1N Show InChI InChI=1S/C25H25N7O2/c1-15-28-20-5-4-18(12-22(20)29-15)32-25(26)19(13-27-32)24(33)23-11-17-3-2-16(10-21(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR3 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM448229 (US10689705, Compound 6) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(OCC4(C)COC4)cc3[nH]2)c1N Show InChI InChI=1S/C25H24N6O3/c1-14-28-19-6-4-16(8-21(19)29-14)31-24(26)18(10-27-31)23(32)22-7-15-3-5-17(9-20(15)30-22)34-13-25(2)11-33-12-25/h3-10,30H,11-13,26H2,1-2H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR3 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448281 (US10689705, Compound 58) Show SMILES COc1cc2[nH]c(cc2cc1Cl)C(=O)c1cnn(c1N)-c1ccc2[nH]c(C)nc2c1 Show InChI InChI=1S/C21H17ClN6O2/c1-10-25-15-4-3-12(7-17(15)26-10)28-21(23)13(9-24-28)20(29)18-6-11-5-14(22)19(30-2)8-16(11)27-18/h3-9,27H,23H2,1-2H3,(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448290 (US10689705, Compound 67) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(OC4CCOCC4)cc3[nH]2)c1N Show InChI InChI=1S/C25H24N6O3/c1-14-28-20-5-3-16(11-22(20)29-14)31-25(26)19(13-27-31)24(32)23-10-15-2-4-18(12-21(15)30-23)34-17-6-8-33-9-7-17/h2-5,10-13,17,30H,6-9,26H2,1H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448226 (US10689705, Compound 3) Show SMILES C[C@H]1COCCN1Cc1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2[nH]c(C)nc2c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50197683 (CHEMBL3907479 | US10689705, Compound 49) Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N Show InChI InChI=1S/C20H16N6O/c1-11-23-16-7-6-13(9-17(16)24-11)26-20(21)14(10-22-26)19(27)18-8-12-4-2-3-5-15(12)25-18/h2-10,25H,21H2,1H3,(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR1 inhibitory activities of compounds were measured based on their activity to inhibit phosphorylation of the biotinylated peptide (EGPWLEEEEE...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448283 (US10689705, Compound 60) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3cc(ccc3[nH]2)C(=O)N2CCCC(F)(F)C2)c1N Show InChI InChI=1S/C26H23F2N7O2/c1-14-31-20-6-4-17(11-21(20)32-14)35-24(29)18(12-30-35)23(36)22-10-16-9-15(3-5-19(16)33-22)25(37)34-8-2-7-26(27,28)13-34/h3-6,9-12,33H,2,7-8,13,29H2,1H3,(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM448226 (US10689705, Compound 3) Show SMILES C[C@H]1COCCN1Cc1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2[nH]c(C)nc2c1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR3 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM448268 (US10689705, Compound 45) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(OCCN4CCOCC4)cc3[nH]2)c1N Show InChI InChI=1S/C26H27N7O3/c1-16-29-21-5-3-18(13-23(21)30-16)33-26(27)20(15-28-33)25(34)24-12-17-2-4-19(14-22(17)31-24)36-11-8-32-6-9-35-10-7-32/h2-5,12-15,31H,6-11,27H2,1H3,(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR3 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448249 (US10689705, Compound 26) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(cc3[nH]2)-c2ccc(F)cn2)c1N Show InChI InChI=1S/C25H18FN7O/c1-13-30-20-7-5-17(10-22(20)31-13)33-25(27)18(12-29-33)24(34)23-9-15-3-2-14(8-21(15)32-23)19-6-4-16(26)11-28-19/h2-12,32H,27H2,1H3,(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM448281 (US10689705, Compound 58) Show SMILES COc1cc2[nH]c(cc2cc1Cl)C(=O)c1cnn(c1N)-c1ccc2[nH]c(C)nc2c1 Show InChI InChI=1S/C21H17ClN6O2/c1-10-25-15-4-3-12(7-17(15)26-10)28-21(23)13(9-24-28)20(29)18-6-11-5-14(22)19(30-2)8-16(11)27-18/h3-9,27H,23H2,1-2H3,(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR1 inhibitory activities of compounds were measured based on their activity to inhibit phosphorylation of the biotinylated peptide (EGPWLEEEEE...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448233 (US10689705, Compound 10) Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3ccc(cc3[nH]2)C#N)c1N Show InChI InChI=1S/C21H15N7O/c1-11-25-16-5-4-14(8-18(16)26-11)28-21(23)15(10-24-28)20(29)19-7-13-3-2-12(9-22)6-17(13)27-19/h2-8,10,27H,23H2,1H3,(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM448290 (US10689705, Compound 67) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(OC4CCOCC4)cc3[nH]2)c1N Show InChI InChI=1S/C25H24N6O3/c1-14-28-20-5-3-16(11-22(20)29-14)31-25(26)19(13-27-31)24(32)23-10-15-2-4-18(12-21(15)30-23)34-17-6-8-33-9-7-17/h2-5,10-13,17,30H,6-9,26H2,1H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR3 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM448225 (US10689705, Compound 2) Show SMILES CN1CCC(CC1)c1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2nc(C)[nH]c2c1 Show InChI InChI=1S/C26H27N7O/c1-15-29-21-6-5-19(13-23(21)30-15)33-26(27)20(14-28-33)25(34)24-12-18-4-3-17(11-22(18)31-24)16-7-9-32(2)10-8-16/h3-6,11-14,16,31H,7-10,27H2,1-2H3,(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR1 inhibitory activities of compounds were measured based on their activity to inhibit phosphorylation of the biotinylated peptide (EGPWLEEEEE...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448237 (US10689705, Compound 14) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3cc4OCCOc4cc3[nH]2)c1N Show InChI InChI=1S/C22H18N6O3/c1-11-25-15-3-2-13(8-17(15)26-11)28-22(23)14(10-24-28)21(29)18-6-12-7-19-20(9-16(12)27-18)31-5-4-30-19/h2-3,6-10,27H,4-5,23H2,1H3,(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM448270 (US10689705, Compound 47) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3cc(CN4CCN(CC4)S(C)(=O)=O)ccc3[nH]2)c1N Show InChI InChI=1S/C26H28N8O3S/c1-16-29-22-6-4-19(13-23(22)30-16)34-26(27)20(14-28-34)25(35)24-12-18-11-17(3-5-21(18)31-24)15-32-7-9-33(10-8-32)38(2,36)37/h3-6,11-14,31H,7-10,15,27H2,1-2H3,(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR1 inhibitory activities of compounds were measured based on their activity to inhibit phosphorylation of the biotinylated peptide (EGPWLEEEEE...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448262 (US10689705, Compound 39) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3cc(OCC4CC4)ccc3[nH]2)c1N Show InChI InChI=1S/C24H22N6O2/c1-13-27-20-6-4-16(10-21(20)28-13)30-24(25)18(11-26-30)23(31)22-9-15-8-17(5-7-19(15)29-22)32-12-14-2-3-14/h4-11,14,29H,2-3,12,25H2,1H3,(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448225 (US10689705, Compound 2) Show SMILES CN1CCC(CC1)c1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2nc(C)[nH]c2c1 Show InChI InChI=1S/C26H27N7O/c1-15-29-21-6-5-19(13-23(21)30-15)33-26(27)20(14-28-33)25(34)24-12-18-4-3-17(11-22(18)31-24)16-7-9-32(2)10-8-16/h3-6,11-14,16,31H,7-10,27H2,1-2H3,(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.40	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448293 (US10689705, Compound 70) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3cc(F)c(Br)cc3[nH]2)c1N Show InChI InChI=1S/C20H14BrFN6O/c1-9-25-15-3-2-11(6-17(15)26-9)28-20(23)12(8-24-28)19(29)18-5-10-4-14(22)13(21)7-16(10)27-18/h2-8,27H,23H2,1H3,(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.5	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448227 (US10689705, Compound 4) Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3cc(CN4CCCC(F)C4)ccc3[nH]2)c1N Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.5	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448245 (US10689705, Compound 22) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(I)cc3[nH]2)c1N Show InChI InChI=1S/C20H15IN6O/c1-10-24-15-5-4-13(8-17(15)25-10)27-20(22)14(9-23-27)19(28)18-6-11-2-3-12(21)7-16(11)26-18/h2-9,26H,22H2,1H3,(H,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM50197712 (CHEMBL3676329 | US10689705, Compound 44) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(Br)cc3[nH]2)c1N Show InChI InChI=1S/C20H15BrN6O/c1-10-24-15-5-4-13(8-17(15)25-10)27-20(22)14(9-23-27)19(28)18-6-11-2-3-12(21)7-16(11)26-18/h2-9,26H,22H2,1H3,(H,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM448233 (US10689705, Compound 10) Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3ccc(cc3[nH]2)C#N)c1N Show InChI InChI=1S/C21H15N7O/c1-11-25-16-5-4-14(8-18(16)26-11)28-21(23)15(10-24-28)20(29)19-7-13-3-2-12(9-22)6-17(13)27-19/h2-8,10,27H,23H2,1H3,(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR1 inhibitory activities of compounds were measured based on their activity to inhibit phosphorylation of the biotinylated peptide (EGPWLEEEEE...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM130903 (US10689705, Compound 7 | US8829199, 196) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCC(F)(F)CC4)cc3[nH]2)c1N Show InChI InChI=1S/C26H25F2N7O/c1-15-31-20-5-4-18(12-22(20)32-15)35-25(29)19(13-30-35)24(36)23-11-17-3-2-16(10-21(17)33-23)14-34-8-6-26(27,28)7-9-34/h2-5,10-13,33H,6-9,14,29H2,1H3,(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM448231 (US10689705, Compound 8) Show SMILES COCCN(CCOC)Cc1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2[nH]c(C)nc2c1 Show InChI InChI=1S/C27H31N7O3/c1-17-30-22-7-6-20(14-24(22)31-17)34-27(28)21(15-29-34)26(35)25-13-19-5-4-18(12-23(19)32-25)16-33(8-10-36-2)9-11-37-3/h4-7,12-15,32H,8-11,16,28H2,1-3H3,(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.60	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR1 inhibitory activities of compounds were measured based on their activity to inhibit phosphorylation of the biotinylated peptide (EGPWLEEEEE...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448236 (US10689705, Compound 13) Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3ccc(cc3[nH]2)-c2cccs2)c1N Show InChI InChI=1S/C24H18N6OS/c1-13-27-18-7-6-16(11-20(18)28-13)30-24(25)17(12-26-30)23(31)21-9-14-4-5-15(10-19(14)29-21)22-3-2-8-32-22/h2-12,29H,25H2,1H3,(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM448232 (US10689705, Compound 9) Show SMILES CN1CCN(CCOc2ccc3cc([nH]c3c2)C(=O)c2cnn(c2N)-c2ccc3[nH]c(C)nc3c2)CC1 Show InChI InChI=1S/C27H30N8O2/c1-17-30-22-6-4-19(14-24(22)31-17)35-27(28)21(16-29-35)26(36)25-13-18-3-5-20(15-23(18)32-25)37-12-11-34-9-7-33(2)8-10-34/h3-6,13-16,32H,7-12,28H2,1-2H3,(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR1 inhibitory activities of compounds were measured based on their activity to inhibit phosphorylation of the biotinylated peptide (EGPWLEEEEE...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM448240 (US10689705, Compound 17) Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3cc(ccc3[nH]2)C2CCN(CC2)C2CCCC2)c1N Show InChI InChI=1S/C30H33N7O/c1-18-33-26-9-7-23(16-27(26)34-18)37-30(31)24(17-32-37)29(38)28-15-21-14-20(6-8-25(21)35-28)19-10-12-36(13-11-19)22-4-2-3-5-22/h6-9,14-17,19,22,35H,2-5,10-13,31H2,1H3,(H,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR1 inhibitory activities of compounds were measured based on their activity to inhibit phosphorylation of the biotinylated peptide (EGPWLEEEEE...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM448234 (US10689705, Compound 11) Show SMILES CC(C)N1CCC(CC1)c1ccc2[nH]c(cc2c1)C(=O)c1cnn(c1N)-c1ccc2nc(C)[nH]c2c1 Show InChI InChI=1S/C28H31N7O/c1-16(2)34-10-8-18(9-11-34)19-4-6-23-20(12-19)13-26(33-23)27(36)22-15-30-35(28(22)29)21-5-7-24-25(14-21)32-17(3)31-24/h4-7,12-16,18,33H,8-11,29H2,1-3H3,(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR1 inhibitory activities of compounds were measured based on their activity to inhibit phosphorylation of the biotinylated peptide (EGPWLEEEEE...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448270 (US10689705, Compound 47) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3cc(CN4CCN(CC4)S(C)(=O)=O)ccc3[nH]2)c1N Show InChI InChI=1S/C26H28N8O3S/c1-16-29-22-6-4-19(13-23(22)30-16)34-26(27)20(14-28-34)25(35)24-12-18-11-17(3-5-21(18)31-24)15-32-7-9-33(10-8-32)38(2,36)37/h3-6,11-14,31H,7-10,15,27H2,1-2H3,(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448229 (US10689705, Compound 6) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(OCC4(C)COC4)cc3[nH]2)c1N Show InChI InChI=1S/C25H24N6O3/c1-14-28-19-6-4-16(8-21(19)29-14)31-24(26)18(10-27-31)23(32)22-7-15-3-5-17(9-20(15)30-22)34-13-25(2)11-33-12-25/h3-10,30H,11-13,26H2,1-2H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM448228 (US10689705, Compound 5) Show SMILES CC1CCC(C)N1Cc1ccc2[nH]c(cc2c1)C(=O)c1cnn(c1N)-c1ccc2nc(C)[nH]c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR3 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448228 (US10689705, Compound 5) Show SMILES CC1CCC(C)N1Cc1ccc2[nH]c(cc2c1)C(=O)c1cnn(c1N)-c1ccc2nc(C)[nH]c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448261 (US10689705, Compound 38) Show SMILES CCCCOc1ccc2[nH]c(cc2c1)C(=O)c1cnn(c1N)-c1ccc2[nH]c(C)nc2c1 Show InChI InChI=1S/C24H24N6O2/c1-3-4-9-32-17-6-8-19-15(10-17)11-22(29-19)23(31)18-13-26-30(24(18)25)16-5-7-20-21(12-16)28-14(2)27-20/h5-8,10-13,29H,3-4,9,25H2,1-2H3,(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448248 (US10689705, Compound 25) Show SMILES COCCOc1ccc2[nH]c(cc2c1)C(=O)c1cnn(c1N)-c1ccc2[nH]c(C)nc2c1 Show InChI InChI=1S/C23H22N6O3/c1-13-26-19-5-3-15(11-20(19)27-13)29-23(24)17(12-25-29)22(30)21-10-14-9-16(32-8-7-31-2)4-6-18(14)28-21/h3-6,9-12,28H,7-8,24H2,1-2H3,(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448240 (US10689705, Compound 17) Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3cc(ccc3[nH]2)C2CCN(CC2)C2CCCC2)c1N Show InChI InChI=1S/C30H33N7O/c1-18-33-26-9-7-23(16-27(26)34-18)37-30(31)24(17-32-37)29(38)28-15-21-14-20(6-8-25(21)35-28)19-10-12-36(13-11-19)22-4-2-3-5-22/h6-9,14-17,19,22,35H,2-5,10-13,31H2,1H3,(H,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448276 (US10689705, Compound 53) Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3cc4OC(F)(F)Oc4cc3[nH]2)c1N Show InChI InChI=1S/C21H14F2N6O3/c1-9-26-13-3-2-11(6-15(13)27-9)29-20(24)12(8-25-29)19(30)16-4-10-5-17-18(7-14(10)28-16)32-21(22,23)31-17/h2-8,28H,24H2,1H3,(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM448260 (US10689705, Compound 37) Show SMILES COc1cc(OC)c2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2[nH]c(C)nc2c1 Show InChI InChI=1S/C22H20N6O3/c1-11-25-16-5-4-12(6-18(16)26-11)28-22(23)15(10-24-28)21(29)19-9-14-17(27-19)7-13(30-2)8-20(14)31-3/h4-10,27H,23H2,1-3H3,(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha US Patent					Assay Description The FGFR2 inhibitory activities of compounds listed in Tables 1-1 to 1-5 were measured based on their activity to inhibit phosphorylation of the biot...				US Patent US10689705 (2020) BindingDB Entry DOI: 10.7270/Q2CV4MSX
					More data for this Ligand-Target Pair

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