Found 326 hits Enz. Inhib. hit(s) with all data for entry = 9297 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Apelin receptor
(Homo sapiens (Human)) | BDBM456559
(US10736883, Example 2.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CCN2Cc3ccccc3C2=O)nnc1-c1ccco1 |(-7.67,1.44,;-6.34,.67,;-5.01,1.44,;-5.01,2.98,;-3.67,3.75,;-2.34,2.98,;-2.34,1.44,;-1.01,.67,;.33,1.44,;-3.67,.67,;-3.67,-.87,;-2.43,-1.77,;-.96,-1.3,;.13,-2.39,;-.64,-3.72,;.9,-3.72,;1.46,-1.62,;2.79,-2.39,;4.13,-1.62,;4.29,-.09,;5.8,.23,;6.57,1.57,;8.11,1.57,;8.88,.23,;8.11,-1.1,;6.57,-1.1,;5.53,-2.24,;5.85,-3.75,;-2.9,-3.24,;-4.44,-3.24,;-4.92,-1.77,;-6.38,-1.3,;-6.86,.17,;-8.4,.17,;-8.88,-1.3,;-7.63,-2.2,)| Show InChI InChI=1S/C24H23N5O6S/c1-33-18-9-5-10-19(34-2)21(18)29-22(20-11-6-13-35-20)25-26-24(29)27-36(31,32)14-12-28-15-16-7-3-4-8-17(16)23(28)30/h3-11,13H,12,14-15H2,1-2H3,(H,26,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456560
(US10736883, Example 3.0)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccc(C)o2)n1-c1c(OC)ncnc1OC)c1ncc(C)cn1 |r,wD:3.3,2.1,(.32,2.87,;1.66,3.64,;2.99,2.87,;2.99,1.33,;4.33,.56,;1.66,.56,;2.43,-.78,;.89,1.89,;.32,-.21,;.32,-1.75,;1.57,-2.66,;1.09,-4.12,;-.45,-4.12,;-1.35,-5.37,;-2.89,-5.37,;-3.37,-6.83,;-2.12,-7.74,;-2.12,-9.28,;-.87,-6.83,;-.92,-2.66,;-2.39,-2.18,;-3.53,-3.21,;-3.21,-4.72,;-4.35,-5.75,;-4.99,-2.74,;-5.31,-1.23,;-4.17,-.2,;-2.71,-.68,;-1.56,.35,;-1.88,1.86,;4.33,3.64,;5.66,2.87,;6.99,3.64,;6.99,5.18,;8.33,5.95,;5.66,5.95,;4.33,5.18,)| Show InChI InChI=1S/C22H26N8O6S/c1-12-9-23-18(24-10-12)17(33-4)14(3)37(31,32)29-22-28-27-19(15-8-7-13(2)36-15)30(22)16-20(34-5)25-11-26-21(16)35-6/h7-11,14,17H,1-6H3,(H,28,29)/t14-,17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.310 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456561
(US10736883, Example 4.0)Show SMILES COCn1cnc2c(C[C@H](C)S(=O)(=O)Nc3nnc(-c4ccco4)n3-c3c(OC)cccc3OC)ncc(F)c12 |r,wU:9.9,(9.72,4,;8.06,3.64,;6.92,4.91,;5.25,4.55,;4.63,3.15,;3.09,3.31,;2.77,4.82,;1.44,5.59,;.11,4.82,;-1.23,5.59,;-1.23,7.13,;-2.56,4.82,;-3.33,3.48,;-1.79,3.48,;-3.65,5.9,;-5.11,5.43,;-5.59,3.96,;-7.13,3.96,;-7.61,5.43,;-9.07,5.9,;-9.55,7.37,;-11.09,7.37,;-11.56,5.9,;-10.32,5,;-6.36,6.33,;-6.36,7.87,;-5.03,8.64,;-3.69,7.87,;-2.36,8.64,;-5.03,10.18,;-6.36,10.95,;-7.69,10.18,;-7.69,8.64,;-9.03,7.87,;-10.36,8.64,;1.44,7.13,;2.77,7.9,;4.11,7.13,;5.44,7.9,;4.11,5.59,)| Show InChI InChI=1S/C25H26FN7O6S/c1-15(11-17-21-22(16(26)12-27-17)32(13-28-21)14-36-2)40(34,35)31-25-30-29-24(20-9-6-10-39-20)33(25)23-18(37-3)7-5-8-19(23)38-4/h5-10,12-13,15H,11,14H2,1-4H3,(H,30,31)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.770 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456568
(US10736883, Example 5.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)c3[nH]cnc23)nnc1-c1ccco1 |r,wD:16.17,(-6.73,-3.35,;-5.39,-4.12,;-4.06,-3.35,;-4.06,-1.81,;-2.73,-1.04,;-1.39,-1.81,;-1.39,-3.35,;-.06,-4.12,;1.28,-3.35,;-2.73,-4.12,;-2.73,-5.66,;-1.48,-6.57,;-.02,-6.09,;1.07,-7.18,;1.84,-8.52,;.3,-8.52,;2.41,-6.41,;2.41,-4.87,;3.74,-7.18,;5.07,-6.41,;5.07,-4.87,;6.41,-4.1,;7.74,-4.87,;9.08,-4.1,;7.74,-6.41,;8.89,-7.44,;8.26,-8.85,;6.73,-8.69,;6.41,-7.18,;-1.96,-8.03,;-3.5,-8.03,;-3.97,-6.57,;-5.44,-6.09,;-5.91,-4.63,;-7.45,-4.63,;-7.93,-6.09,;-6.68,-7,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.950 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456569
(US10736883, Example 6.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)c3n(C)cnc23)nnc1-c1ccco1 |r,wU:16.17,(-8.36,9.28,;-7.02,8.51,;-5.69,9.28,;-5.69,10.82,;-4.36,11.59,;-3.02,10.82,;-3.02,9.28,;-1.69,8.51,;-.36,9.28,;-4.36,8.51,;-4.36,6.97,;-3.11,6.07,;-1.65,6.54,;-.56,5.45,;.21,4.12,;-1.33,4.12,;.78,6.22,;.78,7.76,;2.11,5.45,;3.44,6.22,;3.44,7.76,;4.78,8.53,;6.11,7.76,;7.44,8.53,;6.11,6.22,;7.26,5.19,;8.76,5.51,;6.63,3.79,;5.1,3.95,;4.78,5.45,;-3.59,4.6,;-5.13,4.6,;-5.6,6.07,;-7.07,6.54,;-7.54,8.01,;-9.08,8.01,;-9.56,6.54,;-8.31,5.64,)| Show InChI InChI=1S/C24H24FN7O5S/c1-14(11-16-20-21(15(25)12-26-16)31(2)13-27-20)38(33,34)30-24-29-28-23(19-9-6-10-37-19)32(24)22-17(35-3)7-5-8-18(22)36-4/h5-10,12-14H,11H2,1-4H3,(H,29,30)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.980 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456570
(US10736883, Example 7.0)Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1ccc(C)o1 |r,wU:16.17,(-7.44,9.4,;-6.1,8.64,;-4.77,9.4,;-4.77,10.94,;-3.43,11.72,;-2.1,10.94,;-2.1,9.4,;-.77,8.64,;.57,9.4,;-3.43,8.64,;-3.43,7.1,;-2.19,6.19,;-.72,6.67,;.36,5.58,;1.13,4.24,;-.4,4.24,;1.7,6.35,;1.7,7.89,;3.03,5.58,;4.37,6.35,;5.7,5.58,;7.03,6.35,;7.03,7.89,;8.37,8.66,;5.7,8.66,;4.37,7.89,;-2.66,4.73,;-4.2,4.73,;-4.68,6.19,;-6.15,6.67,;-6.62,8.13,;-8.16,8.13,;-8.64,6.67,;-10.1,6.19,;-7.39,5.76,)| Show InChI InChI=1S/C20H21FN8O5S/c1-11-5-6-14(34-11)17-26-27-20(29(17)16-18(32-3)24-10-25-19(16)33-4)28-35(30,31)12(2)7-15-22-8-13(21)9-23-15/h5-6,8-10,12H,7H2,1-4H3,(H,27,28)/t12-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456571
(US10736883, Example 8.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)c3[nH]cnc23)nnc1-c1ccco1 |r,wU:16.17,(-7.89,9.28,;-6.56,8.51,;-5.22,9.28,;-5.22,10.82,;-3.89,11.59,;-2.56,10.82,;-2.56,9.28,;-1.22,8.51,;.11,9.28,;-3.89,8.51,;-3.89,6.97,;-2.64,6.07,;-1.18,6.54,;-.09,5.45,;.68,4.12,;-.86,4.12,;1.24,6.22,;1.24,7.76,;2.58,5.45,;3.91,6.22,;3.91,7.76,;5.24,8.53,;6.58,7.76,;7.91,8.53,;6.58,6.22,;7.72,5.19,;7.1,3.79,;5.56,3.95,;5.24,5.45,;-3.12,4.6,;-4.66,4.6,;-5.14,6.07,;-6.6,6.54,;-7.08,8.01,;-8.62,8.01,;-9.09,6.54,;-7.85,5.64,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 28 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456572
(US10736883, Example 9.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(Cl)cc2NC(C)=O)nnc1-c1ccco1 |r,wU:16.17,(.14,-3.48,;-.94,-4.57,;-2.43,-4.17,;-2.83,-2.69,;-4.32,-2.29,;-5.41,-3.38,;-5.01,-4.86,;-6.1,-5.95,;-7.58,-5.55,;-3.52,-5.26,;-3.12,-6.75,;-1.66,-7.23,;-.32,-6.46,;1.01,-7.23,;2.34,-8,;.24,-8.56,;1.78,-5.89,;1.01,-4.56,;3.32,-5.89,;4.09,-4.56,;3.32,-3.22,;4.09,-1.89,;5.63,-1.89,;6.4,-.56,;6.4,-3.22,;5.63,-4.56,;6.4,-5.89,;7.94,-5.89,;8.71,-7.23,;8.71,-4.56,;-1.66,-8.77,;-3.12,-9.24,;-4.03,-8,;-5.51,-7.6,;-6.42,-6.35,;-7.88,-6.83,;-7.88,-8.37,;-6.42,-8.84,)| Show InChI InChI=1S/C24H25ClN6O6S/c1-14(11-17-18(27-15(2)32)12-16(25)13-26-17)38(33,34)30-24-29-28-23(21-9-6-10-37-21)31(24)22-19(35-3)7-5-8-20(22)36-4/h5-10,12-14H,11H2,1-4H3,(H,27,32)(H,29,30)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.0910 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456573
(US10736883, Example 10.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](O)c2ccc(cn2)C#N)nnc1-c1ccc(C)o1 |r,wU:16.17,wD:18.19,(-.07,-1.2,;-1.16,-2.29,;-2.65,-1.9,;-3.05,-.41,;-4.54,-.01,;-5.62,-1.1,;-5.23,-2.59,;-6.31,-3.67,;-7.8,-3.28,;-3.74,-2.98,;-3.34,-4.47,;-1.87,-4.95,;-.54,-4.18,;.79,-4.95,;1.56,-3.61,;.02,-6.28,;2.13,-5.72,;2.13,-7.26,;3.46,-4.95,;3.46,-3.41,;4.79,-5.72,;4.79,-7.26,;6.13,-8.03,;7.51,-7.29,;7.46,-5.72,;6.13,-4.95,;8.84,-8.06,;10.18,-8.83,;-1.87,-6.49,;-3.34,-6.96,;-4.24,-5.72,;-5.73,-5.32,;-6.79,-4.23,;-8.1,-4.55,;-8.1,-6.09,;-9.35,-6.99,;-6.64,-6.56,)| Show InChI InChI=1S/C24H24N6O6S/c1-14-8-11-20(36-14)23-27-28-24(30(23)21-18(34-3)6-5-7-19(21)35-4)29-37(32,33)15(2)22(31)17-10-9-16(12-25)13-26-17/h5-11,13,15,22,31H,1-4H3,(H,28,29)/t15-,22+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.110 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456574
(US10736883, Example 11.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ccc(Cl)cn2)nnc1-c1ccco1 |r,wU:16.17,(1.57,-3.44,;.48,-4.53,;-1.01,-4.13,;-1.41,-2.64,;-2.9,-2.24,;-3.99,-3.33,;-3.59,-4.82,;-4.68,-5.91,;-6.16,-5.51,;-2.1,-5.22,;-1.7,-6.71,;-.24,-7.18,;1.1,-6.41,;2.43,-7.18,;3.76,-7.95,;1.66,-8.51,;3.2,-5.85,;2.43,-4.51,;4.74,-5.85,;5.51,-4.51,;7.05,-4.51,;7.82,-3.18,;7.05,-1.85,;7.82,-.51,;5.51,-1.85,;4.74,-3.18,;-.24,-8.72,;-1.7,-9.2,;-2.61,-7.95,;-4.09,-7.55,;-5,-6.31,;-6.46,-6.78,;-6.46,-8.32,;-5,-8.8,)| Show InChI InChI=1S/C22H22ClN5O5S/c1-14(12-16-10-9-15(23)13-24-16)34(29,30)27-22-26-25-21(19-8-5-11-33-19)28(22)20-17(31-2)6-4-7-18(20)32-3/h4-11,13-14H,12H2,1-3H3,(H,26,27)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.140 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456575
(US10736883, Example 12.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ccc(cn2)C#N)nnc1-c1ccc(C)o1 |r,wU:16.17,(1.63,-4.1,;.54,-5.19,;-.95,-4.79,;-1.34,-3.3,;-2.83,-2.9,;-3.92,-3.99,;-3.52,-5.48,;-4.61,-6.57,;-6.1,-6.17,;-2.03,-5.88,;-1.64,-7.37,;-.17,-7.84,;1.16,-7.07,;2.5,-7.84,;3.83,-8.61,;1.73,-9.18,;3.27,-6.51,;2.5,-5.17,;4.81,-6.51,;5.58,-5.17,;7.12,-5.17,;7.89,-3.84,;7.14,-2.46,;5.58,-2.51,;4.81,-3.84,;7.91,-1.13,;8.68,.21,;-.17,-9.38,;-1.64,-9.86,;-2.54,-8.61,;-4.03,-8.21,;-5.09,-7.12,;-6.4,-7.44,;-6.4,-8.98,;-7.64,-9.89,;-4.93,-9.46,)| Show InChI InChI=1S/C24H24N6O5S/c1-15-8-11-21(35-15)23-27-28-24(30(23)22-19(33-3)6-5-7-20(22)34-4)29-36(31,32)16(2)12-18-10-9-17(13-25)14-26-18/h5-11,14,16H,12H2,1-4H3,(H,28,29)/t16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.150 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456576
(US10736883, Example 13.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(Cl)cc2NC(C)=O)nnc1-c1ccco1 |r,wD:16.17,(-6.81,-2.64,;-5.47,-3.41,;-4.14,-2.64,;-4.14,-1.1,;-2.81,-.33,;-1.47,-1.1,;-1.47,-2.64,;-.14,-3.41,;1.19,-2.64,;-2.81,-3.41,;-2.81,-5.09,;-1.56,-6,;-.23,-5.23,;1.11,-6,;.34,-7.33,;1.88,-7.33,;2.44,-5.23,;2.44,-3.69,;3.77,-6,;5.11,-5.23,;5.11,-3.69,;6.44,-2.92,;7.77,-3.69,;9.11,-2.92,;7.77,-5.23,;6.44,-6,;6.44,-7.54,;7.77,-8.31,;7.77,-9.85,;9.11,-7.54,;-2.04,-7.46,;-3.58,-7.46,;-4.05,-6,;-5.42,-5.41,;-5.9,-3.94,;-7.44,-3.94,;-7.91,-5.41,;-6.67,-6.31,)| Show InChI InChI=1S/C24H25ClN6O6S/c1-14(11-17-18(27-15(2)32)12-16(25)13-26-17)38(33,34)30-24-29-28-23(21-9-6-10-37-21)31(24)22-19(35-3)7-5-8-20(22)36-4/h5-10,12-14H,11H2,1-4H3,(H,27,32)(H,29,30)/t14-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.190 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456577
(US10736883, Example 14.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ccc(Cl)cn2)nnc1-c1ccco1 |r,wD:16.17,(1.69,-3.6,;.6,-4.69,;-.88,-4.29,;-1.28,-2.8,;-2.77,-2.41,;-3.86,-3.49,;-3.46,-4.98,;-4.55,-6.07,;-6.04,-5.67,;-1.97,-5.38,;-1.57,-6.87,;-.11,-7.34,;1.22,-6.57,;2.56,-7.34,;3.89,-8.11,;1.79,-8.68,;3.33,-6.01,;2.56,-4.68,;4.87,-6.01,;5.64,-4.68,;7.18,-4.68,;7.95,-3.34,;7.18,-2.01,;7.95,-.68,;5.64,-2.01,;4.87,-3.34,;-.11,-8.88,;-1.57,-9.36,;-2.48,-8.11,;-3.97,-7.72,;-4.87,-6.47,;-6.34,-6.95,;-6.34,-8.49,;-4.87,-8.96,)| Show InChI InChI=1S/C22H22ClN5O5S/c1-14(12-16-10-9-15(23)13-24-16)34(29,30)27-22-26-25-21(19-8-5-11-33-19)28(22)20-17(31-2)6-4-7-18(20)32-3/h4-11,13-14H,12H2,1-3H3,(H,26,27)/t14-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456578
(US10736883, Example 15.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cc2NC(C)=O)nnc1-c1ccco1 |r,wD:16.17,(-.77,6.35,;-1.86,5.26,;-3.34,5.66,;-3.74,7.15,;-5.23,7.55,;-6.32,6.46,;-5.92,4.97,;-7.01,3.88,;-8.5,4.28,;-4.43,4.57,;-4.03,3.09,;-2.57,2.61,;-1.23,3.38,;.1,2.61,;1.43,1.84,;-.67,1.28,;.87,3.94,;.1,5.28,;2.41,3.94,;3.18,5.28,;2.41,6.61,;3.18,7.94,;4.72,7.94,;5.49,9.28,;5.49,6.61,;4.72,5.28,;5.49,3.94,;7.03,3.94,;7.8,2.61,;7.8,5.28,;-2.57,1.07,;-4.03,.59,;-4.94,1.84,;-6.43,2.24,;-7.33,3.48,;-8.8,3.01,;-8.8,1.47,;-7.33,.99,)| Show InChI InChI=1S/C24H25FN6O6S/c1-14(11-17-18(27-15(2)32)12-16(25)13-26-17)38(33,34)30-24-29-28-23(21-9-6-10-37-21)31(24)22-19(35-3)7-5-8-20(22)36-4/h5-10,12-14H,11H2,1-4H3,(H,27,32)(H,29,30)/t14-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456579
(US10736883, Example 16.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(C)cn2)nnc1-c1ccc(C)o1 |r,wD:16.17,(-6.18,-2.72,;-4.85,-3.49,;-3.52,-2.72,;-3.52,-1.18,;-2.18,-.41,;-.85,-1.18,;-.85,-2.72,;.48,-3.49,;1.82,-2.72,;-2.18,-3.49,;-2.18,-5.18,;-.94,-6.08,;.4,-5.31,;1.73,-6.08,;.96,-7.42,;2.5,-7.42,;3.06,-5.31,;3.06,-3.77,;4.4,-6.08,;5.73,-5.31,;7.07,-6.08,;8.4,-5.31,;8.4,-3.77,;9.73,-3,;7.07,-3,;5.73,-3.77,;-1.41,-7.55,;-2.95,-7.55,;-3.43,-6.08,;-4.8,-5.49,;-5.27,-4.03,;-6.81,-4.03,;-7.29,-5.49,;-8.75,-5.97,;-6.04,-6.4,)| Show InChI InChI=1S/C23H26N6O5S/c1-14-12-24-20(25-13-14)11-16(3)35(30,31)28-23-27-26-22(19-10-9-15(2)34-19)29(23)21-17(32-4)7-6-8-18(21)33-5/h6-10,12-13,16H,11H2,1-5H3,(H,27,28)/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.220 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456580
(US10736883, Example 17.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(Cl)cc2C(N)=O)nnc1-c1ccco1 |r,wD:16.17,(-6.97,-2.85,;-5.64,-3.62,;-4.3,-2.85,;-4.3,-1.31,;-2.97,-.54,;-1.64,-1.31,;-1.64,-2.85,;-.3,-3.62,;1.03,-2.85,;-2.97,-3.62,;-2.97,-5.3,;-1.72,-6.21,;-.39,-5.44,;.94,-6.21,;.17,-7.54,;1.71,-7.54,;2.28,-5.44,;2.28,-3.9,;3.61,-6.21,;4.94,-5.44,;4.94,-3.9,;6.28,-3.13,;7.61,-3.9,;8.94,-3.13,;7.61,-5.44,;6.28,-6.21,;6.28,-7.75,;4.94,-8.52,;7.61,-8.52,;-2.2,-7.67,;-3.74,-7.67,;-4.22,-6.21,;-5.59,-5.62,;-6.06,-4.16,;-7.6,-4.16,;-8.08,-5.62,;-6.83,-6.53,)| Show InChI InChI=1S/C23H23ClN6O6S/c1-13(10-16-15(21(25)31)11-14(24)12-26-16)37(32,33)29-23-28-27-22(19-8-5-9-36-19)30(23)20-17(34-2)6-4-7-18(20)35-3/h4-9,11-13H,10H2,1-3H3,(H2,25,31)(H,28,29)/t13-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.260 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456581
(US10736883, Example 18.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(Cl)cc2Br)nnc1-c1ccco1 |r,wD:16.17,(-6.96,-2.72,;-5.63,-3.49,;-4.3,-2.72,;-4.3,-1.18,;-2.96,-.41,;-1.63,-1.18,;-1.63,-2.72,;-.3,-3.49,;1.04,-2.72,;-2.96,-3.49,;-2.96,-5.17,;-1.72,-6.08,;-.38,-5.31,;.95,-6.08,;.18,-7.41,;1.72,-7.41,;2.28,-5.31,;2.28,-3.77,;3.62,-6.08,;4.95,-5.31,;4.95,-3.77,;6.28,-3,;7.62,-3.77,;8.95,-3,;7.62,-5.31,;6.28,-6.08,;6.28,-7.62,;-2.19,-7.54,;-3.73,-7.54,;-4.21,-6.08,;-5.58,-5.49,;-6.06,-4.03,;-7.6,-4.03,;-8.07,-5.49,;-6.83,-6.4,)| Show InChI InChI=1S/C22H21BrClN5O5S/c1-13(10-16-15(23)11-14(24)12-25-16)35(30,31)28-22-27-26-21(19-8-5-9-34-19)29(22)20-17(32-2)6-4-7-18(20)33-3/h4-9,11-13H,10H2,1-3H3,(H,27,28)/t13-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.280 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456582
(US10736883, Example 19.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ccc(cn2)C#N)nnc1-c1ccc(C)o1 |(1.13,.76,;.04,-.32,;-1.45,.07,;-1.85,1.56,;-3.34,1.96,;-4.43,.87,;-4.03,-.62,;-5.12,-1.7,;-6.6,-1.31,;-2.54,-1.01,;-2.14,-2.5,;-.68,-2.98,;.66,-2.21,;1.99,-2.98,;3.32,-3.75,;1.22,-4.31,;2.76,-1.64,;4.3,-1.64,;5.07,-.31,;6.61,-.31,;7.38,1.02,;6.64,2.4,;5.07,2.36,;4.3,1.02,;7.41,3.74,;8.18,5.07,;-.68,-4.52,;-2.14,-4.99,;-3.05,-3.75,;-4.53,-3.35,;-5.59,-2.26,;-6.9,-2.58,;-6.9,-4.12,;-8.15,-5.02,;-5.44,-4.59,)| Show InChI InChI=1S/C23H22N6O5S/c1-15-7-10-20(34-15)22-26-27-23(29(22)21-18(32-2)5-4-6-19(21)33-3)28-35(30,31)12-11-17-9-8-16(13-24)14-25-17/h4-10,14H,11-12H2,1-3H3,(H,27,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.290 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456583
(US10736883, Example 20.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(Cl)cc2C#N)nnc1-c1ccco1 |r,wU:16.17,(1.08,-3.52,;-.01,-4.6,;-1.5,-4.21,;-1.89,-2.72,;-3.38,-2.32,;-4.47,-3.41,;-4.07,-4.9,;-5.16,-5.99,;-6.65,-5.59,;-2.58,-5.29,;-2.19,-6.78,;-.72,-7.26,;.61,-6.49,;1.95,-7.26,;3.28,-8.03,;1.18,-8.59,;2.72,-5.92,;1.95,-4.59,;4.26,-5.92,;5.03,-4.59,;4.26,-3.26,;5.03,-1.92,;6.57,-1.92,;7.34,-.59,;7.34,-3.26,;6.59,-4.64,;7.36,-5.97,;8.13,-7.31,;-.72,-8.8,;-2.19,-9.27,;-3.09,-8.03,;-4.58,-7.63,;-5.64,-6.54,;-6.95,-6.86,;-6.95,-8.4,;-5.48,-8.88,)| Show InChI InChI=1S/C23H21ClN6O5S/c1-14(10-17-15(12-25)11-16(24)13-26-17)36(31,32)29-23-28-27-22(20-8-5-9-35-20)30(23)21-18(33-2)6-4-7-19(21)34-3/h4-9,11,13-14H,10H2,1-3H3,(H,28,29)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456584
(US10736883, Example 21.0)Show SMILES CCN(CC)C(=O)c1cc(Cl)cnc1C[C@H](C)S(=O)(=O)Nc1nnc(-c2ccco2)n1-c1c(OC)cccc1OC |r,wU:15.16,(3.87,-8.47,;4.64,-7.13,;6.18,-7.13,;6.95,-8.47,;6.18,-9.8,;6.95,-5.8,;8.49,-5.8,;6.18,-4.47,;6.95,-3.13,;6.18,-1.8,;6.95,-.47,;4.64,-1.8,;3.87,-3.13,;4.64,-4.47,;3.87,-5.8,;2.33,-5.8,;1.56,-4.47,;1.56,-7.13,;2.89,-7.9,;.79,-8.47,;.22,-6.36,;-1.11,-7.13,;-1.11,-8.67,;-2.57,-9.15,;-3.48,-7.9,;-4.97,-7.51,;-5.87,-6.26,;-7.34,-6.74,;-7.34,-8.28,;-5.87,-8.75,;-2.57,-6.66,;-2.97,-5.17,;-1.88,-4.08,;-.4,-4.48,;.69,-3.39,;-2.28,-2.6,;-3.77,-2.2,;-4.86,-3.29,;-4.46,-4.77,;-5.55,-5.86,;-7.04,-5.46,)| Show InChI InChI=1S/C27H31ClN6O6S/c1-6-33(7-2)26(35)19-15-18(28)16-29-20(19)14-17(3)41(36,37)32-27-31-30-25(23-12-9-13-40-23)34(27)24-21(38-4)10-8-11-22(24)39-5/h8-13,15-17H,6-7,14H2,1-5H3,(H,31,32)/t17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.310 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456585
(US10736883, Example 22.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(Br)cn2)nnc1-c1ccco1 |r,wU:16.17,(-7.77,5.88,;-6.43,5.11,;-5.1,5.88,;-5.1,7.42,;-3.76,8.19,;-2.43,7.42,;-2.43,5.88,;-1.1,5.11,;.24,5.88,;-3.76,5.11,;-3.76,3.43,;-2.52,2.52,;-1.03,2.92,;.06,1.83,;-.71,.5,;.83,.5,;1.39,2.6,;1.39,4.14,;2.73,1.83,;4.06,2.6,;5.39,1.83,;6.73,2.6,;6.73,4.14,;8.06,4.91,;5.39,4.91,;4.06,4.14,;-2.99,1.06,;-4.53,1.06,;-5.01,2.52,;-6.38,3.11,;-6.86,4.57,;-8.4,4.57,;-8.87,3.11,;-7.63,2.2,)| Show InChI InChI=1S/C21H21BrN6O5S/c1-13(10-18-23-11-14(22)12-24-18)34(29,30)27-21-26-25-20(17-8-5-9-33-17)28(21)19-15(31-2)6-4-7-16(19)32-3/h4-9,11-13H,10H2,1-3H3,(H,26,27)/t13-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.310 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456586
(US10736883, Example 23.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ccc(Br)cn2)nnc1-c1ccco1 |r,wU:16.17,(-6.11,-5.5,;-4.62,-5.9,;-3.53,-4.81,;-3.93,-3.32,;-2.84,-2.23,;-1.35,-2.63,;-.96,-4.12,;.53,-4.52,;1.62,-3.43,;-2.04,-5.21,;-1.54,-7.2,;-.2,-7.97,;1.13,-7.2,;2.46,-7.97,;1.69,-9.3,;3.8,-8.74,;3.23,-6.64,;2.46,-5.3,;4.77,-6.64,;5.54,-5.3,;7.08,-5.3,;7.85,-3.97,;7.08,-2.63,;7.85,-1.3,;5.54,-2.63,;4.77,-3.97,;-.52,-9.48,;-2.06,-9.64,;-2.68,-8.23,;-4.17,-7.83,;-4.87,-6.46,;-6.39,-6.7,;-6.63,-8.22,;-5.26,-8.92,)| Show InChI InChI=1S/C22H22BrN5O5S/c1-14(12-16-10-9-15(23)13-24-16)34(29,30)27-22-26-25-21(19-8-5-11-33-19)28(22)20-17(31-2)6-4-7-18(20)32-3/h4-11,13-14H,12H2,1-3H3,(H,26,27)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.360 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456587
(US10736883, Example 24.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2cnc(C)cn2)nnc1-c1ccc(C)o1 |r,wU:16.17,(-5.41,-5.53,;-3.93,-5.93,;-2.84,-4.84,;-3.24,-3.35,;-2.15,-2.27,;-.66,-2.66,;-.26,-4.15,;1.23,-4.55,;2.32,-3.46,;-1.35,-5.24,;-.84,-7.23,;.49,-8,;1.83,-7.23,;3.16,-8,;2.39,-9.34,;4.49,-8.77,;3.93,-6.67,;3.16,-5.34,;5.47,-6.67,;6.24,-5.34,;7.78,-5.34,;8.55,-4,;7.78,-2.67,;8.55,-1.34,;6.24,-2.67,;5.47,-4,;.17,-9.51,;-1.36,-9.67,;-1.99,-8.26,;-3.47,-7.87,;-4.17,-6.49,;-5.69,-6.73,;-5.94,-8.26,;-7.27,-9.03,;-4.56,-8.95,)| Show InChI InChI=1S/C23H26N6O5S/c1-14-12-25-17(13-24-14)11-16(3)35(30,31)28-23-27-26-22(20-10-9-15(2)34-20)29(23)21-18(32-4)7-6-8-19(21)33-5/h6-10,12-13,16H,11H2,1-5H3,(H,27,28)/t16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.360 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456588
(US10736883, Example 25.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ccc(F)cn2)nnc1-c1ccco1 |r,wU:16.17,(-6.08,-5.5,;-4.59,-5.9,;-3.51,-4.81,;-3.9,-3.32,;-2.82,-2.23,;-1.33,-2.63,;-.93,-4.12,;.56,-4.52,;1.65,-3.43,;-2.02,-5.21,;-1.51,-7.2,;-.18,-7.97,;1.16,-7.2,;2.49,-7.97,;1.72,-9.3,;3.82,-8.74,;3.26,-6.64,;2.49,-5.3,;4.8,-6.64,;5.57,-5.3,;7.11,-5.3,;7.88,-3.97,;7.11,-2.63,;7.88,-1.3,;5.57,-2.63,;4.8,-3.97,;-.5,-9.48,;-2.03,-9.64,;-2.66,-8.23,;-4.14,-7.83,;-4.84,-6.46,;-6.36,-6.7,;-6.6,-8.22,;-5.23,-8.92,)| Show InChI InChI=1S/C22H22FN5O5S/c1-14(12-16-10-9-15(23)13-24-16)34(29,30)27-22-26-25-21(19-8-5-11-33-19)28(22)20-17(31-2)6-4-7-18(20)32-3/h4-11,13-14H,12H2,1-3H3,(H,26,27)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.370 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456589
(US10736883, Example 26.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ncc(C)cn2)nnc1-c1ccc(C)o1 |(-6.05,-.03,;-4.57,-.43,;-3.48,.66,;-3.88,2.15,;-2.79,3.24,;-1.3,2.84,;-.9,1.35,;.59,.95,;1.68,2.04,;-1.99,.26,;-1.48,-1.73,;-.15,-2.5,;1.19,-1.73,;2.52,-2.5,;1.75,-3.83,;3.85,-3.27,;3.29,-1.17,;4.83,-1.17,;5.6,.17,;7.14,.17,;7.91,1.5,;7.14,2.83,;7.91,4.17,;5.6,2.83,;4.83,1.5,;-.47,-4.01,;-2,-4.17,;-2.63,-2.76,;-4.11,-2.36,;-4.81,-.99,;-6.33,-1.23,;-6.58,-2.75,;-7.91,-3.52,;-5.2,-3.45,)| Show InChI InChI=1S/C22H24N6O5S/c1-14-12-23-19(24-13-14)10-11-34(29,30)27-22-26-25-21(18-9-8-15(2)33-18)28(22)20-16(31-3)6-5-7-17(20)32-4/h5-9,12-13H,10-11H2,1-4H3,(H,26,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.420 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456590
(US10736883, Example 27.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ncc(Cl)cc2N2CCC2=O)nnc1-c1ccco1 |(-8.13,-.03,;-6.64,-.43,;-5.55,.66,;-5.95,2.15,;-4.86,3.24,;-3.38,2.84,;-2.98,1.35,;-1.49,.95,;-.4,2.04,;-4.07,.26,;-3.56,-1.73,;-2.23,-2.5,;-.89,-1.73,;.44,-2.5,;-.33,-3.83,;1.78,-3.27,;1.21,-1.17,;2.75,-1.17,;3.52,.17,;2.75,1.5,;3.52,2.83,;5.06,2.83,;5.83,4.17,;5.83,1.5,;5.06,.17,;5.83,-1.17,;5.43,-2.65,;6.92,-3.05,;7.32,-1.57,;8.65,-.8,;-2.55,-4.01,;-4.08,-4.17,;-4.7,-2.76,;-6.19,-2.36,;-6.89,-.99,;-8.41,-1.23,;-8.65,-2.75,;-7.28,-3.45,)| Show InChI InChI=1S/C24H23ClN6O6S/c1-35-18-5-3-6-19(36-2)22(18)31-23(20-7-4-11-37-20)27-28-24(31)29-38(33,34)12-9-16-17(13-15(25)14-26-16)30-10-8-21(30)32/h3-7,11,13-14H,8-10,12H2,1-2H3,(H,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.460 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456591
(US10736883, Example 28.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cc2NC(C)=O)nnc1-c1ccco1 |r,wU:16.17,(-7.43,-6.02,;-5.95,-6.42,;-4.86,-5.33,;-5.26,-3.84,;-4.17,-2.75,;-2.68,-3.15,;-2.28,-4.64,;-.79,-5.04,;.29,-3.95,;-3.37,-5.73,;-2.86,-7.72,;-1.53,-8.49,;-.2,-7.72,;1.14,-8.49,;.37,-9.83,;2.47,-9.26,;1.91,-7.16,;1.14,-5.82,;3.45,-7.16,;4.22,-5.82,;3.45,-4.49,;4.22,-3.16,;5.76,-3.16,;6.53,-1.82,;6.53,-4.49,;5.76,-5.82,;6.53,-7.16,;8.07,-7.16,;8.84,-8.49,;8.84,-5.82,;-1.85,-10,;-3.38,-10.16,;-4.01,-8.75,;-5.5,-8.35,;-6.19,-6.98,;-7.72,-7.22,;-7.96,-8.74,;-6.58,-9.44,)| Show InChI InChI=1S/C24H25FN6O6S/c1-14(11-17-18(27-15(2)32)12-16(25)13-26-17)38(33,34)30-24-29-28-23(21-9-6-10-37-21)31(24)22-19(35-3)7-5-8-20(22)36-4/h5-10,12-14H,11H2,1-4H3,(H,27,32)(H,29,30)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.480 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456592
(US10736883, Example 29.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cc2C#N)nnc1-c1ccco1 |r,wU:16.17,(-6.47,-5.5,;-4.99,-5.9,;-3.9,-4.81,;-4.3,-3.32,;-3.21,-2.23,;-1.72,-2.63,;-1.32,-4.12,;.17,-4.52,;1.26,-3.43,;-2.41,-5.21,;-1.9,-7.2,;-.57,-7.97,;.76,-7.2,;2.1,-7.97,;1.33,-9.3,;3.43,-8.74,;2.87,-6.64,;2.1,-5.3,;4.41,-6.64,;5.18,-5.3,;4.41,-3.97,;5.18,-2.63,;6.72,-2.63,;7.49,-1.3,;7.49,-3.97,;6.75,-5.35,;7.52,-6.68,;8.29,-8.02,;-.89,-9.48,;-2.42,-9.64,;-3.05,-8.23,;-4.53,-7.83,;-5.23,-6.46,;-6.75,-6.7,;-7,-8.22,;-5.62,-8.92,)| Show InChI InChI=1S/C23H21FN6O5S/c1-14(10-17-15(12-25)11-16(24)13-26-17)36(31,32)29-23-28-27-22(20-8-5-9-35-20)30(23)21-18(33-2)6-4-7-19(21)34-3/h4-9,11,13-14H,10H2,1-3H3,(H,28,29)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.820 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456593
(US10736883, Example 30.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ccc(cn2)C#N)nnc1-c1ccco1 |r,wU:16.17,(-6.47,-6.16,;-4.99,-6.56,;-3.9,-5.47,;-4.3,-3.99,;-3.21,-2.9,;-1.72,-3.3,;-1.32,-4.78,;.17,-5.18,;1.26,-4.09,;-2.41,-5.87,;-1.9,-7.87,;-.57,-8.64,;.76,-7.87,;2.1,-8.64,;1.33,-9.97,;3.43,-9.41,;2.87,-7.3,;2.1,-5.97,;4.41,-7.3,;5.18,-5.97,;6.72,-5.97,;7.49,-4.63,;6.75,-3.25,;5.18,-3.3,;4.41,-4.63,;7.52,-1.92,;8.29,-.59,;-.89,-10.14,;-2.42,-10.3,;-3.05,-8.9,;-4.53,-8.5,;-5.23,-7.13,;-6.75,-7.37,;-7,-8.89,;-5.62,-9.59,)| Show InChI InChI=1S/C23H22N6O5S/c1-15(12-17-10-9-16(13-24)14-25-17)35(30,31)28-23-27-26-22(20-8-5-11-34-20)29(23)21-18(32-2)6-4-7-19(21)33-3/h4-11,14-15H,12H2,1-3H3,(H,27,28)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456594
(US10736883, Example 31.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ccc(C)nn2)nnc1-c1ccc(C)o1 |r,wU:16.17,(-5.44,-5.53,;-3.95,-5.93,;-2.86,-4.84,;-3.26,-3.35,;-2.17,-2.27,;-.69,-2.66,;-.29,-4.15,;1.2,-4.55,;2.29,-3.46,;-1.38,-5.24,;-.87,-7.23,;.46,-8,;1.8,-7.23,;3.13,-8,;2.36,-9.34,;4.46,-8.77,;3.9,-6.67,;3.13,-5.34,;5.44,-6.67,;6.21,-5.34,;7.75,-5.34,;8.52,-4,;7.75,-2.67,;8.52,-1.34,;6.21,-2.67,;5.44,-4,;.14,-9.51,;-1.39,-9.67,;-2.01,-8.26,;-3.5,-7.87,;-4.2,-6.49,;-5.72,-6.73,;-5.96,-8.26,;-7.3,-9.03,;-4.59,-8.95,)| Show InChI InChI=1S/C23H26N6O5S/c1-14-9-11-17(25-24-14)13-16(3)35(30,31)28-23-27-26-22(20-12-10-15(2)34-20)29(23)21-18(32-4)7-6-8-19(21)33-5/h6-12,16H,13H2,1-5H3,(H,27,28)/t16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456595
(US10736883, Example 32.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2cnc(C)cn2)nnc1-c1ccco1 |r,wU:16.17,(-6.08,-5.53,;-4.59,-5.93,;-3.5,-4.84,;-3.9,-3.35,;-2.81,-2.27,;-1.33,-2.66,;-.93,-4.15,;.56,-4.55,;1.65,-3.46,;-2.02,-5.24,;-1.51,-7.23,;-.18,-8,;1.16,-7.23,;2.49,-8,;1.72,-9.34,;3.83,-8.77,;3.26,-6.67,;2.49,-5.34,;4.8,-6.67,;5.57,-5.34,;7.11,-5.34,;7.88,-4,;7.11,-2.67,;7.88,-1.34,;5.57,-2.67,;4.8,-4,;-.5,-9.51,;-2.03,-9.67,;-2.65,-8.26,;-4.14,-7.87,;-4.84,-6.49,;-6.36,-6.73,;-6.6,-8.26,;-5.23,-8.95,)| Show InChI InChI=1S/C22H24N6O5S/c1-14-12-24-16(13-23-14)11-15(2)34(29,30)27-22-26-25-21(19-9-6-10-33-19)28(22)20-17(31-3)7-5-8-18(20)32-4/h5-10,12-13,15H,11H2,1-4H3,(H,26,27)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456596
(US10736883, Example 33.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ccc(cn2)C#N)nnc1-c1ccc(C)o1 |r,wU:16.17,(-5.81,-6.16,;-4.32,-6.56,;-3.23,-5.47,;-3.63,-3.99,;-2.54,-2.9,;-1.05,-3.3,;-.65,-4.78,;.83,-5.18,;1.92,-4.09,;-1.74,-5.87,;-1.24,-7.87,;.1,-8.64,;1.43,-7.87,;2.77,-8.64,;2,-9.97,;4.1,-9.41,;3.54,-7.3,;2.77,-5.97,;5.08,-7.3,;5.85,-5.97,;7.39,-5.97,;8.16,-4.63,;7.41,-3.25,;5.85,-3.3,;5.08,-4.63,;8.18,-1.92,;8.95,-.59,;-.22,-10.14,;-1.75,-10.3,;-2.38,-8.9,;-3.87,-8.5,;-4.57,-7.13,;-6.09,-7.37,;-6.33,-8.89,;-7.66,-9.66,;-4.96,-9.59,)| Show InChI InChI=1S/C24H24N6O5S/c1-15-8-11-21(35-15)23-27-28-24(30(23)22-19(33-3)6-5-7-20(22)34-4)29-36(31,32)16(2)12-18-10-9-17(13-25)14-26-18/h5-11,14,16H,12H2,1-4H3,(H,28,29)/t16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456597
(US10736883, Example 34.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ncc(F)cn2)nnc1-c1ccco1 |(-6.72,-.03,;-5.23,-.43,;-4.14,.66,;-4.54,2.15,;-3.45,3.24,;-1.97,2.84,;-1.57,1.35,;-.08,.95,;1.01,2.04,;-2.66,.26,;-2.15,-1.73,;-.82,-2.5,;.52,-1.73,;1.85,-2.5,;1.08,-3.83,;3.19,-3.27,;2.62,-1.17,;4.16,-1.17,;4.93,.17,;6.47,.17,;7.24,1.5,;6.47,2.83,;7.24,4.17,;4.93,2.83,;4.16,1.5,;-1.14,-4.01,;-2.67,-4.17,;-3.29,-2.76,;-4.78,-2.36,;-5.48,-.99,;-7,-1.23,;-7.24,-2.75,;-5.87,-3.45,)| Show InChI InChI=1S/C20H19FN6O5S/c1-30-14-5-3-6-15(31-2)18(14)27-19(16-7-4-9-32-16)24-25-20(27)26-33(28,29)10-8-17-22-11-13(21)12-23-17/h3-7,9,11-12H,8,10H2,1-2H3,(H,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456598
(US10736883, Example 35.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ccc(cn2)C#N)nnc1-c1ccco1 |(-7.4,-1.04,;-5.92,-1.44,;-4.83,-.35,;-5.23,1.13,;-4.14,2.22,;-2.65,1.82,;-2.25,.34,;-.76,-.06,;.33,1.03,;-3.34,-.75,;-2.7,-2.48,;-1.26,-3.03,;.07,-2.26,;1.4,-3.03,;2.74,-3.8,;.63,-4.37,;2.17,-1.7,;3.71,-1.7,;4.48,-.37,;6.02,-.37,;6.79,.97,;6.05,2.35,;4.48,2.3,;3.71,.97,;6.82,3.68,;7.59,5.02,;-1.34,-4.57,;-2.83,-4.97,;-3.67,-3.68,;-5.16,-3.28,;-6,-1.99,;-7.48,-2.39,;-7.56,-3.92,;-6.13,-4.48,)| Show InChI InChI=1S/C22H20N6O5S/c1-31-17-5-3-6-18(32-2)20(17)28-21(19-7-4-11-33-19)25-26-22(28)27-34(29,30)12-10-16-9-8-15(13-23)14-24-16/h3-9,11,14H,10,12H2,1-2H3,(H,26,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456599
(US10736883, Example 36.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(Br)cn2)nnc1-c1ccco1 |r,wD:16.17,(-7.14,6.11,;-5.66,5.71,;-4.57,6.8,;-4.96,8.29,;-3.88,9.38,;-2.39,8.98,;-1.99,7.49,;-.5,7.09,;.59,8.18,;-3.08,6.4,;-2.5,4.55,;-1.09,3.93,;.24,4.7,;1.57,3.93,;.49,2.84,;2.91,3.16,;2.34,5.26,;1.57,6.59,;3.88,5.26,;4.65,6.59,;6.19,6.59,;6.96,7.93,;6.19,9.26,;6.96,10.59,;4.65,9.26,;3.88,7.93,;-1.25,2.39,;-2.76,2.07,;-3.53,3.41,;-5.02,3.81,;-5.57,5.24,;-7.11,5.16,;-7.51,3.68,;-6.21,2.84,)| Show InChI InChI=1S/C21H21BrN6O5S/c1-13(10-18-23-11-14(22)12-24-18)34(29,30)27-21-26-25-20(17-8-5-9-33-17)28(21)19-15(31-2)6-4-7-16(19)32-3/h4-9,11-13H,10H2,1-3H3,(H,26,27)/t13-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456600
(US10736883, Example 37.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(Cl)cn2)nnc1-c1ccco1 |r,wU:16.17,(-6.29,-7.06,;-4.8,-7.45,;-3.71,-6.36,;-4.11,-4.88,;-3.02,-3.79,;-1.53,-4.19,;-1.14,-5.67,;.35,-6.07,;1.44,-4.98,;-2.23,-6.76,;-1.59,-8.49,;-.15,-9.04,;1.19,-8.27,;2.52,-9.04,;3.85,-9.81,;1.75,-10.38,;3.29,-7.71,;2.52,-6.38,;4.83,-7.71,;5.6,-6.38,;7.14,-6.38,;7.91,-5.04,;7.14,-3.71,;7.91,-2.37,;5.6,-3.71,;4.83,-5.04,;-.23,-10.58,;-1.72,-10.98,;-2.56,-9.69,;-4.04,-9.29,;-4.88,-8,;-6.37,-8.4,;-6.45,-9.93,;-5.01,-10.49,)| Show InChI InChI=1S/C21H21ClN6O5S/c1-13(10-18-23-11-14(22)12-24-18)34(29,30)27-21-26-25-20(17-8-5-9-33-17)28(21)19-15(31-2)6-4-7-16(19)32-3/h4-9,11-13H,10H2,1-3H3,(H,26,27)/t13-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456601
(US10736883, Example 38.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2cnc(C)cn2)nnc1-c1ccc(C)o1 |r,wD:16.17,(-6.21,-4.58,;-4.87,-5.35,;-3.54,-4.58,;-3.54,-3.04,;-2.2,-2.27,;-.87,-3.04,;-.87,-4.58,;.46,-5.35,;1.8,-4.58,;-2.2,-5.35,;-2.2,-7.37,;-.96,-8.27,;.53,-7.87,;1.62,-8.96,;.85,-10.3,;2.39,-10.3,;2.95,-8.19,;2.95,-6.65,;4.29,-8.96,;5.62,-8.19,;6.95,-8.96,;8.29,-8.19,;8.29,-6.65,;9.62,-5.88,;6.95,-5.88,;5.62,-6.65,;-1.43,-9.74,;-2.97,-9.74,;-3.45,-8.27,;-4.78,-7.5,;-5.26,-6.04,;-6.8,-6.04,;-7.28,-7.5,;-8.61,-8.27,;-6.03,-8.41,)| Show InChI InChI=1S/C23H26N6O5S/c1-14-12-25-17(13-24-14)11-16(3)35(30,31)28-23-27-26-22(20-10-9-15(2)34-20)29(23)21-18(32-4)7-6-8-19(21)33-5/h6-10,12-13,16H,11H2,1-5H3,(H,27,28)/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456602
(US10736883, Example 39.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ncc(C)cn2)nnc1-c1ccco1 |(-7.02,-.38,;-5.53,-.78,;-4.44,.31,;-4.84,1.8,;-3.75,2.89,;-2.26,2.49,;-1.87,1,;-.38,.6,;.71,1.69,;-2.95,-.09,;-2.32,-1.81,;-.88,-2.37,;.46,-1.6,;1.79,-2.37,;3.12,-3.14,;1.02,-3.7,;2.56,-1.03,;4.1,-1.03,;4.87,.3,;6.41,.3,;7.18,1.64,;6.41,2.97,;7.18,4.3,;4.87,2.97,;4.1,1.64,;-.96,-3.9,;-2.45,-4.3,;-3.28,-3.01,;-4.77,-2.61,;-5.61,-1.32,;-7.1,-1.72,;-7.18,-3.26,;-5.74,-3.81,)| Show InChI InChI=1S/C21H22N6O5S/c1-14-12-22-18(23-13-14)9-11-33(28,29)26-21-25-24-20(17-8-5-10-32-17)27(21)19-15(30-2)6-4-7-16(19)31-3/h4-8,10,12-13H,9,11H2,1-3H3,(H,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 6.60 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456603
(US10736883, Example 40.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@@H](O)c2ccc(cn2)C#N)nnc1-c1ccc(C)o1 |r,wU:18.19,16.17,(-7.96,-5.02,;-6.47,-5.42,;-5.38,-4.33,;-5.78,-2.84,;-4.69,-1.75,;-3.2,-2.15,;-2.81,-3.64,;-1.32,-4.04,;-.23,-2.95,;-3.89,-4.73,;-3.26,-6.46,;-1.82,-7.01,;-.48,-6.24,;.85,-7.01,;1.62,-5.67,;.08,-8.34,;2.18,-7.78,;2.18,-9.32,;3.52,-7.01,;3.52,-5.47,;4.85,-7.78,;4.85,-9.32,;6.18,-10.09,;7.57,-9.34,;7.52,-7.78,;6.18,-7.01,;8.9,-10.11,;10.23,-10.88,;-1.9,-8.55,;-3.39,-8.94,;-4.22,-7.65,;-5.71,-7.25,;-6.55,-5.96,;-8.04,-6.36,;-8.12,-7.9,;-9.45,-8.67,;-6.68,-8.45,)| Show InChI InChI=1S/C24H24N6O6S/c1-14-8-11-20(36-14)23-27-28-24(30(23)21-18(34-3)6-5-7-19(21)35-4)29-37(32,33)15(2)22(31)17-10-9-16(12-25)13-26-17/h5-11,13,15,22,31H,1-4H3,(H,28,29)/t15-,22-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 11 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456604
(US10736883, Example 41.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ccc(F)cn2)nnc1-c1ccco1 |(-7.85,2.26,;-6.51,1.49,;-4.97,1.49,;-4.97,3.03,;-3.64,3.8,;-2.31,3.03,;-2.31,1.49,;-.77,1.49,;0,2.82,;-3.64,.72,;-3.64,-.82,;-2.39,-1.73,;-.91,-1.33,;.18,-2.42,;-.91,-3.51,;.95,-3.75,;1.67,-2.02,;2.76,-3.11,;4.25,-2.71,;5.34,-3.8,;6.82,-3.4,;7.22,-1.91,;8.71,-1.51,;6.13,-.82,;4.65,-1.22,;-2.87,-3.19,;-4.41,-3.19,;-4.88,-1.73,;-6.22,-.96,;-6.69,.51,;-8.23,.51,;-8.71,-.96,;-7.46,-1.86,)| Show InChI InChI=1S/C21H20FN5O5S/c1-30-16-5-3-6-17(31-2)19(16)27-20(18-7-4-11-32-18)24-25-21(27)26-33(28,29)12-10-15-9-8-14(22)13-23-15/h3-9,11,13H,10,12H2,1-2H3,(H,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456605
(US10736883, Example 42.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ccc(C)nn2)nnc1-c1ccco1 |r,wU:16.17,(-6.18,-7.22,;-4.69,-7.62,;-3.6,-6.53,;-4,-5.05,;-2.91,-3.96,;-1.43,-4.36,;-1.03,-5.84,;.46,-6.24,;1.55,-5.15,;-2.12,-6.93,;-1.48,-8.66,;-.04,-9.21,;1.29,-8.44,;2.63,-9.21,;3.96,-9.98,;1.86,-10.55,;3.4,-7.88,;2.63,-6.54,;4.94,-7.88,;5.71,-6.54,;7.25,-6.54,;8.02,-5.21,;7.25,-3.88,;8.02,-2.54,;5.71,-3.88,;4.94,-5.21,;-.12,-10.75,;-1.61,-11.15,;-2.45,-9.86,;-3.93,-9.46,;-4.77,-8.17,;-6.26,-8.57,;-6.34,-10.1,;-4.9,-10.65,)| Show InChI InChI=1S/C22H24N6O5S/c1-14-10-11-16(24-23-14)13-15(2)34(29,30)27-22-26-25-21(19-9-6-12-33-19)28(22)20-17(31-3)7-5-8-18(20)32-4/h5-12,15H,13H2,1-4H3,(H,26,27)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456606
(US10736883, Example 43.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ccc(C)nn2)nnc1-c1ccc(C)o1 |r,wU:16.17,(-5.51,-7.22,;-4.03,-7.62,;-2.94,-6.53,;-3.34,-5.05,;-2.25,-3.96,;-.76,-4.36,;-.36,-5.84,;1.13,-6.24,;2.22,-5.15,;-1.45,-6.93,;-.81,-8.66,;.63,-9.21,;1.96,-8.44,;3.3,-9.21,;4.63,-9.98,;2.53,-10.55,;4.07,-7.88,;3.3,-6.54,;5.61,-7.88,;6.38,-6.54,;7.92,-6.54,;8.69,-5.21,;7.92,-3.88,;8.69,-2.54,;6.38,-3.88,;5.61,-5.21,;.55,-10.75,;-.94,-11.15,;-1.78,-9.86,;-3.27,-9.46,;-4.11,-8.17,;-5.59,-8.57,;-5.67,-10.1,;-7.01,-10.87,;-4.24,-10.65,)| Show InChI InChI=1S/C23H26N6O5S/c1-14-9-11-17(25-24-14)13-16(3)35(30,31)28-23-27-26-22(20-12-10-15(2)34-20)29(23)21-18(32-4)7-6-8-19(21)33-5/h6-12,16H,13H2,1-5H3,(H,27,28)/t16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 25 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456607
(US10736883, Example 44.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ccncn2)nnc1-c1ccco1 |r,wU:16.17,(-6.18,-6.69,;-4.69,-7.09,;-3.6,-6,;-4,-4.51,;-2.91,-3.42,;-1.43,-3.82,;-1.03,-5.31,;.46,-5.71,;1.55,-4.62,;-2.12,-6.4,;-1.48,-8.12,;-.04,-8.68,;1.29,-7.91,;2.63,-8.68,;3.96,-9.45,;1.86,-10.01,;3.4,-7.34,;2.63,-6.01,;4.94,-7.34,;5.71,-6.01,;7.25,-6.01,;8.02,-4.68,;7.25,-3.34,;5.71,-3.34,;4.94,-4.68,;-.12,-10.21,;-1.61,-10.61,;-2.45,-9.32,;-3.93,-8.92,;-4.77,-7.63,;-6.26,-8.03,;-6.34,-9.57,;-4.9,-10.12,)| Show InChI InChI=1S/C21H22N6O5S/c1-14(12-15-9-10-22-13-23-15)33(28,29)26-21-25-24-20(18-8-5-11-32-18)27(21)19-16(30-2)6-4-7-17(19)31-3/h4-11,13-14H,12H2,1-3H3,(H,25,26)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 44 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456608
(US10736883, Example 45.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2cncnc2)nnc1-c1ccco1 |r,wD:16.17,(-6.97,-5.22,;-5.48,-5.62,;-4.39,-4.53,;-4.79,-3.05,;-3.7,-1.96,;-2.21,-2.35,;-1.81,-3.84,;-.33,-4.24,;.76,-3.15,;-2.9,-4.93,;-2.26,-6.66,;-.83,-7.21,;.51,-6.44,;1.84,-7.21,;1.07,-8.55,;2.61,-5.88,;3.17,-7.98,;3.17,-9.52,;4.51,-7.21,;5.84,-7.98,;5.84,-9.52,;7.18,-10.29,;8.51,-9.52,;8.51,-7.98,;7.18,-7.21,;-.91,-8.75,;-2.39,-9.15,;-3.23,-7.86,;-4.72,-7.46,;-5.56,-6.17,;-7.05,-6.56,;-7.13,-8.1,;-5.69,-8.65,)| Show InChI InChI=1S/C21H22N6O5S/c1-14(10-15-11-22-13-23-12-15)33(28,29)26-21-25-24-20(18-8-5-9-32-18)27(21)19-16(30-2)6-4-7-17(19)31-3/h4-9,11-14H,10H2,1-3H3,(H,25,26)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 72 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456609
(US10736883, Example 46.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ccncn2)nnc1-c1ccco1 |r,wU:16.17,(-6.31,-5.56,;-4.82,-5.96,;-3.73,-4.87,;-4.13,-3.38,;-3.04,-2.29,;-1.55,-2.69,;-1.16,-4.18,;.33,-4.58,;1.42,-3.49,;-2.24,-5.27,;-1.61,-6.99,;-.17,-7.55,;1.17,-6.78,;2.5,-7.55,;3.83,-8.32,;1.73,-8.88,;3.27,-6.21,;2.5,-4.88,;4.81,-6.21,;5.58,-4.88,;7.12,-4.88,;7.89,-3.55,;7.12,-2.21,;5.58,-2.21,;4.81,-3.55,;-.25,-9.08,;-1.74,-9.48,;-2.57,-8.19,;-4.06,-7.79,;-4.9,-6.5,;-6.39,-6.9,;-6.47,-8.44,;-5.03,-8.99,)| Show InChI InChI=1S/C21H22N6O5S/c1-14(12-15-9-10-22-13-23-15)33(28,29)26-21-25-24-20(18-8-5-11-32-18)27(21)19-16(30-2)6-4-7-17(19)31-3/h4-11,13-14H,12H2,1-3H3,(H,25,26)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 300 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456610
(US10736883, Example 51.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1-c1ccco1 |r,wD:16.17,(-6.74,-4.66,;-5.41,-5.43,;-4.08,-4.66,;-4.08,-3.12,;-2.74,-2.35,;-1.41,-3.12,;-1.41,-4.66,;-.07,-5.43,;1.26,-4.66,;-2.74,-5.43,;-2.74,-6.97,;-1.5,-7.87,;-.03,-7.4,;1.11,-8.43,;.34,-9.76,;1.88,-9.76,;2.45,-7.66,;2.45,-6.12,;3.78,-8.43,;5.11,-7.66,;6.45,-8.43,;7.78,-7.66,;7.78,-6.12,;9.12,-5.35,;6.45,-5.35,;5.11,-6.12,;-1.97,-9.34,;-3.51,-9.34,;-3.99,-7.87,;-5.45,-7.4,;-5.93,-5.93,;-7.47,-5.93,;-7.94,-7.4,;-6.7,-8.3,)| Show InChI InChI=1S/C21H21FN6O5S/c1-13(10-18-23-11-14(22)12-24-18)34(29,30)27-21-26-25-20(17-8-5-9-33-17)28(21)19-15(31-2)6-4-7-16(19)32-3/h4-9,11-13H,10H2,1-3H3,(H,26,27)/t13-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456611
(US10736883, Example 52.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1-c1ccco1 |r,wD:16.17,(.57,6.64,;-.58,5.6,;-2.04,6.08,;-2.37,7.58,;-3.83,8.05,;-4.97,7.02,;-4.65,5.52,;-5.79,4.48,;-7.26,4.96,;-3.18,5.04,;-2.86,3.54,;-1.45,2.91,;-.12,3.69,;1.22,2.92,;2.55,2.15,;.45,1.59,;1.99,4.25,;1.22,5.59,;3.53,4.25,;4.3,5.59,;5.84,5.59,;6.61,6.92,;5.84,8.26,;6.61,9.59,;4.3,8.26,;3.53,6.92,;-1.61,1.38,;-3.12,1.06,;-3.89,2.39,;-5.42,2.55,;-6.19,3.88,;-7.7,3.56,;-7.86,2.02,;-6.45,1.4,)| Show InChI InChI=1S/C21H21FN6O5S/c1-13(10-18-23-11-14(22)12-24-18)34(29,30)27-21-26-25-20(17-8-5-9-33-17)28(21)19-15(31-2)6-4-7-16(19)32-3/h4-9,11-13H,10H2,1-3H3,(H,26,27)/t13-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.290 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456612
(US10736883, Example 53.0)Show SMILES CCc1cnc(nc1)[C@@H](C)[C@H](C)S(=O)(=O)Nc1nnc(-c2ccc(C)o2)n1-c1c(OC)cccc1OC |r,wU:8.9,10.11,(10.12,-.96,;10.12,-2.5,;8.79,-3.27,;8.79,-4.81,;7.45,-5.58,;6.12,-4.81,;6.12,-3.27,;7.45,-2.5,;4.78,-5.58,;4.78,-7.12,;3.45,-4.81,;3.45,-3.27,;2.12,-5.58,;.78,-6.35,;2.89,-6.92,;1.35,-4.25,;-.19,-4.25,;-1.1,-5.49,;-2.56,-5.02,;-2.56,-3.48,;-3.81,-2.57,;-3.81,-1.03,;-5.27,-.56,;-6.18,-1.8,;-7.72,-1.8,;-5.27,-3.05,;-1.1,-3,;-.62,-1.54,;-1.65,-.39,;-3.16,-.71,;-4.19,.43,;-1.18,1.07,;.33,1.39,;1.36,.25,;.88,-1.22,;1.91,-2.36,;3.42,-2.03,)| Show InChI InChI=1S/C25H30N6O5S/c1-7-18-13-26-23(27-14-18)16(3)17(4)37(32,33)30-25-29-28-24(21-12-11-15(2)36-21)31(25)22-19(34-5)9-8-10-20(22)35-6/h8-14,16-17H,7H2,1-6H3,(H,29,30)/t16-,17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456613
(US10736883, Example 54.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](O)c2coc(C)n2)nnc1-c1ccc(C)o1 |r,wU:16.17,wD:18.19,(.9,6.78,;-.43,6.01,;-1.77,6.78,;-1.77,8.32,;-3.1,9.09,;-4.44,8.32,;-4.43,6.78,;-5.77,6.01,;-7.1,6.78,;-3.1,6.01,;-3.1,4.47,;-1.85,3.57,;-.52,4.34,;.82,3.57,;2.15,2.8,;-.52,2.8,;2.15,4.34,;2.15,5.88,;3.48,3.57,;3.48,2.03,;4.82,4.34,;4.98,5.87,;6.48,6.19,;7.25,4.85,;8.79,4.69,;6.22,3.71,;-2.33,2.1,;-3.87,2.1,;-4.34,3.56,;-5.81,4.04,;-6.29,5.5,;-7.83,5.5,;-8.3,4.04,;-9.76,3.56,;-7.05,3.13,)| Show InChI InChI=1S/C22H25N5O7S/c1-12-9-10-18(34-12)21-24-25-22(27(21)19-16(31-4)7-6-8-17(19)32-5)26-35(29,30)13(2)20(28)15-11-33-14(3)23-15/h6-11,13,20,28H,1-5H3,(H,25,26)/t13-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 8.30 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM456614
(US10736883, Example 55.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](O)c2coc(C)n2)nnc1-c1ccc(C)o1 |r,wU:16.17,wD:18.19,(1.03,6.78,;-.3,6.01,;-1.64,6.78,;-1.64,8.32,;-2.98,9.09,;-4.31,8.32,;-4.31,6.78,;-5.64,6.01,;-6.97,6.78,;-2.97,6.01,;-2.97,4.47,;-1.72,3.57,;-.39,4.34,;.94,3.57,;2.28,2.8,;-.39,2.8,;2.28,4.34,;2.28,5.88,;3.61,3.57,;3.61,2.03,;4.94,4.34,;5.11,5.87,;6.61,6.19,;7.38,4.85,;8.91,4.69,;6.35,3.71,;-2.2,2.1,;-3.74,2.1,;-4.22,3.56,;-5.68,4.04,;-6.16,5.5,;-7.7,5.5,;-8.17,4.04,;-9.64,3.56,;-6.93,3.13,)| Show InChI InChI=1S/C22H25N5O7S/c1-12-9-10-18(34-12)21-24-25-22(27(21)19-16(31-4)7-6-8-17(19)32-5)26-35(29,30)13(2)20(28)15-11-33-14(3)23-15/h6-11,13,20,28H,1-5H3,(H,25,26)/t13-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 28 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10736883 (2020)
BindingDB Entry DOI: 10.7270/Q2JW8HXW |
More data for this
Ligand-Target Pair | |
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