Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 1356   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM317638 (5-hydroxy-5-(5-(3-methyl-5-((4-(trifluoromethyl)py...) Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)C1(O)CCCc2cc(ccc12)C(O)=O Show InChI InChI=1S/C26H21F3N4O3S/c1-14-9-17(12-18(10-14)32-24-30-8-6-21(33-24)26(27,28)29)20-13-31-23(37-20)25(36)7-2-3-15-11-16(22(34)35)4-5-19(15)25/h4-6,8-13,36H,2-3,7H2,1H3,(H,34,35)(H,30,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.508	n/a	n/a	n/a	n/a	n/a	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...				US Patent US9624210 (2017) BindingDB Entry DOI: 10.7270/Q2K64M55
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM317640 ((R)-5-hydroxy-5-(5-(3-methyl-5-((4-(trifluoromethy...) Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)[C@@]1(O)CCCc2cc(ccc12)C(O)=O |r| Show InChI InChI=1S/C26H21F3N4O3S/c1-14-9-17(12-18(10-14)32-24-30-8-6-21(33-24)26(27,28)29)20-13-31-23(37-20)25(36)7-2-3-15-11-16(22(34)35)4-5-19(15)25/h4-6,8-13,36H,2-3,7H2,1H3,(H,34,35)(H,30,32,33)/t25-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.508	n/a	n/a	n/a	n/a	n/a	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...				US Patent US9624210 (2017) BindingDB Entry DOI: 10.7270/Q2K64M55
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM317639 ((S)-5-hydroxy-5-(5-(3-methyl-5-((4-(trifluoromethy...) Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)[C@]1(O)CCCc2cc(ccc12)C(O)=O |r| Show InChI InChI=1S/C26H21F3N4O3S/c1-14-9-17(12-18(10-14)32-24-30-8-6-21(33-24)26(27,28)29)20-13-31-23(37-20)25(36)7-2-3-15-11-16(22(34)35)4-5-19(15)25/h4-6,8-13,36H,2-3,7H2,1H3,(H,34,35)(H,30,32,33)/t25-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...				US Patent US9624210 (2017) BindingDB Entry DOI: 10.7270/Q2K64M55
					More data for this Ligand-Target Pair