Found 20 hits Enz. Inhib. hit(s) with all data for assayid = 3 entry = 50013700 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM50568690
(CHEMBL4870188)Show SMILES CC(=O)N1CCCN(CC1)c1cccc(Nc2nccc(n2)-c2c[nH]c3ncccc23)c1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| 51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113215
BindingDB Entry DOI: 10.7270/Q22Z198K |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM50568686
(CHEMBL4864449)Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2nccc(n2)-c2c[nH]c3ncccc23)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 96 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113215
BindingDB Entry DOI: 10.7270/Q22Z198K |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM50568688
(CHEMBL4862206)Show SMILES CN1CCN(CC1)c1cccc(Nc2nccc(n2)-c2c[nH]c3ncccc23)c1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 531 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113215
BindingDB Entry DOI: 10.7270/Q22Z198K |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM50568704
(CHEMBL4867869)Show SMILES CC(=O)N1CCCN(CC1)c1cccc(Nc2nccc(n2)-c2n[nH]c3ccccc23)c1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 727 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113215
BindingDB Entry DOI: 10.7270/Q22Z198K |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM50568699
(CHEMBL4866028)Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(C#N)c(n2)-c2cn(C)c3ccccc23)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113215
BindingDB Entry DOI: 10.7270/Q22Z198K |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM50568703
(CHEMBL4878159)Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(C#N)c(n2)-c2n[nH]c3ccccc23)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113215
BindingDB Entry DOI: 10.7270/Q22Z198K |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM50568691
(CHEMBL4871011)Show SMILES CC(=O)N1CCCN(CC1)c1cccc(Nc2nccc(n2)-c2cnc3n(C)cccc23)c1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113215
BindingDB Entry DOI: 10.7270/Q22Z198K |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM50568698
(CHEMBL4855435)Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(C#N)c(n2)-c2c[nH]c3ccccc23)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 4.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113215
BindingDB Entry DOI: 10.7270/Q22Z198K |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM50568700
(CHEMBL4856641)Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(C#N)c(n2)-c2c(C)[nH]c3ccccc23)cc1 |(87.73,-8.05,;86.39,-7.28,;86.39,-5.74,;85.06,-8.05,;83.72,-7.29,;82.39,-8.06,;82.39,-9.6,;83.73,-10.37,;85.07,-9.6,;81.06,-10.38,;81.06,-11.93,;79.73,-12.69,;78.4,-11.93,;77.06,-12.7,;75.72,-11.93,;74.39,-12.7,;73.05,-11.93,;73.05,-10.39,;71.72,-9.62,;70.39,-8.86,;74.39,-9.61,;75.72,-10.38,;74.37,-8.07,;75.61,-7.17,;77.07,-7.64,;75.13,-5.7,;73.6,-5.71,;72.57,-4.57,;71.06,-4.89,;70.6,-6.36,;71.63,-7.49,;73.12,-7.18,;78.38,-10.39,;79.71,-9.61,)| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113215
BindingDB Entry DOI: 10.7270/Q22Z198K |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM50568701
(CHEMBL4847825)Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2nccc(n2)-c2n[nH]c3ccccc23)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113215
BindingDB Entry DOI: 10.7270/Q22Z198K |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM50568702
(CHEMBL4848999)Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2nccc(n2)-c2nn(C)c3ccccc23)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113215
BindingDB Entry DOI: 10.7270/Q22Z198K |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM50568697
(CHEMBL4869365)Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2nccc(n2)-c2cn(c3ccccc23)S(=O)(=O)c2ccc(C)cc2)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113215
BindingDB Entry DOI: 10.7270/Q22Z198K |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM50568696
(CHEMBL4866358)Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2nccc(n2)-c2cn(C)c3ccccc23)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113215
BindingDB Entry DOI: 10.7270/Q22Z198K |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM50568695
(CHEMBL4865261)Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2nccc(n2)-c2c[nH]c3ccccc23)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113215
BindingDB Entry DOI: 10.7270/Q22Z198K |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM144315
(Gilteritinib | US11512074, Example T-9 | US8969336...)Show SMILES CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(CC3)N3CCN(C)CC3)c(OC)c2)nc1NC1CCOCC1 Show InChI InChI=1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113215
BindingDB Entry DOI: 10.7270/Q22Z198K |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM50568694
(CHEMBL4850334)Show SMILES CC(=O)N1CCCN(CC1)c1cccc(Nc2nccc(n2)-c2c[nH]c3cccnc23)c1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113215
BindingDB Entry DOI: 10.7270/Q22Z198K |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM50568693
(CHEMBL4873875)Show SMILES CN1CCN(CC1)c1cccc(Nc2nccc(n2)-c2c[nH]c3cccnc23)c1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113215
BindingDB Entry DOI: 10.7270/Q22Z198K |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM50568692
(CHEMBL4862054)Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2nccc(n2)-c2c[nH]c3cccnc23)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113215
BindingDB Entry DOI: 10.7270/Q22Z198K |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM50568689
(CHEMBL4868609)Show SMILES CN1CCN(CC1)c1cccc(Nc2nccc(n2)-c2cn(C)c3ncccc23)c1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113215
BindingDB Entry DOI: 10.7270/Q22Z198K |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM50568687
(CHEMBL4876697)Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2nccc(n2)-c2cn(C)c3ncccc23)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113215
BindingDB Entry DOI: 10.7270/Q22Z198K |
More data for this
Ligand-Target Pair | |
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