Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50075373 (1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 0.660 | n/a | n/a | n/a | n/a | n/a | n/a |
Chang Gung Memorial Hospital Curated by ChEMBL | Assay Description Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 1000 ... | J Nat Prod 79: 2135-42 (2016) Article DOI: 10.1021/acs.jnatprod.6b00597 BindingDB Entry DOI: 10.7270/Q29G5PSQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |