Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301431 (4-amino-7-{1-[1-(2-fluorophenyl)-1H-pyrazol-4-yl]p...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50566263 (CHEMBL4776653) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <0.310 | n/a | n/a | n/a | n/a |
TBA | Assay Description Potentiation of CFTR F508del mutant (unknown origin) expressed in human CFBE41o- cells co-expressing YFP incubated for 10 mins by halide potentiator ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01796 BindingDB Entry DOI: 10.7270/Q2HQ43P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50595765 (CHEMBL5178232) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00406 BindingDB Entry DOI: 10.7270/Q26M3BV5 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301470 (4-amino-5-[2-(difluoromethyl)pyrimidin-5-yl]-7-{1-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301443 (4-amino-5-[2-(difluoromethyl)pyrimidin-5-yl]-7-{[1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.410 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301429 (4-amino-7-{1-[1-(2-fluorophenyl)-1H-pyrazol-4-yl]e...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.420 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301433 (4-amino-7-{1-[1-(2,4-difluorophenyl)-1H-pyrazol-4-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.420 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50516910 (CHEMBL4558190) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a |
University of Palermo Curated by ChEMBL | Assay Description Corrector activity at CFTR F508del mutant (unknown origin) | Eur J Med Chem 180: 430-448 (2019) Article DOI: 10.1016/j.ejmech.2019.07.037 BindingDB Entry DOI: 10.7270/Q2TT4VBP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50595762 (CHEMBL5193680) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.510 | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00406 BindingDB Entry DOI: 10.7270/Q26M3BV5 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301431 (4-amino-7-{1-[1-(2-fluorophenyl)-1H-pyrazol-4-yl]p...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.560 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301433 (4-amino-7-{1-[1-(2,4-difluorophenyl)-1H-pyrazol-4-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.560 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301442 (4-amino-7-{[1-(2-fluorophenyl)-1H-pyrazol-4-yl]met...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.570 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301429 (4-amino-7-{1-[1-(2-fluorophenyl)-1H-pyrazol-4-yl]e...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.620 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50595764 (CHEMBL5178488) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.660 | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00406 BindingDB Entry DOI: 10.7270/Q26M3BV5 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301438 (4-amino-7-{(1R)-1-[1-(2,4-difluorophenyl)-1H-pyraz...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.660 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50595761 (CHEMBL5202275) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00406 BindingDB Entry DOI: 10.7270/Q26M3BV5 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50595763 (CHEMBL5186971) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.840 | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00406 BindingDB Entry DOI: 10.7270/Q26M3BV5 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301442 (4-amino-7-{[1-(2-fluorophenyl)-1H-pyrazol-4-yl]met...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.860 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50595766 (CHEMBL5171054) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00406 BindingDB Entry DOI: 10.7270/Q26M3BV5 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301443 (4-amino-5-[2-(difluoromethyl)pyrimidin-5-yl]-7-{[1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 1.05 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50566262 (CHEMBL4799994) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a |
TBA | Assay Description Potentiation of CFTR F508del mutant (unknown origin) expressed in human CFBE41o- cells co-expressing YFP incubated for 10 mins by halide potentiator ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01796 BindingDB Entry DOI: 10.7270/Q2HQ43P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301463 (BDBM301464 | US10131670, Example 87 | {1-[1-(2-Flu...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 1.53 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301435 (4-amino-7-{1-[3-(2-fluorophenyl)-1,2-oxazol-5-yl]e...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 1.67 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301449 (7-{1-[1-(2-fluorophenyl)-1H-1,2,3-triazol-4-yl]pro...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 1.88 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301449 (7-{1-[1-(2-fluorophenyl)-1H-1,2,3-triazol-4-yl]pro...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50035582 (CHEMBL3357142) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc Curated by ChEMBL | Assay Description Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assay | J Med Chem 57: 9776-95 (2014) Article DOI: 10.1021/jm5012808 BindingDB Entry DOI: 10.7270/Q2TH8P9K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301431 (4-amino-7-{1-[1-(2-fluorophenyl)-1H-pyrazol-4-yl]p...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301451 (7-{1-[1-(2,4-difluorophenyl)-1H-1,2,3-triazol-4-yl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301421 (4-amino-7-{1-[1-(2-fluorophenyl)-1H-1,2,3-triazol-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 2.13 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50566258 (CHEMBL4787310) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a |
TBA | Assay Description Potentiation of CFTR F508del mutant (unknown origin) expressed in human CFBE41o- cells co-expressing YFP incubated for 10 mins by halide potentiator ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01796 BindingDB Entry DOI: 10.7270/Q2HQ43P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50035581 (CHEMBL3357141) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc Curated by ChEMBL | Assay Description Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assay | J Med Chem 57: 9776-95 (2014) Article DOI: 10.1021/jm5012808 BindingDB Entry DOI: 10.7270/Q2TH8P9K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301433 (4-amino-7-{1-[1-(2,4-difluorophenyl)-1H-pyrazol-4-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50035583 (CHEMBL3357143) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc Curated by ChEMBL | Assay Description Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assay | J Med Chem 57: 9776-95 (2014) Article DOI: 10.1021/jm5012808 BindingDB Entry DOI: 10.7270/Q2TH8P9K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50032693 (CHEBI:66901 | Ivacaftor | Kalydeco | VX-770) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc Curated by ChEMBL | Assay Description Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assay | J Med Chem 57: 9776-95 (2014) Article DOI: 10.1021/jm5012808 BindingDB Entry DOI: 10.7270/Q2TH8P9K | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50032693 (CHEBI:66901 | Ivacaftor | Kalydeco | VX-770) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
JL3Pharma LLC Curated by ChEMBL | Assay Description Corrector activity at CFTR mutant (unknown origin) by phenotypic screening assay | J Med Chem 57: 9774-5 (2014) Article DOI: 10.1021/jm5016928 BindingDB Entry DOI: 10.7270/Q2J96808 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301421 (4-amino-7-{1-[1-(2-fluorophenyl)-1H-1,2,3-triazol-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3.02 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301435 (4-amino-7-{1-[3-(2-fluorophenyl)-1,2-oxazol-5-yl]e...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301438 (4-amino-7-{(1R)-1-[1-(2,4-difluorophenyl)-1H-pyraz...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3.13 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301451 (7-{1-[1-(2,4-difluorophenyl)-1H-1,2,3-triazol-4-yl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3.36 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50566256 (CHEMBL4798183) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a |
TBA | Assay Description Potentiation of CFTR F508del mutant (unknown origin) expressed in human CFBE41o- cells co-expressing YFP incubated for 10 mins by halide potentiator ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01796 BindingDB Entry DOI: 10.7270/Q2HQ43P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50165000 ((S)-2-(3-Isopropoxy-4-methoxy-benzoyl)-1,2,3,4-tet...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a |
Genzyme Corp. Curated by ChEMBL | Assay Description Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTR | Bioorg Med Chem Lett 15: 2087-91 (2005) Article DOI: 10.1016/j.bmcl.2005.02.041 BindingDB Entry DOI: 10.7270/Q2J965WP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301471 (4-amino-5-[2-(difluoromethyl)pyrimidin-5-yl]-7-{1-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3.87 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301444 (4-Amino-7-{[3-(2-fluorophenyl)-1,2-oxazol-5-yl]met...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301429 (4-amino-7-{1-[1-(2-fluorophenyl)-1H-pyrazol-4-yl]e...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301427 (4-amino-7-{1-[1-(propan-2-yl)-1H-pyrazol-4-yl]prop...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 4.17 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301444 (4-Amino-7-{[3-(2-fluorophenyl)-1,2-oxazol-5-yl]met...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 4.65 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301463 (BDBM301464 | US10131670, Example 87 | {1-[1-(2-Flu...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 4.76 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301449 (7-{1-[1-(2-fluorophenyl)-1H-1,2,3-triazol-4-yl]pro...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 4.93 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50566264 (CHEMBL4781857) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a |
TBA | Assay Description Potentiation of CFTR F508del mutant (unknown origin) expressed in human CFBE41o- cells co-expressing YFP incubated for 10 mins by halide potentiator ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01796 BindingDB Entry DOI: 10.7270/Q2HQ43P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM301435 (4-amino-7-{1-[3-(2-fluorophenyl)-1,2-oxazol-5-yl]e...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent | Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ... | US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF | |||||||||||
More data for this Ligand-Target Pair |
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