Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-lactamase OXA-2 (Escherichia coli) | BDBM50076680 (CHEMBL6461 | Ro-48-1220 | Sodium; (2S,3R,5R)-3-((Z...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-LaRoche Ltd Curated by ChEMBL | Assay Description Compound was tested for inhibition of Beta-lactamase fromOXA-2 | J Med Chem 39: 3712-22 (1996) Article DOI: 10.1021/jm9601967 BindingDB Entry DOI: 10.7270/Q2ZK5H99 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
OXA23 carbapenemase (Acinetobacter baumannii) | BDBM50541448 (CHEMBL4633785) | PDB Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | 0.740 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Qpex Biopharma, Inc. Curated by ChEMBL | Assay Description Inhibition of Acinetobacter baumannii OXA-23 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every 10 ... | J Med Chem 63: 7491-7507 (2020) Article DOI: 10.1021/acs.jmedchem.9b01976 BindingDB Entry DOI: 10.7270/Q2377D7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
OXA23 carbapenemase (Acinetobacter baumannii) | BDBM50339145 (CHEMBL1689063 | trans-7-oxo-6-(sulfooxy)-1,6-diaza...) | PDB Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Qpex Biopharma, Inc. Curated by ChEMBL | Assay Description Inhibition of Acinetobacter baumannii OXA-23 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every 10 ... | J Med Chem 63: 7491-7507 (2020) Article DOI: 10.1021/acs.jmedchem.9b01976 BindingDB Entry DOI: 10.7270/Q2377D7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
OXA23 carbapenemase (Acinetobacter baumannii) | BDBM50089084 (CHEMBL3317857 | Vaborbactam) | PDB Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents | Article PubMed | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Qpex Biopharma, Inc. Curated by ChEMBL | Assay Description Inhibition of Acinetobacter baumannii OXA-23 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every 10 ... | J Med Chem 63: 7491-7507 (2020) Article DOI: 10.1021/acs.jmedchem.9b01976 BindingDB Entry DOI: 10.7270/Q2377D7Q | |||||||||||
More data for this Ligand-Target Pair |