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Compile Data Set for Download or QSAR

Found 297 hits Enz. Inhib. hit(s) with Target = 'CaM kinase I delta'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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Article
PubMed
n/an/a 0.206n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human CAMK1D using KKALRRQETVDAL as substrate by [gamma-33P]-ATP assay


Citation and Details

Article DOI: 10.1016/j.bmc.2018.02.022
BindingDB Entry DOI: 10.7270/Q2DJ5KB8
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 0.298n/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of human CAMK1D using KKALRRQETVDAL as substrate by [gamma-33P]-ATP assay


Eur J Med Chem 161: 456-467 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.052
BindingDB Entry DOI: 10.7270/Q2W380MT
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585168
PNG
(US11530193, Example 79)
Show SMILES CC(C)n1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(-c2ccc(cc2)C(F)(F)F)c1=O |r|
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n/an/a 4n/an/an/an/an/an/a


TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585211
PNG
(US11530193, Example 127)
Show SMILES CC(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(n1)C1CCN(CC1)C(C)=O |r|
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n/an/a 4n/an/an/an/an/an/a


TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585210
PNG
(US11530193, Example 126)
Show SMILES CC(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(n1)C1CCNCC1 |r|
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n/an/a 5n/an/an/an/an/an/a


TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585207
PNG
(US11530193, Example 123)
Show SMILES CC(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(n1)C1CCOCC1 |r|
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TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585158
PNG
(US11530193, Example 69)
Show SMILES CC1(C)C(=O)Nc2c1cc(Nc1nc(ncc1C(N)=O)N1CCC[C@H](N)C1)cc2C1=CCCCC1 |r,t:33|
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n/an/a 6n/an/an/an/an/an/a


TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585167
PNG
(US11530193, Example 78)
Show SMILES CC(C)n1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(-c2ccc(Cl)cc2)c1=O |r|
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n/an/a 6n/an/an/an/an/an/a


TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585159
PNG
(US11530193, Example 70)
Show SMILES CC1(C)C(=O)Nc2c1cc(Nc1nc(ncc1C(N)=O)N1CCC[C@H](N)C1)cc2-c1ccccc1 |r|
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TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585217
PNG
(US11530193, Example 132)
Show SMILES COc1ccc(cc1)-c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(n1)C(C)C |r|
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n/an/a 7n/an/an/an/an/an/a


TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585172
PNG
(US11530193, Example 83)
Show SMILES CC(C)n1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(C2CCC(F)(F)CC2)c1=O |r|
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n/an/a 7n/an/an/an/an/an/a


TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585218
PNG
(US11530193, Example 133)
Show SMILES COc1ccc(cc1)-c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(c1)C(C)(C)O |r|
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n/an/a 7n/an/an/an/an/an/a


TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585208
PNG
(US11530193, Example 124)
Show SMILES CC(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(n1)C1CCS(=O)(=O)CC1 |r|
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n/an/a 8n/an/an/an/an/an/a


TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585215
PNG
(US11530193, Example 130)
Show SMILES CC(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(n1)C1CCCC1 |r|
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TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585216
PNG
(US11530193, Example 131)
Show SMILES CC(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(n1)C1CCCCC1 |r|
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TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM50545573
PNG
(CHEMBL4635883 | US11530193, Example 54)
Show SMILES CC(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(n1)C(C)C |r|
Show InChI InChI=1S/C21H31N7O/c1-12(2)17-8-15(9-18(26-17)13(3)4)25-20-16(19(23)29)10-24-21(27-20)28-7-5-6-14(22)11-28/h8-10,12-14H,5-7,11,22H2,1-4H3,(H2,23,29)(H,24,25,26,27)/t14-/m0/s1
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TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM50545573
PNG
(CHEMBL4635883 | US11530193, Example 54)
Show SMILES CC(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(n1)C(C)C |r|
Show InChI InChI=1S/C21H31N7O/c1-12(2)17-8-15(9-18(26-17)13(3)4)25-20-16(19(23)29)10-24-21(27-20)28-7-5-6-14(22)11-28/h8-10,12-14H,5-7,11,22H2,1-4H3,(H2,23,29)(H,24,25,26,27)/t14-/m0/s1
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n/an/a 8n/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of recombinant human full-length His-tagged CAMK1D expressed in baculovirus expression system using autocamtide-2 as substrate preincubate...


J Med Chem 63: 6784-6801 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01803
BindingDB Entry DOI: 10.7270/Q2QF8XG3
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM50545576
PNG
(CHEMBL4640712 | US11530193, Example 50)
Show SMILES CC(C)(C#N)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(c1)C(C)(C)C#N |r|
Show InChI InChI=1S/C24H30N8O/c1-23(2,13-25)15-8-16(24(3,4)14-26)10-18(9-15)30-21-19(20(28)33)11-29-22(31-21)32-7-5-6-17(27)12-32/h8-11,17H,5-7,12,27H2,1-4H3,(H2,28,33)(H,29,30,31)/t17-/m0/s1
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n/an/a 8n/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of HA-tagged CAMK1D (unknown origin) expressed in human MDA-MB-231 cells assessed as reduction in CAMK1D autophosphorylation measured afte...


J Med Chem 63: 6784-6801 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01803
BindingDB Entry DOI: 10.7270/Q2QF8XG3
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM50545573
PNG
(CHEMBL4635883 | US11530193, Example 54)
Show SMILES CC(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(n1)C(C)C |r|
Show InChI InChI=1S/C21H31N7O/c1-12(2)17-8-15(9-18(26-17)13(3)4)25-20-16(19(23)29)10-24-21(27-20)28-7-5-6-14(22)11-28/h8-10,12-14H,5-7,11,22H2,1-4H3,(H2,23,29)(H,24,25,26,27)/t14-/m0/s1
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n/an/a 8n/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of human CAMK1D using KKALRRQETVDAL as substrate in presence of [gamma-33P]-ATP by hotspot kinase assay


J Med Chem 63: 6784-6801 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01803
BindingDB Entry DOI: 10.7270/Q2QF8XG3
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585209
PNG
(US11530193, Example 125)
Show SMILES CO[C@H]1CC[C@@H](CC1)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(n1)C(C)C |r,wU:5.8,wD:25.27,2.1,(7.49,-5.12,;6.16,-5.89,;4.82,-5.12,;4.82,-3.58,;3.49,-2.81,;2.16,-3.58,;2.16,-5.12,;3.49,-5.89,;.82,-2.81,;.82,-1.27,;-.51,-.5,;-.51,1.04,;-1.84,1.81,;-3.18,1.04,;-4.51,1.81,;-4.51,3.35,;-3.18,4.12,;-1.84,3.35,;-.51,4.12,;.82,3.35,;-.51,5.66,;-5.84,1.04,;-5.84,-.5,;-7.18,-1.27,;-8.51,-.5,;-8.51,1.04,;-9.85,1.81,;-7.18,1.81,;-1.84,-1.27,;-1.84,-2.81,;-.51,-3.58,;-3.18,-3.58,;-3.18,-5.12,;-4.51,-2.81,)|
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TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585213
PNG
(US11530193, Example 128)
Show SMILES CC(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(n1)C1CCC(F)(F)CC1 |r|
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n/an/a 10n/an/an/an/an/an/a


TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585166
PNG
(US11530193, Example 77)
Show SMILES CC(C)n1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(-c2ccccc2)c1=O |r|
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n/an/a 10n/an/an/an/an/an/a


TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585157
PNG
(US11530193, Example 68)
Show SMILES CC1(C)C(=O)Nc2c1cc(Nc1nc(ncc1C(N)=O)N1CCC[C@H](N)C1)cc2C1CCCCC1 |r|
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TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585149
PNG
(US11530193, Example 60)
Show SMILES N[C@H]1CCCN(C1)c1ncc(C(N)=O)c(Nc2cc(-c3ccccc3)c3cnnc3c2)n1 |r|
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TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585169
PNG
(US11530193, Example 80)
Show SMILES CC(C)n1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(C2=CCC(F)(F)CC2)c1=O |r,t:27|
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Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM50545573
PNG
(CHEMBL4635883 | US11530193, Example 54)
Show SMILES CC(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(n1)C(C)C |r|
Show InChI InChI=1S/C21H31N7O/c1-12(2)17-8-15(9-18(26-17)13(3)4)25-20-16(19(23)29)10-24-21(27-20)28-7-5-6-14(22)11-28/h8-10,12-14H,5-7,11,22H2,1-4H3,(H2,23,29)(H,24,25,26,27)/t14-/m0/s1
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University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of HA-tagged CAMK1D (unknown origin) expressed in human MDA-MB-231 cells assessed as reduction in CAMK1D autophosphorylation measured afte...


J Med Chem 63: 6784-6801 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01803
BindingDB Entry DOI: 10.7270/Q2QF8XG3
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585171
PNG
(US11530193, Example 82)
Show SMILES CC(C)n1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(C2CCCCC2)c1=O |r|
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Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585161
PNG
(US11530193, Example 72)
Show SMILES CC(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc2c1NC(=O)C21CCCCC1 |r|
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The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM50545587
PNG
(CHEMBL4633229 | US11530193, Example 135)
Show SMILES CC(C)(C#N)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(c1)-c1ccccc1 |r|
Show InChI InChI=1S/C26H29N7O/c1-26(2,16-27)19-11-18(17-7-4-3-5-8-17)12-21(13-19)31-24-22(23(29)34)14-30-25(32-24)33-10-6-9-20(28)15-33/h3-5,7-8,11-14,20H,6,9-10,15,28H2,1-2H3,(H2,29,34)(H,30,31,32)/t20-/m0/s1
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University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of HA-tagged CAMK1D (unknown origin) expressed in human MDA-MB-231 cells assessed as reduction in CAMK1D autophosphorylation measured afte...


J Med Chem 63: 6784-6801 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01803
BindingDB Entry DOI: 10.7270/Q2QF8XG3
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585174
PNG
(US11530193, Example 85)
Show SMILES CC(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cn(-c2ccccc2)c1=O |r|
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Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585173
PNG
(US11530193, Example 84)
Show SMILES CC(C)n1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(C(=O)N2CCCCC2)c1=O |r|
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Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585156
PNG
(US11530193, Example 67)
Show SMILES CC(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc2c1NC(=O)C2(C)C |r|
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Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM50545587
PNG
(CHEMBL4633229 | US11530193, Example 135)
Show SMILES CC(C)(C#N)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(c1)-c1ccccc1 |r|
Show InChI InChI=1S/C26H29N7O/c1-26(2,16-27)19-11-18(17-7-4-3-5-8-17)12-21(13-19)31-24-22(23(29)34)14-30-25(32-24)33-10-6-9-20(28)15-33/h3-5,7-8,11-14,20H,6,9-10,15,28H2,1-2H3,(H2,29,34)(H,30,31,32)/t20-/m0/s1
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Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585163
PNG
(US11530193, Example 74)
Show SMILES CC(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(C(C)C)c1O |r|
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TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585146
PNG
(US11530193, Example 57)
Show SMILES CC(=C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(n1)C(F)(F)F |r|
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TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM50545587
PNG
(CHEMBL4633229 | US11530193, Example 135)
Show SMILES CC(C)(C#N)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(c1)-c1ccccc1 |r|
Show InChI InChI=1S/C26H29N7O/c1-26(2,16-27)19-11-18(17-7-4-3-5-8-17)12-21(13-19)31-24-22(23(29)34)14-30-25(32-24)33-10-6-9-20(28)15-33/h3-5,7-8,11-14,20H,6,9-10,15,28H2,1-2H3,(H2,29,34)(H,30,31,32)/t20-/m0/s1
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University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of recombinant human full-length His-tagged CAMK1D expressed in baculovirus expression system using autocamtide-2 as substrate preincubate...


J Med Chem 63: 6784-6801 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01803
BindingDB Entry DOI: 10.7270/Q2QF8XG3
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585175
PNG
(US11530193, Example 86)
Show SMILES N[C@H]1CCCN(C1)c1ncc(C(N)=O)c(Nc2cc(-c3ccccc3)c(=O)n(c2)-c2ccccc2)n1 |r|
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Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585225
PNG
(US11530193, Example 139)
Show SMILES CC(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(n1)C(C)(C)C |r|
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TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585224
PNG
(US11530193, Example 138)
Show SMILES CC(C)c1cc(Nc2nc(ncc2C(N)=O)N2C[C@@H](N)C[C@@H](O)C2)cc(n1)C(C)C |r|
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TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585181
PNG
(US11530193, Example 92)
Show SMILES CC(C)(F)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(c1)C(C)(C)F |r|
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Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585153
PNG
(US11530193, Example 64)
Show SMILES CC(C)(C#N)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(n1)C(C)(C)C#N |r|
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TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585222
PNG
(US11530193, Example 137)
Show SMILES CC(C)c1cc(Nc2nc(ncc2C(N)=O)N2C[C@@H](N)C[C@H](O)C2)cc(n1)C(C)C |r|
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TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM50545576
PNG
(CHEMBL4640712 | US11530193, Example 50)
Show SMILES CC(C)(C#N)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(c1)C(C)(C)C#N |r|
Show InChI InChI=1S/C24H30N8O/c1-23(2,13-25)15-8-16(24(3,4)14-26)10-18(9-15)30-21-19(20(28)33)11-29-22(31-21)32-7-5-6-17(27)12-32/h8-11,17H,5-7,12,27H2,1-4H3,(H2,28,33)(H,29,30,31)/t17-/m0/s1
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University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of human CAMK1D using KKALRRQETVDAL as substrate in presence of [gamma-33P]-ATP by hotspot kinase assay


J Med Chem 63: 6784-6801 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01803
BindingDB Entry DOI: 10.7270/Q2QF8XG3
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585219
PNG
(US11530193, Example 134)
Show SMILES COc1ccc(cc1)-c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(c1)C(C)C |r|
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TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM50545586
PNG
(CHEMBL4632457 | US11530193, Example 106)
Show SMILES CC(C)(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(c1)S(C)(=O)=O |r|
Show InChI InChI=1S/C21H30N6O3S/c1-21(2,3)13-8-15(10-16(9-13)31(4,29)30)25-19-17(18(23)28)11-24-20(26-19)27-7-5-6-14(22)12-27/h8-11,14H,5-7,12,22H2,1-4H3,(H2,23,28)(H,24,25,26)/t14-/m0/s1
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Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585147
PNG
(US11530193, Example 58)
Show SMILES CC(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(n1)-c1ccccc1 |r|
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Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM50545586
PNG
(CHEMBL4632457 | US11530193, Example 106)
Show SMILES CC(C)(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(c1)S(C)(=O)=O |r|
Show InChI InChI=1S/C21H30N6O3S/c1-21(2,3)13-8-15(10-16(9-13)31(4,29)30)25-19-17(18(23)28)11-24-20(26-19)27-7-5-6-14(22)12-27/h8-11,14H,5-7,12,22H2,1-4H3,(H2,23,28)(H,24,25,26)/t14-/m0/s1
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University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of recombinant human full-length His-tagged CAMK1D expressed in baculovirus expression system using autocamtide-2 as substrate preincubate...


J Med Chem 63: 6784-6801 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01803
BindingDB Entry DOI: 10.7270/Q2QF8XG3
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM50545586
PNG
(CHEMBL4632457 | US11530193, Example 106)
Show SMILES CC(C)(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(c1)S(C)(=O)=O |r|
Show InChI InChI=1S/C21H30N6O3S/c1-21(2,3)13-8-15(10-16(9-13)31(4,29)30)25-19-17(18(23)28)11-24-20(26-19)27-7-5-6-14(22)12-27/h8-11,14H,5-7,12,22H2,1-4H3,(H2,23,28)(H,24,25,26)/t14-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 28n/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of HA-tagged CAMK1D (unknown origin) expressed in human MDA-MB-231 cells assessed as reduction in CAMK1D autophosphorylation measured afte...


J Med Chem 63: 6784-6801 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01803
BindingDB Entry DOI: 10.7270/Q2QF8XG3
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585139
PNG
(US11530193, Example 52)
Show SMILES N[C@H]1CCCN(C1)c1ncc(C(N)=O)c(Nc2cc(cc(c2)C2(CCC2)C#N)C2(CCC2)C#N)n1 |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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PC cid
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UniChem
US Patent
n/an/a 28n/an/an/an/an/an/a


TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM585113
PNG
(US11530193, Example 18)
Show SMILES N[C@H]1CCCN(C1)c1ncc(C(N)=O)c(Nc2cc(cc(c2)-c2ccccc2Cl)C(=O)N2CCOCC2)n1 |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 28n/an/an/an/an/an/a


TBA

Assay Description
The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2QZ2FTP
More data for this
Ligand-Target Pair
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