BindingDB PrimarySearch

Found 14 hits Enz. Inhib. hit(s) with Target = 'Phospholipase C-gamma-2'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Homo sapiens (Human))	BDBM50256873 (CHEMBL475790 \| N-(4-chlorophenyl)-7-nitro-1H-indol...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...				Bioorg Med Chem 17: 3169-76 (2009) Article DOI: 10.1016/j.bmc.2009.02.049 BindingDB Entry DOI: 10.7270/Q24Q7TVW
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Homo sapiens (Human))	BDBM50256872 (7-nitro-N-phenethyl-1H-indole-2-carboxamide \| CHEM...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...				Bioorg Med Chem 17: 3169-76 (2009) Article DOI: 10.1016/j.bmc.2009.02.049 BindingDB Entry DOI: 10.7270/Q24Q7TVW
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Homo sapiens (Human))	BDBM50256870 (5-(3-chlorophenyl)-3-(5-(isoxazol-3-yl)thiophen-2-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...				Bioorg Med Chem 17: 3169-76 (2009) Article DOI: 10.1016/j.bmc.2009.02.049 BindingDB Entry DOI: 10.7270/Q24Q7TVW
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Homo sapiens (Human))	BDBM50256801 (4-((5-oxo-2-phenyloxazol-4(5H)-ylidene)methyl)benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...				Bioorg Med Chem 17: 3169-76 (2009) Article DOI: 10.1016/j.bmc.2009.02.049 BindingDB Entry DOI: 10.7270/Q24Q7TVW
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Homo sapiens (Human))	BDBM50256871 (5-(5-nitrothiophen-3-yl)-3-(pyridin-2-yl)-1,2,4-ox...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...				Bioorg Med Chem 17: 3169-76 (2009) Article DOI: 10.1016/j.bmc.2009.02.049 BindingDB Entry DOI: 10.7270/Q24Q7TVW
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Homo sapiens (Human))	BDBM50256803 (4-chloro-N-(4-oxo-4H-benzo[d][1,3]thiazin-2-yl)ben...) Show SMILES Clc1ccc(cc1)C(=O)Nc1nc2ccccc2c(=O)s1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...				Bioorg Med Chem 17: 3169-76 (2009) Article DOI: 10.1016/j.bmc.2009.02.049 BindingDB Entry DOI: 10.7270/Q24Q7TVW
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Homo sapiens (Human))	BDBM50256804 (3-(2,2-dimethylchroman-6-yl)-1-(4-methoxyphenylsul...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...				Bioorg Med Chem 17: 3169-76 (2009) Article DOI: 10.1016/j.bmc.2009.02.049 BindingDB Entry DOI: 10.7270/Q24Q7TVW
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Homo sapiens (Human))	BDBM50256875 (6-(4-methoxyphenyl)-3-phenylthieno[2,3-e][1,2,4]tr...) Show SMILES COc1ccc(cc1)-c1cc2nnc(nc2s1)-c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...				Bioorg Med Chem 17: 3169-76 (2009) Article DOI: 10.1016/j.bmc.2009.02.049 BindingDB Entry DOI: 10.7270/Q24Q7TVW
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Homo sapiens (Human))	BDBM50256874 (CHEMBL475466 \| N-(benzo[d]thiazol-2-yl)-5-methoxy-...) Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)Nc1nc2ccccc2s1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...				Bioorg Med Chem 17: 3169-76 (2009) Article DOI: 10.1016/j.bmc.2009.02.049 BindingDB Entry DOI: 10.7270/Q24Q7TVW
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Homo sapiens (Human))	BDBM50066433 (CHEMBL112884 \| Hexadecanoic acid (R)-2-[(3-fluoro-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description In vitro inhibitory activity against bovine Phosphoinositide specific phospholipase C (PI-PLC)				J Med Chem 41: 3303-6 (1998) Article DOI: 10.1021/jm980254j BindingDB Entry DOI: 10.7270/Q2RJ4HMR
Georgetown University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Homo sapiens (Human))	BDBM50256805 (1-(2-Chloro-benzoyl)-3-(1,1-dioxo-1H-1lambda6-be...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...				Bioorg Med Chem 17: 3169-76 (2009) Article DOI: 10.1016/j.bmc.2009.02.049 BindingDB Entry DOI: 10.7270/Q24Q7TVW
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Homo sapiens (Human))	BDBM50066431 (((S)-3-Methoxy-4-octadecyloxy-butyl)-phosphonic ac...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description In vitro inhibitory activity against bovine Phosphoinositide specific phospholipase C (PI-PLC)				J Med Chem 41: 3303-6 (1998) Article DOI: 10.1021/jm980254j BindingDB Entry DOI: 10.7270/Q2RJ4HMR
Georgetown University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Homo sapiens (Human))	BDBM50256819 (2-(4-nitrophenyl)-4-(thiophen-2-ylmethylene)oxazol...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of recombinant phospholipase C gamma2 (unknown origin) expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemica...				Bioorg Med Chem 17: 3169-76 (2009) Article DOI: 10.1016/j.bmc.2009.02.049 BindingDB Entry DOI: 10.7270/Q24Q7TVW
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Homo sapiens (Human))	BDBM50451248 (CHEMBL2368948) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.99E+4	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description In vitro inhibitory activity against bovine Phosphoinositide specific phospholipase C (PI-PLC)				J Med Chem 41: 3303-6 (1998) Article DOI: 10.1021/jm980254j BindingDB Entry DOI: 10.7270/Q2RJ4HMR
Georgetown University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair