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Patent code US9284333

Compile Data Set for Download or QSAR

Found 390 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM218254
PNG
(US9284333, 16d | US9884860, Example 16d)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(C#N)c(Cl)c1 |r|
Show InChI InChI=1S/C24H27ClN4O3/c1-3-20(16-6-7-17(13-26)19(25)11-16)27-23(30)18-12-21(29-9-10-32-14-22(18)29)24(31)28-8-4-5-15(28)2/h6-7,11-12,15,20H,3-5,8-10,14H2,1-2H3,(H,27,30)/t15-,20+/m0/s1
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Sanofi

US Patent


Assay Description
The effect of compounds of the formula I on the cloned human cardiac hERG channel was evaluated in an in vitro model using a whole-cell patch-clampin...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218339
PNG
(US9284333, 16ce | US9884860, Example 16ce)
Show SMILES CCC(NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ncc(s1)C(F)(F)F |r|
Show InChI InChI=1S/C21H25F3N4O3S/c1-3-14(19-25-10-17(32-19)21(22,23)24)26-18(29)13-9-15(28-7-8-31-11-16(13)28)20(30)27-6-4-5-12(27)2/h9-10,12,14H,3-8,11H2,1-2H3,(H,26,29)/t12-,14?/m0/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218351
PNG
(US9284333, 16cq)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(cc1Cl)C(F)(F)F |r|
Show InChI InChI=1S/C24H27ClF3N3O3/c1-3-19(16-7-6-15(11-18(16)25)24(26,27)28)29-22(32)17-12-20(31-9-10-34-13-21(17)31)23(33)30-8-4-5-14(30)2/h6-7,11-12,14,19H,3-5,8-10,13H2,1-2H3,(H,29,32)/t14-,19+/m0/s1
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US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218254
PNG
(US9284333, 16d | US9884860, Example 16d)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(C#N)c(Cl)c1 |r|
Show InChI InChI=1S/C24H27ClN4O3/c1-3-20(16-6-7-17(13-26)19(25)11-16)27-23(30)18-12-21(29-9-10-32-14-22(18)29)24(31)28-8-4-5-15(28)2/h6-7,11-12,15,20H,3-5,8-10,14H2,1-2H3,(H,27,30)/t15-,20+/m0/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218364
PNG
(US9284333, 16dh | US9884860, Example 16dh)
Show SMILES Fc1ccc(cc1)[C@@H](NC(=O)c1cc(C(=O)N2CCCC2)n2CCOCc12)C1CC1 |r|
Show InChI InChI=1S/C23H26FN3O3/c24-17-7-5-16(6-8-17)21(15-3-4-15)25-22(28)18-13-19(23(29)26-9-1-2-10-26)27-11-12-30-14-20(18)27/h5-8,13,15,21H,1-4,9-12,14H2,(H,25,28)/t21-/m0/s1
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US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218375
PNG
(US9284333, 16dt | US9884860, Example 16dt)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)n2CCOCc12)c1cccnc1C(F)(F)F |r|
Show InChI InChI=1S/C26H26F4N4O3/c1-3-20(18-5-4-10-31-23(18)26(28,29)30)33-24(35)19-13-21(34-11-12-37-14-22(19)34)25(36)32-15(2)16-6-8-17(27)9-7-16/h4-10,13,15,20H,3,11-12,14H2,1-2H3,(H,32,36)(H,33,35)/t15-,20-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218607
PNG
(US9284333, 16eh | US9884860, Example 16eh)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCOCC2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C22H27N3O4/c1-2-18(16-6-4-3-5-7-16)23-21(26)17-14-19(25-10-13-29-15-20(17)25)22(27)24-8-11-28-12-9-24/h3-7,14,18H,2,8-13,15H2,1H3,(H,23,26)/t18-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218403
PNG
(US9284333, 16ez | US9884860, Example 16ez)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C(C)OC)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C25H33N3O4/c1-4-20(18-9-6-5-7-10-18)26-24(29)19-15-22(27-13-14-32-16-23(19)27)25(30)28-12-8-11-21(28)17(2)31-3/h5-7,9-10,15,17,20-21H,4,8,11-14,16H2,1-3H3,(H,26,29)/t17?,20-,21-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218409
PNG
(US9284333, 16fh | US9884860, Example 16fh)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2CNC(C)=O)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C25H32N4O4/c1-3-21(18-8-5-4-6-9-18)27-24(31)20-14-22(29-12-13-33-16-23(20)29)25(32)28-11-7-10-19(28)15-26-17(2)30/h4-6,8-9,14,19,21H,3,7,10-13,15-16H2,1-2H3,(H,26,30)(H,27,31)/t19-,21-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218431
PNG
(US9284333, 16gl | US9884860, Example 16gl)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C26H28FN3O3/c1-3-22(19-7-5-4-6-8-19)29-25(31)21-15-23(30-13-14-33-16-24(21)30)26(32)28-17(2)18-9-11-20(27)12-10-18/h4-12,15,17,22H,3,13-14,16H2,1-2H3,(H,28,32)(H,29,31)/t17-,22-/m1/s1
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US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218619
PNG
(US9284333, 16gm | US9884860, Example 16gm)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCCc2ccccn2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C25H28N4O3/c1-2-21(18-8-4-3-5-9-18)28-24(30)20-16-22(29-14-15-32-17-23(20)29)25(31)27-13-11-19-10-6-7-12-26-19/h3-10,12,16,21H,2,11,13-15,17H2,1H3,(H,27,31)(H,28,30)/t21-/m1/s1
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US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218450
PNG
(US9284333, 16hj | US9884860, Example 16hj)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCc2ncccn2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C23H25N5O3/c1-2-18(16-7-4-3-5-8-16)27-22(29)17-13-19(28-11-12-31-15-20(17)28)23(30)26-14-21-24-9-6-10-25-21/h3-10,13,18H,2,11-12,14-15H2,1H3,(H,26,30)(H,27,29)/t18-/m1/s1
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US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218461
PNG
(US9284333, 16hw | US9884860, Example 16hw)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](CC)c2cnccn2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C25H29N5O3/c1-3-19(17-8-6-5-7-9-17)28-24(31)18-14-22(30-12-13-33-16-23(18)30)25(32)29-20(4-2)21-15-26-10-11-27-21/h5-11,14-15,19-20H,3-4,12-13,16H2,1-2H3,(H,28,31)(H,29,32)/t19-,20-/m1/s1
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Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218452
PNG
(BDBM218469 | US9284333, 16hl | US9884860, Example ...)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NC(C)c2cnccn2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C24H27N5O3/c1-3-19(17-7-5-4-6-8-17)28-23(30)18-13-21(29-11-12-32-15-22(18)29)24(31)27-16(2)20-14-25-9-10-26-20/h4-10,13-14,16,19H,3,11-12,15H2,1-2H3,(H,27,31)(H,28,30)/t16?,19-/m1/s1
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US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218476
PNG
(US9284333, 16il | US9884860, Example 16il)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCc2nccs2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C22H24N4O3S/c1-2-17(15-6-4-3-5-7-15)25-21(27)16-12-18(26-9-10-29-14-19(16)26)22(28)24-13-20-23-8-11-30-20/h3-8,11-12,17H,2,9-10,13-14H2,1H3,(H,24,28)(H,25,27)/t17-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218493
PNG
(US9284333, 16jd | US9884860, Example 16jd)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCC(C)(C)O)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C22H29N3O4/c1-4-17(15-8-6-5-7-9-15)24-20(26)16-12-18(21(27)23-14-22(2,3)28)25-10-11-29-13-19(16)25/h5-9,12,17,28H,4,10-11,13-14H2,1-3H3,(H,23,27)(H,24,26)/t17-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218500
PNG
(US9284333, 16jk | US9884860, Example 16jk)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)Nc2c(C)noc2C)c2COCCn12)c1ccccc1 |r|
Show InChI InChI=1S/C23H26N4O4/c1-4-18(16-8-6-5-7-9-16)24-23(29)19-12-17(20-13-30-11-10-27(19)20)22(28)25-21-14(2)26-31-15(21)3/h5-9,12,18H,4,10-11,13H2,1-3H3,(H,24,29)(H,25,28)/t18-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218501
PNG
(US9284333, 16jl | US9884860, Example 16jl)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCc2c(C)noc2C)c2COCCn12)c1ccccc1 |r|
Show InChI InChI=1S/C24H28N4O4/c1-4-20(17-8-6-5-7-9-17)26-24(30)21-12-18(22-14-31-11-10-28(21)22)23(29)25-13-19-15(2)27-32-16(19)3/h5-9,12,20H,4,10-11,13-14H2,1-3H3,(H,25,29)(H,26,30)/t20-/m1/s1
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n/an/a 3.20E+3n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218504
PNG
(US9284333, 16jo)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](CC)c2ccc(OC)nc2)c2COCCn12)c1ccccc1 |r|
Show InChI InChI=1S/C27H32N4O4/c1-4-21(18-9-7-6-8-10-18)30-27(33)23-15-20(24-17-35-14-13-31(23)24)26(32)29-22(5-2)19-11-12-25(34-3)28-16-19/h6-12,15-16,21-22H,4-5,13-14,17H2,1-3H3,(H,29,32)(H,30,33)/t21-,22-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218261
PNG
(US9284333, 16k | US9884860, Example 16k)
Show SMILES CCOC(=O)CNC(=O)c1cc(C(=O)N[C@H](CC)c2ccccc2)c2COCCn12 |r|
Show InChI InChI=1S/C22H27N3O5/c1-3-17(15-8-6-5-7-9-15)24-21(27)16-12-18(25-10-11-29-14-19(16)25)22(28)23-13-20(26)30-4-2/h5-9,12,17H,3-4,10-11,13-14H2,1-2H3,(H,23,28)(H,24,27)/t17-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218524
PNG
(US9284333, 16ki | US9884860, Example 16kr)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)c2COCCn12)c1ccccc1 |r|
Show InChI InChI=1S/C23H29N3O3/c1-3-19(17-9-5-4-6-10-17)24-22(27)20-14-18(21-15-29-13-12-26(20)21)23(28)25-11-7-8-16(25)2/h4-6,9-10,14,16,19H,3,7-8,11-13,15H2,1-2H3,(H,24,27)/t16-,19+/m0/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218525
PNG
(US9284333, 16kj | US9884860, Example 16kj)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@H]2C)c2COCCn12)c1ccccc1 |r|
Show InChI InChI=1S/C23H29N3O3/c1-3-19(17-9-5-4-6-10-17)24-22(27)20-14-18(21-15-29-13-12-26(20)21)23(28)25-11-7-8-16(25)2/h4-6,9-10,14,16,19H,3,7-8,11-13,15H2,1-2H3,(H,24,27)/t16-,19-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218532
PNG
(US9284333, 16kq | US9884860, Example 16kq)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)c2COCCn12)c1ccccc1 |r|
Show InChI InChI=1S/C26H28FN3O3/c1-3-22(19-7-5-4-6-8-19)29-26(32)23-15-21(24-16-33-14-13-30(23)24)25(31)28-17(2)18-9-11-20(27)12-10-18/h4-12,15,17,22H,3,13-14,16H2,1-2H3,(H,28,31)(H,29,32)/t17-,22-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218537
PNG
(US9284333, 16kv | US9884860, Example 16kv)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](CC)c2ccccc2)n2CCSc12)c1ccccc1 |r|
Show InChI InChI=1S/C26H29N3O2S/c1-3-21(18-11-7-5-8-12-18)27-24(30)20-17-23(29-15-16-32-26(20)29)25(31)28-22(4-2)19-13-9-6-10-14-19/h5-14,17,21-22H,3-4,15-16H2,1-2H3,(H,27,30)(H,28,31)/t21-,22-/m1/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218538
PNG
(US9284333, 16kw | US9884860, Example 16kw)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)c2CSCn12)c1ccccc1 |r|
Show InChI InChI=1S/C25H26FN3O2S/c1-3-21(18-7-5-4-6-8-18)28-25(31)22-13-20(23-14-32-15-29(22)23)24(30)27-16(2)17-9-11-19(26)12-10-17/h4-13,16,21H,3,14-15H2,1-2H3,(H,27,30)(H,28,31)/t16-,21-/m1/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218622
PNG
(US9284333, 16lt | US9884860, Example 16lt)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@@H](C)c2ccc(F)cc2)n2CCCCc12)c1ccccc1 |r|
Show InChI InChI=1S/C27H30FN3O2/c1-3-23(20-9-5-4-6-10-20)30-26(32)22-17-25(31-16-8-7-11-24(22)31)27(33)29-18(2)19-12-14-21(28)15-13-19/h4-6,9-10,12-15,17-18,23H,3,7-8,11,16H2,1-2H3,(H,29,33)(H,30,32)/t18-,23+/m0/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218561
PNG
(US9284333, 16lv | US9884860, Example 16lv)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCCCc12)c1ccc(nc1)C#N |r|
Show InChI InChI=1S/C24H29N5O2/c1-3-20(17-9-10-18(14-25)26-15-17)27-23(30)19-13-22(29-11-5-4-8-21(19)29)24(31)28-12-6-7-16(28)2/h9-10,13,15-16,20H,3-8,11-12H2,1-2H3,(H,27,30)/t16-,20+/m0/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218628
PNG
(US9284333, 16mk)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CC[C@H](F)C2)n2CCCCc12)c1ccccc1 |r|
Show InChI InChI=1S/C23H28FN3O2/c1-2-19(16-8-4-3-5-9-16)25-22(28)18-14-21(27-12-7-6-10-20(18)27)23(29)26-13-11-17(24)15-26/h3-5,8-9,14,17,19H,2,6-7,10-13,15H2,1H3,(H,25,28)/t17-,19+/m0/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218638
PNG
(US9284333, 16mu | US9884860, Example 16mu)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N(C)Cc2ccc(F)cc2)n2CCCCc12)c1ccccc1 |r|
Show InChI InChI=1S/C27H30FN3O2/c1-3-23(20-9-5-4-6-10-20)29-26(32)22-17-25(31-16-8-7-11-24(22)31)27(33)30(2)18-19-12-14-21(28)15-13-19/h4-6,9-10,12-15,17,23H,3,7-8,11,16,18H2,1-2H3,(H,29,32)/t23-/m1/s1
PDB

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n/an/a 75n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218273
PNG
(US9284333, 16nf | US9884860, Example 16nf)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCc2ccccc2)n2CCCCc12)c1ccccc1 |r|
Show InChI InChI=1S/C26H29N3O2/c1-2-22(20-13-7-4-8-14-20)28-25(30)21-17-24(29-16-10-9-15-23(21)29)26(31)27-18-19-11-5-3-6-12-19/h3-8,11-14,17,22H,2,9-10,15-16,18H2,1H3,(H,27,31)(H,28,30)/t22-/m1/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218573
PNG
(US9284333, 16nh | US9884860, Example 16nh)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)c2COCCn12)c1ccccc1Cl |r|
Show InChI InChI=1S/C23H28ClN3O3/c1-3-19(16-8-4-5-9-18(16)24)25-22(28)20-13-17(21-14-30-12-11-27(20)21)23(29)26-10-6-7-15(26)2/h4-5,8-9,13,15,19H,3,6-7,10-12,14H2,1-2H3,(H,25,28)/t15-,19+/m0/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218585
PNG
(US9284333, 16nt | US9884860, Example 16nt)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCc2ccc(F)cc2F)c2COCCn12)c1cccc(OC)n1 |r|
Show InChI InChI=1S/C25H26F2N4O4/c1-3-19(20-5-4-6-23(29-20)34-2)30-25(33)21-12-17(22-14-35-10-9-31(21)22)24(32)28-13-15-7-8-16(26)11-18(15)27/h4-8,11-12,19H,3,9-10,13-14H2,1-2H3,(H,28,32)(H,30,33)/t19-/m1/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218587
PNG
(US9284333, 16nv | US9884860, Example 16nv)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)c2COCCn12)c1ncccn1 |r|
Show InChI InChI=1S/C24H26FN5O3/c1-3-19(22-26-9-4-10-27-22)29-24(32)20-13-18(21-14-33-12-11-30(20)21)23(31)28-15(2)16-5-7-17(25)8-6-16/h4-10,13,15,19H,3,11-12,14H2,1-2H3,(H,28,31)(H,29,32)/t15-,19-/m1/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218588
PNG
(US9284333, 16nw | US9884860, Example 16nw)
Show SMILES CC[C@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)c2COCCn12)c1ncccn1 |r|
Show InChI InChI=1S/C24H26FN5O3/c1-3-19(22-26-9-4-10-27-22)29-24(32)20-13-18(21-14-33-12-11-30(20)21)23(31)28-15(2)16-5-7-17(25)8-6-16/h4-10,13,15,19H,3,11-12,14H2,1-2H3,(H,28,31)(H,29,32)/t15-,19+/m1/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218589
PNG
(US9284333, 16nx | US9884860, Example 16nx)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CC(C)(C)OCc12)c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C26H32N4O3/c1-5-21(19-10-8-18(14-27)9-11-19)28-24(31)20-13-22(25(32)29-12-6-7-17(29)2)30-16-26(3,4)33-15-23(20)30/h8-11,13,17,21H,5-7,12,15-16H2,1-4H3,(H,28,31)/t17-,21+/m0/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218598
PNG
(US9284333, 16pg | US9884860, Example 16pg)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C23H28ClN3O3/c1-3-19(16-6-8-17(24)9-7-16)25-22(28)18-13-20(27-11-12-30-14-21(18)27)23(29)26-10-4-5-15(26)2/h6-9,13,15,19H,3-5,10-12,14H2,1-2H3,(H,25,28)/t15-,19+/m0/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218602
PNG
(US9284333, 16pk | US9284333, 16pl | US9884860, Exa...)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NC(C)c2cnccn2)c2COCCn12)c1ccc(F)cc1F |r|
Show InChI InChI=1S/C24H25F2N5O3/c1-3-19(16-5-4-15(25)10-18(16)26)30-24(33)21-11-17(22-13-34-9-8-31(21)22)23(32)29-14(2)20-12-27-6-7-28-20/h4-7,10-12,14,19H,3,8-9,13H2,1-2H3,(H,29,32)(H,30,33)/t14?,19-/m1/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218647
PNG
(US9284333, 16rc | US9884860, Example 16rc)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1cccs1 |r|
Show InChI InChI=1S/C21H27N3O3S/c1-3-16(19-7-5-11-28-19)22-20(25)15-12-17(24-9-10-27-13-18(15)24)21(26)23-8-4-6-14(23)2/h5,7,11-12,14,16H,3-4,6,8-10,13H2,1-2H3,(H,22,25)/t14-,16+/m0/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218661
PNG
(US9284333, 16rq)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NC(C)c2nnn(CC)n2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C23H29N7O3/c1-4-18(16-9-7-6-8-10-16)25-22(31)17-13-19(29-11-12-33-14-20(17)29)23(32)24-15(3)21-26-28-30(5-2)27-21/h6-10,13,15,18H,4-5,11-12,14H2,1-3H3,(H,24,32)(H,25,31)/t15?,18-/m1/s1
PDB

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n/an/a 750n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218282
PNG
(US9284333, 16w | US9884860, Example 16w)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1cc(F)ccc1Cl |r|
Show InChI InChI=1S/C23H27ClFN3O3/c1-3-19(16-11-15(25)6-7-18(16)24)26-22(29)17-12-20(28-9-10-31-13-21(17)28)23(30)27-8-4-5-14(27)2/h6-7,11-12,14,19H,3-5,8-10,13H2,1-2H3,(H,26,29)/t14-,19+/m0/s1
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n/an/a 40n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218291
PNG
(US9284333, 16ah | US9884860, Example 16ah)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1cccc(n1)C#N |r|
Show InChI InChI=1S/C23H27N5O3/c1-3-18(19-8-4-7-16(13-24)25-19)26-22(29)17-12-20(28-10-11-31-14-21(17)28)23(30)27-9-5-6-15(27)2/h4,7-8,12,15,18H,3,5-6,9-11,14H2,1-2H3,(H,26,29)/t15-,18+/m0/s1
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n/an/a 3.20E+3n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218304
PNG
(US9284333, 16au | US9884860, Example 16au)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(cc1)C(F)F |r|
Show InChI InChI=1S/C24H29F2N3O3/c1-3-19(16-6-8-17(9-7-16)22(25)26)27-23(30)18-13-20(29-11-12-32-14-21(18)29)24(31)28-10-4-5-15(28)2/h6-9,13,15,19,22H,3-5,10-12,14H2,1-2H3,(H,27,30)/t15-,19+/m0/s1
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n/an/a 340n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218306
PNG
(US9284333, 16aw | US9884860, Example 16aw)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(OC(F)(F)F)cc1 |r|
Show InChI InChI=1S/C24H28F3N3O4/c1-3-19(16-6-8-17(9-7-16)34-24(25,26)27)28-22(31)18-13-20(30-11-12-33-14-21(18)30)23(32)29-10-4-5-15(29)2/h6-9,13,15,19H,3-5,10-12,14H2,1-2H3,(H,28,31)/t15-,19+/m0/s1
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n/an/a 280n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218309
PNG
(US9284333, 16az | US9884860, Example 16az)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H28FN3O3/c1-3-19(16-6-8-17(24)9-7-16)25-22(28)18-13-20(27-11-12-30-14-21(18)27)23(29)26-10-4-5-15(26)2/h6-9,13,15,19H,3-5,10-12,14H2,1-2H3,(H,25,28)/t15-,19+/m0/s1
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n/an/a 120n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218312
PNG
(US9284333, 16bc | US9884860, Example 16bc)
Show SMILES CCC(NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(cc1)C(C)(F)F |r|
Show InChI InChI=1S/C25H31F2N3O3/c1-4-20(17-7-9-18(10-8-17)25(3,26)27)28-23(31)19-14-21(30-12-13-33-15-22(19)30)24(32)29-11-5-6-16(29)2/h7-10,14,16,20H,4-6,11-13,15H2,1-3H3,(H,28,31)/t16-,20?/m0/s1
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n/an/a 550n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218319
PNG
(US9284333, 16bj | US9884860, Example 16bj)
Show SMILES CC[C@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(nc1)C(F)(F)F |r|
Show InChI InChI=1S/C23H27F3N4O3/c1-3-17(15-6-7-20(27-12-15)23(24,25)26)28-21(31)16-11-18(30-9-10-33-13-19(16)30)22(32)29-8-4-5-14(29)2/h6-7,11-12,14,17H,3-5,8-10,13H2,1-2H3,(H,28,31)/t14-,17-/m0/s1
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n/an/a 4.10E+3n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218335
PNG
(US9284333, 16ca | US9884860, Example 16ca)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1cc(F)c(C#N)c(F)c1 |r|
Show InChI InChI=1S/C24H26F2N4O3/c1-3-20(15-9-18(25)17(12-27)19(26)10-15)28-23(31)16-11-21(30-7-8-33-13-22(16)30)24(32)29-6-4-5-14(29)2/h9-11,14,20H,3-8,13H2,1-2H3,(H,28,31)/t14-,20+/m0/s1
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n/an/a 340n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM218260
PNG
(US9284333, 16j | US9884860, Example 16j)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](CC)c2ccc(OC)nc2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C27H32N4O4/c1-4-21(18-9-7-6-8-10-18)29-26(32)20-15-23(31-13-14-35-17-24(20)31)27(33)30-22(5-2)19-11-12-25(34-3)28-16-19/h6-12,15-16,21-22H,4-5,13-14,17H2,1-3H3,(H,29,32)(H,30,33)/t21-,22-/m1/s1
PDB
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Sanofi

US Patent


Assay Description
The effect of compounds of the formula I on the cloned human cardiac hERG channel was evaluated in an in vitro model using a whole-cell patch-clampin...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218352
PNG
(US9284333, 16cs | US9884860, Example 16cs)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(Cl)c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C24H27ClF3N3O3/c1-3-19(15-6-7-18(25)17(11-15)24(26,27)28)29-22(32)16-12-20(31-9-10-34-13-21(16)31)23(33)30-8-4-5-14(30)2/h6-7,11-12,14,19H,3-5,8-10,13H2,1-2H3,(H,29,32)/t14-,19+/m0/s1
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n/an/a 290n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218353
PNG
(US9284333, 16ct | US9884860, Example 16ct)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(cc1F)C(F)(F)F |r|
Show InChI InChI=1S/C24H27F4N3O3/c1-3-19(16-7-6-15(11-18(16)25)24(26,27)28)29-22(32)17-12-20(31-9-10-34-13-21(17)31)23(33)30-8-4-5-14(30)2/h6-7,11-12,14,19H,3-5,8-10,13H2,1-2H3,(H,29,32)/t14-,19+/m0/s1
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n/an/a 210n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%