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Patent code US10174035

Compile Data Set for Download or QSAR

Found 234 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM320456
PNG
(US10174035, Compound 3 | [2-(1-Methyl-1H-pyrazol-4...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC2(COC2)CC1
Show InChI InChI=1S/C21H26N8O3/c1-27-11-14(10-22-27)16-24-17-15(19(26-16)28-6-8-31-9-7-28)23-18(25-17)20(30)29-4-2-21(3-5-29)12-32-13-21/h10-11H,2-9,12-13H2,1H3,(H,23,24,25,26)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM320461
PNG
(2-(4-{[2-(1,3-Dimethyl-1H-pyrazol-4-yl)-6-(morphol...)
Show SMILES Cc1nn(C)cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCN(CC1)C(C)(C)C(N)=O
Show InChI InChI=1S/C23H32N10O3/c1-14-15(13-30(4)29-14)17-26-18-16(20(28-17)31-9-11-36-12-10-31)25-19(27-18)21(34)32-5-7-33(8-6-32)23(2,3)22(24)35/h13H,5-12H2,1-4H3,(H2,24,35)(H,25,26,27,28)
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n/an/a 6.48E+3n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM320464
PNG
(2-Methyl-2-(4-{[2-(1-methyl-1H-pyrazol-4-yl)-6-(mo...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCN(CC1)C(C)(C)C(N)=O
Show InChI InChI=1S/C22H30N10O3/c1-22(2,21(23)34)32-6-4-31(5-7-32)20(33)18-25-15-17(27-18)26-16(14-12-24-29(3)13-14)28-19(15)30-8-10-35-11-9-30/h12-13H,4-11H2,1-3H3,(H2,23,34)(H,25,26,27,28)
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n/an/a 251n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM320473
PNG
(US10174035, Compound 19 | [4-(Morpholin-4-yl)piper...)
Show SMILES FC(F)(F)c1n[nH]cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C23H28F3N9O3/c24-23(25,26)17-15(13-27-32-17)18-29-19-16(21(31-18)34-7-11-38-12-8-34)28-20(30-19)22(36)35-3-1-14(2-4-35)33-5-9-37-10-6-33/h13-14H,1-12H2,(H,27,32)(H,28,29,30,31)
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n/an/a 4.05E+3n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320495
PNG
(US10174035, Compound 41 | [2-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C24H33N9O3/c1-16-18(15-30(2)29-16)20-26-21-19(23(28-20)32-9-13-36-14-10-32)25-22(27-21)24(34)33-5-3-17(4-6-33)31-7-11-35-12-8-31/h15,17H,3-14H2,1-2H3,(H,25,26,27,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM320519
PNG
(US10174035, Compound 65 | {4-[cis-2,6-Dimethylmorp...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(nc(nc2[nH]1)-c1cn[nH]c1)N1CCOCC1
Show InChI InChI=1S/C24H33N9O3/c1-15-13-33(14-16(2)36-15)18-3-5-32(6-4-18)24(34)22-27-19-21(29-22)28-20(17-11-25-26-12-17)30-23(19)31-7-9-35-10-8-31/h11-12,15-16,18H,3-10,13-14H2,1-2H3,(H,25,26)(H,27,28,29,30)/t15-,16+
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM320527
PNG
(US10174035, Compound 72 | [6-(Morpholin-4-yl)-2-(1...)
Show SMILES O=C(N1CCC2(COC2)CC1)c1nc2c(nc(nc2[nH]1)-c1cn[nH]c1)N1CCOCC1
Show InChI InChI=1S/C20H24N8O3/c29-19(28-3-1-20(2-4-28)11-31-12-20)17-23-14-16(25-17)24-15(13-9-21-22-10-13)26-18(14)27-5-7-30-8-6-27/h9-10H,1-8,11-12H2,(H,21,22)(H,23,24,25,26)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM320542
PNG
(1-{[5-(1,3-Dimethyl-1H-pyrazol-4-yl)-6-fluoro-7-(m...)
Show SMILES Cc1nn(C)cc1-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(CC1)C(N)=O
Show InChI InChI=1S/C22H27FN8O3/c1-12-14(11-29(2)28-12)16-15(23)18(30-7-9-34-10-8-30)17-20(25-16)27-21(26-17)22(33)31-5-3-13(4-6-31)19(24)32/h11,13H,3-10H2,1-2H3,(H2,24,32)(H,25,26,27)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))		BDBM320543
PNG
(US10174035, Compound 86 | [5-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(O)CC1
Show InChI InChI=1S/C21H26FN7O3/c1-12-14(11-27(2)26-12)16-15(22)18(28-7-9-32-10-8-28)17-19(23-16)25-20(24-17)21(31)29-5-3-13(30)4-6-29/h11,13,30H,3-10H2,1-2H3,(H,23,24,25)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM320543
PNG
(US10174035, Compound 86 | [5-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(O)CC1
Show InChI InChI=1S/C21H26FN7O3/c1-12-14(11-27(2)26-12)16-15(22)18(28-7-9-32-10-8-28)17-19(23-16)25-20(24-17)21(31)29-5-3-13(30)4-6-29/h11,13,30H,3-10H2,1-2H3,(H,23,24,25)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM320544
PNG
(US10174035, Compound 87 | [5-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1nc2n(C)c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C26H35FN8O3/c1-17-19(16-31(2)30-17)21-20(27)23(34-10-14-38-15-11-34)22-24(28-21)32(3)25(29-22)26(36)35-6-4-18(5-7-35)33-8-12-37-13-9-33/h16,18H,4-15H2,1-3H3
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))		BDBM320570
PNG
(US10174035, Compound 113 | {4-[cis-2,6-Dimethylmor...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(cc(nc2[nH]1)-c1cn(C)nc1C)N1CCOCC1
Show InChI InChI=1S/C27H38N8O3/c1-17-14-35(15-18(2)38-17)20-5-7-34(8-6-20)27(36)26-29-24-23(33-9-11-37-12-10-33)13-22(28-25(24)30-26)21-16-32(4)31-19(21)3/h13,16-18,20H,5-12,14-15H2,1-4H3,(H,28,29,30)/t17-,18+
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n/an/a 1.15E+3n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320469
PNG
((1,1-Dioxidothiomorpholin-4-yl)[2-(1-methyl-1H-pyr...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCS(=O)(=O)CC1
Show InChI InChI=1S/C18H22N8O4S/c1-24-11-12(10-19-24)14-21-15-13(17(23-14)25-2-6-30-7-3-25)20-16(22-15)18(27)26-4-8-31(28,29)9-5-26/h10-11H,2-9H2,1H3,(H,20,21,22,23)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320474
PNG
(US10174035, Compound 20 | [2-(1-Methyl-1H-pyrazol-...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCNCC1
Show InChI InChI=1S/C18H23N9O2/c1-25-11-12(10-20-25)14-22-15-13(17(24-14)26-6-8-29-9-7-26)21-16(23-15)18(28)27-4-2-19-3-5-27/h10-11,19H,2-9H2,1H3,(H,21,22,23,24)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320476
PNG
(US10174035, Compound 22 | [9-Ethyl-2-(1-methyl-1-p...)
Show SMILES CCn1c(nc2C(N3CCOCC3)[N](C)(C=Nc12)c1cn[nH]c1)C1CC(CCN1C=O)N1CCOCC1 |c:16|
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320478
PNG
(US10174035, Compound 24 | [4-(Dimethylamino)piperi...)
Show SMILES CN(C)C1CCN(CC1)C(=O)c1nc2c(nc(nc2n1C)-c1cnn(C)c1)N1CCOCC1
Show InChI InChI=1S/C22H31N9O2/c1-27(2)16-5-7-31(8-6-16)22(32)21-24-17-19(29(21)4)25-18(15-13-23-28(3)14-15)26-20(17)30-9-11-33-12-10-30/h13-14,16H,5-12H2,1-4H3
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320508
PNG
(US10174035, Compound 54 | [4-(Dimethylamino)piperi...)
Show SMILES CN(C)C1CCN(CC1)C(=O)c1nc2c(nc(nc2[nH]1)-c1cn[nH]c1)N1CCOCC1
Show InChI InChI=1S/C20H27N9O2/c1-27(2)14-3-5-29(6-4-14)20(30)18-23-15-17(25-18)24-16(13-11-21-22-12-13)26-19(15)28-7-9-31-10-8-28/h11-12,14H,3-10H2,1-2H3,(H,21,22)(H,23,24,25,26)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320529
PNG
(4-(1-{[6-(Morpholin-4-yl)-2-(1H-pyrazol-4-yl)-9H-p...)
Show SMILES O=C(N1CCC(CC1)N1CCOCC1=O)c1nc2c(nc(nc2[nH]1)-c1cn[nH]c1)N1CCOCC1
Show InChI InChI=1S/C22H27N9O4/c32-16-13-35-10-7-31(16)15-1-3-30(4-2-15)22(33)20-25-17-19(27-20)26-18(14-11-23-24-12-14)28-21(17)29-5-8-34-9-6-29/h11-12,15H,1-10,13H2,(H,23,24)(H,25,26,27,28)
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n/an/a 8n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320534
PNG
(US10174035, Compound 78 | [5-(1-Methyl-1H-pyrazol-...)
Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC2(COC2)CC1
Show InChI InChI=1S/C22H27N7O3/c1-27-12-15(11-23-27)16-10-17(28-6-8-31-9-7-28)18-19(24-16)26-20(25-18)21(30)29-4-2-22(3-5-29)13-32-14-22/h10-12H,2-9,13-14H2,1H3,(H,24,25,26)
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n/an/a 13n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320545
PNG
(US10174035, Compound 88 | [6-Methyl-7-(morpholin-4...)
Show SMILES Cc1nn(C)c(C)c1-c1nc2[nH]c(nc2c(N2CCOCC2)c1C)C(=O)N1CCC(CC1)N1CCOCC1 |(-3.68,-6.05,;-4.83,-5.02,;-6.33,-5.34,;-7.1,-4.01,;-8.63,-3.85,;-6.07,-2.86,;-6.39,-1.36,;-4.67,-3.49,;-3.33,-2.72,;-2,-3.49,;-.66,-2.72,;.8,-3.2,;1.7,-1.95,;.8,-.7,;-.66,-1.18,;-2,-.41,;-2,1.13,;-3.33,1.9,;-3.33,3.44,;-2,4.21,;-.66,3.44,;-.66,1.9,;-3.33,-1.18,;-4.67,-.41,;3.24,-1.95,;4.01,-3.28,;4.01,-.62,;3.24,.72,;4.01,2.05,;5.55,2.05,;6.32,.72,;5.55,-.62,;6.32,3.38,;5.55,4.72,;6.32,6.05,;7.86,6.05,;8.63,4.72,;7.86,3.38,)|
Show InChI InChI=1S/C27H38N8O3/c1-17-22(21-18(2)31-32(4)19(21)3)28-25-23(24(17)34-11-15-38-16-12-34)29-26(30-25)27(36)35-7-5-20(6-8-35)33-9-13-37-14-10-33/h20H,5-16H2,1-4H3,(H,28,29,30)
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n/an/a 365n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320550
PNG
(US10174035, Compound 93 | [6-Fluoro-7-(morpholin-4...)
Show SMILES Cc1nn(C)c(C)c1-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(CC1)N1CCOCC1 |(-3.68,-6.05,;-4.83,-5.02,;-6.33,-5.34,;-7.1,-4.01,;-8.63,-3.85,;-6.07,-2.86,;-6.39,-1.36,;-4.67,-3.49,;-3.33,-2.72,;-2,-3.49,;-.66,-2.72,;.8,-3.2,;1.7,-1.95,;.8,-.7,;-.66,-1.18,;-2,-.41,;-2,1.13,;-3.33,1.9,;-3.33,3.44,;-2,4.21,;-.66,3.44,;-.66,1.9,;-3.33,-1.18,;-4.67,-.41,;3.24,-1.95,;4.01,-3.28,;4.01,-.62,;3.24,.72,;4.01,2.05,;5.55,2.05,;6.32,.72,;5.55,-.62,;6.32,3.38,;5.55,4.72,;6.32,6.05,;7.86,6.05,;8.63,4.72,;7.86,3.38,)|
Show InChI InChI=1S/C26H35FN8O3/c1-16-19(17(2)32(3)31-16)21-20(27)23(34-10-14-38-15-11-34)22-24(28-21)30-25(29-22)26(36)35-6-4-18(5-7-35)33-8-12-37-13-9-33/h18H,4-15H2,1-3H3,(H,28,29,30)
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n/an/a 26n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320557
PNG
(US10174035, Compound 100 | [4-(Dimethylamino)piper...)
Show SMILES CN(C)C1CCN(CC1)C(=O)c1nc2c(cc(nc2n1C)-c1cnn(C)c1)N1CCOCC1
Show InChI InChI=1S/C23H32N8O2/c1-27(2)17-5-7-31(8-6-17)23(32)22-26-20-19(30-9-11-33-12-10-30)13-18(25-21(20)29(22)4)16-14-24-28(3)15-16/h13-15,17H,5-12H2,1-4H3
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n/an/a 64n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320573
PNG
(5-(1-Methyl-1H-pyrazol-4-yl)-7-(morpholin-4-yl)-N-...)
Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C22H28N8O3/c1-28-14-15(13-24-28)16-12-17(29-8-10-33-11-9-29)19-20(25-16)27-21(26-19)22(32)23-5-3-7-30-6-2-4-18(30)31/h12-14H,2-11H2,1H3,(H,23,32)(H,25,26,27)
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n/an/a 19n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320574
PNG
(US10174035, Compound 117 | [4-(2-Hydroxypropan-2-y...)
Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)C(C)(C)O
Show InChI InChI=1S/C23H31N7O3/c1-23(2,32)16-4-6-30(7-5-16)22(31)21-26-19-18(29-8-10-33-11-9-29)12-17(25-20(19)27-21)15-13-24-28(3)14-15/h12-14,16,32H,4-11H2,1-3H3,(H,25,26,27)
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n/an/a 122n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320575
PNG
(US10174035, Compound 118 | {4-[cis-2,6-Dimethylmor...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(cc(nc2[nH]1)-c1cn[nH]c1)N1CCOCC1
Show InChI InChI=1S/C25H34N8O3/c1-16-14-33(15-17(2)36-16)19-3-5-32(6-4-19)25(34)24-29-22-21(31-7-9-35-10-8-31)11-20(28-23(22)30-24)18-12-26-27-13-18/h11-13,16-17,19H,3-10,14-15H2,1-2H3,(H,26,27)(H,28,29,30)/t16-,17+
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n/an/a 50n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320578
PNG
(N-methyl-5-(1-methyl-1H-pyrazol-4-yl)-7-(morpholin...)
Show SMILES CN(C1CCN(CC1)C1CCOCC1)C(=O)c1nc2c(cc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1
Show InChI InChI=1S/C26H36N8O3/c1-31-17-18(16-27-31)21-15-22(34-9-13-37-14-10-34)23-24(28-21)30-25(29-23)26(35)32(2)19-3-7-33(8-4-19)20-5-11-36-12-6-20/h15-17,19-20H,3-14H2,1-2H3,(H,28,29,30)
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n/an/a 52n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320582
PNG
(US10174035, Compound 125 | [6-Fluoro-7-(morpholin-...)
Show SMILES Fc1c(nc2[nH]c(nc2c1N1CCOCC1)C(=O)N1CCC(CC1)N1CCOCC1)-c1cn[nH]c1
Show InChI InChI=1S/C23H29FN8O3/c24-17-18(15-13-25-26-14-15)27-21-19(20(17)31-7-11-35-12-8-31)28-22(29-21)23(33)32-3-1-16(2-4-32)30-5-9-34-10-6-30/h13-14,16H,1-12H2,(H,25,26)(H,27,28,29)
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n/an/a 43n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320495
PNG
(US10174035, Compound 41 | [2-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C24H33N9O3/c1-16-18(15-30(2)29-16)20-26-21-19(23(28-20)32-9-13-36-14-10-32)25-22(27-21)24(34)33-5-3-17(4-6-33)31-7-11-35-12-8-31/h15,17H,3-14H2,1-2H3,(H,25,26,27,28)
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n/an/a 14n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM320456
PNG
(US10174035, Compound 3 | [2-(1-Methyl-1H-pyrazol-4...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC2(COC2)CC1
Show InChI InChI=1S/C21H26N8O3/c1-27-11-14(10-22-27)16-24-17-15(19(26-16)28-6-8-31-9-7-28)23-18(25-17)20(30)29-4-2-21(3-5-29)12-32-13-21/h10-11H,2-9,12-13H2,1H3,(H,23,24,25,26)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))		BDBM320461
PNG
(2-(4-{[2-(1,3-Dimethyl-1H-pyrazol-4-yl)-6-(morphol...)
Show SMILES Cc1nn(C)cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCN(CC1)C(C)(C)C(N)=O
Show InChI InChI=1S/C23H32N10O3/c1-14-15(13-30(4)29-14)17-26-18-16(20(28-17)31-9-11-36-12-10-31)25-19(27-18)21(34)32-5-7-33(8-6-32)23(2,3)22(24)35/h13H,5-12H2,1-4H3,(H2,24,35)(H,25,26,27,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM320495
PNG
(US10174035, Compound 41 | [2-(1,3-Dimethyl-1H-pyra...)
Show SMILES Cc1nn(C)cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C24H33N9O3/c1-16-18(15-30(2)29-16)20-26-21-19(23(28-20)32-9-13-36-14-10-32)25-22(27-21)24(34)33-5-3-17(4-6-33)31-7-11-35-12-8-31/h15,17H,3-14H2,1-2H3,(H,25,26,27,28)
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n/an/a 8.82E+3n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320518
PNG
(2-(1-Methyl-1H-pyrazol-4-yl)-N-{2-[1-methylpyrroli...)
Show SMILES CN1CCCC1CCNC(=O)c1nc2c(nc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1
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n/an/a 17n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))		BDBM320519
PNG
(US10174035, Compound 65 | {4-[cis-2,6-Dimethylmorp...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(nc(nc2[nH]1)-c1cn[nH]c1)N1CCOCC1
Show InChI InChI=1S/C24H33N9O3/c1-15-13-33(14-16(2)36-15)18-3-5-32(6-4-18)24(34)22-27-19-21(29-22)28-20(17-11-25-26-12-17)30-23(19)31-7-9-35-10-8-31/h11-12,15-16,18H,3-10,13-14H2,1-2H3,(H,25,26)(H,27,28,29,30)/t15-,16+
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM320519
PNG
(US10174035, Compound 65 | {4-[cis-2,6-Dimethylmorp...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(nc(nc2[nH]1)-c1cn[nH]c1)N1CCOCC1
Show InChI InChI=1S/C24H33N9O3/c1-15-13-33(14-16(2)36-15)18-3-5-32(6-4-18)24(34)22-27-19-21(29-22)28-20(17-11-25-26-12-17)30-23(19)31-7-9-35-10-8-31/h11-12,15-16,18H,3-10,13-14H2,1-2H3,(H,25,26)(H,27,28,29,30)/t15-,16+
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n/an/a 9.77E+3n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM320521
PNG
(9-Methyl-2-(1-methyl-1H-pyrazol-4-yl)-6-(morpholin...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc(C(=O)NCCCN3CCOCC3)n(C)c2n1
Show InChI InChI=1S/C22H31N9O3/c1-28-15-16(14-24-28)18-26-19-17(20(27-18)31-8-12-34-13-9-31)25-21(29(19)2)22(32)23-4-3-5-30-6-10-33-11-7-30/h14-15H,3-13H2,1-2H3,(H,23,32)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))		BDBM320530
PNG
(N-{3-[cis-2,6-dimethylmorpholin-4-yl]propyl}-2-(1-...)
Show SMILES C[C@H]1CN(CCCNC(=O)c2nc3c(nc(nc3[nH]2)-c2cnn(C)c2)N2CCOCC2)C[C@@H](C)O1
Show InChI InChI=1S/C23H33N9O3/c1-15-12-31(13-16(2)35-15)6-4-5-24-23(33)21-26-18-20(28-21)27-19(17-11-25-30(3)14-17)29-22(18)32-7-9-34-10-8-32/h11,14-16H,4-10,12-13H2,1-3H3,(H,24,33)(H,26,27,28,29)/t15-,16+
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM320534
PNG
(US10174035, Compound 78 | [5-(1-Methyl-1H-pyrazol-...)
Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC2(COC2)CC1
Show InChI InChI=1S/C22H27N7O3/c1-27-12-15(11-23-27)16-10-17(28-6-8-31-9-7-28)18-19(24-16)26-20(25-18)21(30)29-4-2-22(3-5-29)13-32-14-22/h10-12H,2-9,13-14H2,1H3,(H,24,25,26)
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n/an/a 2.19E+3n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))		BDBM320538
PNG
(2-(4-{[6-Fluoro-5-(1-methyl-1H-pyrazol-4-yl)-7-(mo...)
Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCN(CC1)C(C)(C)C(N)=O
Show InChI InChI=1S/C23H30FN9O3/c1-23(2,22(25)35)33-6-4-32(5-7-33)21(34)20-28-17-18(31-8-10-36-11-9-31)15(24)16(27-19(17)29-20)14-12-26-30(3)13-14/h12-13H,4-11H2,1-3H3,(H2,25,35)(H,27,28,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM320554
PNG
(US10174035, Compound 97 | [4-(Dimethylamino)piperi...)
Show SMILES CN(C)C1CCN(CC1)C(=O)c1nc2c(N3CCOCC3)c(F)c(nc2[nH]1)-c1cn(C)nc1C
Show InChI InChI=1S/C23H31FN8O2/c1-14-16(13-30(4)28-14)18-17(24)20(31-9-11-34-12-10-31)19-21(25-18)27-22(26-19)23(33)32-7-5-15(6-8-32)29(2)3/h13,15H,5-12H2,1-4H3,(H,25,26,27)
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n/an/a 1.08E+3n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))		BDBM320555
PNG
(US10174035, Compound 98 | [6-Fluoro-5-(1-methyl-1H...)
Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C24H31FN8O3/c1-30-15-16(14-26-30)19-18(25)21(32-8-12-36-13-9-32)20-22(27-19)29-23(28-20)24(34)33-4-2-17(3-5-33)31-6-10-35-11-7-31/h14-15,17H,2-13H2,1H3,(H,27,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))		BDBM320573
PNG
(5-(1-Methyl-1H-pyrazol-4-yl)-7-(morpholin-4-yl)-N-...)
Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C22H28N8O3/c1-28-14-15(13-24-28)16-12-17(29-8-10-33-11-9-29)19-20(25-16)27-21(26-19)22(32)23-5-3-7-30-6-2-4-18(30)31/h12-14H,2-11H2,1H3,(H,23,32)(H,25,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM320573
PNG
(5-(1-Methyl-1H-pyrazol-4-yl)-7-(morpholin-4-yl)-N-...)
Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C22H28N8O3/c1-28-14-15(13-24-28)16-12-17(29-8-10-33-11-9-29)19-20(25-16)27-21(26-19)22(32)23-5-3-7-30-6-2-4-18(30)31/h12-14H,2-11H2,1H3,(H,23,32)(H,25,26,27)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320573
PNG
(5-(1-Methyl-1H-pyrazol-4-yl)-7-(morpholin-4-yl)-N-...)
Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C22H28N8O3/c1-28-14-15(13-24-28)16-12-17(29-8-10-33-11-9-29)19-20(25-16)27-21(26-19)22(32)23-5-3-7-30-6-2-4-18(30)31/h12-14H,2-11H2,1H3,(H,23,32)(H,25,26,27)
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n/an/a 19n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320467
PNG
(US10174035, Compound 13 | [2-(1-Methyl-1H-pyrazol-...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC[C@@H](C1)N1CCOCC1
Show InChI InChI=1S/C23H31N9O3/c1-29-14-16(13-24-29)19-26-20-18(22(28-19)31-7-11-35-12-8-31)25-21(27-20)23(33)32-4-2-3-17(15-32)30-5-9-34-10-6-30/h13-14,17H,2-12,15H2,1H3,(H,25,26,27,28)/t17-/m0/s1
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320470
PNG
(US10174035, Compound 16 | [2-(3,5-Dimethyl-1H-pyra...)
Show SMILES Cc1n[nH]c(C)c1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C24H33N9O3/c1-15-18(16(2)30-29-15)20-26-21-19(23(28-20)32-9-13-36-14-10-32)25-22(27-21)24(34)33-5-3-17(4-6-33)31-7-11-35-12-8-31/h17H,3-14H2,1-2H3,(H,29,30)(H,25,26,27,28)
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n/an/a 88n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320473
PNG
(US10174035, Compound 19 | [4-(Morpholin-4-yl)piper...)
Show SMILES FC(F)(F)c1n[nH]cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C23H28F3N9O3/c24-23(25,26)17-15(13-27-32-17)18-29-19-16(21(31-18)34-7-11-38-12-8-34)28-20(30-19)22(36)35-3-1-14(2-4-35)33-5-9-37-10-6-33/h13-14H,1-12H2,(H,27,32)(H,28,29,30,31)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320479
PNG
(US10174035, Compound 25 | [2-(1-Methyl-1H-pyrazol-...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCN(CC1)C(=O)c1ncccn1
Show InChI InChI=1S/C23H25N11O3/c1-31-14-15(13-26-31)17-28-18-16(21(30-17)32-9-11-37-12-10-32)27-20(29-18)23(36)34-7-5-33(6-8-34)22(35)19-24-3-2-4-25-19/h2-4,13-14H,5-12H2,1H3,(H,27,28,29,30)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320486
PNG
(US10174035, Compound 32 | [2-(1-Methyl-1H-pyrazol-...)
Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C24H27N9O2/c1-30-16-17(15-25-30)20-27-21-19(23(29-20)32-11-13-35-14-12-32)26-22(28-21)24(34)33-9-7-31(8-10-33)18-5-3-2-4-6-18/h2-6,15-16H,7-14H2,1H3,(H,26,27,28,29)
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n/an/a 56n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320493
PNG
(1-(4-{[2-(1-Methyl-1H-pyrazol-4-yl)-6-(morpholin-4...)
Show SMILES CC(=O)N1CCN(CC1)C(=O)c1nc2c(nc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1
Show InChI InChI=1S/C20H25N9O3/c1-13(30)27-3-5-29(6-4-27)20(31)18-22-15-17(24-18)23-16(14-11-21-26(2)12-14)25-19(15)28-7-9-32-10-8-28/h11-12H,3-10H2,1-2H3,(H,22,23,24,25)
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n/an/a 26n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM320494
PNG
(US10174035, Compound 40 | [2-(1,5-Dimethyl-1H-pyra...)
Show SMILES Cc1c(cnn1C)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C24H33N9O3/c1-16-18(15-25-30(16)2)20-27-21-19(23(29-20)32-9-13-36-14-10-32)26-22(28-21)24(34)33-5-3-17(4-6-33)31-7-11-35-12-8-31/h15,17H,3-14H2,1-2H3,(H,26,27,28,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...

US Patent US10174035 (2019)


BindingDB Entry DOI: 10.7270/Q2FB552Z
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 234 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%