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Patent code US10793574

Compile Data Set for Download or QSAR
Found 1 hit of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM50271150
PNG
(CHEMBL4127116)
Show SMILES CC(Nc1cc(F)cc(F)c1)c1cc(cc2ncc(nc12)N1CCOCC1)C(=O)NCCN(C)C
Show InChI InChI=1S/C25H30F2N6O2/c1-16(30-20-13-18(26)12-19(27)14-20)21-10-17(25(34)28-4-5-32(2)3)11-22-24(21)31-23(15-29-22)33-6-8-35-9-7-33/h10-16,30H,4-9H2,1-3H3,(H,28,34)
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 2.51E+3n/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Binding affinity to wild-type human PIK3Calpha (R108 to N1068 residues) expressed in mammalian expression system by KINOMEScan assay

ACS Med Chem Lett 8: 778-780 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00254
BindingDB Entry DOI: 10.7270/Q2TT4TFM
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%