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Patent code US10864192

Compile Data Set for Download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Acetylcholinesterase


(Homo sapiens (Human))		BDBM476179
PNG
((−)-N1, N8-bisnorphenylcarbamoyleseroline | ...)
Show SMILES C[C@@]12CCN[C@@H]1Nc1ccc(OC(=O)Nc3ccccc3)cc21 |r|
Show InChI InChI=1S/C18H19N3O2/c1-18-9-10-19-16(18)21-15-8-7-13(11-14(15)18)23-17(22)20-12-5-3-2-4-6-12/h2-8,11,16,19,21H,9-10H2,1H3,(H,20,22)/t16-,18+/m1/s1
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US Patent
n/an/an/an/a 100n/an/an/an/a



Aristea Translational Medicine Corporation

US Patent


Assay Description
To address these issues, the present disclosure relates to the development and utilization of a (−)-phenserine extended release formulation. To...

US Patent US10864192 (2020)


BindingDB Entry DOI: 10.7270/Q2TT4V23
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Homo sapiens (Human))		BDBM476174
PNG
((−)-N1-norphenylcarbamoyleseroline | US10864...)
Show SMILES CN1[C@H]2NCC[C@@]2(C)c2cc(OC(=O)Nc3ccccc3)ccc12 |r|
Show InChI InChI=1S/C19H21N3O2/c1-19-10-11-20-17(19)22(2)16-9-8-14(12-15(16)19)24-18(23)21-13-6-4-3-5-7-13/h3-9,12,17,20H,10-11H2,1-2H3,(H,21,23)/t17-,19+/m1/s1
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US Patent
n/an/an/an/a 62n/an/an/an/a



Aristea Translational Medicine Corporation

US Patent


Assay Description
To address these issues, the present disclosure relates to the development and utilization of a (−)-phenserine extended release formulation. To...

US Patent US10864192 (2020)


BindingDB Entry DOI: 10.7270/Q2TT4V23
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Homo sapiens (Human))		BDBM10958
PNG
((3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyr...)
Show SMILES [H][C@]12N(C)CC[C@@]1(C)c1cc(OC(=O)Nc3ccccc3)ccc1N2C |r|
Show InChI InChI=1S/C20H23N3O2/c1-20-11-12-22(2)18(20)23(3)17-10-9-15(13-16(17)20)25-19(24)21-14-7-5-4-6-8-14/h4-10,13,18H,11-12H2,1-3H3,(H,21,24)/t18-,20+/m1/s1
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Patents

Similars
US Patent
n/an/an/an/a 25n/an/an/an/a



Aristea Translational Medicine Corporation

US Patent


Assay Description
To address these issues, the present disclosure relates to the development and utilization of a (−)-phenserine extended release formulation. To...

US Patent US10864192 (2020)


BindingDB Entry DOI: 10.7270/Q2TT4V23
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Homo sapiens (Human))		BDBM476178
PNG
((−)-N8-norphenylcarbamoyleseroline | US10864...)
Show SMILES CN1CC[C@]2(C)[C@H]1Nc1ccc(OC(=O)Nc3ccccc3)cc21 |r|
Show InChI InChI=1S/C19H21N3O2/c1-19-10-11-22(2)17(19)21-16-9-8-14(12-15(16)19)24-18(23)20-13-6-4-3-5-7-13/h3-9,12,17,21H,10-11H2,1-2H3,(H,20,23)/t17-,19-/m0/s1
PDB
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PC cid
PC sid
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US Patent
n/an/an/an/a 62n/an/an/an/a



Aristea Translational Medicine Corporation

US Patent


Assay Description
To address these issues, the present disclosure relates to the development and utilization of a (−)-phenserine extended release formulation. To...

US Patent US10864192 (2020)


BindingDB Entry DOI: 10.7270/Q2TT4V23
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%