Found 31 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Chymase
(Homo sapiens (Human)) | BDBM100340
(US8501749, 40)Show SMILES CCCCC(CC(O)=O)n1c(=O)n(Cc2cn(C)c3cc(C)cc(C)c23)c2cccnc2c1=O Show InChI InChI=1S/C26H30N4O4/c1-5-6-8-19(13-22(31)32)30-25(33)24-20(9-7-10-27-24)29(26(30)34)15-18-14-28(4)21-12-16(2)11-17(3)23(18)21/h7,9-12,14,19H,5-6,8,13,15H2,1-4H3,(H,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100336
(US8501749, 36)Show SMILES CC[C@H](CC(O)=O)n1c(=O)n(Cc2cn(C)c3cc(C)cc(C)c23)c2cccnc2c1=O |r| Show InChI InChI=1S/C24H26N4O4/c1-5-17(11-20(29)30)28-23(31)22-18(7-6-8-25-22)27(24(28)32)13-16-12-26(4)19-10-14(2)9-15(3)21(16)19/h6-10,12,17H,5,11,13H2,1-4H3,(H,29,30)/t17-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100335
(US8501749, 35)Show SMILES Cc1cc(C)c2c(Cn3c4cccnc4c(=O)n(C(CC(O)=O)C4CC4)c3=O)cn(C)c2c1 Show InChI InChI=1S/C25H26N4O4/c1-14-9-15(2)22-17(12-27(3)20(22)10-14)13-28-18-5-4-8-26-23(18)24(32)29(25(28)33)19(11-21(30)31)16-6-7-16/h4-5,8-10,12,16,19H,6-7,11,13H2,1-3H3,(H,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100338
(US8501749, 38)Show SMILES CC[C@H](CC(O)=O)n1c(=O)n(Cc2cn(C)c3cc(C)cc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C24H26N4O4/c1-5-17(10-21(29)30)28-23(31)18-11-25-7-6-19(18)27(24(28)32)13-16-12-26(4)20-9-14(2)8-15(3)22(16)20/h6-9,11-12,17H,5,10,13H2,1-4H3,(H,29,30)/t17-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100324
(US8501749, 24)Show SMILES CCCC[C@H](C(O)=O)n1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C24H26N4O4/c1-4-5-8-20(23(30)31)28-22(29)17-12-25-11-10-18(17)27(24(28)32)14-16-13-26(3)19-9-6-7-15(2)21(16)19/h6-7,9-13,20H,4-5,8,14H2,1-3H3,(H,30,31)/t20-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100341
(US8501749, 41)Show SMILES CCCC(CC(O)=O)n1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2cccnc2c1=O Show InChI InChI=1S/C24H26N4O4/c1-4-7-17(12-20(29)30)28-23(31)22-19(10-6-11-25-22)27(24(28)32)14-16-13-26(3)18-9-5-8-15(2)21(16)18/h5-6,8-11,13,17H,4,7,12,14H2,1-3H3,(H,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100330
(US8501749, 30)Show SMILES CC[C@H](CC(O)=O)n1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2cccnc2c1=O |r| Show InChI InChI=1S/C23H24N4O4/c1-4-16(11-19(28)29)27-22(30)21-18(9-6-10-24-21)26(23(27)31)13-15-12-25(3)17-8-5-7-14(2)20(15)17/h5-10,12,16H,4,11,13H2,1-3H3,(H,28,29)/t16-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100339
(US8501749, 39)Show SMILES CCCCC(CC(O)=O)n1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2cccnc2c1=O Show InChI InChI=1S/C25H28N4O4/c1-4-5-9-18(13-21(30)31)29-24(32)23-20(11-7-12-26-23)28(25(29)33)15-17-14-27(3)19-10-6-8-16(2)22(17)19/h6-8,10-12,14,18H,4-5,9,13,15H2,1-3H3,(H,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100320
(US8501749, 20)Show SMILES CCC[C@@H](C(O)=O)n1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C23H24N4O4/c1-4-6-19(22(29)30)27-21(28)16-11-24-10-9-17(16)26(23(27)31)13-15-12-25(3)18-8-5-7-14(2)20(15)18/h5,7-12,19H,4,6,13H2,1-3H3,(H,29,30)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100331
(US8501749, 31)Show SMILES CC[C@H](CC(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2cccnc2c1=O |r| Show InChI InChI=1S/C22H22N4O4S/c1-4-14(10-18(27)28)26-21(29)20-16(6-5-7-23-20)25(22(26)30)11-15-19-13(3)8-12(2)9-17(19)31-24-15/h5-9,14H,4,10-11H2,1-3H3,(H,27,28)/t14-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100325
(US8501749, 25)Show SMILES CC[C@H](CC(O)=O)n1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C23H24N4O4/c1-4-16(10-20(28)29)27-22(30)17-11-24-9-8-18(17)26(23(27)31)13-15-12-25(3)19-7-5-6-14(2)21(15)19/h5-9,11-12,16H,4,10,13H2,1-3H3,(H,28,29)/t16-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100318
(US8501749, 18)Show SMILES CCCC[C@H](C(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C23H24N4O4S/c1-4-5-6-18(22(29)30)27-21(28)15-11-24-8-7-17(15)26(23(27)31)12-16-20-14(3)9-13(2)10-19(20)32-25-16/h7-11,18H,4-6,12H2,1-3H3,(H,29,30)/t18-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100334
(US8501749, 34)Show SMILES CC[C@H](C(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C21H20N4O4S/c1-4-15(20(27)28)25-19(26)13-9-22-6-5-16(13)24(21(25)29)10-14-18-12(3)7-11(2)8-17(18)30-23-14/h5-9,15H,4,10H2,1-3H3,(H,27,28)/t15-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100337
(US8501749, 37)Show SMILES CC[C@@H](C(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2cccnc2c1=O |r| Show InChI InChI=1S/C21H20N4O4S/c1-4-14(20(27)28)25-19(26)18-15(6-5-7-22-18)24(21(25)29)10-13-17-12(3)8-11(2)9-16(17)30-23-13/h5-9,14H,4,10H2,1-3H3,(H,27,28)/t14-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100327
(US8501749, 27)Show SMILES CC[C@@H](CC(O)=O)n1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2cccnc2c1=O |r| Show InChI InChI=1S/C23H24N4O4/c1-4-16(11-19(28)29)27-22(30)21-18(9-6-10-24-21)26(23(27)31)13-15-12-25(3)17-8-5-7-14(2)20(15)17/h5-10,12,16H,4,11,13H2,1-3H3,(H,28,29)/t16-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100312
(US8501749, 12)Show SMILES Cc1cccc2n(C)cc(Cn3c4ccncc4c(=O)n([C@H](C(O)=O)c4ccccc4)c3=O)c12 |r| Show InChI InChI=1S/C26H22N4O4/c1-16-7-6-10-21-22(16)18(14-28(21)2)15-29-20-11-12-27-13-19(20)24(31)30(26(29)34)23(25(32)33)17-8-4-3-5-9-17/h3-14,23H,15H2,1-2H3,(H,32,33)/t23-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100321
(US8501749, 21)Show SMILES CCC[C@H](C(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C22H22N4O4S/c1-4-5-17(21(28)29)26-20(27)14-10-23-7-6-16(14)25(22(26)30)11-15-19-13(3)8-12(2)9-18(19)31-24-15/h6-10,17H,4-5,11H2,1-3H3,(H,28,29)/t17-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100322
(US8501749, 22)Show SMILES CCC[C@@H](C(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C22H22N4O4S/c1-4-5-17(21(28)29)26-20(27)14-10-23-7-6-16(14)25(22(26)30)11-15-19-13(3)8-12(2)9-18(19)31-24-15/h6-10,17H,4-5,11H2,1-3H3,(H,28,29)/t17-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100326
(US8501749, 26)Show SMILES CC[C@H](CC(O)=O)n1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2cnccc2c1=O |r| Show InChI InChI=1S/C23H24N4O4/c1-4-16(10-20(28)29)27-22(30)17-8-9-24-11-19(17)26(23(27)31)13-15-12-25(3)18-7-5-6-14(2)21(15)18/h5-9,11-12,16H,4,10,13H2,1-3H3,(H,28,29)/t16-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100308
(US8501749, 8)Show SMILES Cc1cccc2n(C)cc(Cn3c4cccnc4c(=O)n(CC(O)=O)c3=O)c12 Show InChI InChI=1S/C20H18N4O4/c1-12-5-3-6-14-17(12)13(9-22(14)2)10-23-15-7-4-8-21-18(15)19(27)24(20(23)28)11-16(25)26/h3-9H,10-11H2,1-2H3,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100317
(US8501749, 17)Show SMILES CC[C@@H](C(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C21H20N4O4S/c1-4-15(20(27)28)25-19(26)13-9-22-6-5-16(13)24(21(25)29)10-14-18-12(3)7-11(2)8-17(18)30-23-14/h5-9,15H,4,10H2,1-3H3,(H,27,28)/t15-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100319
(US8501749, 19)Show SMILES CCCC[C@@H](C(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C23H24N4O4S/c1-4-5-6-18(22(29)30)27-21(28)15-11-24-8-7-17(15)26(23(27)31)12-16-20-14(3)9-13(2)10-19(20)32-25-16/h7-11,18H,4-6,12H2,1-3H3,(H,29,30)/t18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100333
(US8501749, 33)Show SMILES CC[C@@H](CC(O)=O)n1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2cnccc2c1=O |r| Show InChI InChI=1S/C23H24N4O4/c1-4-16(10-20(28)29)27-22(30)17-8-9-24-11-19(17)26(23(27)31)13-15-12-25(3)18-7-5-6-14(2)21(15)18/h5-9,11-12,16H,4,10,13H2,1-3H3,(H,28,29)/t16-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100315
(US8501749, 15)Show SMILES CC[C@@H](CC(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2cccnc2c1=O |r| Show InChI InChI=1S/C22H22N4O4S/c1-4-14(10-18(27)28)26-21(29)20-16(6-5-7-23-20)25(22(26)30)11-15-19-13(3)8-12(2)9-17(19)31-24-15/h5-9,14H,4,10-11H2,1-3H3,(H,27,28)/t14-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100307
(US8501749, 7)Show SMILES Cc1cccc2n(C)cc(Cn3c4ccncc4c(=O)n(CC(O)=O)c3=O)c12 Show InChI InChI=1S/C20H18N4O4/c1-12-4-3-5-16-18(12)13(9-22(16)2)10-23-15-6-7-21-8-14(15)19(27)24(20(23)28)11-17(25)26/h3-9H,10-11H2,1-2H3,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100329
(US8501749, 29)Show SMILES CC[C@H](CC(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C22H22N4O4S/c1-4-14(9-19(27)28)26-21(29)15-10-23-6-5-17(15)25(22(26)30)11-16-20-13(3)7-12(2)8-18(20)31-24-16/h5-8,10,14H,4,9,11H2,1-3H3,(H,27,28)/t14-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 9.90 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100314
(US8501749, 14)Show SMILES CCCCC(Cn1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2ccncc2c1=O)C(O)=O Show InChI InChI=1S/C25H28N4O4/c1-4-5-8-17(24(31)32)14-29-23(30)19-12-26-11-10-20(19)28(25(29)33)15-18-13-27(3)21-9-6-7-16(2)22(18)21/h6-7,9-13,17H,4-5,8,14-15H2,1-3H3,(H,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100316
(US8501749, 16)Show SMILES CC[C@@H](CC(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C22H22N4O4S/c1-4-14(9-19(27)28)26-21(29)15-10-23-6-5-17(15)25(22(26)30)11-16-20-13(3)7-12(2)8-18(20)31-24-16/h5-8,10,14H,4,9,11H2,1-3H3,(H,27,28)/t14-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100328
(US8501749, 28)Show SMILES CC[C@H](CC(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2cnccc2c1=O |r| Show InChI InChI=1S/C22H22N4O4S/c1-4-14(9-19(27)28)26-21(29)15-5-6-23-10-17(15)25(22(26)30)11-16-20-13(3)7-12(2)8-18(20)31-24-16/h5-8,10,14H,4,9,11H2,1-3H3,(H,27,28)/t14-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100332
(US8501749, 32)Show SMILES CC[C@@H](CC(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2cnccc2c1=O |r| Show InChI InChI=1S/C22H22N4O4S/c1-4-14(9-19(27)28)26-21(29)15-5-6-23-10-17(15)25(22(26)30)11-16-20-13(3)7-12(2)8-18(20)31-24-16/h5-8,10,14H,4,9,11H2,1-3H3,(H,27,28)/t14-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100306
(US8501749, 6)Show SMILES Cc1cccc2n(C)cc(Cn3c4cnccc4c(=O)n(CC(O)=O)c3=O)c12 Show InChI InChI=1S/C20H18N4O4/c1-12-4-3-5-15-18(12)13(9-22(15)2)10-23-16-8-21-7-6-14(16)19(27)24(20(23)28)11-17(25)26/h3-9H,10-11H2,1-2H3,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | 8.0 | 28 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
In vitro inhibition assay of Chymase. |
US Patent US8501749 (2013)
BindingDB Entry DOI: 10.7270/Q28G8JB2 |
More data for this
Ligand-Target Pair | |
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