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Patent code US8551989

Compile Data Set for Download or QSAR
Found 12 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM103461
PNG
(US8551989, 18)
Show SMILES CC(C)OCCOc1n[nH]c2ccc(cc12)C1C(C#N)C(C)=NC(C)=C1C#N |c:23,26|
Show InChI InChI=1S/C21H23N5O2/c1-12(2)27-7-8-28-21-16-9-15(5-6-19(16)25-26-21)20-17(10-22)13(3)24-14(4)18(20)11-23/h5-6,9,12,17,20H,7-8H2,1-4H3,(H,25,26)
PDB
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US Patent
n/an/a 1n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
Homogeneous time-resolved fluorescence assay using c-Met receptor tyrosine kinase.

US Patent US8551989 (2013)


BindingDB Entry DOI: 10.7270/Q24F1PCX
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM103457
PNG
(US8551989, 2)
Show SMILES CC1=NC(C)=C(C#N)C(C1C#N)c1ccc2[nH]nc(SCc3ccccc3)c2c1 |t:1,4|
Show InChI InChI=1S/C23H19N5S/c1-14-19(11-24)22(20(12-25)15(2)26-14)17-8-9-21-18(10-17)23(28-27-21)29-13-16-6-4-3-5-7-16/h3-10,19,22H,13H2,1-2H3,(H,27,28)
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US Patent
n/an/a 7n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out) using c-Met receptor.

US Patent US8551989 (2013)


BindingDB Entry DOI: 10.7270/Q24F1PCX
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM103464
PNG
(US8551989, 25)
Show SMILES COCCN(C)c1n[nH]c2ccc(cc12)C1C(C#N)C(C)=NC(C)=C1C#N |c:22,25|
Show InChI InChI=1S/C20H22N6O/c1-12-16(10-21)19(17(11-22)13(2)23-12)14-5-6-18-15(9-14)20(25-24-18)26(3)7-8-27-4/h5-6,9,16,19H,7-8H2,1-4H3,(H,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

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DrugBank
antibodypedia
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US Patent
n/an/a 8n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out) using c-Met receptor.

US Patent US8551989 (2013)


BindingDB Entry DOI: 10.7270/Q24F1PCX
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM103457
PNG
(US8551989, 2)
Show SMILES CC1=NC(C)=C(C#N)C(C1C#N)c1ccc2[nH]nc(SCc3ccccc3)c2c1 |t:1,4|
Show InChI InChI=1S/C23H19N5S/c1-14-19(11-24)22(20(12-25)15(2)26-14)17-8-9-21-18(10-17)23(28-27-21)29-13-16-6-4-3-5-7-16/h3-10,19,22H,13H2,1-2H3,(H,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

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antibodypedia
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US Patent
n/an/a 8n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
Homogeneous time-resolved fluorescence assay using c-Met receptor tyrosine kinase.

US Patent US8551989 (2013)


BindingDB Entry DOI: 10.7270/Q24F1PCX
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM103460
PNG
(US8551989, 13)
Show SMILES COc1n[nH]c2ccc(cc12)C1C(C#N)C(C)=NC(C)=C1C#N |c:18,21|
Show InChI InChI=1S/C17H15N5O/c1-9-13(7-18)16(14(8-19)10(2)20-9)11-4-5-15-12(6-11)17(23-3)22-21-15/h4-6,13,16H,1-3H3,(H,21,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

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US Patent
n/an/a 8n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out) using c-Met receptor.

US Patent US8551989 (2013)


BindingDB Entry DOI: 10.7270/Q24F1PCX
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM103464
PNG
(US8551989, 25)
Show SMILES COCCN(C)c1n[nH]c2ccc(cc12)C1C(C#N)C(C)=NC(C)=C1C#N |c:22,25|
Show InChI InChI=1S/C20H22N6O/c1-12-16(10-21)19(17(11-22)13(2)23-12)14-5-6-18-15(9-14)20(25-24-18)26(3)7-8-27-4/h5-6,9,16,19H,7-8H2,1-4H3,(H,24,25)
PDB
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KEGG

UniProtKB/SwissProt

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US Patent
n/an/a 13n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
Homogeneous time-resolved fluorescence assay using c-Met receptor tyrosine kinase.

US Patent US8551989 (2013)


BindingDB Entry DOI: 10.7270/Q24F1PCX
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM103462
PNG
(US8551989, 20)
Show SMILES CC1=NC(C)=C(C#N)C(C1C#N)c1ccc2[nH]nc(OCCN3CCCCC3)c2c1 |t:1,4|
Show InChI InChI=1S/C23H26N6O/c1-15-19(13-24)22(20(14-25)16(2)26-15)17-6-7-21-18(12-17)23(28-27-21)30-11-10-29-8-4-3-5-9-29/h6-7,12,19,22H,3-5,8-11H2,1-2H3,(H,27,28)
PDB
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KEGG

UniProtKB/SwissProt

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US Patent
n/an/a 15n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
Homogeneous time-resolved fluorescence assay using c-Met receptor tyrosine kinase.

US Patent US8551989 (2013)


BindingDB Entry DOI: 10.7270/Q24F1PCX
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM103463
PNG
(US8551989, 24)
Show SMILES CC(C)OCCOc1n[nH]c2ccc(cc12)C1C(C#N)C(=NC(C(F)F)=C1C#N)C(F)F |c:22,27|
Show InChI InChI=1S/C21H19F4N5O2/c1-10(2)31-5-6-32-21-12-7-11(3-4-15(12)29-30-21)16-13(8-26)17(19(22)23)28-18(20(24)25)14(16)9-27/h3-4,7,10,13,16,19-20H,5-6H2,1-2H3,(H,29,30)
PDB
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KEGG

UniProtKB/SwissProt

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antibodypedia
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US Patent
n/an/a 38n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out) using c-Met receptor.

US Patent US8551989 (2013)


BindingDB Entry DOI: 10.7270/Q24F1PCX
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM103458
PNG
(US8551989, 3)
Show SMILES CC1=NC(C)=C(C#N)C(C1C#N)c1ccc2[nH]nc(c2c1)S(C)(=O)=O |t:1,4|
Show InChI InChI=1S/C17H15N5O2S/c1-9-13(7-18)16(14(8-19)10(2)20-9)11-4-5-15-12(6-11)17(22-21-15)25(3,23)24/h4-6,13,16H,1-3H3,(H,21,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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PC sid
UniChem

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US Patent
n/an/a 77n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out) using c-Met receptor.

US Patent US8551989 (2013)


BindingDB Entry DOI: 10.7270/Q24F1PCX
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM103458
PNG
(US8551989, 3)
Show SMILES CC1=NC(C)=C(C#N)C(C1C#N)c1ccc2[nH]nc(c2c1)S(C)(=O)=O |t:1,4|
Show InChI InChI=1S/C17H15N5O2S/c1-9-13(7-18)16(14(8-19)10(2)20-9)11-4-5-15-12(6-11)17(22-21-15)25(3,23)24/h4-6,13,16H,1-3H3,(H,21,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 130n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
Homogeneous time-resolved fluorescence assay using c-Met receptor tyrosine kinase.

US Patent US8551989 (2013)


BindingDB Entry DOI: 10.7270/Q24F1PCX
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM103459
PNG
(US8551989, 12)
Show SMILES CCCS(=O)(=O)Nc1n[nH]c2ccc(cc12)C1C(C#N)C(C)=NC(C)=C1C#N |c:23,26|
Show InChI InChI=1S/C19H20N6O2S/c1-4-7-28(26,27)25-19-14-8-13(5-6-17(14)23-24-19)18-15(9-20)11(2)22-12(3)16(18)10-21/h5-6,8,15,18H,4,7H2,1-3H3,(H2,23,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 475n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out) using c-Met receptor.

US Patent US8551989 (2013)


BindingDB Entry DOI: 10.7270/Q24F1PCX
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM103459
PNG
(US8551989, 12)
Show SMILES CCCS(=O)(=O)Nc1n[nH]c2ccc(cc12)C1C(C#N)C(C)=NC(C)=C1C#N |c:23,26|
Show InChI InChI=1S/C19H20N6O2S/c1-4-7-28(26,27)25-19-14-8-13(5-6-17(14)23-24-19)18-15(9-20)11(2)22-12(3)16(18)10-21/h5-6,8,15,18H,4,7H2,1-3H3,(H2,23,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 761n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
Homogeneous time-resolved fluorescence assay using c-Met receptor tyrosine kinase.

US Patent US8551989 (2013)


BindingDB Entry DOI: 10.7270/Q24F1PCX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%