Found 16 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50340726
(5,7-dimethyl-2-(methylthio)-3-(phenylsulfonyl)pyra...)Show InChI InChI=1S/C15H15N3O2S2/c1-10-9-11(2)18-14(16-10)13(15(17-18)21-3)22(19,20)12-7-5-4-6-8-12/h4-9H,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| US Patent
| 2.14 | n/a | 4.61 | n/a | n/a | n/a | n/a | n/a | n/a |
Avincuro Pharmaceuticals, Inc.
US Patent
| Assay Description Radioligand binding assay using 5-HT6 receptors. |
US Patent US8552005 (2013)
BindingDB Entry DOI: 10.7270/Q2MG7N4B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50340727
(2,5,7-Triimethyl-phenylsulfonyl-pyrazolo[1,5-a]pyr...)Show InChI InChI=1S/C15H15N3O2S/c1-10-9-11(2)18-15(16-10)14(12(3)17-18)21(19,20)13-7-5-4-6-8-13/h4-9H,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| US Patent
| 68.4 | n/a | 147 | n/a | n/a | n/a | n/a | n/a | n/a |
Avincuro Pharmaceuticals, Inc.
US Patent
| Assay Description Radioligand binding assay using 5-HT6 receptors. |
US Patent US8552005 (2013)
BindingDB Entry DOI: 10.7270/Q2MG7N4B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50340728
(2-{[5,7-Dimethyl-3-(phenylsulfonyl)pyrazolo[1,5-a]...)Show InChI InChI=1S/C16H17N3O4S/c1-11-10-12(2)19-15(17-11)14(16(18-19)23-9-8-20)24(21,22)13-6-4-3-5-7-13/h3-7,10,20H,8-9H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| US Patent
| 222 | n/a | 477 | n/a | n/a | n/a | n/a | n/a | n/a |
Avincuro Pharmaceuticals, Inc.
US Patent
| Assay Description Radioligand binding assay using 5-HT6 receptors. |
US Patent US8552005 (2013)
BindingDB Entry DOI: 10.7270/Q2MG7N4B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50340729
(5,7-Dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrim...)Show InChI InChI=1S/C14H13N3O2S/c1-10-8-11(2)17-14(16-10)13(9-15-17)20(18,19)12-6-4-3-5-7-12/h3-9H,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| US Patent
| 237 | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
Avincuro Pharmaceuticals, Inc.
US Patent
| Assay Description Radioligand binding assay using 5-HT6 receptors. |
US Patent US8552005 (2013)
BindingDB Entry DOI: 10.7270/Q2MG7N4B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50417908
(CHEMBL1668574 | US8552005, 1.1(7))Show InChI InChI=1S/C15H14FN3O2S2/c1-9-8-10(2)19-14(17-9)13(15(18-19)22-3)23(20,21)12-6-4-11(16)5-7-12/h4-8H,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Avincuro Pharmaceuticals, Inc.
US Patent
| Assay Description Radioligand binding assay using 5-HT6 receptors. |
US Patent US8552005 (2013)
BindingDB Entry DOI: 10.7270/Q2MG7N4B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50417906
(CHEMBL1668571 | US8552005, 1.1(11))Show InChI InChI=1S/C15H14ClN3O2S2/c1-9-7-10(2)19-14(17-9)13(15(18-19)22-3)23(20,21)12-6-4-5-11(16)8-12/h4-8H,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Avincuro Pharmaceuticals, Inc.
US Patent
| Assay Description Functional assay using 5-HT6 receptors. |
US Patent US8552005 (2013)
BindingDB Entry DOI: 10.7270/Q2MG7N4B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50417907
(CHEMBL1668572 | US8552005, 1.1(9))Show InChI InChI=1S/C15H14FN3O2S2/c1-9-7-10(2)19-14(17-9)13(15(18-19)22-3)23(20,21)12-6-4-5-11(16)8-12/h4-8H,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Avincuro Pharmaceuticals, Inc.
US Patent
| Assay Description Functional assay using 5-HT6 receptors. |
US Patent US8552005 (2013)
BindingDB Entry DOI: 10.7270/Q2MG7N4B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50340726
(5,7-dimethyl-2-(methylthio)-3-(phenylsulfonyl)pyra...)Show InChI InChI=1S/C15H15N3O2S2/c1-10-9-11(2)18-14(16-10)13(15(17-18)21-3)22(19,20)12-7-5-4-6-8-12/h4-9H,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| US Patent
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Avincuro Pharmaceuticals, Inc.
US Patent
| Assay Description Functional assay using 5-HT6 receptors. |
US Patent US8552005 (2013)
BindingDB Entry DOI: 10.7270/Q2MG7N4B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50417912
(CHEMBL1668580 | US8552005, 1.1(20))Show SMILES CSc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccc(F)c(Cl)c1 Show InChI InChI=1S/C15H13ClFN3O2S2/c1-8-6-9(2)20-14(18-8)13(15(19-20)23-3)24(21,22)10-4-5-12(17)11(16)7-10/h4-7H,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Avincuro Pharmaceuticals, Inc.
US Patent
| Assay Description Functional assay using 5-HT6 receptors. |
US Patent US8552005 (2013)
BindingDB Entry DOI: 10.7270/Q2MG7N4B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50340730
(5,7-Dimethyl-2-(ethylthio)-3-phenylsulfonyl-pyrazo...)Show InChI InChI=1S/C16H17N3O2S2/c1-4-22-16-14(23(20,21)13-8-6-5-7-9-13)15-17-11(2)10-12(3)19(15)18-16/h5-10H,4H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| US Patent
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Avincuro Pharmaceuticals, Inc.
US Patent
| Assay Description Functional assay using 5-HT6 receptors. |
US Patent US8552005 (2013)
BindingDB Entry DOI: 10.7270/Q2MG7N4B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM103508
(US8552005, 1.1(15))Show InChI InChI=1S/C17H19N3O2S2/c1-5-23-17-15(16-18-12(3)10-13(4)20(16)19-17)24(21,22)14-8-6-11(2)7-9-14/h6-10H,5H2,1-4H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Avincuro Pharmaceuticals, Inc.
US Patent
| Assay Description Functional assay using 5-HT6 receptors. |
US Patent US8552005 (2013)
BindingDB Entry DOI: 10.7270/Q2MG7N4B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50417908
(CHEMBL1668574 | US8552005, 1.1(7))Show InChI InChI=1S/C15H14FN3O2S2/c1-9-8-10(2)19-14(17-9)13(15(18-19)22-3)23(20,21)12-6-4-11(16)5-7-12/h4-8H,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 112 | n/a | n/a | n/a | n/a | n/a | n/a |
Avincuro Pharmaceuticals, Inc.
US Patent
| Assay Description Functional assay using 5-HT6 receptors. |
US Patent US8552005 (2013)
BindingDB Entry DOI: 10.7270/Q2MG7N4B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50417928
(CHEMBL1668573 | US8552005, 1.1(16))Show InChI InChI=1S/C15H14ClN3O2S2/c1-9-8-10(2)19-14(17-9)13(15(18-19)22-3)23(20,21)12-6-4-11(16)5-7-12/h4-8H,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Avincuro Pharmaceuticals, Inc.
US Patent
| Assay Description Functional assay using 5-HT6 receptors. |
US Patent US8552005 (2013)
BindingDB Entry DOI: 10.7270/Q2MG7N4B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM103509
(US8552005, 1.1(18))Show SMILES CCSc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccc(OC)cc1 Show InChI InChI=1S/C17H19N3O3S2/c1-5-24-17-15(16-18-11(2)10-12(3)20(16)19-17)25(21,22)14-8-6-13(23-4)7-9-14/h6-10H,5H2,1-4H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Avincuro Pharmaceuticals, Inc.
US Patent
| Assay Description Functional assay using 5-HT6 receptors. |
US Patent US8552005 (2013)
BindingDB Entry DOI: 10.7270/Q2MG7N4B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50417910
(CHEMBL1668577 | US8552005, 1.1(17))Show SMILES COc1ccc(cc1)S(=O)(=O)c1c(SC)nn2c(C)cc(C)nc12 Show InChI InChI=1S/C16H17N3O3S2/c1-10-9-11(2)19-15(17-10)14(16(18-19)23-4)24(20,21)13-7-5-12(22-3)6-8-13/h5-9H,1-4H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Avincuro Pharmaceuticals, Inc.
US Patent
| Assay Description Functional assay using 5-HT6 receptors. |
US Patent US8552005 (2013)
BindingDB Entry DOI: 10.7270/Q2MG7N4B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50340729
(5,7-Dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrim...)Show InChI InChI=1S/C14H13N3O2S/c1-10-8-11(2)17-14(16-10)13(9-15-17)20(18,19)12-6-4-3-5-7-12/h3-9H,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| US Patent
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Avincuro Pharmaceuticals, Inc.
US Patent
| Assay Description Functional assay using 5-HT6 receptors. |
US Patent US8552005 (2013)
BindingDB Entry DOI: 10.7270/Q2MG7N4B |
More data for this Ligand-Target Pair | |