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Patent code US8598184

Compile Data Set for Download or QSAR
Found 5 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM108123
PNG
(US8598184, 5)
Show SMILES OCCn1cc(cn1)-c1ncc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C19H16N8O/c28-7-6-26-12-15(9-22-26)18-21-10-17-19(23-18)27(25-24-17)11-13-3-4-16-14(8-13)2-1-5-20-16/h1-5,8-10,12,28H,6-7,11H2
PDB
MMDB

KEGG

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n/an/a 9n/an/an/an/an/an/a



Tiger Pharmatech

US Patent


Assay Description
The compounds of the instant invention described in the Examples were screened for their ability to inhibit c-Met kinase activity using a standard c-...

US Patent US8598184 (2013)


BindingDB Entry DOI: 10.7270/Q2222SF1
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM108122
PNG
(US8598184, 4)
Show SMILES Cn1cc(cn1)-c1ncc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C18H14N8/c1-25-11-14(8-21-25)17-20-9-16-18(22-17)26(24-23-16)10-12-4-5-15-13(7-12)3-2-6-19-15/h2-9,11H,10H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem

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US Patent
n/an/a 24n/an/an/an/an/an/a



Tiger Pharmatech

US Patent


Assay Description
The compounds of the instant invention described in the Examples were screened for their ability to inhibit c-Met kinase activity using a standard c-...

US Patent US8598184 (2013)


BindingDB Entry DOI: 10.7270/Q2222SF1
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM108120
PNG
(US8598184, 2)
Show SMILES Nc1ncc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C14H11N7/c15-14-17-7-12-13(18-14)21(20-19-12)8-9-3-4-11-10(6-9)2-1-5-16-11/h1-7H,8H2,(H2,15,17,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

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DrugBank
antibodypedia
GoogleScholar
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PC sid
UniChem

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US Patent
n/an/a 40n/an/an/an/an/an/a



Tiger Pharmatech

US Patent


Assay Description
The compounds of the instant invention described in the Examples were screened for their ability to inhibit c-Met kinase activity using a standard c-...

US Patent US8598184 (2013)


BindingDB Entry DOI: 10.7270/Q2222SF1
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM108121
PNG
(US8598184, 3)
Show SMILES Ic1ncc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C14H9IN6/c15-14-17-7-12-13(18-14)21(20-19-12)8-9-3-4-11-10(6-9)2-1-5-16-11/h1-7H,8H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 79n/an/an/an/an/an/a



Tiger Pharmatech

US Patent


Assay Description
The compounds of the instant invention described in the Examples were screened for their ability to inhibit c-Met kinase activity using a standard c-...

US Patent US8598184 (2013)


BindingDB Entry DOI: 10.7270/Q2222SF1
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM108119
PNG
(US8598184, 1)
Show SMILES Clc1ncc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C14H9ClN6/c15-14-17-7-12-13(18-14)21(20-19-12)8-9-3-4-11-10(6-9)2-1-5-16-11/h1-7H,8H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 167n/an/an/an/an/an/a



Tiger Pharmatech

US Patent


Assay Description
The compounds of the instant invention described in the Examples were screened for their ability to inhibit c-Met kinase activity using a standard c-...

US Patent US8598184 (2013)


BindingDB Entry DOI: 10.7270/Q2222SF1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%