Affinity Data by Patent

Patent code US8735593

Found 10 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM122537 (US8735593, I-5) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.5	30
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Compounds of the present invention were screened for their ability to inhibit GSK-3β (AA 1-420) activity using a standard coupled enzyme system ...				US Patent US8735593 (2014) BindingDB Entry DOI: 10.7270/Q2H130PQ
Vertex Pharmaceuticals Incorporated US Patent					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM122535 (US8735593, I-3) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.5	30
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Compounds of the present invention were screened for their ability to inhibit GSK-3β (AA 1-420) activity using a standard coupled enzyme system ...				US Patent US8735593 (2014) BindingDB Entry DOI: 10.7270/Q2H130PQ
Vertex Pharmaceuticals Incorporated US Patent					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM122533 (US8735593, I-1) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	30
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Compounds of the present invention were screened for their ability to inhibit GSK-3β (AA 1-420) activity using a standard coupled enzyme system ...				US Patent US8735593 (2014) BindingDB Entry DOI: 10.7270/Q2H130PQ
Vertex Pharmaceuticals Incorporated US Patent					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM122534 (US8735593, I-2) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	30
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Compounds of the present invention were screened for their ability to inhibit GSK-3β (AA 1-420) activity using a standard coupled enzyme system ...				US Patent US8735593 (2014) BindingDB Entry DOI: 10.7270/Q2H130PQ
Vertex Pharmaceuticals Incorporated US Patent					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM122537 (US8735593, I-5) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	30
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Compounds of the present invention were screened for their ability to inhibit GSK-3β (AA 1-420) activity using a standard coupled enzyme system ...				US Patent US8735593 (2014) BindingDB Entry DOI: 10.7270/Q2H130PQ
Vertex Pharmaceuticals Incorporated US Patent					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM122536 (US8735593, I-4) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	30
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Compounds of the present invention were screened for their ability to inhibit GSK-3β (AA 1-420) activity using a standard coupled enzyme system ...				US Patent US8735593 (2014) BindingDB Entry DOI: 10.7270/Q2H130PQ
Vertex Pharmaceuticals Incorporated US Patent					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM122535 (US8735593, I-3) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	30
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Compounds of the present invention were screened for their ability to inhibit GSK-3β (AA 1-420) activity using a standard coupled enzyme system ...				US Patent US8735593 (2014) BindingDB Entry DOI: 10.7270/Q2H130PQ
Vertex Pharmaceuticals Incorporated US Patent					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM122533 (US8735593, I-1) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	7.5	30
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Compounds of the present invention were screened for their ability to inhibit GSK-3β (AA 1-420) activity using a standard coupled enzyme system ...				US Patent US8735593 (2014) BindingDB Entry DOI: 10.7270/Q2H130PQ
Vertex Pharmaceuticals Incorporated US Patent					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM122534 (US8735593, I-2) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	200	n/a	n/a	n/a	n/a	7.5	30
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Compounds of the present invention were screened for their ability to inhibit GSK-3β (AA 1-420) activity using a standard coupled enzyme system ...				US Patent US8735593 (2014) BindingDB Entry DOI: 10.7270/Q2H130PQ
Vertex Pharmaceuticals Incorporated US Patent					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM122536 (US8735593, I-4) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	7.5	30
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Compounds of the present invention were screened for their ability to inhibit GSK-3β (AA 1-420) activity using a standard coupled enzyme system ...				US Patent US8735593 (2014) BindingDB Entry DOI: 10.7270/Q2H130PQ
Vertex Pharmaceuticals Incorporated US Patent					More data for this Ligand-Target Pair

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* indicates data uncertainty>20%