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Patent code US8802712

Compile Data Set for Download or QSAR
Found 80 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128760
PNG
(US8802712, 18)
Show SMILES COC(=O)C(Oc1cc2c3c(nn(C)c3cnc2cc1OC)-c1ccc(cc1)C#N)c1ccc(F)cc1
Show InChI InChI=1S/C28H21FN4O4/c1-33-22-15-31-21-13-23(35-2)24(37-27(28(34)36-3)18-8-10-19(29)11-9-18)12-20(21)25(22)26(32-33)17-6-4-16(14-30)5-7-17/h4-13,15,27H,1-3H3
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US Patent
n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128817
PNG
(US8802712, 75)
Show SMILES CCN1CCN(CC1)c1ccc(cc1)-c1nn(C)c2cnc3cc(OC)c(OC)cc3c12
Show InChI InChI=1S/C25H29N5O2/c1-5-29-10-12-30(13-11-29)18-8-6-17(7-9-18)25-24-19-14-22(31-3)23(32-4)15-20(19)26-16-21(24)28(2)27-25/h6-9,14-16H,5,10-13H2,1-4H3
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US Patent
n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128767
PNG
(US8802712, 25)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OP(O)(=O)c1ccccc1
Show InChI InChI=1S/C25H19N4O4P/c1-29-21-15-27-20-13-22(32-2)23(33-34(30,31)18-6-4-3-5-7-18)12-19(20)24(21)25(28-29)17-10-8-16(14-26)9-11-17/h3-13,15H,1-2H3,(H,30,31)
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US Patent
n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128780
PNG
(US8802712, 38)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1ccnc(c1)C#N
Show InChI InChI=1S/C26H18N6O2/c1-32-22-14-30-21-11-23(33-2)24(34-15-17-7-8-29-19(9-17)13-28)10-20(21)25(22)26(31-32)18-5-3-16(12-27)4-6-18/h3-11,14H,15H2,1-2H3
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US Patent
n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128783
PNG
(US8802712, 41)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1cccc(c1)N(C)C
Show InChI InChI=1S/C28H25N5O2/c1-32(2)21-7-5-6-19(12-21)17-35-26-13-22-23(14-25(26)34-4)30-16-24-27(22)28(31-33(24)3)20-10-8-18(15-29)9-11-20/h5-14,16H,17H2,1-4H3
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US Patent
n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128793
PNG
(US8802712, 51)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OC(C(=O)NOCC#N)c1ccc(F)cc1
Show InChI InChI=1S/C29H21FN6O4/c1-36-23-16-33-22-14-24(38-2)25(13-21(22)26(23)27(34-36)18-5-3-17(15-32)4-6-18)40-28(29(37)35-39-12-11-31)19-7-9-20(30)10-8-19/h3-10,13-14,16,28H,12H2,1-2H3,(H,35,37)
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US Patent
n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128756
PNG
(US8802712, 14)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1ccccc1C#N
Show InChI InChI=1S/C27H19N5O2/c1-32-23-15-30-22-12-24(33-2)25(34-16-20-6-4-3-5-19(20)14-29)11-21(22)26(23)27(31-32)18-9-7-17(13-28)8-10-18/h3-12,15H,16H2,1-2H3
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US Patent
n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128759
PNG
(US8802712, 17)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OC(F)(F)c1ccccc1
Show InChI InChI=1S/C26H18F2N4O2/c1-32-21-15-30-20-13-22(33-2)23(34-26(27,28)18-6-4-3-5-7-18)12-19(20)24(21)25(31-32)17-10-8-16(14-29)9-11-17/h3-13,15H,1-2H3
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US Patent
n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128787
PNG
(US8802712, 45)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1cccc(c1)-c1csc(C)n1
Show InChI InChI=1S/C30H23N5O2S/c1-18-33-25(17-38-18)22-6-4-5-20(11-22)16-37-28-12-23-24(13-27(28)36-3)32-15-26-29(23)30(34-35(26)2)21-9-7-19(14-31)8-10-21/h4-13,15,17H,16H2,1-3H3
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US Patent
n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128790
PNG
(US8802712, 48)
Show SMILES CCN1CCN(CCNC(=O)C(Oc2cc3c4c(nn(C)c4cnc3cc2OC)-c2ccc(cc2)C#N)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C35H36FN7O3/c1-4-42-15-17-43(18-16-42)14-13-38-35(44)34(25-9-11-26(36)12-10-25)46-31-19-27-28(20-30(31)45-3)39-22-29-32(27)33(40-41(29)2)24-7-5-23(21-37)6-8-24/h5-12,19-20,22,34H,4,13-18H2,1-3H3,(H,38,44)
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US Patent
n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128799
PNG
(US8802712, 57)
Show SMILES CCn1nc(-c2ccc(cc2F)C#N)c2c1cnc1cc(OC)c(OC)cc21
Show InChI InChI=1S/C21H17FN4O2/c1-4-26-17-11-24-16-9-19(28-3)18(27-2)8-14(16)20(17)21(25-26)13-6-5-12(10-23)7-15(13)22/h5-9,11H,4H2,1-3H3
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US Patent
n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128802
PNG
(US8802712, 60)
Show SMILES COc1cc2ncc3n(nc(-c4ccc(cc4)C#N)c3c2cc1OC)C(C)C
Show InChI InChI=1S/C22H20N4O2/c1-13(2)26-18-12-24-17-10-20(28-4)19(27-3)9-16(17)21(18)22(25-26)15-7-5-14(11-23)6-8-15/h5-10,12-13H,1-4H3
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US Patent
n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128809
PNG
(US8802712, 67)
Show SMILES COc1cc2ncc3n(CC(O)=O)nc(-c4ccc(cc4)C#N)c3c2cc1OC
Show InChI InChI=1S/C21H16N4O4/c1-28-17-7-14-15(8-18(17)29-2)23-10-16-20(14)21(24-25(16)11-19(26)27)13-5-3-12(9-22)4-6-13/h3-8,10H,11H2,1-2H3,(H,26,27)
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US Patent
n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128774
PNG
(US8802712, 32)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1cccc(CN)c1
Show InChI InChI=1S/C27H23N5O2/c1-32-23-15-30-22-12-24(33-2)25(34-16-19-5-3-4-18(10-19)14-29)11-21(22)26(23)27(31-32)20-8-6-17(13-28)7-9-20/h3-12,15H,14,16,29H2,1-2H3
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US Patent
n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128807
PNG
(US8802712, 65)
Show SMILES COc1cc2ncc3n(nc(-c4ccc(cc4)C#N)c3c2cc1OC)C#N
Show InChI InChI=1S/C20H13N5O2/c1-26-17-7-14-15(8-18(17)27-2)23-10-16-19(14)20(24-25(16)11-22)13-5-3-12(9-21)4-6-13/h3-8,10H,1-2H3
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US Patent
n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128772
PNG
(US8802712, 30)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1cnc2[nH]ccc2c1
Show InChI InChI=1S/C27H20N6O2/c1-33-22-14-30-21-11-23(34-2)24(35-15-17-9-19-7-8-29-27(19)31-13-17)10-20(21)25(22)26(32-33)18-5-3-16(12-28)4-6-18/h3-11,13-14H,15H2,1-2H3,(H,29,31)
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US Patent
n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128805
PNG
(US8802712, 63)
Show SMILES COc1cc2ncc3n(CC=C)nc(-c4ccc(cc4)C#N)c3c2cc1OC
Show InChI InChI=1S/C22H18N4O2/c1-4-9-26-18-13-24-17-11-20(28-3)19(27-2)10-16(17)21(18)22(25-26)15-7-5-14(12-23)6-8-15/h4-8,10-11,13H,1,9H2,2-3H3
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US Patent
n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128791
PNG
(US8802712, 49)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OC(C(=O)NCCN(C)C)c1ccc(F)cc1
Show InChI InChI=1S/C31H29FN6O3/c1-37(2)14-13-34-31(39)30(21-9-11-22(32)12-10-21)41-27-15-23-24(16-26(27)40-4)35-18-25-28(23)29(36-38(25)3)20-7-5-19(17-33)6-8-20/h5-12,15-16,18,30H,13-14H2,1-4H3,(H,34,39)
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US Patent
n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128770
PNG
(US8802712, 28)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1cccc(CN2CCOCC2)c1
Show InChI InChI=1S/C31H29N5O3/c1-35-27-18-33-26-16-28(37-2)29(15-25(26)30(27)31(34-35)24-8-6-21(17-32)7-9-24)39-20-23-5-3-4-22(14-23)19-36-10-12-38-13-11-36/h3-9,14-16,18H,10-13,19-20H2,1-2H3
PDB

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US Patent
n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128801
PNG
(US8802712, 59)
Show SMILES CCCn1nc(-c2ccc(cc2)C#N)c2c1cnc1cc(OC)c(OC)cc21
Show InChI InChI=1S/C22H20N4O2/c1-4-9-26-18-13-24-17-11-20(28-3)19(27-2)10-16(17)21(18)22(25-26)15-7-5-14(12-23)6-8-15/h5-8,10-11,13H,4,9H2,1-3H3
PDB

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US Patent
n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128804
PNG
(US8802712, 62)
Show SMILES COc1cc2ncc3n(nc(-c4ccc(cc4)C#N)c3c2cc1OC)C1CC1
Show InChI InChI=1S/C22H18N4O2/c1-27-19-9-16-17(10-20(19)28-2)24-12-18-21(16)22(25-26(18)15-7-8-15)14-5-3-13(11-23)4-6-14/h3-6,9-10,12,15H,7-8H2,1-2H3
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n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128810
PNG
(US8802712, 68)
Show SMILES COc1cc2ncc3n(CC(N)=O)nc(-c4ccc(cc4)C#N)c3c2cc1OC
Show InChI InChI=1S/C21H17N5O3/c1-28-17-7-14-15(8-18(17)29-2)24-10-16-20(14)21(25-26(16)11-19(23)27)13-5-3-12(9-22)4-6-13/h3-8,10H,11H2,1-2H3,(H2,23,27)
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n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128794
PNG
(US8802712, 52)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OC(C(=O)NCCS(N)(=O)=O)c1ccc(F)cc1
Show InChI InChI=1S/C29H25FN6O5S/c1-36-23-16-34-22-14-24(40-2)25(13-21(22)26(23)27(35-36)18-5-3-17(15-31)4-6-18)41-28(19-7-9-20(30)10-8-19)29(37)33-11-12-42(32,38)39/h3-10,13-14,16,28H,11-12H2,1-2H3,(H,33,37)(H2,32,38,39)
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n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128766
PNG
(US8802712, 24)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OS(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C26H20N4O4S/c1-16-4-10-19(11-5-16)35(31,32)34-24-12-20-21(13-23(24)33-3)28-15-22-25(20)26(29-30(22)2)18-8-6-17(14-27)7-9-18/h4-13,15H,1-3H3
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n/an/a 0.300n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128757
PNG
(US8802712, 15)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1ccc(F)cc1
Show InChI InChI=1S/C26H19FN4O2/c1-31-22-14-29-21-12-23(32-2)24(33-15-17-5-9-19(27)10-6-17)11-20(21)25(22)26(30-31)18-7-3-16(13-28)4-8-18/h3-12,14H,15H2,1-2H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128777
PNG
(US8802712, 35)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1ccsc1
Show InChI InChI=1S/C24H18N4O2S/c1-28-20-12-26-19-10-21(29-2)22(30-13-16-7-8-31-14-16)9-18(19)23(20)24(27-28)17-5-3-15(11-25)4-6-17/h3-10,12,14H,13H2,1-2H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128785
PNG
(US8802712, 43)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1cncs1
Show InChI InChI=1S/C23H17N5O2S/c1-28-19-11-26-18-8-20(29-2)21(30-12-16-10-25-13-31-16)7-17(18)22(19)23(27-28)15-5-3-14(9-24)4-6-15/h3-8,10-11,13H,12H2,1-2H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128747
PNG
(US8802712, 5)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1O
Show InChI InChI=1S/C19H14N4O2/c1-23-15-10-21-14-8-17(25-2)16(24)7-13(14)18(15)19(22-23)12-5-3-11(9-20)4-6-12/h3-8,10,24H,1-2H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128752
PNG
(US8802712, 10)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1O[C@H](C(N)=O)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C27H20FN5O3/c1-33-21-14-31-20-12-22(35-2)23(36-26(27(30)34)17-7-9-18(28)10-8-17)11-19(20)24(21)25(32-33)16-5-3-15(13-29)4-6-16/h3-12,14,26H,1-2H3,(H2,30,34)/t26-/m0/s1
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128782
PNG
(US8802712, 40)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCCN(C)C
Show InChI InChI=1S/C23H23N5O2/c1-27(2)9-10-30-21-11-17-18(12-20(21)29-4)25-14-19-22(17)23(26-28(19)3)16-7-5-15(13-24)6-8-16/h5-8,11-12,14H,9-10H2,1-4H3
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n/an/a>100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128743
PNG
(US8802712, 1)
Show SMILES COc1cc2ncc3[nH]nc(-c4ccc(cc4)C#N)c3c2cc1OC
Show InChI InChI=1S/C19H14N4O2/c1-24-16-7-13-14(8-17(16)25-2)21-10-15-18(13)19(23-22-15)12-5-3-11(9-20)4-6-12/h3-8,10H,1-2H3,(H,22,23)
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128751
PNG
(US8802712, 9)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1O[C@@H](C(N)=O)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C27H20FN5O3/c1-33-21-14-31-20-12-22(35-2)23(36-26(27(30)34)17-7-9-18(28)10-8-17)11-19(20)24(21)25(32-33)16-5-3-15(13-29)4-6-16/h3-12,14,26H,1-2H3,(H2,30,34)/t26-/m1/s1
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128758
PNG
(US8802712, 16)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OC(F)F
Show InChI InChI=1S/C20H14F2N4O2/c1-26-15-10-24-14-8-16(27-2)17(28-20(21)22)7-13(14)18(15)19(25-26)12-5-3-11(9-23)4-6-12/h3-8,10,20H,1-2H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128765
PNG
(US8802712, 23)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4F)C#N)c3c2cc1OC(C(N)=O)c1ccc(F)cc1
Show InChI InChI=1S/C27H19F2N5O3/c1-34-21-13-32-20-11-22(36-2)23(37-26(27(31)35)15-4-6-16(28)7-5-15)10-18(20)24(21)25(33-34)17-8-3-14(12-30)9-19(17)29/h3-11,13,26H,1-2H3,(H2,31,35)
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128811
PNG
(US8802712, 69)
Show SMILES COc1cc2ncc3n(nc(-c4ccc(cc4)C#N)c3c2cc1OC)C(F)F
Show InChI InChI=1S/C20H14F2N4O2/c1-27-16-7-13-14(8-17(16)28-2)24-10-15-18(13)19(25-26(15)20(21)22)12-5-3-11(9-23)4-6-12/h3-8,10,20H,1-2H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128815
PNG
(US8802712, 73)
Show SMILES COc1cc2ncc3n[nH]c(-c4ccc(C#N)c(c4)C(O)=O)c3c2cc1OC
Show InChI InChI=1S/C20H14N4O4/c1-27-16-6-13-14(7-17(16)28-2)22-9-15-18(13)19(24-23-15)10-3-4-11(8-21)12(5-10)20(25)26/h3-7,9H,1-2H3,(H,23,24)(H,25,26)
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128746
PNG
(US8802712, 4)
Show SMILES COc1cc2c3c(nn(C)c3cnc2cc1O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C19H14N4O2/c1-23-15-10-21-14-8-16(24)17(25-2)7-13(14)18(15)19(22-23)12-5-3-11(9-20)4-6-12/h3-8,10,24H,1-2H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128761
PNG
(US8802712, 19)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OC(C(O)=O)c1ccc(F)cc1
Show InChI InChI=1S/C27H19FN4O4/c1-32-21-14-30-20-12-22(35-2)23(36-26(27(33)34)17-7-9-18(28)10-8-17)11-19(20)24(21)25(31-32)16-5-3-15(13-29)4-6-16/h3-12,14,26H,1-2H3,(H,33,34)
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128769
PNG
(US8802712, 27)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1ccc(CO)cc1
Show InChI InChI=1S/C27H22N4O3/c1-31-23-14-29-22-12-24(33-2)25(34-16-19-5-3-18(15-32)4-6-19)11-21(22)26(23)27(30-31)20-9-7-17(13-28)8-10-20/h3-12,14,32H,15-16H2,1-2H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128795
PNG
(US8802712, 53)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OC(C(=O)NO)c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN5O4/c1-33-21-14-30-20-12-22(36-2)23(37-26(27(34)32-35)17-7-9-18(28)10-8-17)11-19(20)24(21)25(31-33)16-5-3-15(13-29)4-6-16/h3-12,14,26,35H,1-2H3,(H,32,34)
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128797
PNG
(US8802712, 55)
Show SMILES COCCNC(=O)C(Oc1cc2c3c(nn(C)c3cnc2cc1OC)-c1ccc(cc1)C#N)c1ccc(F)cc1
Show InChI InChI=1S/C30H26FN5O4/c1-36-24-17-34-23-15-25(39-3)26(14-22(23)27(24)28(35-36)19-6-4-18(16-32)5-7-19)40-29(30(37)33-12-13-38-2)20-8-10-21(31)11-9-20/h4-11,14-15,17,29H,12-13H2,1-3H3,(H,33,37)
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128831
PNG
(US8802712, 89)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4F)C#N)c3c2cc1-c1cc[nH]c1
Show InChI InChI=1S/C23H16FN5O/c1-29-20-12-27-19-9-21(30-2)16(14-5-6-26-11-14)8-17(19)22(20)23(28-29)15-4-3-13(10-25)7-18(15)24/h3-9,11-12,26H,1-2H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128744
PNG
(US8802712, 2)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OC
Show InChI InChI=1S/C20H16N4O2/c1-24-16-11-22-15-9-18(26-3)17(25-2)8-14(15)19(16)20(23-24)13-6-4-12(10-21)5-7-13/h4-9,11H,1-3H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128749
PNG
(US8802712, 7)
Show SMILES COc1cc2ncc3[nH]nc(-c4ccc(C#N)c(Cl)c4)c3c2cc1OC
Show InChI InChI=1S/C19H13ClN4O2/c1-25-16-6-12-14(7-17(16)26-2)22-9-15-18(12)19(24-23-15)10-3-4-11(8-21)13(20)5-10/h3-7,9H,1-2H3,(H,23,24)
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128762
PNG
(US8802712, 20)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OC(C(O)=O)c1ccccc1
Show InChI InChI=1S/C27H20N4O4/c1-31-21-15-29-20-13-22(34-2)23(35-26(27(32)33)18-6-4-3-5-7-18)12-19(20)24(21)25(30-31)17-10-8-16(14-28)9-11-17/h3-13,15,26H,1-2H3,(H,32,33)
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128778
PNG
(US8802712, 36)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1cc(Br)cs1
Show InChI InChI=1S/C24H17BrN4O2S/c1-29-20-11-27-19-9-21(30-2)22(31-12-17-7-16(25)13-32-17)8-18(19)23(20)24(28-29)15-5-3-14(10-26)4-6-15/h3-9,11,13H,12H2,1-2H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128781
PNG
(US8802712, 39)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1nccs1
Show InChI InChI=1S/C23H17N5O2S/c1-28-18-12-26-17-10-19(29-2)20(30-13-21-25-7-8-31-21)9-16(17)22(18)23(27-28)15-5-3-14(11-24)4-6-15/h3-10,12H,13H2,1-2H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128808
PNG
(US8802712, 66)
Show SMILES COc1cc2ncc3n(CC#N)nc(-c4ccc(cc4)C#N)c3c2cc1OC
Show InChI InChI=1S/C21H15N5O2/c1-27-18-9-15-16(10-19(18)28-2)24-12-17-20(15)21(25-26(17)8-7-22)14-5-3-13(11-23)4-6-14/h3-6,9-10,12H,8H2,1-2H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128820
PNG
(US8802712, 78)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4F)C#N)c3c2cc1-c1cnc2ccccc2c1
Show InChI InChI=1S/C28H18FN5O/c1-34-25-15-32-24-12-26(35-2)20(18-10-17-5-3-4-6-23(17)31-14-18)11-21(24)27(25)28(33-34)19-8-7-16(13-30)9-22(19)29/h3-12,14-15H,1-2H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128745
PNG
(US8802712, 3)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(C#N)c(Br)c4)c3c2cc1OC
Show InChI InChI=1S/C20H15BrN4O2/c1-25-16-10-23-15-8-18(27-3)17(26-2)7-13(15)19(16)20(24-25)11-4-5-12(9-22)14(21)6-11/h4-8,10H,1-3H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128754
PNG
(US8802712, 12)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1cccnc1
Show InChI InChI=1S/C25H19N5O2/c1-30-21-14-28-20-11-22(31-2)23(32-15-17-4-3-9-27-13-17)10-19(20)24(21)25(29-30)18-7-5-16(12-26)6-8-18/h3-11,13-14H,15H2,1-2H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128796
PNG
(US8802712, 54)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OC(C(=O)NC(N)=N)c1ccc(F)cc1
Show InChI InChI=1S/C28H22FN7O3/c1-36-21-14-33-20-12-22(38-2)23(39-26(27(37)34-28(31)32)17-7-9-18(29)10-8-17)11-19(20)24(21)25(35-36)16-5-3-15(13-30)4-6-16/h3-12,14,26H,1-2H3,(H4,31,32,34,37)
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128814
PNG
(US8802712, 72)
Show SMILES COC(=O)c1cc(ccc1C#N)-c1[nH]nc2cnc3cc(OC)c(OC)cc3c12
Show InChI InChI=1S/C21H16N4O4/c1-27-17-7-14-15(8-18(17)28-2)23-10-16-19(14)20(25-24-16)11-4-5-12(9-22)13(6-11)21(26)29-3/h4-8,10H,1-3H3,(H,24,25)
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128819
PNG
(US8802712, 77)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4F)C#N)c3c2cc1-c1cccnc1
Show InChI InChI=1S/C24H16FN5O/c1-30-21-13-28-20-10-22(31-2)17(15-4-3-7-27-12-15)9-18(20)23(21)24(29-30)16-6-5-14(11-26)8-19(16)25/h3-10,12-13H,1-2H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128748
PNG
(US8802712, 6)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4F)C#N)c3c2cc1O
Show InChI InChI=1S/C19H13FN4O2/c1-24-15-9-22-14-7-17(26-2)16(25)6-12(14)18(15)19(23-24)11-4-3-10(8-21)5-13(11)20/h3-7,9,25H,1-2H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128750
PNG
(US8802712, 8)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OC(C(N)=O)c1ccc(F)cc1
Show InChI InChI=1S/C27H20FN5O3/c1-33-21-14-31-20-12-22(35-2)23(36-26(27(30)34)17-7-9-18(28)10-8-17)11-19(20)24(21)25(32-33)16-5-3-15(13-29)4-6-16/h3-12,14,26H,1-2H3,(H2,30,34)
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128753
PNG
(US8802712, 11)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1ccncc1
Show InChI InChI=1S/C25H19N5O2/c1-30-21-14-28-20-12-22(31-2)23(32-15-17-7-9-27-10-8-17)11-19(20)24(21)25(29-30)18-5-3-16(13-26)4-6-18/h3-12,14H,15H2,1-2H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128775
PNG
(US8802712, 33)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1ccnc(N)c1
Show InChI InChI=1S/C25H20N6O2/c1-31-20-13-29-19-11-21(32-2)22(33-14-16-7-8-28-23(27)9-16)10-18(19)24(20)25(30-31)17-5-3-15(12-26)4-6-17/h3-11,13H,14H2,1-2H3,(H2,27,28)
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128776
PNG
(US8802712, 34)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1cccs1
Show InChI InChI=1S/C24H18N4O2S/c1-28-20-13-26-19-11-21(29-2)22(30-14-17-4-3-9-31-17)10-18(19)23(20)24(27-28)16-7-5-15(12-25)6-8-16/h3-11,13H,14H2,1-2H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128818
PNG
(US8802712, 76)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccccc4F)c3c2cc1OC
Show InChI InChI=1S/C19H16FN3O2/c1-23-15-10-21-14-9-17(25-3)16(24-2)8-12(14)18(15)19(22-23)11-6-4-5-7-13(11)20/h4-10H,1-3H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM6069
PNG
(US8802712, 88)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)-c4ccn[nH]4)c3c2cc1-c1cn[nH]c1
Show InChI InChI=1S/C24H19N7O/c1-31-21-13-25-20-10-22(32-2)17(16-11-27-28-12-16)9-18(20)23(21)24(30-31)15-5-3-14(4-6-15)19-7-8-26-29-19/h3-13H,1-2H3,(H,26,29)(H,27,28)
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128763
PNG
(US8802712, 21)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OC(C(O)=O)c1cccs1
Show InChI InChI=1S/C25H18N4O4S/c1-29-18-13-27-17-11-19(32-2)20(33-24(25(30)31)21-4-3-9-34-21)10-16(17)22(18)23(28-29)15-7-5-14(12-26)6-8-15/h3-11,13,24H,1-2H3,(H,30,31)
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128784
PNG
(US8802712, 42)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1cscn1
Show InChI InChI=1S/C23H17N5O2S/c1-28-19-10-25-18-8-20(29-2)21(30-11-16-12-31-13-26-16)7-17(18)22(19)23(27-28)15-5-3-14(9-24)4-6-15/h3-8,10,12-13H,11H2,1-2H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128798
PNG
(US8802712, 56)
Show SMILES CCn1nc(-c2ccc(cc2)C#N)c2c1cnc1cc(OC)c(OC)cc21
Show InChI InChI=1S/C21H18N4O2/c1-4-25-17-12-23-16-10-19(27-3)18(26-2)9-15(16)20(17)21(24-25)14-7-5-13(11-22)6-8-14/h5-10,12H,4H2,1-3H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128812
PNG
(US8802712, 70)
Show SMILES COc1cc2ncc3n[nH]c(-c4ccc(C#N)c(c4)N4CCCC4)c3c2cc1OC
Show InChI InChI=1S/C23H21N5O2/c1-29-20-10-16-17(11-21(20)30-2)25-13-18-22(16)23(27-26-18)14-5-6-15(12-24)19(9-14)28-7-3-4-8-28/h5-6,9-11,13H,3-4,7-8H2,1-2H3,(H,26,27)
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128813
PNG
(US8802712, 71)
Show SMILES COCc1cc(ccc1C#N)-c1nn(C)c2cnc3cc(OC)c(OC)cc3c12
Show InChI InChI=1S/C22H20N4O3/c1-26-18-11-24-17-9-20(29-4)19(28-3)8-16(17)21(18)22(25-26)13-5-6-14(10-23)15(7-13)12-27-2/h5-9,11H,12H2,1-4H3
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n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128792
PNG
(US8802712, 50)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OC(C(=O)NCCN1CCNCC1)c1ccc(F)cc1
Show InChI InChI=1S/C33H32FN7O3/c1-40-27-20-38-26-18-28(43-2)29(17-25(26)30(27)31(39-40)22-5-3-21(19-35)4-6-22)44-32(23-7-9-24(34)10-8-23)33(42)37-13-16-41-14-11-36-12-15-41/h3-10,17-18,20,32,36H,11-16H2,1-2H3,(H,37,42)
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n/an/a>500n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128806
PNG
(US8802712, 64)
Show SMILES COc1cc2ncc3n(Cc4cccnc4)nc(-c4ccc(cc4F)C#N)c3c2cc1OC
Show InChI InChI=1S/C25H18FN5O2/c1-32-22-9-18-20(10-23(22)33-2)29-13-21-24(18)25(17-6-5-15(11-27)8-19(17)26)30-31(21)14-16-4-3-7-28-12-16/h3-10,12-13H,14H2,1-2H3
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n/an/a>500n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128755
PNG
(US8802712, 13)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1ccccn1
Show InChI InChI=1S/C25H19N5O2/c1-30-21-14-28-20-12-22(31-2)23(32-15-18-5-3-4-10-27-18)11-19(20)24(21)25(29-30)17-8-6-16(13-26)7-9-17/h3-12,14H,15H2,1-2H3
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n/an/a>500n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128768
PNG
(US8802712, 26)
Show SMILES COc1cc2c3c(nn(C)c3cnc2cc1OC(F)F)-c1ccc(cc1)C#N
Show InChI InChI=1S/C20H14F2N4O2/c1-26-15-10-24-14-8-17(28-20(21)22)16(27-2)7-13(14)18(15)19(25-26)12-5-3-11(9-23)4-6-12/h3-8,10,20H,1-2H3
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n/an/a>500n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128771
PNG
(US8802712, 29)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1ccc(nc1)-n1cccn1
Show InChI InChI=1S/C28H21N7O2/c1-34-23-16-30-22-13-24(36-2)25(37-17-19-6-9-26(31-15-19)35-11-3-10-32-35)12-21(22)27(23)28(33-34)20-7-4-18(14-29)5-8-20/h3-13,15-16H,17H2,1-2H3
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n/an/a>500n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128788
PNG
(US8802712, 46)
Show SMILES COc1cc2c3c(nn(C)c3cnc2cc1OCCN(C)C)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H23N5O2/c1-27(2)9-10-30-21-12-18-17(11-20(21)29-4)22-19(14-25-18)28(3)26-23(22)16-7-5-15(13-24)6-8-16/h5-8,11-12,14H,9-10H2,1-4H3
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n/an/a>500n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128786
PNG
(US8802712, 44)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1cccc(CN2CCN(C)CC2)c1
Show InChI InChI=1S/C32H32N6O2/c1-36-11-13-38(14-12-36)20-23-5-4-6-24(15-23)21-40-30-16-26-27(17-29(30)39-3)34-19-28-31(26)32(35-37(28)2)25-9-7-22(18-33)8-10-25/h4-10,15-17,19H,11-14,20-21H2,1-3H3
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n/an/a>500n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128800
PNG
(US8802712, 58)
Show SMILES CCCCn1nc(-c2ccc(cc2)C#N)c2c1cnc1cc(OC)c(OC)cc21
Show InChI InChI=1S/C23H22N4O2/c1-4-5-10-27-19-14-25-18-12-21(29-3)20(28-2)11-17(18)22(19)23(26-27)16-8-6-15(13-24)7-9-16/h6-9,11-12,14H,4-5,10H2,1-3H3
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n/an/a>500n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128803
PNG
(US8802712, 61)
Show SMILES COc1cc2ncc3n(CC(C)C)nc(-c4ccc(cc4)C#N)c3c2cc1OC
Show InChI InChI=1S/C23H22N4O2/c1-14(2)13-27-19-12-25-18-10-21(29-4)20(28-3)9-17(18)22(19)23(26-27)16-7-5-15(11-24)6-8-16/h5-10,12,14H,13H2,1-4H3
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n/an/a>500n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128816
PNG
(US8802712, 74)
Show SMILES COc1cc2ncc3n[nH]c(-c4ccc(C#N)c(c4)-c4ccccc4)c3c2cc1OC
Show InChI InChI=1S/C25H18N4O2/c1-30-22-11-19-20(12-23(22)31-2)27-14-21-24(19)25(29-28-21)16-8-9-17(13-26)18(10-16)15-6-4-3-5-7-15/h3-12,14H,1-2H3,(H,28,29)
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n/an/a>500n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128764
PNG
(US8802712, 22)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OC(C)(C(O)=O)c1ccccc1
Show InChI InChI=1S/C28H22N4O4/c1-28(27(33)34,19-7-5-4-6-8-19)36-24-13-20-21(14-23(24)35-3)30-16-22-25(20)26(31-32(22)2)18-11-9-17(15-29)10-12-18/h4-14,16H,1-3H3,(H,33,34)
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n/an/a>500n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128779
PNG
(US8802712, 37)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1cc2ccccc2s1
Show InChI InChI=1S/C28H20N4O2S/c1-32-23-15-30-22-13-24(33-2)25(34-16-20-11-19-5-3-4-6-26(19)35-20)12-21(22)27(23)28(31-32)18-9-7-17(14-29)8-10-18/h3-13,15H,16H2,1-2H3
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n/an/a>500n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128789
PNG
(US8802712, 47)
Show SMILES COc1cc2c3c(nn(C)c3cnc2cc1OCC(O)CO)-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H20N4O4/c1-26-18-10-24-17-8-20(30-12-15(28)11-27)19(29-2)7-16(17)21(18)22(25-26)14-5-3-13(9-23)4-6-14/h3-8,10,15,27-28H,11-12H2,1-2H3
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n/an/a>500n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))
BDBM128773
PNG
(US8802712, 31)
Show SMILES COc1cc2ncc3n(C)nc(-c4ccc(cc4)C#N)c3c2cc1OCc1ccc(cc1)-n1cncn1
Show InChI InChI=1S/C28H21N7O2/c1-34-24-14-31-23-12-25(36-2)26(37-15-19-5-9-21(10-6-19)35-17-30-16-32-35)11-22(23)27(24)28(33-34)20-7-3-18(13-29)4-8-20/h3-12,14,16-17H,15H2,1-2H3
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n/an/a>500n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...


US Patent US8802712 (2014)


BindingDB Entry DOI: 10.7270/Q2VM49ZC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%