BindingDB logo
myBDB logout

Patent code US9073893

Compile Data Set for Download or QSAR
Found 60 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167422
PNG
(US9073893, 22)
Show SMILES Cn1n(C2CCN(CC2)C2CCCCC2)c(=O)c2c(cc(F)cc12)C(N)=O
Show InChI InChI=1S/C20H27FN4O2/c1-23-17-12-13(21)11-16(19(22)26)18(17)20(27)25(23)15-7-9-24(10-8-15)14-5-3-2-4-6-14/h11-12,14-15H,2-10H2,1H3,(H2,22,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 15n/an/an/an/an/a37



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167419
PNG
(US9073893, 18)
Show SMILES Cn1n(C2CCN(CC2)C2CCC2)c(=O)c2c(cccc12)C(N)=O
Show InChI InChI=1S/C18H24N4O2/c1-20-15-7-3-6-14(17(19)23)16(15)18(24)22(20)13-8-10-21(11-9-13)12-4-2-5-12/h3,6-7,12-13H,2,4-5,8-11H2,1H3,(H2,19,23)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 23n/an/an/an/an/a37



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167412
PNG
(US9073893, 5)
Show SMILES Cn1n(C2CCN(CC2)C2CCCCC2)c(=O)c2c(cccc12)C(N)=O
Show InChI InChI=1S/C20H28N4O2/c1-22-17-9-5-8-16(19(21)25)18(17)20(26)24(22)15-10-12-23(13-11-15)14-6-3-2-4-7-14/h5,8-9,14-15H,2-4,6-7,10-13H2,1H3,(H2,21,25)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 26n/an/an/an/an/a37



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167427
PNG
(US9073893, 65)
Show SMILES Cn1n(C2CCN(CC3CCC=CC3)CC2)c(=O)c2c(cccc12)C(N)=O |c:11|
Show InChI InChI=1S/C21H28N4O2/c1-23-18-9-5-8-17(20(22)26)19(18)21(27)25(23)16-10-12-24(13-11-16)14-15-6-3-2-4-7-15/h2-3,5,8-9,15-16H,4,6-7,10-14H2,1H3,(H2,22,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 44n/an/an/an/an/a37



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167416
PNG
(US9073893, 9)
Show SMILES Cn1n(C2CCNCC2)c(=O)c2c(cccc12)C(N)=O
Show InChI InChI=1S/C14H18N4O2/c1-17-11-4-2-3-10(13(15)19)12(11)14(20)18(17)9-5-7-16-8-6-9/h2-4,9,16H,5-8H2,1H3,(H2,15,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 50n/an/an/an/an/a37



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167426
PNG
(US9073893, 62)
Show SMILES NC(=O)c1cccc2[nH]n(C3CCN(Cc4cccs4)CC3)c(=O)c12
Show InChI InChI=1S/C18H20N4O2S/c19-17(23)14-4-1-5-15-16(14)18(24)22(20-15)12-6-8-21(9-7-12)11-13-3-2-10-25-13/h1-5,10,12,20H,6-9,11H2,(H2,19,23)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 70n/an/an/an/an/a37



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167424
PNG
(US9073893, 31)
Show SMILES NC(=O)c1cccc2[nH]n(C3CCN(CC4CCCCC4)CC3)c(=O)c12
Show InChI InChI=1S/C20H28N4O2/c21-19(25)16-7-4-8-17-18(16)20(26)24(22-17)15-9-11-23(12-10-15)13-14-5-2-1-3-6-14/h4,7-8,14-15,22H,1-3,5-6,9-13H2,(H2,21,25)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 95n/an/an/an/an/a37



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167413
PNG
(US9073893, 6)
Show SMILES Cn1n(C2CCN(CC2)C2CCC(F)(F)CC2)c(=O)c2c(cccc12)C(N)=O
Show InChI InChI=1S/C20H26F2N4O2/c1-24-16-4-2-3-15(18(23)27)17(16)19(28)26(24)14-7-11-25(12-8-14)13-5-9-20(21,22)10-6-13/h2-4,13-14H,5-12H2,1H3,(H2,23,27)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 100n/an/an/an/an/a37



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167430
PNG
(US9073893, 63)
Show SMILES Cn1n(C2CCN(Cc3cccs3)CC2)c(=O)c2c(cccc12)C(N)=O
Show InChI InChI=1S/C19H22N4O2S/c1-21-16-6-2-5-15(18(20)24)17(16)19(25)23(21)13-7-9-22(10-8-13)12-14-4-3-11-26-14/h2-6,11,13H,7-10,12H2,1H3,(H2,20,24)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 130n/an/an/an/an/a37



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167417
PNG
(US9073893, 14)
Show SMILES CC(C)N1CCC(CC1)n1n(C)c2cccc(C(N)=O)c2c1=O
Show InChI InChI=1S/C17H24N4O2/c1-11(2)20-9-7-12(8-10-20)21-17(23)15-13(16(18)22)5-4-6-14(15)19(21)3/h4-6,11-12H,7-10H2,1-3H3,(H2,18,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 130n/an/an/an/an/a37



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167414
PNG
(US9073893, 7)
Show SMILES Cn1n(C2CCN(CC2)C2CCCC2)c(=O)c2c(cccc12)C(N)=O
Show InChI InChI=1S/C19H26N4O2/c1-21-16-8-4-7-15(18(20)24)17(16)19(25)23(21)14-9-11-22(12-10-14)13-5-2-3-6-13/h4,7-8,13-14H,2-3,5-6,9-12H2,1H3,(H2,20,24)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 130n/an/an/an/an/a37



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167428
PNG
(US9073893, 64)
Show SMILES NC(=O)c1cccc2[nH]n(C3CCN(CC4CCC=CC4)CC3)c(=O)c12 |c:18|
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 150n/an/an/an/an/a37



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167411
PNG
(US9073893, 4)
Show SMILES NC(=O)c1cccc2[nH]n(C3CCN(CC3)C3CCC(F)(F)CC3)c(=O)c12
Show InChI InChI=1S/C19H24F2N4O2/c20-19(21)8-4-12(5-9-19)24-10-6-13(7-11-24)25-18(27)16-14(17(22)26)2-1-3-15(16)23-25/h1-3,12-13,23H,4-11H2,(H2,22,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 150n/an/an/an/an/a37



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167425
PNG
(US9073893, 33)
Show SMILES Cn1n(C2CCN(CC3CCCCC3)CC2)c(=O)c2c(cccc12)C(N)=O
Show InChI InChI=1S/C21H30N4O2/c1-23-18-9-5-8-17(20(22)26)19(18)21(27)25(23)16-10-12-24(13-11-16)14-15-6-3-2-4-7-15/h5,8-9,15-16H,2-4,6-7,10-14H2,1H3,(H2,22,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 190n/an/an/an/an/a37



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167429
PNG
(US9073893, 66)
Show SMILES NC(=O)c1cccc2[nH]n(C3CCN(Cc4ccco4)CC3)c(=O)c12
Show InChI InChI=1S/C18H20N4O3/c19-17(23)14-4-1-5-15-16(14)18(24)22(20-15)12-6-8-21(9-7-12)11-13-3-2-10-25-13/h1-5,10,12,20H,6-9,11H2,(H2,19,23)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 230n/an/an/an/an/a37



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167410
PNG
(US9073893, 3)
Show SMILES NC(=O)c1cccc2[nH]n(C3CCN(CC3)C3CCCCC3)c(=O)c12
Show InChI InChI=1S/C19H26N4O2/c20-18(24)15-7-4-8-16-17(15)19(25)23(21-16)14-9-11-22(12-10-14)13-5-2-1-3-6-13/h4,7-8,13-14,21H,1-3,5-6,9-12H2,(H2,20,24)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 230n/an/an/an/an/a37



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167409
PNG
(US9073893, 2)
Show SMILES NC(=O)c1cccc2[nH]n(C3CCN(CC3)C3CCCC3)c(=O)c12
Show InChI InChI=1S/C18H24N4O2/c19-17(23)14-6-3-7-15-16(14)18(24)22(20-15)13-8-10-21(11-9-13)12-4-1-2-5-12/h3,6-7,12-13,20H,1-2,4-5,8-11H2,(H2,19,23)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 240n/an/an/an/an/a37



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167423
PNG
(US9073893, 23)
Show SMILES NC(=O)c1cc(F)cc2[nH]n(C3CCN(CC3)C3CCCCC3)c(=O)c12
Show InChI InChI=1S/C19H25FN4O2/c20-12-10-15(18(21)25)17-16(11-12)22-24(19(17)26)14-6-8-23(9-7-14)13-4-2-1-3-5-13/h10-11,13-14,22H,1-9H2,(H2,21,25)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 340n/an/an/an/an/a37



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167415
PNG
(US9073893, 8)
Show SMILES CN1CCC(CC1)n1[nH]c2cccc(C(N)=O)c2c1=O
Show InChI InChI=1S/C14H18N4O2/c1-17-7-5-9(6-8-17)18-14(20)12-10(13(15)19)3-2-4-11(12)16-18/h2-4,9,16H,5-8H2,1H3,(H2,15,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 600n/an/an/an/an/a37



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167431
PNG
(US9073893, 67)
Show SMILES Cn1n(C2CCN(Cc3ccco3)CC2)c(=O)c2c(cccc12)C(N)=O
Show InChI InChI=1S/C19H22N4O3/c1-21-16-6-2-5-15(18(20)24)17(16)19(25)23(21)13-7-9-22(10-8-13)12-14-4-3-11-26-14/h2-6,11,13H,7-10,12H2,1H3,(H2,20,24)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.30E+3n/an/an/an/an/a37



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167418
PNG
(US9073893, 16)
Show SMILES NC(=O)c1cccc2[nH]n(C3CCN(CC3)C3CCC3)c(=O)c12
Show InChI InChI=1S/C17H22N4O2/c18-16(22)13-5-2-6-14-15(13)17(23)21(19-14)12-7-9-20(10-8-12)11-3-1-4-11/h2,5-6,11-12,19H,1,3-4,7-10H2,(H2,18,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2.50E+3n/an/an/an/an/a37



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167431
PNG
(US9073893, 67)
Show SMILES Cn1n(C2CCN(Cc3ccco3)CC2)c(=O)c2c(cccc12)C(N)=O
Show InChI InChI=1S/C19H22N4O3/c1-21-16-6-2-5-15(18(20)24)17(16)19(25)23(21)13-7-9-22(10-8-13)12-14-4-3-11-26-14/h2-6,11,13H,7-10,12H2,1H3,(H2,20,24)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 15n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM167414
PNG
(US9073893, 7)
Show SMILES Cn1n(C2CCN(CC2)C2CCCC2)c(=O)c2c(cccc12)C(N)=O
Show InChI InChI=1S/C19H26N4O2/c1-21-16-8-4-7-15(18(20)24)17(16)19(25)23(21)14-9-11-22(12-10-14)13-5-2-3-6-13/h4,7-8,13-14H,2-3,5-6,9-12H2,1H3,(H2,20,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 50n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM167420
PNG
(US9073893, 20)
Show SMILES NC(=O)c1cc(F)cc2[nH]n(C3CCNCC3)c(=O)c12
Show InChI InChI=1S/C13H15FN4O2/c14-7-5-9(12(15)19)11-10(6-7)17-18(13(11)20)8-1-3-16-4-2-8/h5-6,8,16-17H,1-4H2,(H2,15,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 300n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP3 [R100H]


(Homo sapiens (Human))		BDBM167420
PNG
(US9073893, 20)
Show SMILES NC(=O)c1cc(F)cc2[nH]n(C3CCNCC3)c(=O)c12
Show InChI InChI=1S/C13H15FN4O2/c14-7-5-9(12(15)19)11-10(6-7)17-18(13(11)20)8-1-3-16-4-2-8/h5-6,8,16-17H,1-4H2,(H2,15,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 50n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP3 [R100H]


(Homo sapiens (Human))		BDBM167421
PNG
(US9073893, 21)
Show SMILES Cn1n(C2CCNCC2)c(=O)c2c(cc(F)cc12)C(N)=O
Show InChI InChI=1S/C14H17FN4O2/c1-18-11-7-8(15)6-10(13(16)20)12(11)14(21)19(18)9-2-4-17-5-3-9/h6-7,9,17H,2-5H2,1H3,(H2,16,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 40n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167412
PNG
(US9073893, 5)
Show SMILES Cn1n(C2CCN(CC2)C2CCCCC2)c(=O)c2c(cccc12)C(N)=O
Show InChI InChI=1S/C20H28N4O2/c1-22-17-9-5-8-16(19(21)25)18(17)20(26)24(22)15-10-12-23(13-11-15)14-6-3-2-4-7-14/h5,8-9,14-15H,2-4,6-7,10-13H2,1H3,(H2,21,25)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a<10n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM167412
PNG
(US9073893, 5)
Show SMILES Cn1n(C2CCN(CC2)C2CCCCC2)c(=O)c2c(cccc12)C(N)=O
Show InChI InChI=1S/C20H28N4O2/c1-22-17-9-5-8-16(19(21)25)18(17)20(26)24(22)15-10-12-23(13-11-15)14-6-3-2-4-7-14/h5,8-9,14-15H,2-4,6-7,10-13H2,1H3,(H2,21,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 540n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM167421
PNG
(US9073893, 21)
Show SMILES Cn1n(C2CCNCC2)c(=O)c2c(cc(F)cc12)C(N)=O
Show InChI InChI=1S/C14H17FN4O2/c1-18-11-7-8(15)6-10(13(16)20)12(11)14(21)19(18)9-2-4-17-5-3-9/h6-7,9,17H,2-5H2,1H3,(H2,16,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 70n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167414
PNG
(US9073893, 7)
Show SMILES Cn1n(C2CCN(CC2)C2CCCC2)c(=O)c2c(cccc12)C(N)=O
Show InChI InChI=1S/C19H26N4O2/c1-21-16-8-4-7-15(18(20)24)17(16)19(25)23(21)14-9-11-22(12-10-14)13-5-2-3-6-13/h4,7-8,13-14H,2-3,5-6,9-12H2,1H3,(H2,20,24)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a<10n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167424
PNG
(US9073893, 31)
Show SMILES NC(=O)c1cccc2[nH]n(C3CCN(CC4CCCCC4)CC3)c(=O)c12
Show InChI InChI=1S/C20H28N4O2/c21-19(25)16-7-4-8-17-18(16)20(26)24(22-17)15-9-11-23(12-10-15)13-14-5-2-1-3-6-14/h4,7-8,14-15,22H,1-3,5-6,9-13H2,(H2,21,25)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 60n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM167422
PNG
(US9073893, 22)
Show SMILES Cn1n(C2CCN(CC2)C2CCCCC2)c(=O)c2c(cc(F)cc12)C(N)=O
Show InChI InChI=1S/C20H27FN4O2/c1-23-17-12-13(21)11-16(19(22)26)18(17)20(27)25(23)15-7-9-24(10-8-15)14-5-3-2-4-6-14/h11-12,14-15H,2-10H2,1H3,(H2,22,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 500n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167411
PNG
(US9073893, 4)
Show SMILES NC(=O)c1cccc2[nH]n(C3CCN(CC3)C3CCC(F)(F)CC3)c(=O)c12
Show InChI InChI=1S/C19H24F2N4O2/c20-19(21)8-4-12(5-9-19)24-10-6-13(7-11-24)25-18(27)16-14(17(22)26)2-1-3-15(16)23-25/h1-3,12-13,23H,4-11H2,(H2,22,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 60n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167416
PNG
(US9073893, 9)
Show SMILES Cn1n(C2CCNCC2)c(=O)c2c(cccc12)C(N)=O
Show InChI InChI=1S/C14H18N4O2/c1-17-11-4-2-3-10(13(15)19)12(11)14(20)18(17)9-5-7-16-8-6-9/h2-4,9,16H,5-8H2,1H3,(H2,15,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 14n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167420
PNG
(US9073893, 20)
Show SMILES NC(=O)c1cc(F)cc2[nH]n(C3CCNCC3)c(=O)c12
Show InChI InChI=1S/C13H15FN4O2/c14-7-5-9(12(15)19)11-10(6-7)17-18(13(11)20)8-1-3-16-4-2-8/h5-6,8,16-17H,1-4H2,(H2,15,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a<10n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM167409
PNG
(US9073893, 2)
Show SMILES NC(=O)c1cccc2[nH]n(C3CCN(CC3)C3CCCC3)c(=O)c12
Show InChI InChI=1S/C18H24N4O2/c19-17(23)14-6-3-7-15-16(14)18(24)22(20-15)13-8-10-21(11-9-13)12-4-1-2-5-12/h3,6-7,12-13,20H,1-2,4-5,8-11H2,(H2,19,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 1.49E+3n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM167415
PNG
(US9073893, 8)
Show SMILES CN1CCC(CC1)n1[nH]c2cccc(C(N)=O)c2c1=O
Show InChI InChI=1S/C14H18N4O2/c1-17-7-5-9(6-8-17)18-14(20)12-10(13(15)19)3-2-4-11(12)16-18/h2-4,9,16H,5-8H2,1H3,(H2,15,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 40n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP3 [R100H]


(Homo sapiens (Human))		BDBM167422
PNG
(US9073893, 22)
Show SMILES Cn1n(C2CCN(CC2)C2CCCCC2)c(=O)c2c(cc(F)cc12)C(N)=O
Show InChI InChI=1S/C20H27FN4O2/c1-23-17-12-13(21)11-16(19(22)26)18(17)20(27)25(23)15-7-9-24(10-8-15)14-5-3-2-4-6-14/h11-12,14-15H,2-10H2,1H3,(H2,22,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 270n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167430
PNG
(US9073893, 63)
Show SMILES Cn1n(C2CCN(Cc3cccs3)CC2)c(=O)c2c(cccc12)C(N)=O
Show InChI InChI=1S/C19H22N4O2S/c1-21-16-6-2-5-15(18(20)24)17(16)19(25)23(21)13-7-9-22(10-8-13)12-14-4-3-11-26-14/h2-6,11,13H,7-10,12H2,1H3,(H2,20,24)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a<10n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167429
PNG
(US9073893, 66)
Show SMILES NC(=O)c1cccc2[nH]n(C3CCN(Cc4ccco4)CC3)c(=O)c12
Show InChI InChI=1S/C18H20N4O3/c19-17(23)14-4-1-5-15-16(14)18(24)22(20-15)12-6-8-21(9-7-12)11-13-3-2-10-25-13/h1-5,10,12,20H,6-9,11H2,(H2,19,23)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 140n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167427
PNG
(US9073893, 65)
Show SMILES Cn1n(C2CCN(CC3CCC=CC3)CC2)c(=O)c2c(cccc12)C(N)=O |c:11|
Show InChI InChI=1S/C21H28N4O2/c1-23-18-9-5-8-17(20(22)26)19(18)21(27)25(23)16-10-12-24(13-11-16)14-15-6-3-2-4-7-15/h2-3,5,8-9,15-16H,4,6-7,10-14H2,1H3,(H2,22,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 11n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167413
PNG
(US9073893, 6)
Show SMILES Cn1n(C2CCN(CC2)C2CCC(F)(F)CC2)c(=O)c2c(cccc12)C(N)=O
Show InChI InChI=1S/C20H26F2N4O2/c1-24-16-4-2-3-15(18(23)27)17(16)19(28)26(24)14-7-11-25(12-8-14)13-5-9-20(21,22)10-6-13/h2-4,13-14H,5-12H2,1H3,(H2,23,27)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a<10n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167410
PNG
(US9073893, 3)
Show SMILES NC(=O)c1cccc2[nH]n(C3CCN(CC3)C3CCCCC3)c(=O)c12
Show InChI InChI=1S/C19H26N4O2/c20-18(24)15-7-4-8-16-17(15)19(25)23(21-16)14-9-11-22(12-10-14)13-5-2-1-3-6-13/h4,7-8,13-14,21H,1-3,5-6,9-12H2,(H2,20,24)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 60n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM167423
PNG
(US9073893, 23)
Show SMILES NC(=O)c1cc(F)cc2[nH]n(C3CCN(CC3)C3CCCCC3)c(=O)c12
Show InChI InChI=1S/C19H25FN4O2/c20-12-10-15(18(21)25)17-16(11-12)22-24(19(17)26)14-6-8-23(9-7-14)13-4-2-1-3-5-13/h10-11,13-14,22H,1-9H2,(H2,21,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 5.00E+3n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167428
PNG
(US9073893, 64)
Show SMILES NC(=O)c1cccc2[nH]n(C3CCN(CC4CCC=CC4)CC3)c(=O)c12 |c:18|
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 120n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167426
PNG
(US9073893, 62)
Show SMILES NC(=O)c1cccc2[nH]n(C3CCN(Cc4cccs4)CC3)c(=O)c12
Show InChI InChI=1S/C18H20N4O2S/c19-17(23)14-4-1-5-15-16(14)18(24)22(20-15)12-6-8-21(9-7-12)11-13-3-2-10-25-13/h1-5,10,12,20H,6-9,11H2,(H2,19,23)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 22n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167422
PNG
(US9073893, 22)
Show SMILES Cn1n(C2CCN(CC2)C2CCCCC2)c(=O)c2c(cc(F)cc12)C(N)=O
Show InChI InChI=1S/C20H27FN4O2/c1-23-17-12-13(21)11-16(19(22)26)18(17)20(27)25(23)15-7-9-24(10-8-15)14-5-3-2-4-6-14/h11-12,14-15H,2-10H2,1H3,(H2,22,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a<10n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167418
PNG
(US9073893, 16)
Show SMILES NC(=O)c1cccc2[nH]n(C3CCN(CC3)C3CCC3)c(=O)c12
Show InChI InChI=1S/C17H22N4O2/c18-16(22)13-5-2-6-14-15(13)17(23)21(19-14)12-7-9-20(10-8-12)11-3-1-4-11/h2,5-6,11-12,19H,1,3-4,7-10H2,(H2,18,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 220n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167417
PNG
(US9073893, 14)
Show SMILES CC(C)N1CCC(CC1)n1n(C)c2cccc(C(N)=O)c2c1=O
Show InChI InChI=1S/C17H24N4O2/c1-11(2)20-9-7-12(8-10-20)21-17(23)15-13(16(18)22)5-4-6-14(15)19(21)3/h4-6,11-12H,7-10H2,1-3H3,(H2,18,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 11n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM167417
PNG
(US9073893, 14)
Show SMILES CC(C)N1CCC(CC1)n1n(C)c2cccc(C(N)=O)c2c1=O
Show InChI InChI=1S/C17H24N4O2/c1-11(2)20-9-7-12(8-10-20)21-17(23)15-13(16(18)22)5-4-6-14(15)19(21)3/h4-6,11-12H,7-10H2,1-3H3,(H2,18,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 30n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM167416
PNG
(US9073893, 9)
Show SMILES Cn1n(C2CCNCC2)c(=O)c2c(cccc12)C(N)=O
Show InChI InChI=1S/C14H18N4O2/c1-17-11-4-2-3-10(13(15)19)12(11)14(20)18(17)9-5-7-16-8-6-9/h2-4,9,16H,5-8H2,1H3,(H2,15,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 140n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM167413
PNG
(US9073893, 6)
Show SMILES Cn1n(C2CCN(CC2)C2CCC(F)(F)CC2)c(=O)c2c(cccc12)C(N)=O
Show InChI InChI=1S/C20H26F2N4O2/c1-24-16-4-2-3-15(18(23)27)17(16)19(28)26(24)14-7-11-25(12-8-14)13-5-9-20(21,22)10-6-13/h2-4,13-14H,5-12H2,1H3,(H2,23,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 1.88E+3n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167425
PNG
(US9073893, 33)
Show SMILES Cn1n(C2CCN(CC3CCCCC3)CC2)c(=O)c2c(cccc12)C(N)=O
Show InChI InChI=1S/C21H30N4O2/c1-23-18-9-5-8-17(20(22)26)19(18)21(27)25(23)16-10-12-24(13-11-16)14-15-6-3-2-4-7-15/h5,8-9,15-16H,2-4,6-7,10-14H2,1H3,(H2,22,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 22n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167423
PNG
(US9073893, 23)
Show SMILES NC(=O)c1cc(F)cc2[nH]n(C3CCN(CC3)C3CCCCC3)c(=O)c12
Show InChI InChI=1S/C19H25FN4O2/c20-12-10-15(18(21)25)17-16(11-12)22-24(19(17)26)14-6-8-23(9-7-14)13-4-2-1-3-5-13/h10-11,13-14,22H,1-9H2,(H2,21,25)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 30n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167421
PNG
(US9073893, 21)
Show SMILES Cn1n(C2CCNCC2)c(=O)c2c(cc(F)cc12)C(N)=O
Show InChI InChI=1S/C14H17FN4O2/c1-18-11-7-8(15)6-10(13(16)20)12(11)14(21)19(18)9-2-4-17-5-3-9/h6-7,9,17H,2-5H2,1H3,(H2,16,20)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a<10n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167408
PNG
(US9073893, 1)
Show SMILES NC(=O)c1cccc2[nH]n(C3CCNCC3)c(=O)c12
Show InChI InChI=1S/C13H16N4O2/c14-12(18)9-2-1-3-10-11(9)13(19)17(16-10)8-4-6-15-7-5-8/h1-3,8,15-16H,4-7H2,(H2,14,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 80n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM167408
PNG
(US9073893, 1)
Show SMILES NC(=O)c1cccc2[nH]n(C3CCNCC3)c(=O)c12
Show InChI InChI=1S/C13H16N4O2/c14-12(18)9-2-1-3-10-11(9)13(19)17(16-10)8-4-6-15-7-5-8/h1-3,8,15-16H,4-7H2,(H2,14,18)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 780n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167419
PNG
(US9073893, 18)
Show SMILES Cn1n(C2CCN(CC2)C2CCC2)c(=O)c2c(cccc12)C(N)=O
Show InChI InChI=1S/C18H24N4O2/c1-20-15-7-3-6-14(17(19)23)16(15)18(24)22(20)13-8-10-21(11-9-13)12-4-2-5-12/h3,6-7,12-13H,2,4-5,8-11H2,1H3,(H2,19,23)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a<10n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167409
PNG
(US9073893, 2)
Show SMILES NC(=O)c1cccc2[nH]n(C3CCN(CC3)C3CCCC3)c(=O)c12
Show InChI InChI=1S/C18H24N4O2/c19-17(23)14-6-3-7-15-16(14)18(24)22(20-15)13-8-10-21(11-9-13)12-4-1-2-5-12/h3,6-7,12-13,20H,1-2,4-5,8-11H2,(H2,19,23)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 50n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM167415
PNG
(US9073893, 8)
Show SMILES CN1CCC(CC1)n1[nH]c2cccc(C(N)=O)c2c1=O
Show InChI InChI=1S/C14H18N4O2/c1-17-7-5-9(6-8-17)18-14(20)12-10(13(15)19)3-2-4-11(12)16-18/h2-4,9,16H,5-8H2,1H3,(H2,15,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/a 140n/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...

US Patent US9073893 (2015)


BindingDB Entry DOI: 10.7270/Q2WM1C52
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%