BindingDB logo
myBDB logout

Patent code US9255103

Compile Data Set for Download or QSAR
Found 59 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206006
PNG
(US9255103, 7)
Show SMILES Fc1cccc(C(=O)N2CCn3nc(COc4ccccc4)cc3C2)c1F
Show InChI InChI=1S/C20H17F2N3O2/c21-18-8-4-7-17(19(18)22)20(26)24-9-10-25-15(12-24)11-14(23-25)13-27-16-5-2-1-3-6-16/h1-8,11H,9-10,12-13H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 406n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206025
PNG
(US9255103, 26)
Show SMILES Fc1cc(cc(c1)C(=O)N1CCn2nc(COc3ccccc3)cc2C1)C#N
Show InChI InChI=1S/C21H17FN4O2/c22-17-9-15(12-23)8-16(10-17)21(27)25-6-7-26-19(13-25)11-18(24-26)14-28-20-4-2-1-3-5-20/h1-5,8-11H,6-7,13-14H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 83n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206019
PNG
(US9255103, 20)
Show SMILES Fc1cccc(OCc2cc3CN(CCn3n2)C(=O)c2ncccc2F)c1
Show InChI InChI=1S/C19H16F2N4O2/c20-13-3-1-4-16(9-13)27-12-14-10-15-11-24(7-8-25(15)23-14)19(26)18-17(21)5-2-6-22-18/h1-6,9-10H,7-8,11-12H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.95E+3n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206022
PNG
(US9255103, 23)
Show SMILES Fc1cccc(OCc2cc3CN(CCn3n2)C(=O)c2cncc(F)c2)c1
Show InChI InChI=1S/C19H16F2N4O2/c20-14-2-1-3-18(7-14)27-12-16-8-17-11-24(4-5-25(17)23-16)19(26)13-6-15(21)10-22-9-13/h1-3,6-10H,4-5,11-12H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.37E+3n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206027
PNG
(US9255103, 28)
Show SMILES Fc1ccc(cc1C#N)C(=O)N1CCn2nc(COc3ccccc3)cc2C1
Show InChI InChI=1S/C21H17FN4O2/c22-20-7-6-15(10-16(20)12-23)21(27)25-8-9-26-18(13-25)11-17(24-26)14-28-19-4-2-1-3-5-19/h1-7,10-11H,8-9,13-14H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.66E+3n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206042
PNG
(US9255103, 43)
Show SMILES CC1CN(Cc2cc(COc3ccccc3)nn12)C(=O)c1cccc(c1)C#N
Show InChI InChI=1S/C22H20N4O2/c1-16-13-25(22(27)18-7-5-6-17(10-18)12-23)14-20-11-19(24-26(16)20)15-28-21-8-3-2-4-9-21/h2-11,16H,13-15H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 562n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206048
PNG
(US9255103, 49 | US9255103, 50)
Show SMILES CC1Cn2nc(COc3ccccc3)cc2CN1C(=O)c1cccc(c1)C#N
Show InChI InChI=1S/C22H20N4O2/c1-16-13-26-20(11-19(24-26)15-28-21-8-3-2-4-9-21)14-25(16)22(27)18-7-5-6-17(10-18)12-23/h2-11,16H,13-15H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 437n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206054
PNG
(US9255103, 55)
Show SMILES Fc1ccc(cc1)C(=O)N1CCn2nc(COc3ccccc3)c(Cl)c2C1
Show InChI InChI=1S/C20H17ClFN3O2/c21-19-17(13-27-16-4-2-1-3-5-16)23-25-11-10-24(12-18(19)25)20(26)14-6-8-15(22)9-7-14/h1-9H,10-13H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.95E+3n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206056
PNG
(US9255103, 57)
Show SMILES Cc1c(COc2ccccc2)nn2CCN(Cc12)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H20FN3O2/c1-15-19(14-27-18-5-3-2-4-6-18)23-25-12-11-24(13-20(15)25)21(26)16-7-9-17(22)10-8-16/h2-10H,11-14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.02E+3n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206002
PNG
(US9255103, 3)
Show SMILES Fc1cccc(c1)C(=O)N1CCn2nc(COc3ccccc3)cc2C1
Show InChI InChI=1S/C20H18FN3O2/c21-16-6-4-5-15(11-16)20(25)23-9-10-24-18(13-23)12-17(22-24)14-26-19-7-2-1-3-8-19/h1-8,11-12H,9-10,13-14H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 169n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206013
PNG
(US9255103, 14)
Show SMILES Cc1cccnc1C(=O)N1CCn2nc(COc3cccc(F)c3)cc2C1
Show InChI InChI=1S/C20H19FN4O2/c1-14-4-3-7-22-19(14)20(26)24-8-9-25-17(12-24)11-16(23-25)13-27-18-6-2-5-15(21)10-18/h2-7,10-11H,8-9,12-13H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206029
PNG
(US9255103, 30)
Show SMILES Fc1cccc(OCc2cc3CN(CCn3n2)C(=O)c2cccc(c2)C#N)c1
Show InChI InChI=1S/C21H17FN4O2/c22-17-5-2-6-20(10-17)28-14-18-11-19-13-25(7-8-26(19)24-18)21(27)16-4-1-3-15(9-16)12-23/h1-6,9-11H,7-8,13-14H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 331n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206033
PNG
(US9255103, 34)
Show SMILES Fc1cccc(OCc2cc3CN(CCn3n2)C(=O)c2cnccn2)c1
Show InChI InChI=1S/C18H16FN5O2/c19-13-2-1-3-16(8-13)26-12-14-9-15-11-23(6-7-24(15)22-14)18(25)17-10-20-4-5-21-17/h1-5,8-10H,6-7,11-12H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.02E+3n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206035
PNG
(US9255103, 36)
Show SMILES Fc1cccc(OCc2cc3CN(CCn3n2)C(=O)c2ccnnc2)c1
Show InChI InChI=1S/C18H16FN5O2/c19-14-2-1-3-17(8-14)26-12-15-9-16-11-23(6-7-24(16)22-15)18(25)13-4-5-20-21-10-13/h1-5,8-10H,6-7,11-12H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206046
PNG
(US9255103, 47 | US9255103, 48)
Show SMILES CC1Cn2nc(COc3ccccc3)cc2CN1C(=O)c1cccc(F)c1
Show InChI InChI=1S/C21H20FN3O2/c1-15-12-25-19(11-18(23-25)14-27-20-8-3-2-4-9-20)13-24(15)21(26)16-6-5-7-17(22)10-16/h2-11,15H,12-14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 490n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206048
PNG
(US9255103, 49 | US9255103, 50)
Show SMILES CC1Cn2nc(COc3ccccc3)cc2CN1C(=O)c1cccc(c1)C#N
Show InChI InChI=1S/C22H20N4O2/c1-16-13-26-20(11-19(24-26)15-28-21-8-3-2-4-9-21)14-25(16)22(27)18-7-5-6-17(10-18)12-23/h2-11,16H,13-15H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.75E+3n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206050
PNG
(US9255103, 51 | US9255103, 52)
Show SMILES CC1Cn2nc(COc3ccccc3)cc2CN1C(=O)c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C22H19FN4O2/c1-15-12-27-20(10-19(25-27)14-29-21-5-3-2-4-6-21)13-26(15)22(28)17-7-16(11-24)8-18(23)9-17/h2-10,15H,12-14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 759n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206050
PNG
(US9255103, 51 | US9255103, 52)
Show SMILES CC1Cn2nc(COc3ccccc3)cc2CN1C(=O)c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C22H19FN4O2/c1-15-12-27-20(10-19(25-27)14-29-21-5-3-2-4-6-21)13-26(15)22(28)17-7-16(11-24)8-18(23)9-17/h2-10,15H,12-14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206057
PNG
(US9255103, 58)
Show SMILES Nc1c(COc2ccccc2)nn2CCN(Cc12)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C20H19FN4O2/c21-15-8-6-14(7-9-15)20(26)24-10-11-25-18(12-24)19(22)17(23-25)13-27-16-4-2-1-3-5-16/h1-9H,10-13,22H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4.57E+3n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206001
PNG
(US9255103, 2)
Show SMILES Fc1ccccc1C(=O)N1CCn2nc(COc3ccccc3)cc2C1
Show InChI InChI=1S/C20H18FN3O2/c21-19-9-5-4-8-18(19)20(25)23-10-11-24-16(13-23)12-15(22-24)14-26-17-6-2-1-3-7-17/h1-9,12H,10-11,13-14H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 201n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206008
PNG
(US9255103, 9)
Show SMILES Fc1cccc(OCc2cc3CN(CCn3n2)C(=O)c2ccccc2)c1
Show InChI InChI=1S/C20H18FN3O2/c21-16-7-4-8-19(11-16)26-14-17-12-18-13-23(9-10-24(18)22-17)20(25)15-5-2-1-3-6-15/h1-8,11-12H,9-10,13-14H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 257n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206018
PNG
(US9255103, 19)
Show SMILES CC1N(CCn2nc(COc3ccccc3)cc12)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H20FN3O2/c1-15-20-13-18(14-27-19-5-3-2-4-6-19)23-25(20)12-11-24(15)21(26)16-7-9-17(22)10-8-16/h2-10,13,15H,11-12,14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.07E+3n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206024
PNG
(US9255103, 25)
Show SMILES O=C(N1CCn2nc(COc3ccccc3)cc2C1)c1cccc(c1)C#N
Show InChI InChI=1S/C21H18N4O2/c22-13-16-5-4-6-17(11-16)21(26)24-9-10-25-19(14-24)12-18(23-25)15-27-20-7-2-1-3-8-20/h1-8,11-12H,9-10,14-15H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 457n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206038
PNG
(US9255103, 39)
Show SMILES Fc1ccc(OCc2cc3CN(CCn3n2)C(=O)c2cccc(F)c2)cc1
Show InChI InChI=1S/C20H17F2N3O2/c21-15-4-6-19(7-5-15)27-13-17-11-18-12-24(8-9-25(18)23-17)20(26)14-2-1-3-16(22)10-14/h1-7,10-11H,8-9,12-13H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 209n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206015
PNG
(US9255103, 16 | US9255103, 40 | US9255103, 41)
Show SMILES CC1CN(Cc2cc(COc3ccccc3)nn12)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H20FN3O2/c1-15-12-24(21(26)16-7-9-17(22)10-8-16)13-19-11-18(23-25(15)19)14-27-20-5-3-2-4-6-20/h2-11,15H,12-14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 708n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206043
PNG
(US9255103, 44)
Show SMILES CC1CN(Cc2cc(COc3ccccc3)nn12)C(=O)c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C22H19FN4O2/c1-15-12-26(22(28)17-7-16(11-24)8-18(23)9-17)13-20-10-19(25-27(15)20)14-29-21-5-3-2-4-6-21/h2-10,15H,12-14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 692n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206009
PNG
(US9255103, 10)
Show SMILES Fc1cccc(OCc2cc3CN(CCn3n2)C(=O)c2cccc(F)c2)c1
Show InChI InChI=1S/C20H17F2N3O2/c21-15-4-1-3-14(9-15)20(26)24-7-8-25-18(12-24)11-17(23-25)13-27-19-6-2-5-16(22)10-19/h1-6,9-11H,7-8,12-13H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 269n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206016
PNG
(US9255103, 17 | US9255103, 45 | US9255103, 46)
Show SMILES CC1Cn2nc(COc3ccccc3)cc2CN1C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H20FN3O2/c1-15-12-25-19(11-18(23-25)14-27-20-5-3-2-4-6-20)13-24(15)21(26)16-7-9-17(22)10-8-16/h2-11,15H,12-14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 673n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206021
PNG
(US9255103, 22)
Show SMILES Cc1ncccc1C(=O)N1CCn2nc(COc3cccc(F)c3)cc2C1
Show InChI InChI=1S/C20H19FN4O2/c1-14-19(6-3-7-22-14)20(26)24-8-9-25-17(12-24)11-16(23-25)13-27-18-5-2-4-15(21)10-18/h2-7,10-11H,8-9,12-13H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.91E+3n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206037
PNG
(US9255103, 38)
Show SMILES Fc1ccc(OCc2cc3CN(CCn3n2)C(=O)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H17F2N3O2/c21-15-3-1-14(2-4-15)20(26)24-9-10-25-18(12-24)11-17(23-25)13-27-19-7-5-16(22)6-8-19/h1-8,11H,9-10,12-13H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 295n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206046
PNG
(US9255103, 47 | US9255103, 48)
Show SMILES CC1Cn2nc(COc3ccccc3)cc2CN1C(=O)c1cccc(F)c1
Show InChI InChI=1S/C21H20FN3O2/c1-15-12-25-19(11-18(23-25)14-27-20-8-3-2-4-9-20)13-24(15)21(26)16-6-5-7-17(22)10-16/h2-11,15H,12-14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.07E+3n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206052
PNG
(US9255103, 53)
Show SMILES Fc1ccc(cc1)C(=O)N1CCn2nc(COc3ccccc3)cc2C1C(F)(F)F
Show InChI InChI=1S/C21H17F4N3O2/c22-15-8-6-14(7-9-15)20(29)27-10-11-28-18(19(27)21(23,24)25)12-16(26-28)13-30-17-4-2-1-3-5-17/h1-9,12,19H,10-11,13H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.63E+3n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206053
PNG
(US9255103, 54)
Show SMILES CC(Oc1ccccc1)c1cc2CN(CCn2n1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H20FN3O2/c1-15(27-19-5-3-2-4-6-19)20-13-18-14-24(11-12-25(18)23-20)21(26)16-7-9-17(22)10-8-16/h2-10,13,15H,11-12,14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>3.02E+4n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206007
PNG
(US9255103, 8)
Show SMILES Fc1ccc(C(=O)N2CCn3nc(COc4ccccc4)cc3C2)c(F)c1
Show InChI InChI=1S/C20H17F2N3O2/c21-14-6-7-18(19(22)10-14)20(26)24-8-9-25-16(12-24)11-15(23-25)13-27-17-4-2-1-3-5-17/h1-7,10-11H,8-9,12-13H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 208n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206014
PNG
(US9255103, 15)
Show SMILES Cc1ccc(cn1)C(=O)N1CCn2nc(COc3cccc(F)c3)cc2C1
Show InChI InChI=1S/C20H19FN4O2/c1-14-5-6-15(11-22-14)20(26)24-7-8-25-18(12-24)10-17(23-25)13-27-19-4-2-3-16(21)9-19/h2-6,9-11H,7-8,12-13H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>3.02E+4n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206017
PNG
(US9255103, 18)
Show SMILES CC1(C)CN(Cc2cc(COc3ccccc3)nn12)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H22FN3O2/c1-22(2)15-25(21(27)16-8-10-17(23)11-9-16)13-19-12-18(24-26(19)22)14-28-20-6-4-3-5-7-20/h3-12H,13-15H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 256n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206023
PNG
(US9255103, 24)
Show SMILES Cc1cccc(n1)C(=O)N1CCn2nc(COc3cccc(F)c3)cc2C1
Show InChI InChI=1S/C20H19FN4O2/c1-14-4-2-7-19(22-14)20(26)24-8-9-25-17(12-24)11-16(23-25)13-27-18-6-3-5-15(21)10-18/h2-7,10-11H,8-9,12-13H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.03E+3n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206026
PNG
(US9255103, 27)
Show SMILES Fc1cc(ccc1C#N)C(=O)N1CCn2nc(COc3ccccc3)cc2C1
Show InChI InChI=1S/C21H17FN4O2/c22-20-10-15(6-7-16(20)12-23)21(27)25-8-9-26-18(13-25)11-17(24-26)14-28-19-4-2-1-3-5-19/h1-7,10-11H,8-9,13-14H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>3.02E+4n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206028
PNG
(US9255103, 29)
Show SMILES Clc1cccnc1C(=O)N1CCn2nc(COc3ccccc3)cc2C1
Show InChI InChI=1S/C19H17ClN4O2/c20-17-7-4-8-21-18(17)19(25)23-9-10-24-15(12-23)11-14(22-24)13-26-16-5-2-1-3-6-16/h1-8,11H,9-10,12-13H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206030
PNG
(US9255103, 31)
Show SMILES Fc1cccc(OCc2cc3CN(CCn3n2)C(=O)c2cc(F)cc(c2)C#N)c1
Show InChI InChI=1S/C21H16F2N4O2/c22-16-2-1-3-20(9-16)29-13-18-10-19-12-26(4-5-27(19)25-18)21(28)15-6-14(11-24)7-17(23)8-15/h1-3,6-10H,4-5,12-13H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 170n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206036
PNG
(US9255103, 37)
Show SMILES Cc1ncc(cn1)C(=O)N1CCn2nc(COc3cccc(F)c3)cc2C1
Show InChI InChI=1S/C19H18FN5O2/c1-13-21-9-14(10-22-13)19(26)24-5-6-25-17(11-24)8-16(23-25)12-27-18-4-2-3-15(20)7-18/h2-4,7-10H,5-6,11-12H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>3.02E+4n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206041
PNG
(US9255103, 42)
Show SMILES CC1CN(Cc2cc(COc3ccccc3)nn12)C(=O)c1cccc(F)c1
Show InChI InChI=1S/C21H20FN3O2/c1-15-12-24(21(26)16-6-5-7-17(22)10-16)13-19-11-18(23-25(15)19)14-27-20-8-3-2-4-9-20/h2-11,15H,12-14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 138n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206016
PNG
(US9255103, 17 | US9255103, 45 | US9255103, 46)
Show SMILES CC1Cn2nc(COc3ccccc3)cc2CN1C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H20FN3O2/c1-15-12-25-19(11-18(23-25)14-27-20-5-3-2-4-6-20)13-24(15)21(26)16-7-9-17(22)10-8-16/h2-11,15H,12-14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 240n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206055
PNG
(US9255103, 56)
Show SMILES Fc1c(COc2ccccc2)nn2CCN(Cc12)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C20H17F2N3O2/c21-15-8-6-14(7-9-15)20(26)24-10-11-25-18(12-24)19(22)17(23-25)13-27-16-4-2-1-3-5-16/h1-9H,10-13H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 550n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206000
PNG
(US9255103, 1)
Show SMILES Fc1ccc(cc1)C(=O)N1CCn2nc(COc3ccccc3)cc2C1
Show InChI InChI=1S/C20H18FN3O2/c21-16-8-6-15(7-9-16)20(25)23-10-11-24-18(13-23)12-17(22-24)14-26-19-4-2-1-3-5-19/h1-9,12H,10-11,13-14H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 161n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206011
PNG
(US9255103, 12)
Show SMILES Fc1ccc(cc1)C(=O)N1CCn2nc(COc3cccc(F)c3)cc2C1
Show InChI InChI=1S/C20H17F2N3O2/c21-15-6-4-14(5-7-15)20(26)24-8-9-25-18(12-24)11-17(23-25)13-27-19-3-1-2-16(22)10-19/h1-7,10-11H,8-9,12-13H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 322n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206012
PNG
(US9255103, 13)
Show SMILES Fc1cccc(OCc2cc3CN(CCn3n2)C(=O)c2ccc(F)c(F)c2)c1
Show InChI InChI=1S/C20H16F3N3O2/c21-14-2-1-3-17(9-14)28-12-15-10-16-11-25(6-7-26(16)24-15)20(27)13-4-5-18(22)19(23)8-13/h1-5,8-10H,6-7,11-12H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 587n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206031
PNG
(US9255103, 32)
Show SMILES Fc1cccc(OCc2cc3CN(CCn3n2)C(=O)c2ccc(C#N)c(F)c2)c1
Show InChI InChI=1S/C21H16F2N4O2/c22-16-2-1-3-19(9-16)29-13-17-10-18-12-26(6-7-27(18)25-17)21(28)14-4-5-15(11-24)20(23)8-14/h1-5,8-10H,6-7,12-13H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.78E+3n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206016
PNG
(US9255103, 17 | US9255103, 45 | US9255103, 46)
Show SMILES CC1Cn2nc(COc3ccccc3)cc2CN1C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H20FN3O2/c1-15-12-25-19(11-18(23-25)14-27-20-5-3-2-4-6-20)13-24(15)21(26)16-7-9-17(22)10-8-16/h2-11,15H,12-14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>3.02E+4n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206003
PNG
(US9255103, 4)
Show SMILES Fc1ccc(cc1F)C(=O)N1CCn2nc(COc3ccccc3)cc2C1
Show InChI InChI=1S/C20H17F2N3O2/c21-18-7-6-14(10-19(18)22)20(26)24-8-9-25-16(12-24)11-15(23-25)13-27-17-4-2-1-3-5-17/h1-7,10-11H,8-9,12-13H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 414n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206020
PNG
(US9255103, 21)
Show SMILES Fc1cccc(OCc2cc3CN(CCn3n2)C(=O)c2ncc(F)cc2F)c1
Show InChI InChI=1S/C19H15F3N4O2/c20-12-2-1-3-16(6-12)28-11-14-8-15-10-25(4-5-26(15)24-14)19(27)18-17(22)7-13(21)9-23-18/h1-3,6-9H,4-5,10-11H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.28E+3n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206032
PNG
(US9255103, 33)
Show SMILES Fc1cccc(OCc2cc3CN(CCn3n2)C(=O)c2ccc(F)c(c2)C#N)c1
Show InChI InChI=1S/C21H16F2N4O2/c22-16-2-1-3-19(9-16)29-13-17-10-18-12-26(6-7-27(18)25-17)21(28)14-4-5-20(23)15(8-14)11-24/h1-5,8-10H,6-7,12-13H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.05E+3n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206034
PNG
(US9255103, 35)
Show SMILES Cc1cnc(cn1)C(=O)N1CCn2nc(COc3cccc(F)c3)cc2C1
Show InChI InChI=1S/C19H18FN5O2/c1-13-9-22-18(10-21-13)19(26)24-5-6-25-16(11-24)8-15(23-25)12-27-17-4-2-3-14(20)7-17/h2-4,7-10H,5-6,11-12H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>3.02E+4n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206015
PNG
(US9255103, 16 | US9255103, 40 | US9255103, 41)
Show SMILES CC1CN(Cc2cc(COc3ccccc3)nn12)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H20FN3O2/c1-15-12-24(21(26)16-7-9-17(22)10-8-16)13-19-11-18(23-25(15)19)14-27-20-5-3-2-4-6-20/h2-11,15H,12-14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 162n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206058
PNG
(US9255103, 59)
Show SMILES COc1c(COc2ccccc2)nn2CCN(Cc12)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H20FN3O3/c1-27-20-18(14-28-17-5-3-2-4-6-17)23-25-12-11-24(13-19(20)25)21(26)15-7-9-16(22)10-8-15/h2-10H,11-14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.82E+3n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206004
PNG
(US9255103, 5)
Show SMILES Fc1cc(F)cc(c1)C(=O)N1CCn2nc(COc3ccccc3)cc2C1
Show InChI InChI=1S/C20H17F2N3O2/c21-15-8-14(9-16(22)10-15)20(26)24-6-7-25-18(12-24)11-17(23-25)13-27-19-4-2-1-3-5-19/h1-5,8-11H,6-7,12-13H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 79.6n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206005
PNG
(US9255103, 6)
Show SMILES Fc1cccc(F)c1C(=O)N1CCn2nc(COc3ccccc3)cc2C1
Show InChI InChI=1S/C20H17F2N3O2/c21-17-7-4-8-18(22)19(17)20(26)24-9-10-25-15(12-24)11-14(23-25)13-27-16-5-2-1-3-6-16/h1-8,11H,9-10,12-13H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 292n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206015
PNG
(US9255103, 16 | US9255103, 40 | US9255103, 41)
Show SMILES CC1CN(Cc2cc(COc3ccccc3)nn12)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H20FN3O2/c1-15-12-24(21(26)16-7-9-17(22)10-8-16)13-19-11-18(23-25(15)19)14-27-20-5-3-2-4-6-20/h2-11,15H,12-14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 172n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM206010
PNG
(US9255103, 11)
Show SMILES Fc1ccc(C(=O)N2CCn3nc(COc4cccc(F)c4)cc3C2)c(F)c1
Show InChI InChI=1S/C20H16F3N3O2/c21-13-2-1-3-17(8-13)28-12-15-10-16-11-25(6-7-26(16)24-15)20(27)18-5-4-14(22)9-19(18)23/h1-5,8-10H,6-7,11-12H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 273n/an/a7.4n/a



Vanderbilt University

US Patent


Assay Description
HEK cells transfected with the human mGluR5a receptor (H10H cell line) were plated at 15,000 cells/well in clear-bottomed poly-D-lysine-coated assay ...

US Patent US9255103 (2016)


BindingDB Entry DOI: 10.7270/Q29S1PV6
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%