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Patent code US9340534

Compile Data Set for Download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM227559
PNG
(US9340534, 14)
Show SMILES OC(Cc1cccc(OC(F)(F)F)c1)\C=C\[C@H]1CCS(=O)(=O)N1CCCc1ccc(s1)C(O)=O |r|
Show InChI InChI=1S/C22H24F3NO6S2/c23-22(24,25)32-18-4-1-3-15(14-18)13-17(27)7-6-16-10-12-34(30,31)26(16)11-2-5-19-8-9-20(33-19)21(28)29/h1,3-4,6-9,14,16-17,27H,2,5,10-13H2,(H,28,29)/b7-6+/t16-,17?/m0/s1
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US Patent
n/an/an/an/a 1n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
EP4 receptors couple to Gs and mediate elevations in cAMP concentration, although they do participate in other pathways as well. There are some redun...

US Patent US9340534 (2016)


BindingDB Entry DOI: 10.7270/Q25719WB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM227559
PNG
(US9340534, 14)
Show SMILES OC(Cc1cccc(OC(F)(F)F)c1)\C=C\[C@H]1CCS(=O)(=O)N1CCCc1ccc(s1)C(O)=O |r|
Show InChI InChI=1S/C22H24F3NO6S2/c23-22(24,25)32-18-4-1-3-15(14-18)13-17(27)7-6-16-10-12-34(30,31)26(16)11-2-5-19-8-9-20(33-19)21(28)29/h1,3-4,6-9,14,16-17,27H,2,5,10-13H2,(H,28,29)/b7-6+/t16-,17?/m0/s1
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US Patent
n/an/an/an/a 53n/an/a7.44



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...

US Patent US9340534 (2016)


BindingDB Entry DOI: 10.7270/Q25719WB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM227559
PNG
(US9340534, 14)
Show SMILES OC(Cc1cccc(OC(F)(F)F)c1)\C=C\[C@H]1CCS(=O)(=O)N1CCCc1ccc(s1)C(O)=O |r|
Show InChI InChI=1S/C22H24F3NO6S2/c23-22(24,25)32-18-4-1-3-15(14-18)13-17(27)7-6-16-10-12-34(30,31)26(16)11-2-5-19-8-9-20(33-19)21(28)29/h1,3-4,6-9,14,16-17,27H,2,5,10-13H2,(H,28,29)/b7-6+/t16-,17?/m0/s1
PDB

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US Patent
n/an/an/an/a 96n/an/a7.44



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...

US Patent US9340534 (2016)


BindingDB Entry DOI: 10.7270/Q25719WB
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM227559
PNG
(US9340534, 14)
Show SMILES OC(Cc1cccc(OC(F)(F)F)c1)\C=C\[C@H]1CCS(=O)(=O)N1CCCc1ccc(s1)C(O)=O |r|
Show InChI InChI=1S/C22H24F3NO6S2/c23-22(24,25)32-18-4-1-3-15(14-18)13-17(27)7-6-16-10-12-34(30,31)26(16)11-2-5-19-8-9-20(33-19)21(28)29/h1,3-4,6-9,14,16-17,27H,2,5,10-13H2,(H,28,29)/b7-6+/t16-,17?/m0/s1
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 38n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
EP4 receptors couple to Gs and mediate elevations in cAMP concentration, although they do participate in other pathways as well. There are some redun...

US Patent US9340534 (2016)


BindingDB Entry DOI: 10.7270/Q25719WB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%