Affinity Data by Patent

Patent code US9359293

Found 24 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM234208 (US9359293, TM) Show SMILES Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM234207 (US9359293, TH) Show SMILES Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM234207 (US9359293, TH) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	310	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM234206 (US9359293, TB) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM234206 (US9359293, TB) Show SMILES Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM234205 (US9359293, TA) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM234205 (US9359293, TA) Show SMILES Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.05E+5	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human))	BDBM234207 (US9359293, TH) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.05E+5	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human))	BDBM234206 (US9359293, TB) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.13E+5	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human))	BDBM234208 (US9359293, TM) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.24E+5	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-7 (Homo sapiens (Human))	BDBM234207 (US9359293, TH) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.05E+5	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-7 (Homo sapiens (Human))	BDBM234208 (US9359293, TM) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.05E+5	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6 (Homo sapiens (Human))	BDBM234206 (US9359293, TB) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.05E+5	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6 (Homo sapiens (Human))	BDBM234207 (US9359293, TH) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.05E+5	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-5, mitochondrial (Homo sapiens (Human))	BDBM234207 (US9359293, TH) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.05E+5	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-7 (Homo sapiens (Human))	BDBM234206 (US9359293, TB) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.05E+5	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-7 (Homo sapiens (Human))	BDBM234205 (US9359293, TA) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.05E+5	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6 (Homo sapiens (Human))	BDBM234205 (US9359293, TA) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.05E+5	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human))	BDBM234205 (US9359293, TA) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.05E+5	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-5, mitochondrial (Homo sapiens (Human))	BDBM234205 (US9359293, TA) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.05E+5	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM234208 (US9359293, TM) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.05E+5	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6 (Homo sapiens (Human))	BDBM234208 (US9359293, TM) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.05E+5	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-5, mitochondrial (Homo sapiens (Human))	BDBM234206 (US9359293, TB) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.05E+5	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-5, mitochondrial (Homo sapiens (Human))	BDBM234208 (US9359293, TM) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.05E+5	n/a	n/a	n/a	n/a	8.0	n/a
CORNELL UNIVERSITY US Patent					Assay Description Different concentrations of TA, TB, TH, or TM were pre-incubated with 1 μM of the sirtuin and 1 mM NAD in 20 mM Tris-HCl buffer (pH 8.0) with 1 ...				US Patent US9359293 (2016) BindingDB Entry DOI: 10.7270/Q2QC02CP
CORNELL UNIVERSITY US Patent					More data for this Ligand-Target Pair

Reorder this table by EC50
Reorder this table by IC50
Reorder this table by Kd
Reorder this table by KON
Reorder this table by KOFF
Reorder this table by pH
Reorder this table by T
Reorder this table by ΔH°
Reorder this table by -TΔS°
Change energy units to:kcal/mole

* indicates data uncertainty>20%