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Patent code US9493441

Compile Data Set for Download or QSAR

Found 222 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257392
PNG
(US9493441, 1-3)
Show SMILES CC(C)(C)OC(=O)N1CCC(C1)C(CC#N)n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1
Show InChI InChI=1S/C22H27FN6O3/c1-22(2,3)32-21(31)28-11-9-14(12-28)18(8-10-24)29-13-17(19(25)30)20(27-29)26-16-6-4-15(23)5-7-16/h4-7,13-14,18H,8-9,11-12H2,1-3H3,(H2,25,30)(H,26,27)
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US Patent
n/an/a 267n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257405
PNG
(US9493441, 1-16)
Show SMILES CC(CC#N)n1cc(C(N)=O)c(Nc2ccc(cc2)C(=O)N2CCS(=O)(=O)CC2)n1
Show InChI InChI=1S/C19H22N6O4S/c1-13(6-7-20)25-12-16(17(21)26)18(23-25)22-15-4-2-14(3-5-15)19(27)24-8-10-30(28,29)11-9-24/h2-5,12-13H,6,8-11H2,1H3,(H2,21,26)(H,22,23)
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n/an/a 19n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257406
PNG
(US9493441, 1-17)
Show SMILES CCC(CC#N)n1cc(C(N)=O)c(Nc2ccc(cc2)C(=O)N2CCS(=O)(=O)CC2)n1
Show InChI InChI=1S/C20H24N6O4S/c1-2-16(7-8-21)26-13-17(18(22)27)19(24-26)23-15-5-3-14(4-6-15)20(28)25-9-11-31(29,30)12-10-25/h3-6,13,16H,2,7,9-12H2,1H3,(H2,22,27)(H,23,24)
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n/an/a 19n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257408
PNG
(US9493441, 1-19)
Show SMILES NC(=O)c1cn(nc1Nc1ccccc1)C(CC#N)C1CCC1
Show InChI InChI=1S/C17H19N5O/c18-10-9-15(12-5-4-6-12)22-11-14(16(19)23)17(21-22)20-13-7-2-1-3-8-13/h1-3,7-8,11-12,15H,4-6,9H2,(H2,19,23)(H,20,21)
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n/an/a 31n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257416
PNG
(US9493441, 3-3)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C(C)(CC#N)n1cc(C(N)=O)c(Nc2ccccc2)n1
Show InChI InChI=1S/C24H32N6O3/c1-23(2,3)33-22(32)29-14-10-17(11-15-29)24(4,12-13-25)30-16-19(20(26)31)21(28-30)27-18-8-6-5-7-9-18/h5-9,16-17H,10-12,14-15H2,1-4H3,(H2,26,31)(H,27,28)
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n/an/a 5n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257432
PNG
(US9493441, 4-16)
Show SMILES NC(=O)c1cn(nc1Nc1cccc(c1)C#N)C(CC#N)C1CC1
Show InChI InChI=1S/C17H16N6O/c18-7-6-15(12-4-5-12)23-10-14(16(20)24)17(22-23)21-13-3-1-2-11(8-13)9-19/h1-3,8,10,12,15H,4-6H2,(H2,20,24)(H,21,22)
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n/an/a 19n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257446
PNG
(US9493441, 4-30)
Show SMILES CN1C(=O)c2ccc(Nc3nn(cc3C(N)=O)C(CC#N)C3CC3)cc2C1(C)C
Show InChI InChI=1S/C21H24N6O2/c1-21(2)16-10-13(6-7-14(16)20(29)26(21)3)24-19-15(18(23)28)11-27(25-19)17(8-9-22)12-4-5-12/h6-7,10-12,17H,4-5,8H2,1-3H3,(H2,23,28)(H,24,25)
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n/an/a 15n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257421
PNG
(BDBM257456 | US9493441, 4-5)
Show SMILES NC(=O)c1cn(nc1Nc1ccccc1F)C(CC#N)C1CC1
Show InChI InChI=1S/C16H16FN5O/c17-12-3-1-2-4-13(12)20-16-11(15(19)23)9-22(21-16)14(7-8-18)10-5-6-10/h1-4,9-10,14H,5-7H2,(H2,19,23)(H,20,21)
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n/an/a 360n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257483
PNG
(US9493441, 14-2)
Show SMILES CS(=O)(=O)c1ccc(Nc2nn(cc2C(N)=O)[C@@H](CC#N)C2CC2)cc1 |r|
Show InChI InChI=1S/C17H19N5O3S/c1-26(24,25)13-6-4-12(5-7-13)20-17-14(16(19)23)10-22(21-17)15(8-9-18)11-2-3-11/h4-7,10-11,15H,2-3,8H2,1H3,(H2,19,23)(H,20,21)/t15-/m0/s1
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n/an/a 5n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257495
PNG
(US9493441, 19-1)
Show SMILES NC(=O)c1cn(nc1Nc1ccc2C(=O)NCc2c1)[C@H](CC#N)C1CC1 |r|
Show InChI InChI=1S/C18H18N6O2/c19-6-5-15(10-1-2-10)24-9-14(16(20)25)17(23-24)22-12-3-4-13-11(7-12)8-21-18(13)26/h3-4,7,9-10,15H,1-2,5,8H2,(H2,20,25)(H,21,26)(H,22,23)/t15-/m1/s1
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n/an/a 1n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM257397
PNG
(US9493441, 1-8)
Show SMILES CC(C)(O)c1cn(Cc2cccc(Nc3nn(cc3C(N)=O)C(CC#N)C3CCCC3)c2)nn1
Show InChI InChI=1S/C24H30N8O2/c1-24(2,34)21-15-31(30-28-21)13-16-6-5-9-18(12-16)27-23-19(22(26)33)14-32(29-23)20(10-11-25)17-7-3-4-8-17/h5-6,9,12,14-15,17,20,34H,3-4,7-8,10,13H2,1-2H3,(H2,26,33)(H,27,29)
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n/an/a 999n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM257416
PNG
(US9493441, 3-3)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C(C)(CC#N)n1cc(C(N)=O)c(Nc2ccccc2)n1
Show InChI InChI=1S/C24H32N6O3/c1-23(2,3)33-22(32)29-14-10-17(11-15-29)24(4,12-13-25)30-16-19(20(26)31)21(28-30)27-18-8-6-5-7-9-18/h5-9,16-17H,10-12,14-15H2,1-4H3,(H2,26,31)(H,27,28)
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n/an/a 236n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM257418
PNG
(US9493441, 4-2)
Show SMILES CC(C)(C)OC(=O)N1Cc2cc(Nc3nn(cc3C(N)=O)C(CC#N)C3CC3)ccc2C1=O
Show InChI InChI=1S/C23H26N6O4/c1-23(2,3)33-22(32)28-11-14-10-15(6-7-16(14)21(28)31)26-20-17(19(25)30)12-29(27-20)18(8-9-24)13-4-5-13/h6-7,10,12-13,18H,4-5,8,11H2,1-3H3,(H2,25,30)(H,26,27)
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n/an/a 35n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM257457
PNG
(US9493441, 6-3)
Show SMILES NC(=O)c1cn(nc1Nc1ccc(cc1)S(N)(=O)=O)C(CC#N)C1CC1
Show InChI InChI=1S/C16H18N6O3S/c17-8-7-14(10-1-2-10)22-9-13(15(18)23)16(21-22)20-11-3-5-12(6-4-11)26(19,24)25/h3-6,9-10,14H,1-2,7H2,(H2,18,23)(H,20,21)(H2,19,24,25)
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n/an/a 10n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM257391
PNG
(BDBM257486 | US9493441, 1-2)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C(CC#N)n1cc(C(N)=O)c(Nc2ccccc2)n1
Show InChI InChI=1S/C23H30N6O3/c1-23(2,3)32-22(31)28-13-10-16(11-14-28)19(9-12-24)29-15-18(20(25)30)21(27-29)26-17-7-5-4-6-8-17/h4-8,15-16,19H,9-11,13-14H2,1-3H3,(H2,25,30)(H,26,27)
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n/an/a 601n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM257490
PNG
(US9493441, 17-2)
Show SMILES C[C@H](CC#N)n1cc(C(N)=O)c(Nc2ccccc2)n1 |r|
Show InChI InChI=1S/C14H15N5O/c1-10(7-8-15)19-9-12(13(16)20)14(18-19)17-11-5-3-2-4-6-11/h2-6,9-10H,7H2,1H3,(H2,16,20)(H,17,18)/t10-/m1/s1
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n/an/a 469n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM257491
PNG
(US9493441, 17-3)
Show SMILES NC(=O)c1cn(nc1Nc1ccccc1)[C@@H](CC#N)C1CC1 |r|
Show InChI InChI=1S/C16H17N5O/c17-9-8-14(11-6-7-11)21-10-13(15(18)22)16(20-21)19-12-4-2-1-3-5-12/h1-5,10-11,14H,6-8H2,(H2,18,22)(H,19,20)/t14-/m0/s1
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n/an/a 79n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM257492
PNG
(US9493441, 17-4)
Show SMILES NC(=O)c1cn(nc1Nc1ccnc(F)c1)[C@H](CC#N)C1CC1 |r|
Show InChI InChI=1S/C15H15FN6O/c16-13-7-10(4-6-19-13)20-15-11(14(18)23)8-22(21-15)12(3-5-17)9-1-2-9/h4,6-9,12H,1-3H2,(H2,18,23)(H,19,20,21)/t12-/m1/s1
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n/an/a 16n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257427
PNG
(US9493441, 4-11)
Show SMILES NC(=O)c1cn(nc1Nc1ccc(F)cc1)C(CC#N)C1CC1
Show InChI InChI=1S/C16H16FN5O/c17-11-3-5-12(6-4-11)20-16-13(15(19)23)9-22(21-16)14(7-8-18)10-1-2-10/h3-6,9-10,14H,1-2,7H2,(H2,19,23)(H,20,21)
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n/an/a 9n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257447
PNG
(US9493441, 4-31)
Show SMILES NC(=O)c1cn(nc1Nc1ccc2C(=O)N(CC(F)(F)F)Cc2c1)C(CC#N)C1CC1
Show InChI InChI=1S/C20H19F3N6O2/c21-20(22,23)10-28-8-12-7-13(3-4-14(12)19(28)31)26-18-15(17(25)30)9-29(27-18)16(5-6-24)11-1-2-11/h3-4,7,9,11,16H,1-2,5,8,10H2,(H2,25,30)(H,26,27)
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n/an/a 2n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257451
PNG
(US9493441, 4-35)
Show SMILES NC(=O)c1cn(nc1Nc1ccc2c(C=CS2(=O)=O)c1)C(CC#N)C1CC1 |c:15|
Show InChI InChI=1S/C18H17N5O3S/c19-7-5-15(11-1-2-11)23-10-14(17(20)24)18(22-23)21-13-3-4-16-12(9-13)6-8-27(16,25)26/h3-4,6,8-11,15H,1-2,5H2,(H2,20,24)(H,21,22)
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n/an/a 2n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257459
PNG
(US9493441, 7)
Show SMILES NC(=O)c1cn(nc1Nc1ccc2C(=O)NCc2c1)C(CC#N)C1CC1
Show InChI InChI=1S/C18H18N6O2/c19-6-5-15(10-1-2-10)24-9-14(16(20)25)17(23-24)22-12-3-4-13-11(7-12)8-21-18(13)26/h3-4,7,9-10,15H,1-2,5,8H2,(H2,20,25)(H,21,26)(H,22,23)
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n/an/a 2n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257461
PNG
(US9493441, 9)
Show SMILES CC(Cn1cc(C(N)=O)c(Nc2ccc(F)cc2)n1)C#N
Show InChI InChI=1S/C14H14FN5O/c1-9(6-16)7-20-8-12(13(17)21)14(19-20)18-11-4-2-10(15)3-5-11/h2-5,8-9H,7H2,1H3,(H2,17,21)(H,18,19)
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n/an/a 59n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257473
PNG
(US9493441, 11-11)
Show SMILES CC(OC(=O)N1CCC(CC1)[C@H](CC#N)n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1)C(F)(F)F |r|
Show InChI InChI=1S/C22H24F4N6O3/c1-13(22(24,25)26)35-21(34)31-10-7-14(8-11-31)18(6-9-27)32-12-17(19(28)33)20(30-32)29-16-4-2-15(23)3-5-16/h2-5,12-14,18H,6-8,10-11H2,1H3,(H2,28,33)(H,29,30)/t13?,18-/m0/s1
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n/an/a 46n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM257407
PNG
(US9493441, 1-18)
Show SMILES CC(CC#N)(C1CC1)n1cc(C(N)=O)c(Nc2ccccc2)n1
Show InChI InChI=1S/C17H19N5O/c1-17(9-10-18,12-7-8-12)22-11-14(15(19)23)16(21-22)20-13-5-3-2-4-6-13/h2-6,11-12H,7-9H2,1H3,(H2,19,23)(H,20,21)
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n/an/a 413n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM257421
PNG
(BDBM257456 | US9493441, 4-5)
Show SMILES NC(=O)c1cn(nc1Nc1ccccc1F)C(CC#N)C1CC1
Show InChI InChI=1S/C16H16FN5O/c17-12-3-1-2-4-13(12)20-16-11(15(19)23)9-22(21-16)14(7-8-18)10-5-6-10/h1-4,9-10,14H,5-7H2,(H2,19,23)(H,20,21)
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n/an/a 1.48E+3n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM257428
PNG
(US9493441, 4-12)
Show SMILES COc1cc(Nc2nn(cc2C(N)=O)C(CC#N)C2CC2)ccn1
Show InChI InChI=1S/C16H18N6O2/c1-24-14-8-11(5-7-19-14)20-16-12(15(18)23)9-22(21-16)13(4-6-17)10-2-3-10/h5,7-10,13H,2-4H2,1H3,(H2,18,23)(H,19,20,21)
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n/an/a 66n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM257436
PNG
(US9493441, 4-20)
Show SMILES NC(=O)c1cn(nc1Nc1ccc2OCCOc2c1)C(CC#N)C1CC1
Show InChI InChI=1S/C18H19N5O3/c19-6-5-14(11-1-2-11)23-10-13(17(20)24)18(22-23)21-12-3-4-15-16(9-12)26-8-7-25-15/h3-4,9-11,14H,1-2,5,7-8H2,(H2,20,24)(H,21,22)
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n/an/a 87n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM257442
PNG
(US9493441, 4-26)
Show SMILES Cc1nc(no1)-c1ccc(Nc2nn(cc2C(N)=O)C(CC#N)C2CC2)cc1
Show InChI InChI=1S/C19H19N7O2/c1-11-22-18(25-28-11)13-4-6-14(7-5-13)23-19-15(17(21)27)10-26(24-19)16(8-9-20)12-2-3-12/h4-7,10,12,16H,2-3,8H2,1H3,(H2,21,27)(H,23,24)
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n/an/a 277n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM257444
PNG
(US9493441, 4-28)
Show SMILES NC(=O)c1cn(nc1Nc1ccc(cc1)S(=O)(=O)C(F)(F)F)C(CC#N)C1CC1
Show InChI InChI=1S/C17H16F3N5O3S/c18-17(19,20)29(27,28)12-5-3-11(4-6-12)23-16-13(15(22)26)9-25(24-16)14(7-8-21)10-1-2-10/h3-6,9-10,14H,1-2,7H2,(H2,22,26)(H,23,24)
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n/an/a 75n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM257460
PNG
(US9493441, 8)
Show SMILES NC(=O)c1cn(nc1Nc1ccc2C(=O)N(CC(O)=O)Cc2c1)C(CC#N)C1CC1
Show InChI InChI=1S/C20H20N6O4/c21-6-5-16(11-1-2-11)26-9-15(18(22)29)19(24-26)23-13-3-4-14-12(7-13)8-25(20(14)30)10-17(27)28/h3-4,7,9,11,16H,1-2,5,8,10H2,(H2,22,29)(H,23,24)(H,27,28)
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n/an/a 34n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM257462
PNG
(US9493441, 10)
Show SMILES CC(CC#N)n1cc(C(N)=O)c(Nc2ccc(cc2)S(C)(=O)=O)n1
Show InChI InChI=1S/C15H17N5O3S/c1-10(7-8-16)20-9-13(14(17)21)15(19-20)18-11-3-5-12(6-4-11)24(2,22)23/h3-6,9-10H,7H2,1-2H3,(H2,17,21)(H,18,19)
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n/an/a 45n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257390
PNG
(US9493441, 1-1)
Show SMILES NC(=O)c1cn(nc1Nc1ccccc1)C(CC#N)C1CC1
Show InChI InChI=1S/C16H17N5O/c17-9-8-14(11-6-7-11)21-10-13(15(18)22)16(20-21)19-12-4-2-1-3-5-12/h1-5,10-11,14H,6-8H2,(H2,18,22)(H,19,20)
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n/an/a 10n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257398
PNG
(US9493441, 1-9)
Show SMILES NC(=O)c1cn(nc1Nc1ccccc1)C(CC#N)C1CCOCC1
Show InChI InChI=1S/C18H21N5O2/c19-9-6-16(13-7-10-25-11-8-13)23-12-15(17(20)24)18(22-23)21-14-4-2-1-3-5-14/h1-5,12-13,16H,6-8,10-11H2,(H2,20,24)(H,21,22)
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n/an/a 241n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257411
PNG
(US9493441, 1-22)
Show SMILES C[C@H](C#N)[C@H](C)n1cc(C(N)=O)c(Nc2ccccc2)n1 |r|
Show InChI InChI=1S/C15H17N5O/c1-10(8-16)11(2)20-9-13(14(17)21)15(19-20)18-12-6-4-3-5-7-12/h3-7,9-11H,1-2H3,(H2,17,21)(H,18,19)/t10-,11+/m1/s1
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n/an/a 32n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257413
PNG
(US9493441, 2)
Show SMILES NC(=O)c1cn(nc1Nc1ccccc1)C(CC#N)C(F)(F)F
Show InChI InChI=1S/C14H12F3N5O/c15-14(16,17)11(6-7-18)22-8-10(12(19)23)13(21-22)20-9-4-2-1-3-5-9/h1-5,8,11H,6H2,(H2,19,23)(H,20,21)
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n/an/a 124n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257422
PNG
(US9493441, 4-6)
Show SMILES NC(=O)c1cn(nc1Nc1cccnc1)C(CC#N)C1CC1
Show InChI InChI=1S/C15H16N6O/c16-6-5-13(10-3-4-10)21-9-12(14(17)22)15(20-21)19-11-2-1-7-18-8-11/h1-2,7-10,13H,3-5H2,(H2,17,22)(H,19,20)
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n/an/a 33n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257438
PNG
(US9493441, 4-22)
Show SMILES CN(C)C(=O)c1ccc(Nc2nn(cc2C(N)=O)C(CC#N)C2CC2)cc1
Show InChI InChI=1S/C19H22N6O2/c1-24(2)19(27)13-5-7-14(8-6-13)22-18-15(17(21)26)11-25(23-18)16(9-10-20)12-3-4-12/h5-8,11-12,16H,3-4,9H2,1-2H3,(H2,21,26)(H,22,23)
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n/an/a 3n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257474
PNG
(US9493441, 11-12)
Show SMILES NC(=O)c1cn(nc1Nc1ccc(F)cc1)[C@@H](CC#N)C1CCN(CC1)C(=O)OCC1CCOC1 |r|
Show InChI InChI=1S/C24H29FN6O4/c25-18-1-3-19(4-2-18)28-23-20(22(27)32)13-31(29-23)21(5-9-26)17-6-10-30(11-7-17)24(33)35-15-16-8-12-34-14-16/h1-4,13,16-17,21H,5-8,10-12,14-15H2,(H2,27,32)(H,28,29)/t16?,21-/m0/s1
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n/an/a 181n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257478
PNG
(US9493441, 12-3)
Show SMILES CC(C)COC(=O)N1CCC(CC1)[C@H](CC#N)n1cc(C(N)=O)c(Nc2ccc(F)cc2)n1 |r|
Show InChI InChI=1S/C23H29FN6O3/c1-15(2)14-33-23(32)29-11-8-16(9-12-29)20(7-10-25)30-13-19(21(26)31)22(28-30)27-18-5-3-17(24)4-6-18/h3-6,13,15-16,20H,7-9,11-12,14H2,1-2H3,(H2,26,31)(H,27,28)/t20-/m0/s1
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n/an/a 245n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257480
PNG
(US9493441, 12-5)
Show SMILES NC(=O)c1cn(nc1Nc1ccc(F)cc1)[C@@H](CC#N)C1CCN(CC1)C(=O)OC1CCCCC1 |r|
Show InChI InChI=1S/C25H31FN6O3/c26-18-6-8-19(9-7-18)29-24-21(23(28)33)16-32(30-24)22(10-13-27)17-11-14-31(15-12-17)25(34)35-20-4-2-1-3-5-20/h6-9,16-17,20,22H,1-5,10-12,14-15H2,(H2,28,33)(H,29,30)/t22-/m0/s1
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n/an/a 628n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257498
PNG
(US9493441, 17-1)
Show SMILES C[C@@H](CC#N)n1cc(C(N)=O)c(Nc2ccccc2)n1 |r|
Show InChI InChI=1S/C14H15N5O/c1-10(7-8-15)19-9-12(13(16)20)14(18-19)17-11-5-3-2-4-6-11/h2-6,9-10H,7H2,1H3,(H2,16,20)(H,17,18)/t10-/m0/s1
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n/an/a 224n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM257399
PNG
(US9493441, 1-10)
Show SMILES NC(=O)c1cn(nc1Nc1ccccc1)C(CC#N)CC1CCOCC1
Show InChI InChI=1S/C19H23N5O2/c20-9-6-16(12-14-7-10-26-11-8-14)24-13-17(18(21)25)19(23-24)22-15-4-2-1-3-5-15/h1-5,13-14,16H,6-8,10-12H2,(H2,21,25)(H,22,23)
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n/an/a 1.48E+3n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM257429
PNG
(BDBM257439 | US9493441, 4-13)
Show SMILES CNC(=O)c1ccc(Nc2nn(cc2C(N)=O)C(CC#N)C2CC2)cc1
Show InChI InChI=1S/C18H20N6O2/c1-21-18(26)12-4-6-13(7-5-12)22-17-14(16(20)25)10-24(23-17)15(8-9-19)11-2-3-11/h4-7,10-11,15H,2-3,8H2,1H3,(H2,20,25)(H,21,26)(H,22,23)
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n/an/a 21n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM257451
PNG
(US9493441, 4-35)
Show SMILES NC(=O)c1cn(nc1Nc1ccc2c(C=CS2(=O)=O)c1)C(CC#N)C1CC1 |c:15|
Show InChI InChI=1S/C18H17N5O3S/c19-7-5-15(11-1-2-11)23-10-14(17(20)24)18(22-23)21-13-3-4-16-12(9-13)6-8-27(16,25)26/h3-4,6,8-11,15H,1-2,5H2,(H2,20,24)(H,21,22)
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n/an/a 34n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM257469
PNG
(US9493441, 11-7)
Show SMILES NC(=O)c1cn(nc1Nc1ccc(F)cc1)[C@@H](CC#N)C1CCN(CC1)C(=O)OCC(F)(F)F |r|
Show InChI InChI=1S/C21H22F4N6O3/c22-14-1-3-15(4-2-14)28-19-16(18(27)32)11-31(29-19)17(5-8-26)13-6-9-30(10-7-13)20(33)34-12-21(23,24)25/h1-4,11,13,17H,5-7,9-10,12H2,(H2,27,32)(H,28,29)/t17-/m0/s1
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n/an/a 425n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM257481
PNG
(US9493441, 12-6)
Show SMILES NC(=O)c1cn(nc1Nc1ccc(F)cc1)[C@@H](CC#N)C1CCN(CC1)C(=O)OCc1ccccc1 |r|
Show InChI InChI=1S/C26H27FN6O3/c27-20-6-8-21(9-7-20)30-25-22(24(29)34)16-33(31-25)23(10-13-28)19-11-14-32(15-12-19)26(35)36-17-18-4-2-1-3-5-18/h1-9,16,19,23H,10-12,14-15,17H2,(H2,29,34)(H,30,31)/t23-/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257429
PNG
(BDBM257439 | US9493441, 4-13)
Show SMILES CNC(=O)c1ccc(Nc2nn(cc2C(N)=O)C(CC#N)C2CC2)cc1
Show InChI InChI=1S/C18H20N6O2/c1-21-18(26)12-4-6-13(7-5-12)22-17-14(16(20)25)10-24(23-17)15(8-9-19)11-2-3-11/h4-7,10-11,15H,2-3,8H2,1H3,(H2,20,25)(H,21,26)(H,22,23)
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n/an/a 2n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257435
PNG
(US9493441, 4-19)
Show SMILES NC(=O)c1cn(nc1Nc1ccc2C(=O)CCc2c1)C(CC#N)C1CC1
Show InChI InChI=1S/C19H19N5O2/c20-8-7-16(11-1-2-11)24-10-15(18(21)26)19(23-24)22-13-4-5-14-12(9-13)3-6-17(14)25/h4-5,9-11,16H,1-3,6-7H2,(H2,21,26)(H,22,23)
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n/an/a 2n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
Glutathione S-transferase P/Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM257441
PNG
(US9493441, 4-25)
Show SMILES Cc1nnc(o1)-c1ccc(Nc2nn(cc2C(N)=O)C(CC#N)C2CC2)cc1
Show InChI InChI=1S/C19H19N7O2/c1-11-23-24-19(28-11)13-4-6-14(7-5-13)22-18-15(17(21)27)10-26(25-18)16(8-9-20)12-2-3-12/h4-7,10,12,16H,2-3,8H2,1H3,(H2,21,27)(H,22,25)
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n/an/a 42n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...

US Patent US9493441 (2016)


BindingDB Entry DOI: 10.7270/Q22J69S2
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%