Found 18 hits Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Carbonic anhydrase 2
(259/259 = 100%)† (Homo sapiens (Human)) | BDBM26992
(CHEMBL183495 | SO4(2-) | SODIUM SULFATE | sulfate ...)Show InChI InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 | PDB MMDB
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| >2.00E+8 | >-3.92 | n/a | n/a | n/a | n/a | n/a | 7.5 | 20 |
Universit£ degli Studi di Firenze
| Assay Description Inhibition of Helicobacter pylori alpha carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydrase assay |
Bioorg Med Chem 24: 3413-7 (2016)
Article DOI: 10.1016/j.bmc.2016.05.029 BindingDB Entry DOI: 10.7270/Q2W9583B |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 2
(259/259 = 100%)† (Homo sapiens (Human)) | BDBM50167367
((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pheny...)Show InChI InChI=1S/C12H19BN2O4S/c1-11(2)12(3,4)19-13(18-11)9-5-7-10(8-6-9)15-20(14,16)17/h5-8,15H,1-4H3,(H2,14,16,17) | PDB MMDB
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| 48 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto di Biostrutture e Bioimmagini-CNR
Curated by ChEMBL
| Assay Description Inhibition of full length human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay |
Bioorg Med Chem Lett 20: 3601-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.114 BindingDB Entry DOI: 10.7270/Q2NV9K7Q |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 2
(259/259 = 100%)† (Homo sapiens (Human)) | BDBM50167367
((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pheny...)Show InChI InChI=1S/C12H19BN2O4S/c1-11(2)12(3,4)19-13(18-11)9-5-7-10(8-6-9)15-20(14,16)17/h5-8,15H,1-4H3,(H2,14,16,17) | PDB MMDB
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| 48 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition constant against human recombinant carbonic anhydrase II |
Bioorg Med Chem Lett 15: 3302-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.058 BindingDB Entry DOI: 10.7270/Q2C828V2 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 2
(259/259 = 100%)† (Homo sapiens (Human)) | BDBM26992
(CHEMBL183495 | SO4(2-) | SODIUM SULFATE | sulfate ...)Show InChI InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 | PDB MMDB
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| 8.90E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibitory constant against carbonic anhydrase II |
Bioorg Med Chem Lett 14: 4563-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.073 BindingDB Entry DOI: 10.7270/Q2H995ZD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 2
(259/259 = 100%)† (Homo sapiens (Human)) | BDBM26992
(CHEMBL183495 | SO4(2-) | SODIUM SULFATE | sulfate ...)Show InChI InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 | PDB MMDB
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| 1.83E+8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibitory activity against human Carbonic anhydrase II |
Bioorg Med Chem Lett 15: 567-71 (2005)
Article DOI: 10.1016/j.bmcl.2004.11.056 BindingDB Entry DOI: 10.7270/Q22R3SDV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 2
(259/259 = 100%)† (Homo sapiens (Human)) | BDBM26992
(CHEMBL183495 | SO4(2-) | SODIUM SULFATE | sulfate ...)Show InChI InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 | PDB MMDB
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| >2.00E+8 | n/a | n/a | n/a | n/a | n/a | n/a | 8.3 | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay at pH 8.3 |
Bioorg Med Chem Lett 21: 3591-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.105 BindingDB Entry DOI: 10.7270/Q2930TGN |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 2
(259/259 = 100%)† (Homo sapiens (Human)) | BDBM26992
(CHEMBL183495 | SO4(2-) | SODIUM SULFATE | sulfate ...)Show InChI InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 | PDB MMDB
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| >2.00E+8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibitory constant against carbonic anhydrase II |
Bioorg Med Chem Lett 14: 4563-7 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.073 BindingDB Entry DOI: 10.7270/Q2H995ZD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 2
(259/259 = 100%)† (Homo sapiens (Human)) | BDBM26992
(CHEMBL183495 | SO4(2-) | SODIUM SULFATE | sulfate ...)Show InChI InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 | PDB MMDB
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| >2.00E+8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibitory activity against human carbonic anhydrase II expressed in Escherichia coli |
Bioorg Med Chem Lett 14: 5435-9 (2004)
Checked by Author Article DOI: 10.1016/j.bmcl.2004.07.086 BindingDB Entry DOI: 10.7270/Q2SN09QF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 2
(259/259 = 100%)† (Homo sapiens (Human)) | BDBM26992
(CHEMBL183495 | SO4(2-) | SODIUM SULFATE | sulfate ...)Show InChI InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 | PDB MMDB
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| >2.00E+8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition constant of anion against human carbonic anhydrase isozyme hCA II |
Bioorg Med Chem Lett 14: 5769-73 (2004)
Article DOI: 10.1016/j.bmcl.2004.09.063 BindingDB Entry DOI: 10.7270/Q24X58JJ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 2
(259/259 = 100%)† (Homo sapiens (Human)) | BDBM26992
(CHEMBL183495 | SO4(2-) | SODIUM SULFATE | sulfate ...)Show InChI InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 | PDB MMDB
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| >2.00E+8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto di Biostrutture e Bioimmagini
Curated by ChEMBL
| Assay Description Inhibition of human cytosolic carbonic anhydrase-2 preincubated for 15 mins by stopped flow CO2 hydration assay |
Bioorg Med Chem Lett 23: 1626-30 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.087 BindingDB Entry DOI: 10.7270/Q23X8806 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 2
(259/259 = 100%)† (Homo sapiens (Human)) | BDBM26992
(CHEMBL183495 | SO4(2-) | SODIUM SULFATE | sulfate ...)Show InChI InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 | PDB MMDB
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| >2.00E+8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay |
Bioorg Med Chem Lett 23: 1636-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.084 BindingDB Entry DOI: 10.7270/Q2VD70TX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 2
(259/259 = 100%)† (Homo sapiens (Human)) | BDBM26992
(CHEMBL183495 | SO4(2-) | SODIUM SULFATE | sulfate ...)Show InChI InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 | PDB MMDB
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| >2.00E+8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze
| Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... |
Bioorg Med Chem Lett 19: 1155-8 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.082 BindingDB Entry DOI: 10.7270/Q2KD1W79 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 2
(259/259 = 100%)† (Homo sapiens (Human)) | BDBM26992
(CHEMBL183495 | SO4(2-) | SODIUM SULFATE | sulfate ...)Show InChI InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 | PDB MMDB
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| >2.00E+8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centre Scientifique de Monaco
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 21: 710-4 (2011)
Checked by Author Article DOI: 10.1016/j.bmcl.2010.11.124 BindingDB Entry DOI: 10.7270/Q26D5T7K |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 2
(259/259 = 100%)† (Homo sapiens (Human)) | BDBM26992
(CHEMBL183495 | SO4(2-) | SODIUM SULFATE | sulfate ...)Show InChI InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 | PDB MMDB
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| >2.00E+8 | n/a | n/a | n/a | n/a | n/a | n/a | 7.5 | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5 |
Bioorg Med Chem 19: 1847-51 (2011)
Article DOI: 10.1016/j.bmc.2011.02.015 BindingDB Entry DOI: 10.7270/Q2QN672R |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 2
(259/259 = 100%)† (Homo sapiens (Human)) | BDBM26992
(CHEMBL183495 | SO4(2-) | SODIUM SULFATE | sulfate ...)Show InChI InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 | PDB MMDB
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| >2.00E+8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kochi Medical School
Curated by ChEMBL
| Assay Description Inhibition of human recombinant wild type CA2 by stopped-flow CO2 hydration method |
Bioorg Med Chem Lett 23: 256-60 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.103 BindingDB Entry DOI: 10.7270/Q2ZC846G |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 2
(259/259 = 100%)† (Homo sapiens (Human)) | BDBM26992
(CHEMBL183495 | SO4(2-) | SODIUM SULFATE | sulfate ...)Show InChI InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 | PDB MMDB
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| >2.00E+8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay |
Bioorg Med Chem Lett 22: 7142-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.09.065 BindingDB Entry DOI: 10.7270/Q2930VB8 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 2
(259/259 = 100%)† (Homo sapiens (Human)) | BDBM26992
(CHEMBL183495 | SO4(2-) | SODIUM SULFATE | sulfate ...)Show InChI InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 | PDB MMDB
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| >2.00E+8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ondokuz Mayis University
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 2 by Lineweaver-Burk curves |
Bioorg Med Chem 19: 744-8 (2011)
Article DOI: 10.1016/j.bmc.2010.12.033 BindingDB Entry DOI: 10.7270/Q2ST7QT4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 2
(259/259 = 100%)† (Homo sapiens (Human)) | BDBM26992
(CHEMBL183495 | SO4(2-) | SODIUM SULFATE | sulfate ...)Show InChI InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 | PDB MMDB
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| >3.00E+8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto di Biochimica delle Proteine (IBP)
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay |
Bioorg Med Chem 21: 1465-9 (2013)
Article DOI: 10.1016/j.bmc.2012.09.047 BindingDB Entry DOI: 10.7270/Q20R9QQQ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |