Found 14 hits Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
D-amino-acid oxidase
(347/347 = 100%)† (Homo sapiens (Human)) | BDBM50260725
(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)Show InChI InChI=1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serine |
J Med Chem 56: 3710-24 (2013)
Article DOI: 10.1021/jm4002583 BindingDB Entry DOI: 10.7270/Q2X92CPC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(347/347 = 100%)† (Homo sapiens (Human)) | BDBM50260725
(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)Show InChI InChI=1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | 11.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Healthcare Products B.V.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DAAO expressed in Escherichia coli assessed as H2O2 production from D-serine degradation after 30 mins by fluorescenc... |
Eur J Med Chem 46: 4808-19 (2011)
Article DOI: 10.1016/j.ejmech.2011.04.023 BindingDB Entry DOI: 10.7270/Q2BK1CRC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(347/347 = 100%)† (Homo sapiens (Human)) | BDBM50260725
(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)Show InChI InChI=1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | 145 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Healthcare Products B.V.
Curated by ChEMBL
| Assay Description Inhibition of human DAAO |
Eur J Med Chem 46: 4808-19 (2011)
Article DOI: 10.1016/j.ejmech.2011.04.023 BindingDB Entry DOI: 10.7270/Q2BK1CRC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(347/347 = 100%)† (Homo sapiens (Human)) | BDBM50260725
(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)Show InChI InChI=1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a |
Abbott Healthcare Products B.V.
Curated by ChEMBL
| Assay Description Binding affinity to human recombinant DAAO by isothermal titration calorimeter analysis |
Eur J Med Chem 46: 4808-19 (2011)
Article DOI: 10.1016/j.ejmech.2011.04.023 BindingDB Entry DOI: 10.7270/Q2BK1CRC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(347/347 = 100%)† (Homo sapiens (Human)) | BDBM50260725
(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)Show InChI InChI=1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a |
Abbott Healthcare Products B.V.
Curated by ChEMBL
| Assay Description Binding affinity to human recombinant DAAO by kinetic study scintillation proximity assay |
Eur J Med Chem 46: 4808-19 (2011)
Article DOI: 10.1016/j.ejmech.2011.04.023 BindingDB Entry DOI: 10.7270/Q2BK1CRC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(347/347 = 100%)† (Homo sapiens (Human)) | BDBM50260725
(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)Show InChI InChI=1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a |
Abbott Healthcare Products B.V.
Curated by ChEMBL
| Assay Description Binding affinity to human recombinant DAAO by steady state study scintillation proximity assay |
Eur J Med Chem 46: 4808-19 (2011)
Article DOI: 10.1016/j.ejmech.2011.04.023 BindingDB Entry DOI: 10.7270/Q2BK1CRC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(347/347 = 100%)† (Homo sapiens (Human)) | BDBM50260725
(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)Show InChI InChI=1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DAAO after 30 mins by plate reader analysis |
J Med Chem 56: 3582-92 (2013)
Article DOI: 10.1021/jm400095b BindingDB Entry DOI: 10.7270/Q2HT2QPZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(347/347 = 100%)† (Homo sapiens (Human)) | BDBM50260725
(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)Show InChI InChI=1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Competitive inhibition of human recombinant DAAO after 1 hr by coupled enzyme assay in presence of D-serine |
J Med Chem 56: 3710-24 (2013)
Article DOI: 10.1021/jm4002583 BindingDB Entry DOI: 10.7270/Q2X92CPC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(347/347 = 100%)† (Homo sapiens (Human)) | BDBM50260725
(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)Show InChI InChI=1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Binding affinity to human recombinant DAAO by stopped flow spectrophotometric analysis in presence of FAD |
J Med Chem 56: 3710-24 (2013)
Article DOI: 10.1021/jm4002583 BindingDB Entry DOI: 10.7270/Q2X92CPC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(347/347 = 100%)† (Homo sapiens (Human)) | BDBM50260725
(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)Show InChI InChI=1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Binding affinity to human recombinant DAAO at 490 nm spectral modification by spectrophotometric analysis in presence of FAD |
J Med Chem 56: 3710-24 (2013)
Article DOI: 10.1021/jm4002583 BindingDB Entry DOI: 10.7270/Q2X92CPC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(347/347 = 100%)† (Homo sapiens (Human)) | BDBM50260725
(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)Show InChI InChI=1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Binding affinity to human recombinant DAAO at 520 nm spectral modification by spectrophotometric analysis in presence of FAD |
J Med Chem 56: 3710-24 (2013)
Article DOI: 10.1021/jm4002583 BindingDB Entry DOI: 10.7270/Q2X92CPC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(347/347 = 100%)† (Homo sapiens (Human)) | BDBM50260725
(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)Show InChI InChI=1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | 147 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description Inhibition of DAAO (unknown origin) by cell based assay |
J Med Chem 56: 3582-92 (2013)
Article DOI: 10.1021/jm400095b BindingDB Entry DOI: 10.7270/Q2HT2QPZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(347/347 = 100%)† (Homo sapiens (Human)) | BDBM50260725
(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)Show InChI InChI=1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | 245 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Inhibition of human DAO |
Bioorg Med Chem Lett 18: 3386-91 (2008)
Article DOI: 10.1016/j.bmcl.2008.04.020 BindingDB Entry DOI: 10.7270/Q2WQ03KS |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(347/347 = 100%)† (Homo sapiens (Human)) | BDBM50260725
(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)Show InChI InChI=1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of DAAO (unknown origin) |
J Med Chem 56: 3710-24 (2013)
Article DOI: 10.1021/jm4002583 BindingDB Entry DOI: 10.7270/Q2X92CPC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |