Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA damage-binding protein 1/Protein cereblon (439/451 = 97%)† (Homo sapiens (Human)) | BDBM65454![]() (191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | 8.0 | 70 |
Celgene | Assay Description Thermal stabilities of CRBN-DDB1 in the presence or absence of phthalimide, thalidomide, lenalidomide and pomalidomide were done in the presence of S... | Leukemia 26: 2326-35 (2012) Article DOI: 10.1038/leu.2012.119 BindingDB Entry DOI: 10.7270/Q26971RH | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
DNA damage-binding protein 1/Protein cereblon (439/451 = 97%)† (Homo sapiens (Human)) | BDBM65454![]() (191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Celgene Corporation | Assay Description The 6XHis-tagged full length human CRBN bound to full length human DDB1 used in the assay was purified as described elsewhere with the exception that... | J Med Chem 61: 535-542 (2017) Article DOI: 10.1021/acs.jmedchem.6b01921 BindingDB Entry DOI: 10.7270/Q2PC30HG | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Protein cereblon (403/407 > 99%)† (Homo sapiens (Human)) | BDBM65454![]() (191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene | Assay Description To measure compound binding to endogenous CRBN. | Leukemia 26: 2326-35 (2012) Article DOI: 10.1038/leu.2012.119 BindingDB Entry DOI: 10.7270/Q26971RH | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |