Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nitric oxide synthase, endothelial (443/444 > 99%)† (Bos taurus (bovine)) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 720 | -35.6 | n/a | n/a | n/a | n/a | n/a | 7.5 | 30 |
Northwestern University | Assay Description Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401... | J Med Chem 50: 2089-99 (2007) Article DOI: 10.1021/jm061305c BindingDB Entry DOI: 10.7270/Q2W0947W | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nitric oxide synthase, endothelial (414/444 = 93%)† (Homo sapiens (Human)) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development Curated by ChEMBL | Assay Description Inhibitory activity against human endothelial nitric oxide synthase (eNOS) isoenzyme. | J Med Chem 41: 2858-71 (1998) Article DOI: 10.1021/jm980072p BindingDB Entry DOI: 10.7270/Q2862H4X | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nitric oxide synthase, endothelial (443/444 > 99%)† (Bos taurus (bovine)) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 750 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Curated by ChEMBL | Assay Description Inhibition of bovine recombinant eNOS | J Med Chem 53: 7804-24 (2010) Article DOI: 10.1021/jm100947x BindingDB Entry DOI: 10.7270/Q2NC61FT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nitric oxide synthase, endothelial (414/444 = 93%)† (Homo sapiens (Human)) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of cloned (from RNA) human endothelial constitutive Endothelial nitric oxide synthase (heNOS) | J Med Chem 41: 3675-83 (1998) Article DOI: 10.1021/jm970840x BindingDB Entry DOI: 10.7270/Q2XP75MP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nitric oxide synthase, endothelial (414/444 = 93%)† (Homo sapiens (Human)) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering AG Curated by ChEMBL | Assay Description Inhibitory concentration against recombinant human Endothelial nitric oxide synthase | Bioorg Med Chem Lett 13: 1981-4 (2003) BindingDB Entry DOI: 10.7270/Q2FN16QG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nitric oxide synthase, endothelial (414/444 = 93%)† (Homo sapiens (Human)) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering AG Curated by ChEMBL | Assay Description In vitro inhibition of endothelial nitric oxide synthase. | Bioorg Med Chem Lett 12: 2561-4 (2002) BindingDB Entry DOI: 10.7270/Q2VD6XS8 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nitric oxide synthase, endothelial (443/444 > 99%)† (Bos taurus (bovine)) | BDBM50225106 ((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibitory activity of conversion of radiolabeled arginine to citrulline by isomeric form of nitric oxide synthase Endothelial nitric oxide synthase ... | J Med Chem 41: 2636-42 (1998) Article DOI: 10.1021/jm980073h BindingDB Entry DOI: 10.7270/Q26Q1WD7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |