Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Fructose-1,6-bisphosphatase 1 (333/337 = 99%)† (Homo sapiens (Human)) | BDBM18137 (AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Inhibition of FBPase in human liver using fructose-2,6phosphate as a substrate | Bioorg Med Chem Lett 20: 594-9 (2010) Article DOI: 10.1016/j.bmcl.2009.11.093 BindingDB Entry DOI: 10.7270/Q27H1JPX | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Fructose-1,6-bisphosphatase 1 (333/337 = 99%)† (Homo sapiens (Human)) | BDBM18137 (AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Inhibition of FBPase in human liver | Bioorg Med Chem Lett 20: 594-9 (2010) Article DOI: 10.1016/j.bmcl.2009.11.093 BindingDB Entry DOI: 10.7270/Q27H1JPX | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Fructose-1,6-bisphosphatase 1 (333/337 = 99%)† (Homo sapiens (Human)) | BDBM18137 (AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research Curated by ChEMBL | Assay Description Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase. | Bioorg Med Chem Lett 11: 17-21 (2001) BindingDB Entry DOI: 10.7270/Q2HD7W52 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Fructose-1,6-bisphosphatase 1 (333/337 = 99%)† (Homo sapiens (Human)) | BDBM18137 (AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry | J Med Chem 52: 2880-98 (2009) Article DOI: 10.1021/jm900078f BindingDB Entry DOI: 10.7270/Q2V40V20 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Fructose-1,6-bisphosphatase 1 (305/336 = 91%)† (Sus scrofa (Pig)) | BDBM18137 (AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boston College Curated by ChEMBL | Assay Description Inhibition of pig kidney fructose-1,6-bisphosphatase expressed in Escherichia coli BL21 (DE3) assessed as reduction of NADP+ to NADPH by phosphogluco... | Eur J Med Chem 45: 1478-84 (2010) Article DOI: 10.1016/j.ejmech.2009.12.055 BindingDB Entry DOI: 10.7270/Q2445MMN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Fructose-1,6-bisphosphatase 1 (305/336 = 91%)† (Sus scrofa (Pig)) | BDBM18137 (AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boston College Curated by ChEMBL | Assay Description Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry | Bioorg Med Chem 17: 3916-22 (2009) Article DOI: 10.1016/j.bmc.2009.04.030 BindingDB Entry DOI: 10.7270/Q25T3KGW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Fructose-1,6-bisphosphatase 1 (333/337 = 99%)† (Homo sapiens (Human)) | BDBM18137 (AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Medical Sciences& Peking Union Medical College Curated by ChEMBL | Assay Description Inhibition of human recombinant FBPase expressed in Escherichia coli BL21(DE3) by phosphoglucose isomerase and glucose-6-phosphate dehydrogenase coup... | Bioorg Med Chem 22: 1850-62 (2014) Article DOI: 10.1016/j.bmc.2014.01.047 BindingDB Entry DOI: 10.7270/Q2B56M79 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Fructose-1,6-bisphosphatase 1 (333/337 = 99%)† (Homo sapiens (Human)) | BDBM18137 (AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Medical Sciences&Peking Union Medical College Curated by ChEMBL | Assay Description Inhibition of human liver FBPase expressed in Escherichia coli BL21(DE3) Rosetta cells assessed as reduction of NADP+ to NADPH by phosphoglucose isom... | Eur J Med Chem 90: 394-405 (2015) Article DOI: 10.1016/j.ejmech.2014.11.049 BindingDB Entry DOI: 10.7270/Q2CJ8G7H | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Fructose-1,6-bisphosphatase 1 (333/337 = 99%)† (Homo sapiens (Human)) | BDBM18137 (AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 9.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boston College Curated by ChEMBL | Assay Description Inhibition of human liver fructose-1,6-bisphosphatase expressed in Escherichia coli BL21 (DE3) assessed as reduction of NADP+ to NADPH by phosphogluc... | Eur J Med Chem 45: 1478-84 (2010) Article DOI: 10.1016/j.ejmech.2009.12.055 BindingDB Entry DOI: 10.7270/Q2445MMN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |