Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gag-Pol polyprotein [588-1027]/[588-1147] (439/440 > 99%)† (Human immunodeficiency virus type 1) | BDBM12078 (6-Chloro-4-cyclohexyloxy-3-propyl-1H-quinol-2-one ...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 710 | n/a | n/a | n/a | n/a | 7.8 | 22 |
University of Oxford | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 47: 5912-22 (2004) Article DOI: 10.1021/jm040071z BindingDB Entry DOI: 10.7270/Q2ZG6QGC | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Gag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C] (438/440 > 99%)† (Human immunodeficiency virus type 1) | BDBM12078 (6-Chloro-4-cyclohexyloxy-3-propyl-1H-quinol-2-one ...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 1.13E+3 | n/a | n/a | n/a | n/a | 7.8 | 22 |
University of Oxford | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 47: 5912-22 (2004) Article DOI: 10.1021/jm040071z BindingDB Entry DOI: 10.7270/Q2ZG6QGC | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Gag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I] (438/440 > 99%)† (Human immunodeficiency virus type 1) | BDBM12078 (6-Chloro-4-cyclohexyloxy-3-propyl-1H-quinol-2-one ...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 1.36E+3 | n/a | n/a | n/a | n/a | 7.8 | 22 |
University of Oxford | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 47: 5912-22 (2004) Article DOI: 10.1021/jm040071z BindingDB Entry DOI: 10.7270/Q2ZG6QGC | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |