Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glutaminyl-peptide cyclotransferase (329/329 = 100%)† (Homo sapiens (Human)) | BDBM7949 (Imidazole C-4(5) deriv. 1 | N-[2-(1H-Imidazol-4-yl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | 1.70E+3 | -32.9 | n/a | n/a | n/a | n/a | n/a | 8.0 | 25 |
Academia Sinica | Assay Description The testing for the inhibition activities of imidazole derivatives and cacodylate on gQC and sQC was evaluated at 25 C using the fluorescent substrat... | J Biol Chem 286: 12439-49 (2011) Article DOI: 10.1074/jbc.M110.208595 BindingDB Entry DOI: 10.7270/Q2CN72HS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutaminyl-peptide cyclotransferase (329/329 = 100%)† (Homo sapiens (Human)) | BDBM7949 (Imidazole C-4(5) deriv. 1 | N-[2-(1H-Imidazol-4-yl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | 5.75E+3 | -29.9 | n/a | n/a | n/a | n/a | n/a | 8.0 | 25 |
Academia Sinica | Assay Description The testing for the inhibition activities of imidazole derivatives and cacodylate on gQC and sQC was evaluated at 25 C using the fluorescent substrat... | J Biol Chem 286: 12439-49 (2011) Article DOI: 10.1074/jbc.M110.208595 BindingDB Entry DOI: 10.7270/Q2CN72HS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutaminyl-peptide cyclotransferase (329/329 = 100%)† (Homo sapiens (Human)) | BDBM7949 (Imidazole C-4(5) deriv. 1 | N-[2-(1H-Imidazol-4-yl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | 1.70E+4 | -27.7 | n/a | n/a | n/a | n/a | n/a | 8.0 | 30 |
Probiodrug AG | Assay Description QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM... | J Biol Chem 278: 49773-9 (2003) Article DOI: 10.1074/jbc.M309077200 BindingDB Entry DOI: 10.7270/Q2513WDS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |