Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dipeptidyl peptidase 4 (728/728 = 100%)† (Homo sapiens (Human)) | BDBM11559 (N-({(2S)-1-[(3R)-3-amino-4-(2-fluorophenyl)butanoy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 90 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Santhera Pharmaceuticals | Assay Description The DPP4 activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 370 nm and mea... | Bioorg Med Chem Lett 16: 1744-8 (2006) Article DOI: 10.1016/j.bmcl.2005.11.103 BindingDB Entry DOI: 10.7270/Q2639MZX | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dipeptidyl peptidase 4 (728/728 = 100%)† (Homo sapiens (Human)) | BDBM11559 (N-({(2S)-1-[(3R)-3-amino-4-(2-fluorophenyl)butanoy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article | n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of dipeptidyl peptidase 4 (unknown origin) | Citation and Details Article DOI: 10.1007/s00044-012-0455-6 BindingDB Entry DOI: 10.7270/Q2HH6NZ4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dipeptidyl peptidase 4 (728/728 = 100%)† (Homo sapiens (Human)) | BDBM11559 (N-({(2S)-1-[(3R)-3-amino-4-(2-fluorophenyl)butanoy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Santhera Pharmaceuticals (Switzerland) Ltd Curated by ChEMBL | Assay Description Inhibition of DPP4 by continuous fluorimetric assay | Bioorg Med Chem Lett 19: 4201-3 (2009) Article DOI: 10.1016/j.bmcl.2009.05.109 BindingDB Entry DOI: 10.7270/Q24749XM | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dipeptidyl peptidase 4 (642/728 = 88%)† (Sus scrofa (pig)) | BDBM11559 (N-({(2S)-1-[(3R)-3-amino-4-(2-fluorophenyl)butanoy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 410 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Santhera Pharmaceuticals | Assay Description The DPP4 activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 370 nm and mea... | Bioorg Med Chem Lett 16: 1744-8 (2006) Article DOI: 10.1016/j.bmcl.2005.11.103 BindingDB Entry DOI: 10.7270/Q2639MZX | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |