Found 11 hits Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Acetylcholinesterase
(481/543 = 89%)† (Homo sapiens (Human)) | BDBM50005579
(CHEMBL139148 | Obidoxime)Show InChI InChI=1S/C14H14N4O3/c19-15-9-13-1-5-17(6-2-13)11-21-12-18-7-3-14(4-8-18)10-16-20/h1-10H,11-12H2/p+2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 6.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Grenoble Alpes
Curated by ChEMBL
| Assay Description Inhibition of human recombinant AChE by spectrophotometry based Ellman's assay |
J Med Chem 61: 7630-7639 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00592 BindingDB Entry DOI: 10.7270/Q2RF5XM2 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Acetylcholinesterase
(481/543 = 89%)† (Homo sapiens (Human)) | BDBM50005579
(CHEMBL139148 | Obidoxime)Show InChI InChI=1S/C14H14N4O3/c19-15-9-13-1-5-17(6-2-13)11-21-12-18-7-3-14(4-8-18)10-16-20/h1-10H,11-12H2/p+2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 2.17E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Fourth Military Medical University
Curated by ChEMBL
| Assay Description Inhibition of human AChE using acetylthiocholine as substrate preincubated for 30 mins followed by substrate addition measured every 5 mins for 20 mi... |
Bioorg Med Chem 25: 4497-4505 (2017)
Article DOI: 10.1016/j.bmc.2017.06.041 BindingDB Entry DOI: 10.7270/Q2SJ1P2T |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Acetylcholinesterase
(481/543 = 89%)† (Homo sapiens (Human)) | BDBM50005579
(CHEMBL139148 | Obidoxime)Show InChI InChI=1S/C14H14N4O3/c19-15-9-13-1-5-17(6-2-13)11-21-12-18-7-3-14(4-8-18)10-16-20/h1-10H,11-12H2/p+2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 3.22E+4 | n/a | n/a | n/a | n/a | n/a |
Universit£ de Strasbourg
Curated by ChEMBL
| Assay Description Reactivation of paraoxon-inhibited recombinant human AChE measured up to 10 mins by Ellman's method |
Eur J Med Chem 78: 455-67 (2014)
Article DOI: 10.1016/j.ejmech.2014.03.044 BindingDB Entry DOI: 10.7270/Q2RJ4M0X |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Acetylcholinesterase
(481/543 = 89%)† (Homo sapiens (Human)) | BDBM50005579
(CHEMBL139148 | Obidoxime)Show InChI InChI=1S/C14H14N4O3/c19-15-9-13-1-5-17(6-2-13)11-21-12-18-7-3-14(4-8-18)10-16-20/h1-10H,11-12H2/p+2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 1.95E+4 | n/a | n/a | n/a | n/a | n/a |
Defence Research & Development Establishment (DRDE)
Curated by ChEMBL
| Assay Description Reactivation of sarin-inhibited human acetylcholinesterase assessed as dissociation constant incubated for 60 mins using ATChI substrate by DTNB dye ... |
Bioorg Med Chem 23: 4899-910 (2015)
Article DOI: 10.1016/j.bmc.2015.05.027 BindingDB Entry DOI: 10.7270/Q2GQ70J1 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Acetylcholinesterase
(481/543 = 89%)† (Homo sapiens (Human)) | BDBM50005579
(CHEMBL139148 | Obidoxime)Show InChI InChI=1S/C14H14N4O3/c19-15-9-13-1-5-17(6-2-13)11-21-12-18-7-3-14(4-8-18)10-16-20/h1-10H,11-12H2/p+2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 2.02E+4 | n/a | n/a | n/a | n/a | n/a |
Defence Research & Development Establishment (DRDE)
Curated by ChEMBL
| Assay Description Reactivation of O-ethylsarin-inhibited human acetylcholinesterase assessed as dissociation constant incubated for 60 mins using ATChI substrate by DT... |
Bioorg Med Chem 23: 4899-910 (2015)
Article DOI: 10.1016/j.bmc.2015.05.027 BindingDB Entry DOI: 10.7270/Q2GQ70J1 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Acetylcholinesterase
(481/543 = 89%)† (Homo sapiens (Human)) | BDBM50005579
(CHEMBL139148 | Obidoxime)Show InChI InChI=1S/C14H14N4O3/c19-15-9-13-1-5-17(6-2-13)11-21-12-18-7-3-14(4-8-18)10-16-20/h1-10H,11-12H2/p+2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 9.10E+4 | n/a | n/a | n/a | n/a | n/a |
Fourth Military Medical University
Curated by ChEMBL
| Assay Description Reactivation of tabun-induced inhibition of human AChE assessed as dissociation constant using acetylthiocholine as substrate preincubated for 30 min... |
Bioorg Med Chem 25: 4497-4505 (2017)
Article DOI: 10.1016/j.bmc.2017.06.041 BindingDB Entry DOI: 10.7270/Q2SJ1P2T |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Acetylcholinesterase
(481/543 = 89%)† (Homo sapiens (Human)) | BDBM50005579
(CHEMBL139148 | Obidoxime)Show InChI InChI=1S/C14H14N4O3/c19-15-9-13-1-5-17(6-2-13)11-21-12-18-7-3-14(4-8-18)10-16-20/h1-10H,11-12H2/p+2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 5.00E+5 | n/a | n/a | n/a | n/a | n/a |
Universit£ Grenoble Alpes
Curated by ChEMBL
| Assay Description Reactivation of NIMP-inhibited human recombinant AChE assessed as dissociation constant of inhibited enzyme-compound complex incubated for 1 to 10 mi... |
J Med Chem 61: 7630-7639 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00592 BindingDB Entry DOI: 10.7270/Q2RF5XM2 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Acetylcholinesterase
(481/543 = 89%)† (Homo sapiens (Human)) | BDBM50005579
(CHEMBL139148 | Obidoxime)Show InChI InChI=1S/C14H14N4O3/c19-15-9-13-1-5-17(6-2-13)11-21-12-18-7-3-14(4-8-18)10-16-20/h1-10H,11-12H2/p+2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 5.50E+5 | n/a | n/a | n/a | n/a | n/a |
Universit£ Grenoble Alpes
Curated by ChEMBL
| Assay Description Reactivation of ethyl paraoxon-inhibited human recombinant AChE assessed as dissociation constant of inhibited enzyme-compound complex incubated for ... |
J Med Chem 61: 7630-7639 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00592 BindingDB Entry DOI: 10.7270/Q2RF5XM2 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Acetylcholinesterase
(481/543 = 89%)† (Homo sapiens (Human)) | BDBM50005579
(CHEMBL139148 | Obidoxime)Show InChI InChI=1S/C14H14N4O3/c19-15-9-13-1-5-17(6-2-13)11-21-12-18-7-3-14(4-8-18)10-16-20/h1-10H,11-12H2/p+2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 2.50E+5 | n/a | n/a | n/a | n/a | n/a |
Universit£ de Strasbourg
Curated by ChEMBL
| Assay Description Reactivation of tabun-inhibited recombinant human AChE measured up to 10 mins by Ellman's method |
Eur J Med Chem 78: 455-67 (2014)
Article DOI: 10.1016/j.ejmech.2014.03.044 BindingDB Entry DOI: 10.7270/Q2RJ4M0X |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Acetylcholinesterase
(481/543 = 89%)† (Homo sapiens (Human)) | BDBM50005579
(CHEMBL139148 | Obidoxime)Show InChI InChI=1S/C14H14N4O3/c19-15-9-13-1-5-17(6-2-13)11-21-12-18-7-3-14(4-8-18)10-16-20/h1-10H,11-12H2/p+2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 5.40E+4 | n/a | n/a | n/a | n/a | n/a |
Universit£ de Strasbourg
Curated by ChEMBL
| Assay Description Reactivation of methylphosphonothioate VX-inhibited recombinant human AChE measured up to 10 mins by Ellman's method |
Eur J Med Chem 78: 455-67 (2014)
Article DOI: 10.1016/j.ejmech.2014.03.044 BindingDB Entry DOI: 10.7270/Q2RJ4M0X |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Acetylcholinesterase
(481/543 = 89%)† (Homo sapiens (Human)) | BDBM50005579
(CHEMBL139148 | Obidoxime)Show InChI InChI=1S/C14H14N4O3/c19-15-9-13-1-5-17(6-2-13)11-21-12-18-7-3-14(4-8-18)10-16-20/h1-10H,11-12H2/p+2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 1.44E+4 | n/a | n/a | n/a | n/a | n/a |
Defence Research & Development Establishment (DRDE)
Curated by ChEMBL
| Assay Description Reactivation of VX-inhibited human acetylcholinesterase assessed as dissociation constant incubated for 60 mins using ATChI substrate by DTNB dye bas... |
Bioorg Med Chem 23: 4899-910 (2015)
Article DOI: 10.1016/j.bmc.2015.05.027 BindingDB Entry DOI: 10.7270/Q2GQ70J1 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |